Incidental Mutation 'R1178:Stk25'
ID 100106
Institutional Source Beutler Lab
Gene Symbol Stk25
Ensembl Gene ENSMUSG00000026277
Gene Name serine/threonine kinase 25 (yeast)
Synonyms SOK-1, Ste20-like, 1500019J11Rik, Ysk1
MMRRC Submission 039250-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1178 (G1)
Quality Score 82
Status Validated
Chromosome 1
Chromosomal Location 93548473-93581937 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 93551111 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140396 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027498] [ENSMUST00000120301] [ENSMUST00000133769] [ENSMUST00000186287]
AlphaFold Q9Z2W1
Predicted Effect probably benign
Transcript: ENSMUST00000027498
SMART Domains Protein: ENSMUSP00000027498
Gene: ENSMUSG00000026277

DomainStartEndE-ValueType
S_TKc 20 270 2.92e-98 SMART
low complexity region 292 314 N/A INTRINSIC
PDB:3W8H|B 355 426 8e-43 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000120301
SMART Domains Protein: ENSMUSP00000112725
Gene: ENSMUSG00000034066

DomainStartEndE-ValueType
B41 40 234 1.48e-66 SMART
FERM_C 238 328 3.29e-35 SMART
FA 332 378 1.13e-15 SMART
low complexity region 409 421 N/A INTRINSIC
low complexity region 440 459 N/A INTRINSIC
low complexity region 462 473 N/A INTRINSIC
low complexity region 478 492 N/A INTRINSIC
RhoGEF 542 728 1.57e-56 SMART
PH 759 857 1.45e-19 SMART
low complexity region 879 890 N/A INTRINSIC
PH 931 1029 2.62e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125778
Predicted Effect probably benign
Transcript: ENSMUST00000133769
SMART Domains Protein: ENSMUSP00000117765
Gene: ENSMUSG00000026277

DomainStartEndE-ValueType
Pfam:Pkinase 20 233 1.7e-63 PFAM
Pfam:Pkinase_Tyr 20 233 2.1e-47 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151068
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154008
Predicted Effect probably benign
Transcript: ENSMUST00000186287
SMART Domains Protein: ENSMUSP00000140396
Gene: ENSMUSG00000026277

