Mutagenetix > Incidental Mutation

Incidental Mutation 'R1162:Or2h15'

100527

Institutional Source

Beutler Lab

Gene Symbol

Or2h15

Ensembl Gene

ENSMUSG00000067186

Gene Name

olfactory receptor family 2 subfamily H member 15

Synonyms

Olfr132, MOR256-49, GA_x6K02T2PSCP-2579687-2578746

MMRRC Submission

039235-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.158) question?

Stock #

R1162 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

38441140-38442081 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 38441984 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 33 (V33D)

Ref Sequence

ENSEMBL: ENSMUSP00000149593 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087128] [ENSMUST00000216804]

AlphaFold

Q7TRI8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000087128
AA Change: V33D

PolyPhen 2 Score 0.689 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000084368
Gene: ENSMUSG00000067186
AA Change: V33D

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	25	244	3.1e-6	PFAM
Pfam:7tm_4	31	308	4.6e-46	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.9e-7	PFAM
Pfam:7tm_1	41	290	8.1e-23	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216804
AA Change: V33D

PolyPhen 2 Score 0.689 (Sensitivity: 0.86; Specificity: 0.92)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217361

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 96.0%
20x: 91.9%

Validation Efficiency

98% (55/56)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9430015G10Rik	T	C	4: 156,206,875 (GRCm39)		probably null	Het
Adamts12	T	A	15: 11,277,544 (GRCm39)		probably null	Het
Ccn3	T	A	15: 54,611,178 (GRCm39)	C104*	probably null	Het
Cops4	T	C	5: 100,678,023 (GRCm39)		probably benign	Het
Cul7	T	A	17: 46,974,116 (GRCm39)	L1467H	probably damaging	Het
Dgkh	A	G	14: 78,861,891 (GRCm39)	C125R	probably damaging	Het
Dgkz	A	T	2: 91,774,789 (GRCm39)	I65N	probably damaging	Het
Dock10	T	A	1: 80,546,559 (GRCm39)	H743L	possibly damaging	Het
Dscaml1	T	C	9: 45,663,647 (GRCm39)		probably benign	Het
Flt4	C	T	11: 49,527,166 (GRCm39)		probably benign	Het
Gbe1	A	T	16: 70,178,738 (GRCm39)		probably benign	Het
Gm7275	A	G	16: 47,894,395 (GRCm39)		noncoding transcript	Het
Gpatch1	A	G	7: 35,002,905 (GRCm39)		probably benign	Het
Gpr137c	A	G	14: 45,481,615 (GRCm39)	I144V	possibly damaging	Het
Igsf9b	T	C	9: 27,238,185 (GRCm39)	S563P	probably benign	Het
Insl5	C	T	4: 102,875,438 (GRCm39)	R104Q	probably benign	Het
Kcnj2	T	A	11: 110,963,793 (GRCm39)	V395D	probably benign	Het
Ksr2	A	G	5: 117,693,020 (GRCm39)		probably benign	Het
Lrrc4	C	A	6: 28,831,083 (GRCm39)	L177F	probably damaging	Het
Mapkbp1	A	G	2: 119,855,799 (GRCm39)	E1506G	possibly damaging	Het
Morc3	A	C	16: 93,649,996 (GRCm39)	Y259S	probably damaging	Het
Mrpl43	T	G	19: 44,994,797 (GRCm39)	S13R	possibly damaging	Het
Myh4	A	G	11: 67,149,439 (GRCm39)	N1724D	probably damaging	Het
Nab1	A	G	1: 52,529,186 (GRCm39)	M237T	probably damaging	Het
Nav2	A	G	7: 49,185,788 (GRCm39)		probably benign	Het
Nfix	G	A	8: 85,453,155 (GRCm39)	R300C	probably damaging	Het
Nup155	A	T	15: 8,187,244 (GRCm39)	H1391L	probably damaging	Het
Or5ac15	T	C	16: 58,939,735 (GRCm39)	R233G	probably damaging	Het
Or5p80	A	G	7: 108,230,120 (GRCm39)	N307S	probably benign	Het
Phf2	A	T	13: 48,973,117 (GRCm39)		probably benign	Het
Ppef2	A	C	5: 92,400,980 (GRCm39)	F13L	probably benign	Het
Pwwp4a	G	T	X: 72,171,261 (GRCm39)	G218C	probably damaging	Het
Sap130	C	T	18: 31,781,226 (GRCm39)	P130S	probably damaging	Het
Scn11a	A	G	9: 119,634,710 (GRCm39)		probably benign	Het
Sec31b	C	A	19: 44,506,087 (GRCm39)	E940*	probably null	Het
Sgce	A	G	6: 4,691,419 (GRCm39)		probably benign	Het
Sh3glb2	A	T	2: 30,240,600 (GRCm39)	I155N	probably damaging	Het
Sirt2	A	T	7: 28,485,247 (GRCm39)	D218V	probably damaging	Het
Slc16a10	T	C	10: 39,952,549 (GRCm39)	H315R	probably benign	Het
Sox5	A	G	6: 143,906,538 (GRCm39)	Y306H	probably damaging	Het
Sucla2	C	T	14: 73,798,074 (GRCm39)		probably benign	Het
Tab2	A	G	10: 7,800,483 (GRCm39)	V23A	probably damaging	Het
Trak1	G	T	9: 121,282,407 (GRCm39)	V429F	possibly damaging	Het
Trat1	T	C	16: 48,560,572 (GRCm39)	S102G	possibly damaging	Het
Trub1	G	A	19: 57,461,191 (GRCm39)	V156I	probably benign	Het
Tspan32	T	A	7: 142,560,735 (GRCm39)	M61K	probably damaging	Het
Unc13a	T	A	8: 72,100,561 (GRCm39)	T1076S	probably benign	Het
Vangl2	A	G	1: 171,832,414 (GRCm39)	Y481H	probably damaging	Het
Vmn2r105	C	T	17: 20,447,973 (GRCm39)	E284K	probably benign	Het
Vmn2r60	A	T	7: 41,845,195 (GRCm39)	I853F	probably benign	Het
Yrdc	T	C	4: 124,748,254 (GRCm39)		probably benign	Het
Zfp595	A	T	13: 67,465,259 (GRCm39)	C335S	probably damaging	Het
Zfp872	A	G	9: 22,110,910 (GRCm39)	S149G	possibly damaging	Het

