Incidental Mutation 'R1191:Or5k8'
ID 100843
Institutional Source Beutler Lab
Gene Symbol Or5k8
Ensembl Gene ENSMUSG00000060663
Gene Name olfactory receptor family 5 subfamily K member 8
Synonyms GA_x54KRFPKG5P-55026345-55025418, MOR184-10P, MOR184-1, GA_x54KRFPKG5P-54993816-54992890, Olfr175-ps1, Olfr175, Olfr174
MMRRC Submission 039263-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R1191 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 58644144-58647124 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 58644922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 50 (Y50F)
Ref Sequence ENSEMBL: ENSMUSP00000150202 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079955] [ENSMUST00000215069]
AlphaFold A0A140T8K4
Predicted Effect probably benign
Transcript: ENSMUST00000079955
AA Change: Y50F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078873
Gene: ENSMUSG00000060663
AA Change: Y50F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 6.8e-6 PFAM
Pfam:7tm_1 41 290 2.5e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215069
AA Change: Y50F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.3%
  • 10x: 95.1%
  • 20x: 87.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd27 T C 7: 35,301,912 (GRCm39) F144L probably damaging Het
C8b C T 4: 104,650,520 (GRCm39) P377S probably damaging Het
Cfi C A 3: 129,662,176 (GRCm39) T385N probably benign Het
Col15a1 G T 4: 47,254,083 (GRCm39) G300* probably null Het
Crlf1 G A 8: 70,951,478 (GRCm39) C119Y probably damaging Het
Dcaf4 A T 12: 83,582,741 (GRCm39) S279C probably damaging Het
Gde1 A T 7: 118,304,664 (GRCm39) H70Q probably damaging Het
Gpt2 A T 8: 86,235,901 (GRCm39) N179I probably damaging Het
Grik5 G A 7: 24,757,750 (GRCm39) Q410* probably null Het
Hspa2 C T 12: 76,452,655 (GRCm39) R450W probably damaging Het
Idh3b A T 2: 130,123,810 (GRCm39) M118K probably benign Het
Ighv5-21 T C 12: 114,286,423 (GRCm39) probably benign Het
Il12rb2 C T 6: 67,275,200 (GRCm39) V642M possibly damaging Het
Iqcg A G 16: 32,870,313 (GRCm39) V60A probably benign Het
Irx6 T A 8: 93,403,580 (GRCm39) Y102N probably damaging Het
Itgb6 C T 2: 60,483,481 (GRCm39) probably null Het
Mmp27 A T 9: 7,579,067 (GRCm39) probably null Het
Or10d5j A T 9: 39,868,264 (GRCm39) M1K probably null Het
Or1j21 T A 2: 36,683,350 (GRCm39) M34K probably damaging Het
Or2f2 C A 6: 42,767,451 (GRCm39) H159Q probably benign Het
Or8c8 G T 9: 38,165,501 (GRCm39) V263F probably damaging Het
Pcdhb16 A G 18: 37,612,926 (GRCm39) R629G probably damaging Het
Pde3b A T 7: 114,118,810 (GRCm39) M650L probably benign Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Skint3 T A 4: 112,092,939 (GRCm39) M1K probably null Het
Strn T C 17: 78,999,855 (GRCm39) Q127R possibly damaging Het
Taar2 T G 10: 23,816,927 (GRCm39) W156G probably damaging Het
Trpt1 G T 19: 6,974,138 (GRCm39) M45I probably benign Het
Ubap2l T C 3: 89,930,882 (GRCm39) T357A probably damaging Het
Ubr3 C T 2: 69,851,525 (GRCm39) R1831* probably null Het
Unc79 T A 12: 103,013,271 (GRCm39) Y287* probably null Het
Utrn T A 10: 12,509,777 (GRCm39) K2398N probably benign Het
Vav2 A T 2: 27,182,792 (GRCm39) probably null Het
Vps9d1 A T 8: 123,974,706 (GRCm39) H249Q possibly damaging Het
Vwf T A 6: 125,576,215 (GRCm39) C432S probably damaging Het
