Incidental Mutation 'R1203:Tead3'
ID 100301
Institutional Source Beutler Lab
Gene Symbol Tead3
Ensembl Gene ENSMUSG00000002249
Gene Name TEA domain family member 3
Synonyms DTEF-1, Tcf13r2, TEF-5, ETFR-1, TEAD-3
MMRRC Submission 039273-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1203 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 28550645-28569779 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 28560536 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 23 (A23T)
Ref Sequence ENSEMBL: ENSMUSP00000110447 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114799] [ENSMUST00000154873] [ENSMUST00000156862] [ENSMUST00000219703]
AlphaFold P70210
Predicted Effect probably benign
Transcript: ENSMUST00000114799
AA Change: A23T

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000110447
Gene: ENSMUSG00000002249
AA Change: A23T

DomainStartEndE-ValueType
low complexity region 8 19 N/A INTRINSIC
TEA 52 123 9.04e-52 SMART
low complexity region 150 165 N/A INTRINSIC
low complexity region 181 202 N/A INTRINSIC
low complexity region 208 222 N/A INTRINSIC
low complexity region 227 244 N/A INTRINSIC
PDB:3KYS|C 248 465 1e-120 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127212
Predicted Effect probably benign
Transcript: ENSMUST00000154873
SMART Domains Protein: ENSMUSP00000118582
Gene: ENSMUSG00000002249

DomainStartEndE-ValueType
Pfam:TEA 1 366 3.8e-149 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000156862
SMART Domains Protein: ENSMUSP00000115443
Gene: ENSMUSG00000002249