Other mutations in Or2h15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02276:Or2h15	APN	17	38,441,484 (GRCm39)	missense	probably damaging	0.97
IGL02659:Or2h15	APN	17	38,441,427 (GRCm39)	missense	possibly damaging	0.78
IGL02831:Or2h15	APN	17	38,441,403 (GRCm39)	missense	probably benign	0.10
R0070:Or2h15	UTSW	17	38,441,780 (GRCm39)	missense	probably damaging	1.00
R0070:Or2h15	UTSW	17	38,441,780 (GRCm39)	missense	probably damaging	1.00
R2697:Or2h15	UTSW	17	38,441,900 (GRCm39)	missense	probably damaging	0.99
R4694:Or2h15	UTSW	17	38,441,748 (GRCm39)	missense	probably damaging	1.00
R4883:Or2h15	UTSW	17	38,441,508 (GRCm39)	missense	probably damaging	1.00
R4933:Or2h15	UTSW	17	38,441,441 (GRCm39)	missense	probably damaging	1.00
R4982:Or2h15	UTSW	17	38,441,468 (GRCm39)	missense	probably damaging	0.99
R5058:Or2h15	UTSW	17	38,441,432 (GRCm39)	missense	probably damaging	1.00
R5653:Or2h15	UTSW	17	38,442,075 (GRCm39)	missense	possibly damaging	0.63
R5946:Or2h15	UTSW	17	38,441,598 (GRCm39)	missense	probably benign	0.07
R7083:Or2h15	UTSW	17	38,441,601 (GRCm39)	missense	probably benign
R7226:Or2h15	UTSW	17	38,441,324 (GRCm39)	missense	probably benign	0.01
R7391:Or2h15	UTSW	17	38,441,941 (GRCm39)	missense	probably benign
R8297:Or2h15	UTSW	17	38,441,484 (GRCm39)	missense	probably damaging	0.97
R8378:Or2h15	UTSW	17	38,441,678 (GRCm39)	missense	probably benign	0.05
R8425:Or2h15	UTSW	17	38,441,927 (GRCm39)	missense	possibly damaging	0.83
R8554:Or2h15	UTSW	17	38,441,489 (GRCm39)	missense	probably damaging	1.00
R9223:Or2h15	UTSW	17	38,442,012 (GRCm39)	missense	possibly damaging	0.66
R9278:Or2h15	UTSW	17	38,441,693 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

Posted On

2014-01-15