Zfp369 T A 13: 65,439,776 (GRCm39) Y153* probably null Het
Zfp760 C T 17: 21,942,286 (GRCm39) P487L probably damaging Het
Zswim2 A C 2: 83,754,039 (GRCm39) V207G possibly damaging Het
Other mutations in Or5k8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Or5k8 APN 16 58,644,958 (GRCm39) missense probably damaging 1.00
IGL01404:Or5k8 APN 16 58,644,958 (GRCm39) missense probably damaging 1.00
IGL01867:Or5k8 APN 16 58,644,337 (GRCm39) missense probably damaging 1.00
IGL02073:Or5k8 APN 16 58,644,169 (GRCm39) missense probably benign
IGL02393:Or5k8 APN 16 58,644,409 (GRCm39) missense probably damaging 0.99
IGL02474:Or5k8 APN 16 58,645,019 (GRCm39) missense probably benign
IGL02548:Or5k8 APN 16 58,644,691 (GRCm39) missense probably benign 0.42
IGL02948:Or5k8 APN 16 58,644,451 (GRCm39) missense probably benign 0.00
PIT4504001:Or5k8 UTSW 16 58,644,671 (GRCm39) missense probably benign 0.00
R0553:Or5k8 UTSW 16 58,644,518 (GRCm39) missense probably damaging 0.99
R1201:Or5k8 UTSW 16 58,644,226 (GRCm39) missense probably damaging 0.98
R1458:Or5k8 UTSW 16 58,645,039 (GRCm39) missense probably null 0.68
R1469:Or5k8 UTSW 16 58,644,973 (GRCm39) missense probably benign
R1469:Or5k8 UTSW 16 58,644,973 (GRCm39) missense probably benign
R1843:Or5k8 UTSW 16 58,644,440 (GRCm39) missense probably damaging 0.99
R2147:Or5k8 UTSW 16 58,644,842 (GRCm39) missense probably damaging 0.99
R2421:Or5k8 UTSW 16 58,644,709 (GRCm39) missense probably damaging 1.00
R4370:Or5k8 UTSW 16 58,644,956 (GRCm39) missense probably benign 0.00
R4621:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4622:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4623:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4711:Or5k8 UTSW 16 58,645,069 (GRCm39) start codon destroyed probably null 0.98
R5323:Or5k8 UTSW 16 58,645,066 (GRCm39) missense probably benign
R5447:Or5k8 UTSW 16 58,644,846 (GRCm39) nonsense probably null
R5457:Or5k8 UTSW 16 58,644,796 (GRCm39) missense probably damaging 0.97
R5546:Or5k8 UTSW 16 58,644,516 (GRCm39) nonsense probably null
R5623:Or5k8 UTSW 16 58,644,706 (GRCm39) missense probably benign 0.02
R5767:Or5k8 UTSW 16 58,644,316 (GRCm39) missense probably benign 0.42
R6270:Or5k8 UTSW 16 58,644,782 (GRCm39) missense probably damaging 1.00
R6449:Or5k8 UTSW 16 58,644,889 (GRCm39) missense probably damaging 1.00
R7356:Or5k8 UTSW 16 58,644,718 (GRCm39) missense probably damaging 0.99
R7521:Or5k8 UTSW 16 58,644,257 (GRCm39) missense probably benign 0.00
R7638:Or5k8 UTSW 16 58,644,958 (GRCm39) missense probably damaging 1.00
R7814:Or5k8 UTSW 16 58,644,365 (GRCm39) missense probably damaging 0.98
R9109:Or5k8 UTSW 16 58,644,677 (GRCm39) missense probably damaging 1.00
R9276:Or5k8 UTSW 16 58,644,734 (GRCm39) missense probably benign 0.09
R9681:Or5k8 UTSW 16 58,644,176 (GRCm39) missense possibly damaging 0.90
X0011:Or5k8 UTSW 16 58,645,026 (GRCm39) missense probably benign
Z1176:Or5k8 UTSW 16 58,644,670 (GRCm39) frame shift probably null
Z1177:Or5k8 UTSW 16 58,645,061 (GRCm39) missense possibly damaging 0.47
Predicted Primers PCR Primer
(F):5'- CCTGTGGTCATTTGAAGGCAGAGC -3'
(R):5'- CTGATCCCTTGTCAACAGAGGAGC -3'

Sequencing Primer
(F):5'- AGGCAGAGCTTCTTGGACATC -3'
(R):5'- CTGAAGATGACTGAGGACAACTACTC -3'
Posted On 2014-01-15