Incidental Mutation 'R1209:Or13a20'
ID 100593
Institutional Source Beutler Lab
Gene Symbol Or13a20
Ensembl Gene ENSMUSG00000094819
Gene Name olfactory receptor family 13 subfamily A member 20
Synonyms MOR253-5, GA_x6K02T2PBJ9-42798103-42799038, Olfr53, IE12
MMRRC Submission 039278-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R1209 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 140226365-140232832 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 140231927 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 12 (T12A)
Ref Sequence ENSEMBL: ENSMUSP00000148158 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084456] [ENSMUST00000211057] [ENSMUST00000211399]
AlphaFold Q8VGL8
Predicted Effect probably benign
Transcript: ENSMUST00000084456
AA Change: T12A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000081494
Gene: ENSMUSG00000094819
AA Change: T12A

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.5e-51 PFAM
Pfam:7TM_GPCR_Srsx 37 208 9.7e-7 PFAM
Pfam:7tm_1 43 292 1.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211057
AA Change: T12A

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000211399
AA Change: T12A

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 97.8%
  • 10x: 94.2%
  • 20x: 85.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 A G 10: 20,839,629 (GRCm39) D180G probably damaging Het
Aopep A G 13: 63,338,878 (GRCm39) probably null Het
Banp G A 8: 122,702,656 (GRCm39) V30I possibly damaging Het
Btn2a2 C T 13: 23,664,736 (GRCm39) probably null Het
Cdh15 G C 8: 123,584,234 (GRCm39) E112Q probably damaging Het
Cdhr1 C T 14: 36,804,899 (GRCm39) probably null Het
Cfap44 T C 16: 44,242,780 (GRCm39) I728T possibly damaging Het
Fbn2 A G 18: 58,203,088 (GRCm39) M1212T probably benign Het
Fmo3 C T 1: 162,791,597 (GRCm39) D227N probably benign Het
Klk1b5 G T 7: 43,496,422 (GRCm39) R118L probably damaging Het
Krtap4-1 A G 11: 99,518,983 (GRCm39) V9A unknown Het
Muc5b A G 7: 141,411,647 (GRCm39) N1531S unknown Het
Mypn A G 10: 62,954,278 (GRCm39) S1234P probably damaging Het
Nme5 A G 18: 34,702,949 (GRCm39) L113S probably damaging Het
Oprk1 T C 1: 5,672,484 (GRCm39) V207A probably benign Het
Or4f52 T C 2: 111,061,958 (GRCm39) Y60C probably damaging Het
Otop2 A G 11: 115,215,469 (GRCm39) E130G possibly damaging Het
Pard6a A G 8: 106,429,023 (GRCm39) K78R probably benign Het
Pbrm1 T A 14: 30,840,809 (GRCm39) L1637H probably damaging Het
Rims4 C T 2: 163,705,849 (GRCm39) V262M possibly damaging Het
Rnaset2b T A 17: 7,246,475 (GRCm39) C27S probably benign Het
Rps24 A G 14: 24,541,830 (GRCm39) T6A probably damaging Het
Speer4a1 T C 5: 26,240,123 (GRCm39) probably null Het
Srsf4 A G 4: 131,628,370 (GRCm39) probably benign Het
Syt11 G A 3: 88,655,147 (GRCm39) R79C probably damaging Het
Tbx3 T C 5: 119,819,018 (GRCm39) V531A probably benign Het
Tmem132d T A 5: 127,861,934 (GRCm39) D729V probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Other mutations in Or13a20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01017:Or13a20 APN 7 140,232,389 (GRCm39) missense probably benign 0.00
IGL01071:Or13a20 APN 7 140,232,827 (GRCm39) missense possibly damaging 0.76
IGL02590:Or13a20 APN 7 140,232,305 (GRCm39) splice site probably null
IGL02694:Or13a20 APN 7 140,232,093 (GRCm39) missense probably damaging 0.99
R0071:Or13a20 UTSW 7 140,232,170 (GRCm39) missense probably benign 0.00
R0071:Or13a20 UTSW 7 140,232,170 (GRCm39) missense probably benign 0.00
R0089:Or13a20 UTSW 7 140,232,224 (GRCm39) missense probably damaging 0.99
R0586:Or13a20 UTSW 7 140,231,976 (GRCm39) missense probably benign 0.35
R1491:Or13a20 UTSW 7 140,232,650 (GRCm39) missense probably damaging 1.00
R1781:Or13a20 UTSW 7 140,232,419 (GRCm39) missense probably damaging 0.99
R4060:Or13a20 UTSW 7 140,232,033 (GRCm39) missense probably damaging 1.00
R4231:Or13a20 UTSW 7 140,232,653 (GRCm39) missense probably damaging 1.00
R4236:Or13a20 UTSW 7 140,232,653 (GRCm39) missense probably damaging 1.00
R4299:Or13a20 UTSW 7 140,232,156 (GRCm39) missense probably benign 0.00
R4398:Or13a20 UTSW 7 140,232,741 (GRCm39) missense possibly damaging 0.65
R4675:Or13a20 UTSW 7 140,232,074 (GRCm39) missense probably damaging 1.00
R4937:Or13a20 UTSW 7 140,232,534 (GRCm39) missense probably benign 0.00
R5854:Or13a20 UTSW 7 140,232,491 (GRCm39) missense probably benign 0.03
R6124:Or13a20 UTSW 7 140,232,507 (GRCm39) missense probably damaging 1.00
R7092:Or13a20 UTSW 7 140,232,150 (GRCm39) missense probably benign 0.16
R7167:Or13a20 UTSW 7 140,232,466 (GRCm39) nonsense probably null
R7846:Or13a20 UTSW 7 140,232,374 (GRCm39) missense probably damaging 0.96
R7896:Or13a20 UTSW 7 140,232,814 (GRCm39) missense probably benign 0.00
R8080:Or13a20 UTSW 7 140,232,387 (GRCm39) missense probably benign 0.05
R8847:Or13a20 UTSW 7 140,232,326 (GRCm39) missense possibly damaging 0.80
R8926:Or13a20 UTSW 7 140,232,113 (GRCm39) missense probably benign 0.03
R9391:Or13a20 UTSW 7 140,232,272 (GRCm39) missense probably damaging 0.99
R9414:Or13a20 UTSW 7 140,232,263 (GRCm39) missense probably damaging 0.96
R9484:Or13a20 UTSW 7 140,231,904 (GRCm39) missense probably benign 0.00
Z1177:Or13a20 UTSW 7 140,232,700 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- CAGAGCACAGGGCTTAGTAGCAATG -3'
(R):5'- CACACAATATCCGTGGTAGCCAGG -3'

Sequencing Primer
(F):5'- GAGTAAAGAATGCTTCTCTCTTTCCG -3'
(R):5'- TGGTAGCCAGGTTGCACAG -3'
Posted On 2014-01-15