Incidental Mutation 'R1205:Or4c107'
ID 100386
Institutional Source Beutler Lab
Gene Symbol Or4c107
Ensembl Gene ENSMUSG00000048226
Gene Name olfactory receptor family 4 subfamily C member 107
Synonyms Olfr1212, MOR233-17, GA_x6K02T2Q125-50437014-50437949, MOR233-20
MMRRC Submission 039275-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R1205 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88788812-88789747 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88788932 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 41 (I41L)
Ref Sequence ENSEMBL: ENSMUSP00000149781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055895] [ENSMUST00000215781]
AlphaFold Q7TR08
Predicted Effect probably benign
Transcript: ENSMUST00000055895
AA Change: I41L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000052837
Gene: ENSMUSG00000048226
AA Change: I41L

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.9e-46 PFAM
Pfam:7tm_1 39 286 7.1e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215781
AA Change: I41L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg6 T A 10: 14,310,083 (GRCm39) N774I probably damaging Het
Bpifc T A 10: 85,817,168 (GRCm39) D230V probably damaging Het
Chrna2 C T 14: 66,380,812 (GRCm39) A27V probably benign Het
Duox1 C T 2: 122,158,406 (GRCm39) Q630* probably null Het
Dzip3 C T 16: 48,772,044 (GRCm39) G542R probably damaging Het
Epha3 ATGAACTGCT AT 16: 63,418,611 (GRCm39) probably null Het
Fnip1 G T 11: 54,393,132 (GRCm39) V523L possibly damaging Het
Hc T A 2: 34,893,536 (GRCm39) D1225V possibly damaging Het
Hnrnpu C T 1: 178,159,734 (GRCm39) probably benign Het
Ift172 C T 5: 31,443,136 (GRCm39) V125I probably benign Het
Kcnip2 T A 19: 45,783,422 (GRCm39) Q93L probably null Het
Kif27 A T 13: 58,492,019 (GRCm39) H373Q probably benign Het
Kl T C 5: 150,904,153 (GRCm39) S302P probably damaging Het
Lyst G A 13: 13,854,787 (GRCm39) V2386I probably benign Het
Map4k4 G A 1: 40,043,004 (GRCm39) A128T probably damaging Het
Marchf6 A C 15: 31,469,819 (GRCm39) M717R probably benign Het
Morc2b A G 17: 33,354,908 (GRCm39) Y955H probably damaging Het
Myo7b A G 18: 32,127,395 (GRCm39) S636P probably damaging Het
Neb T A 2: 52,112,996 (GRCm39) D4266V probably damaging Het
Nynrin G A 14: 56,091,646 (GRCm39) probably benign Het
Or1j18 G A 2: 36,624,767 (GRCm39) V145I probably benign Het
Or5b104 T C 19: 13,072,899 (GRCm39) I38V probably benign Het
Pcdh9 A G 14: 94,123,501 (GRCm39) S890P probably benign Het
Pcnx1 G T 12: 82,003,017 (GRCm39) D1052Y probably damaging Het
Pibf1 G A 14: 99,338,639 (GRCm39) E52K probably damaging Het
Siglec1 T G 2: 130,922,384 (GRCm39) S564R possibly damaging Het
Sin3a T A 9: 57,026,459 (GRCm39) V1125E probably damaging Het
Slco4c1 G T 1: 96,795,613 (GRCm39) D148E probably damaging Het
Spag6l A T 16: 16,605,171 (GRCm39) L127Q probably damaging Het
Syne4 C A 7: 30,014,761 (GRCm39) T68N probably damaging Het
Tas2r134 A G 2: 51,517,998 (GRCm39) Y159C probably benign Het
Tasor A T 14: 27,183,275 (GRCm39) D578V probably damaging Het
Thoc2l T C 5: 104,668,079 (GRCm39) L867S probably benign Het
Tmem132a C A 19: 10,836,448 (GRCm39) R694L probably benign Het