DomainStartEndE-ValueType
STYKc 20 107 1.9e-4 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.8%
  • 20x: 91.5%
Validation Efficiency 98% (51/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Germ line null mutants display normal cortical layers and neuronal migration. Acute loss of expression results in impaired neuronal migration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 G T 13: 81,588,156 (GRCm39) probably benign Het
Apcdd1 A T 18: 63,070,168 (GRCm39) Y145F probably damaging Het
Brinp1 C T 4: 68,680,790 (GRCm39) G580E probably damaging Het
Cep128 G A 12: 91,226,929 (GRCm39) T227M probably damaging Het
Cxcr2 A T 1: 74,197,527 (GRCm39) D7V probably benign Het
Dync2h1 C T 9: 7,101,193 (GRCm39) probably benign Het
Eps8 T C 6: 137,499,852 (GRCm39) Q209R possibly damaging Het
Gabrg3 C T 7: 56,384,839 (GRCm39) V241I probably benign Het
Gfpt2 T C 11: 49,714,136 (GRCm39) S298P probably benign Het
Gm6797 T A X: 8,508,004 (GRCm39) noncoding transcript Het
Gp1ba C T 11: 70,532,253 (GRCm39) P673L probably damaging Het
Heatr5b A G 17: 79,120,698 (GRCm39) L742P probably damaging Het
Hgd A G 16: 37,435,756 (GRCm39) I115V possibly damaging Het
Hmgcll1 A T 9: 76,037,613 (GRCm39) D169V probably damaging Het
Ifi202b A T 1: 173,799,788 (GRCm39) I231K probably benign Het
Itpripl1 A G 2: 126,983,819 (GRCm39) I101T probably benign Het
Kcnj9 A G 1: 172,150,530 (GRCm39) V361A probably benign Het
Map4k5 G A 12: 69,863,152 (GRCm39) T567M probably damaging Het
Ncapd3 A G 9: 26,952,717 (GRCm39) D82G probably benign Het
Nup58 A T 14: 60,482,119 (GRCm39) probably benign Het
Or5d16 G A 2: 87,773,490 (GRCm39) L161F probably benign Het
Or8d2b A G 9: 38,789,051 (GRCm39) E193G probably damaging Het
Or8g50 A G 9: 39,648,642 (GRCm39) Y177C probably damaging Het
Pfn2 C T 3: 57,752,766 (GRCm39) V3I probably benign Het
Pirb A T 7: 3,720,637 (GRCm39) L287Q probably benign Het
Pkhd1 C T 1: 20,655,381 (GRCm39) probably null Het
Plekha2 A C 8: 25,549,218 (GRCm39) S189A probably benign Het
Prune2 T C 19: 17,100,469 (GRCm39) V1991A probably benign Het
Psg17 T C 7: 18,548,380 (GRCm39) T464A probably benign Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Rab8b A G 9: 66,760,249 (GRCm39) M125T possibly damaging Het
Rbl1 T A 2: 156,989,575 (GRCm39) M1015L possibly damaging Het
Ryr3 T A 2: 112,794,725 (GRCm39) Q149L probably benign Het
Scn2a C A 2: 65,517,123 (GRCm39) probably benign Het
Sec61g A C 11: 16,454,722 (GRCm39) probably benign Het
Smcr8 G A 11: 60,670,358 (GRCm39) R502H probably damaging Het
Spag16 G A 1: 69,962,817 (GRCm39) probably benign Het
Spink13 A G 18: 62,741,241 (GRCm39) probably benign Het
Syngap1 A G 17: 27,176,779 (GRCm39) N314D probably damaging Het
Tek T C 4: 94,692,524 (GRCm39) C160R probably damaging Het
Tenm2 C T 11: 35,954,004 (GRCm39) G1236R possibly damaging Het
Tll2 T G 19: 41,081,286 (GRCm39) D712A probably damaging Het
Tmprss13 A T 9: 45,239,945 (GRCm39) R84S unknown Het
Ttn A T 2: 76,800,047 (GRCm39) I387N probably damaging Het
Ubr1 T A 2: 120,756,510 (GRCm39) K706* probably null Het
Upk2 A T 9: 44,365,470 (GRCm39) S33T probably benign Het
Usp47 T G 7: 111,709,205 (GRCm39) M1317R possibly damaging Het
Wdr19 T C 5: 65,381,208 (GRCm39) Y411H probably damaging Het
Zfp143 C T 7: 109,674,928 (GRCm39) probably benign Het
Zfp473 T C 7: 44,384,018 (GRCm39) D105G probably benign Het
Zfp474 C T 18: 52,771,814 (GRCm39) Q156* probably null Het
Other mutations in Stk25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01291:Stk25 APN 1 93,551,145 (GRCm39) splice site probably null
IGL02952:Stk25 APN 1 93,553,798 (GRCm39) missense probably damaging 1.00
IGL03144:Stk25 APN 1 93,556,858 (GRCm39) missense probably damaging 1.00
ANU05:Stk25 UTSW 1 93,551,145 (GRCm39) splice site probably null
IGL02980:Stk25 UTSW 1 93,555,390 (GRCm39) missense probably damaging 1.00
PIT4531001:Stk25 UTSW 1 93,552,346 (GRCm39) missense probably benign
R0240:Stk25 UTSW 1 93,554,782 (GRCm39) missense probably damaging 1.00
R0240:Stk25 UTSW 1 93,554,782 (GRCm39) missense probably damaging 1.00
R0555:Stk25 UTSW 1 93,552,313 (GRCm39) missense probably benign 0.00
R1406:Stk25 UTSW 1 93,552,875 (GRCm39) unclassified probably benign
R1493:Stk25 UTSW 1 93,553,322 (GRCm39) missense probably benign 0.04
R2875:Stk25 UTSW 1 93,556,973 (GRCm39) missense possibly damaging 0.91
R4657:Stk25 UTSW 1 93,553,378 (GRCm39) unclassified probably benign
R4668:Stk25 UTSW 1 93,553,205 (GRCm39) missense probably damaging 1.00
R4686:Stk25 UTSW 1 93,551,142 (GRCm39) splice site probably null
R5089:Stk25 UTSW 1 93,552,330 (GRCm39) missense probably benign 0.05
R5493:Stk25 UTSW 1 93,563,031 (GRCm39) missense probably benign
R6013:Stk25 UTSW 1 93,553,181 (GRCm39) critical splice donor site probably null
R8723:Stk25 UTSW 1 93,553,666 (GRCm39) missense probably damaging 1.00
R8905:Stk25 UTSW 1 93,556,929 (GRCm39) missense probably damaging 1.00
R9249:Stk25 UTSW 1 93,552,806 (GRCm39) missense probably benign
R9274:Stk25 UTSW 1 93,552,806 (GRCm39) missense probably benign
X0063:Stk25 UTSW 1 93,553,683 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-01-15