Incidental Mutation 'R1204:Zfp964'
| ID |
100338 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp964
|
| Ensembl Gene |
ENSMUSG00000091764 |
| Gene Name |
zinc finger protein 964 |
| Synonyms |
Gm7187 |
| MMRRC Submission |
039274-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.094)
|
| Stock # |
R1204 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
70107129-70119632 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 70116668 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 423
(I423L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145354
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169125]
[ENSMUST00000204285]
|
| AlphaFold |
B2RR88 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169125
AA Change: I422L
PolyPhen 2
Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000129822
Gene: ENSMUSG00000091764
AA Change: I422L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
56 |
5.24e-18 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
1.28e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000204062
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204285
AA Change: I423L
PolyPhen 2
Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000145354
Gene: ENSMUSG00000091764
AA Change: I423L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
57 |
5.24e-18 |
SMART |
|
ZnF_C2H2
|
217 |
239 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
245 |
267 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
273 |
295 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
413 |
435 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
441 |
463 |
1.28e-3 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.1%
- 20x: 92.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acacb |
A |
T |
5: 114,328,214 (GRCm39) |
I133F |
probably damaging |
Het |
| Acyp1 |
A |
T |
12: 85,326,866 (GRCm39) |
|
probably null |
Het |
| Ermap |
T |
C |
4: 119,046,064 (GRCm39) |
K22R |
possibly damaging |
Het |
| Glce |
T |
C |
9: 61,977,849 (GRCm39) |
T12A |
probably damaging |
Het |
| Hao1 |
G |
A |
2: 134,364,947 (GRCm39) |
R227* |
probably null |
Het |
| Hectd4 |
A |
G |
5: 121,488,548 (GRCm39) |
D3613G |
possibly damaging |
Het |
| Hspa2 |
A |
G |
12: 76,451,641 (GRCm39) |
M112V |
probably benign |
Het |
| Knl1 |
A |
G |
2: 118,901,670 (GRCm39) |
I1124V |
probably benign |
Het |
| Lrch3 |
T |
C |
16: 32,829,584 (GRCm39) |
I738T |
probably damaging |
Het |
| Mgrn1 |
T |
G |
16: 4,725,273 (GRCm39) |
F44V |
probably damaging |
Het |
| Or1af1 |
A |
G |
2: 37,109,651 (GRCm39) |
Q50R |
probably benign |
Het |
| Otog |
G |
A |
7: 45,909,335 (GRCm39) |
V602M |
probably benign |
Het |
| Pik3r5 |
T |
G |
11: 68,385,050 (GRCm39) |
L652V |
probably benign |
Het |
| Pkdrej |
G |
A |
15: 85,702,513 (GRCm39) |
T1141M |
probably damaging |
Het |
| Sema3a |
T |
C |
5: 13,573,142 (GRCm39) |
|
probably benign |
Het |
| Syt3 |
A |
T |
7: 44,042,091 (GRCm39) |
I317F |
probably damaging |
Het |
| Tmem214 |
C |
T |
5: 31,033,134 (GRCm39) |
A509V |
probably damaging |
Het |
| Tmem25 |
T |
C |
9: 44,706,529 (GRCm39) |
E284G |
probably benign |
Het |
| Trim9 |
T |
C |
12: 70,393,501 (GRCm39) |
N148D |
probably damaging |
Het |
| Vmn2r107 |
A |
G |
17: 20,578,031 (GRCm39) |
R447G |
probably benign |
Het |
|
| Other mutations in Zfp964 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00580:Zfp964
|
APN |
8 |
70,112,043 (GRCm39) |
splice site |
probably null |
|
|
R0506:Zfp964
|
UTSW |
8 |
70,116,587 (GRCm39) |
missense |
unknown |
|
|
R0740:Zfp964
|
UTSW |
8 |
70,115,828 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0786:Zfp964
|
UTSW |
8 |
70,116,731 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1158:Zfp964
|
UTSW |
8 |
70,116,503 (GRCm39) |
missense |
unknown |
|
|
R1413:Zfp964
|
UTSW |
8 |
70,115,720 (GRCm39) |
missense |
unknown |
|
|
R1562:Zfp964
|
UTSW |
8 |
70,115,654 (GRCm39) |
missense |
probably benign |
|
|
R1663:Zfp964
|
UTSW |
8 |
70,116,733 (GRCm39) |
splice site |
probably null |
|
|
R1693:Zfp964
|
UTSW |
8 |
70,116,800 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R2029:Zfp964
|
UTSW |
8 |
70,116,567 (GRCm39) |
missense |
unknown |
|
|
R2847:Zfp964
|
UTSW |
8 |
70,116,504 (GRCm39) |
missense |
unknown |
|
|
R2849:Zfp964
|
UTSW |
8 |
70,116,504 (GRCm39) |
missense |
unknown |
|
|
R4111:Zfp964
|
UTSW |
8 |
70,116,754 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4792:Zfp964
|
UTSW |
8 |
70,116,665 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4907:Zfp964
|
UTSW |
8 |
70,115,972 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4938:Zfp964
|
UTSW |
8 |
70,116,758 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5688:Zfp964
|
UTSW |
8 |
70,116,766 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5905:Zfp964
|
UTSW |
8 |
70,116,563 (GRCm39) |
missense |
unknown |
|
|
R6009:Zfp964
|
UTSW |
8 |
70,116,106 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6021:Zfp964
|
UTSW |
8 |
70,115,742 (GRCm39) |
missense |
unknown |
|
|
R6028:Zfp964
|
UTSW |
8 |
70,116,563 (GRCm39) |
missense |
unknown |
|
|
R6374:Zfp964
|
UTSW |
8 |
70,111,994 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6583:Zfp964
|
UTSW |
8 |
70,115,633 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7730:Zfp964
|
UTSW |
8 |
70,116,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8263:Zfp964
|
UTSW |
8 |
70,116,345 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8309:Zfp964
|
UTSW |
8 |
70,115,924 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8889:Zfp964
|
UTSW |
8 |
70,116,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8892:Zfp964
|
UTSW |
8 |
70,116,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9133:Zfp964
|
UTSW |
8 |
70,115,783 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9185:Zfp964
|
UTSW |
8 |
70,115,873 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCGGTACATGAGAACTCACGTTG -3'
(R):5'- ctggactGAATCATTTTCTGGGGCA -3'
Sequencing Primer
(F):5'- tgaatgtaaacgatgtgggaaag -3'
(R):5'- GCATGTAGACATTTGCCtgtgag -3'
|
| Posted On |
2014-01-15 |
Incidental Mutation