Ttc28 C T 5: 111,433,635 (GRCm39) P2192L probably benign Het
Ttc34 T G 4: 154,946,671 (GRCm39) V857G probably benign Het
Ugt1a7c A T 1: 88,023,678 (GRCm39) H279L probably benign Het
Vmn1r32 G A 6: 66,530,539 (GRCm39) T79I probably benign Het
Vps13a A T 19: 16,617,905 (GRCm39) V2960D probably damaging Het
Wee2 G T 6: 40,420,875 (GRCm39) probably benign Het
Other mutations in Or4c107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Or4c107 APN 2 88,789,110 (GRCm39) missense probably damaging 0.98
IGL01398:Or4c107 APN 2 88,789,193 (GRCm39) missense probably damaging 1.00
IGL01537:Or4c107 APN 2 88,788,885 (GRCm39) missense probably benign 0.00
IGL02197:Or4c107 APN 2 88,789,028 (GRCm39) missense probably benign 0.05
IGL02557:Or4c107 APN 2 88,789,025 (GRCm39) missense probably benign 0.00
R0276:Or4c107 UTSW 2 88,789,099 (GRCm39) nonsense probably null
R0568:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R0699:Or4c107 UTSW 2 88,788,960 (GRCm39) missense probably benign 0.31
R1101:Or4c107 UTSW 2 88,789,328 (GRCm39) missense possibly damaging 0.60
R1468:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R1468:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R1845:Or4c107 UTSW 2 88,789,211 (GRCm39) missense probably damaging 0.99
R2031:Or4c107 UTSW 2 88,789,643 (GRCm39) missense probably benign 0.19
R2418:Or4c107 UTSW 2 88,789,380 (GRCm39) missense probably benign 0.01
R2419:Or4c107 UTSW 2 88,789,380 (GRCm39) missense probably benign 0.01
R3781:Or4c107 UTSW 2 88,789,091 (GRCm39) nonsense probably null
R4049:Or4c107 UTSW 2 88,789,617 (GRCm39) missense probably benign 0.09
R4440:Or4c107 UTSW 2 88,789,685 (GRCm39) missense probably benign 0.22
R4583:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4646:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4648:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4674:Or4c107 UTSW 2 88,789,216 (GRCm39) missense probably damaging 0.98
R4851:Or4c107 UTSW 2 88,788,930 (GRCm39) missense probably damaging 1.00
R4971:Or4c107 UTSW 2 88,788,863 (GRCm39) missense probably damaging 1.00
R5610:Or4c107 UTSW 2 88,789,170 (GRCm39) missense probably damaging 1.00
R5805:Or4c107 UTSW 2 88,788,985 (GRCm39) missense possibly damaging 0.50
R5887:Or4c107 UTSW 2 88,789,098 (GRCm39) missense possibly damaging 0.60
R6023:Or4c107 UTSW 2 88,789,059 (GRCm39) missense possibly damaging 0.76
R6118:Or4c107 UTSW 2 88,789,462 (GRCm39) nonsense probably null
R7490:Or4c107 UTSW 2 88,789,392 (GRCm39) missense probably benign 0.00
R7542:Or4c107 UTSW 2 88,789,119 (GRCm39) missense probably benign 0.01
R7612:Or4c107 UTSW 2 88,788,849 (GRCm39) missense probably damaging 1.00
R7972:Or4c107 UTSW 2 88,789,177 (GRCm39) nonsense probably null
R8422:Or4c107 UTSW 2 88,789,341 (GRCm39) missense probably benign 0.05
R9111:Or4c107 UTSW 2 88,789,055 (GRCm39) missense probably benign 0.00
Z1177:Or4c107 UTSW 2 88,789,721 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGGATGCCTTTTAACACTTCACACCAG -3'
(R):5'- GGTTTTGCTTTCATTGACAGAGTCAACA -3'

Sequencing Primer
(F):5'- tctacacaaagacttagagagcc -3'
(R):5'- CAGAGTCAACAATCATCTTTGGTGTG -3'
Posted On 2014-01-15