|List |< first << previous [record 40 of 217] next >> last >||
|Institutional Source||Beutler Lab|
|Gene Name||claudin 8|
|Is this an essential gene?||Probably non essential (E-score: 0.164)|
|Stock #||R0332 (G1)|
|Chromosomal Location||88560828-88563183 bp(-) (GRCm38)|
|Type of Mutation||synonymous|
|DNA Base Change (assembly)||C to T at 88562358 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000051887 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000049697]|
|Coding Region Coverage||
|Validation Efficiency||100% (63/63)|
|MGI Phenotype||FUNCTION: This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a paracellular cation barrier. [provided by RefSeq, Aug 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cldn8||
(F):5'- AACTGCCACCCGCATCTACTTG -3'
(R):5'- AGAAGCCCTCTACATAGGCTGGAC -3'
(F):5'- AGCCAACAGTCTTTCGATGTG -3'
(R):5'- TCTACATAGGCTGGACCACAG -3'