DomainStartEndE-ValueType
Pfam:TEA 1 366 3.8e-149 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000219703
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.4%
  • 10x: 95.6%
  • 20x: 89.3%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A T 1: 11,588,818 (GRCm39) R78S probably damaging Het
Aadacl3 T C 4: 144,190,140 (GRCm39) T54A probably benign Het
Adcy8 A G 15: 64,618,780 (GRCm39) I791T probably damaging Het
Aldh1b1 A G 4: 45,803,359 (GRCm39) D299G probably damaging Het
Aoah A G 13: 21,000,764 (GRCm39) E66G probably damaging Het
Atl2 G T 17: 80,160,334 (GRCm39) H418N probably damaging Het
Atp6v1d A G 12: 78,908,214 (GRCm39) I7T possibly damaging Het
Calhm3 C T 19: 47,143,839 (GRCm39) V155M probably damaging Het
Carmil1 A T 13: 24,282,989 (GRCm39) I105K probably damaging Het
Csrp3 C A 7: 48,489,278 (GRCm39) M1I probably null Het
Dnah10 T A 5: 124,837,078 (GRCm39) probably null Het
Dnah11 T C 12: 117,897,547 (GRCm39) N3561S possibly damaging Het
Dzip3 A T 16: 48,772,180 (GRCm39) D496E probably damaging Het
Eif2ak1 T C 5: 143,820,797 (GRCm39) V246A probably benign Het
Fam171b T A 2: 83,643,313 (GRCm39) V74E probably benign Het
Gm14137 C T 2: 119,005,605 (GRCm39) R55W probably damaging Het
Gm4950 T C 18: 51,998,830 (GRCm39) I42V probably benign Het
Gpr35 T C 1: 92,910,870 (GRCm39) V194A probably damaging Het
Kdm5d C T Y: 941,011 (GRCm39) S1132F probably damaging Het
Muc4 C A 16: 32,754,529 (GRCm38) H1468N probably benign Het
Ncln A G 10: 81,332,027 (GRCm39) V24A possibly damaging Het
Nphp4 A G 4: 152,573,289 (GRCm39) K76E probably damaging Het
Nsf CAATAATAATAATAATA CAATAATAATAATAATAATA 11: 103,816,952 (GRCm39) probably benign Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or52h2 A T 7: 103,839,060 (GRCm39) L118* probably null Het
Pabpc1l G T 2: 163,879,091 (GRCm39) V313F possibly damaging Het
Pcbd2 G A 13: 55,880,881 (GRCm39) probably null Het
Rapgef6 T A 11: 54,582,525 (GRCm39) V1479D probably benign Het
Rnf43 T C 11: 87,618,301 (GRCm39) probably benign Het
Robo3 A G 9: 37,329,978 (GRCm39) W1113R probably damaging Het
Sall1 A T 8: 89,758,562 (GRCm39) V514E probably damaging Het
Sgpp1 A G 12: 75,763,056 (GRCm39) I375T probably benign Het
Strc T C 2: 121,202,604 (GRCm39) N1187S possibly damaging Het
Tbc1d17 G A 7: 44,492,895 (GRCm39) R363W probably damaging Het
Tbcd A G 11: 121,366,451 (GRCm39) Q242R probably benign Het
Tbcel A C 9: 42,362,947 (GRCm39) V50G probably damaging Het
Tedc2 T A 17: 24,435,291 (GRCm39) E366V probably damaging Het
Tedc2 C A 17: 24,435,292 (GRCm39) E366* probably null Het
Tlcd5 A G 9: 43,022,775 (GRCm39) V193A probably benign Het
Tmem241 G T 18: 12,217,035 (GRCm39) probably benign Het
Tmtc3 G T 10: 100,312,606 (GRCm39) T79K probably damaging Het
Utrn A G 10: 12,362,281 (GRCm39) V241A probably damaging Het
Vps8 A T 16: 21,330,307 (GRCm39) I729F probably damaging Het
Zfp407 C T 18: 84,577,898 (GRCm39) A1072T probably benign Het
Other mutations in Tead3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Tead3 APN 17 28,551,780 (GRCm39) missense possibly damaging 0.91
IGL01752:Tead3 APN 17 28,552,568 (GRCm39) missense probably damaging 1.00
IGL01760:Tead3 APN 17 28,552,055 (GRCm39) missense probably benign 0.07
IGL02868:Tead3 APN 17 28,552,069 (GRCm39) nonsense probably null
IGL02932:Tead3 APN 17 28,560,325 (GRCm39) missense probably damaging 1.00
R0015:Tead3 UTSW 17 28,560,325 (GRCm39) missense probably damaging 1.00
R0376:Tead3 UTSW 17 28,560,339 (GRCm39) missense probably damaging 0.98
R0383:Tead3 UTSW 17 28,553,672 (GRCm39) splice site probably null
R1699:Tead3 UTSW 17 28,553,698 (GRCm39) missense possibly damaging 0.52
R2037:Tead3 UTSW 17 28,555,544 (GRCm39) missense probably damaging 0.98
R2148:Tead3 UTSW 17 28,552,638 (GRCm39) missense probably damaging 1.00
R4871:Tead3 UTSW 17 28,553,962 (GRCm39) missense probably benign 0.42
R4871:Tead3 UTSW 17 28,552,589 (GRCm39) missense probably damaging 1.00
R5070:Tead3 UTSW 17 28,560,451 (GRCm39) missense probably benign 0.06
R5557:Tead3 UTSW 17 28,555,244 (GRCm39) intron probably benign
R5891:Tead3 UTSW 17 28,560,339 (GRCm39) missense probably damaging 0.98
R5991:Tead3 UTSW 17 28,553,352 (GRCm39) splice site probably null
R6335:Tead3 UTSW 17 28,552,299 (GRCm39) missense probably damaging 1.00
R6999:Tead3 UTSW 17 28,560,506 (GRCm39) missense probably benign 0.00
R7165:Tead3 UTSW 17 28,552,228 (GRCm39) missense probably benign 0.00
R7718:Tead3 UTSW 17 28,552,491 (GRCm39) missense probably damaging 1.00
R7743:Tead3 UTSW 17 28,551,801 (GRCm39) missense probably benign 0.06
R8025:Tead3 UTSW 17 28,554,009 (GRCm39) missense probably benign 0.23
R8034:Tead3 UTSW 17 28,552,203 (GRCm39) missense probably damaging 1.00
R8851:Tead3 UTSW 17 28,551,704 (GRCm39) missense probably damaging 0.97
R9245:Tead3 UTSW 17 28,551,709 (GRCm39) missense probably benign 0.34
R9262:Tead3 UTSW 17 28,560,495 (GRCm39) missense probably benign 0.01
X0066:Tead3 UTSW 17 28,560,401 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCTCATCTGACAGGATGATCTTGC -3'
(R):5'- TCCACAGACTGTTTATAGGACCCCG -3'

Sequencing Primer
(F):5'- GATGATCTTGCGCCGTCC -3'
(R):5'- GTTTATAGGACCCCGTGCTCAG -3'
Posted On 2014-01-15