Incidental Mutation 'R1191:Zfp760'
| ID |
100845 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp760
|
| Ensembl Gene |
ENSMUSG00000067928 |
| Gene Name |
zinc finger protein 760 |
| Synonyms |
|
| MMRRC Submission |
039263-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.130)
|
| Stock # |
R1191 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
21926723-21944617 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 21942286 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Leucine
at position 487
(P487L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073038
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073312]
|
| AlphaFold |
E9QAF5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000073312
AA Change: P487L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000073038
Gene: ENSMUSG00000067928
AA Change: P487L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
69 |
3.62e-21 |
SMART |
|
ZnF_C2H2
|
183 |
202 |
1.78e2 |
SMART |
|
ZnF_C2H2
|
208 |
230 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
236 |
258 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
264 |
286 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
292 |
314 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
320 |
342 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
376 |
398 |
1.72e-4 |
SMART |
|
ZnF_C2H2
|
404 |
426 |
1.14e0 |
SMART |
|
ZnF_C2H2
|
432 |
454 |
4.05e-1 |
SMART |
|
ZnF_C2H2
|
460 |
482 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
488 |
510 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
516 |
538 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
600 |
622 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
628 |
650 |
1.28e-3 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.3%
- 10x: 95.1%
- 20x: 87.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankrd27 |
T |
C |
7: 35,301,912 (GRCm39) |
F144L |
probably damaging |
Het |
| C8b |
C |
T |
4: 104,650,520 (GRCm39) |
P377S |
probably damaging |
Het |
| Cfi |
C |
A |
3: 129,662,176 (GRCm39) |
T385N |
probably benign |
Het |
| Col15a1 |
G |
T |
4: 47,254,083 (GRCm39) |
G300* |
probably null |
Het |
| Crlf1 |
G |
A |
8: 70,951,478 (GRCm39) |
C119Y |
probably damaging |
Het |
| Dcaf4 |
A |
T |
12: 83,582,741 (GRCm39) |
S279C |
probably damaging |
Het |
| Gde1 |
A |
T |
7: 118,304,664 (GRCm39) |
H70Q |
probably damaging |
Het |
| Gpt2 |
A |
T |
8: 86,235,901 (GRCm39) |
N179I |
probably damaging |
Het |
| Grik5 |
G |
A |
7: 24,757,750 (GRCm39) |
Q410* |
probably null |
Het |
| Hspa2 |
C |
T |
12: 76,452,655 (GRCm39) |
R450W |
probably damaging |
Het |
| Idh3b |
A |
T |
2: 130,123,810 (GRCm39) |
M118K |
probably benign |
Het |
| Ighv5-21 |
T |
C |
12: 114,286,423 (GRCm39) |
|
probably benign |
Het |
| Il12rb2 |
C |
T |
6: 67,275,200 (GRCm39) |
V642M |
possibly damaging |
Het |
| Iqcg |
A |
G |
16: 32,870,313 (GRCm39) |
V60A |
probably benign |
Het |
| Irx6 |
T |
A |
8: 93,403,580 (GRCm39) |
Y102N |
probably damaging |
Het |
| Itgb6 |
C |
T |
2: 60,483,481 (GRCm39) |
|
probably null |
Het |
| Mmp27 |
A |
T |
9: 7,579,067 (GRCm39) |
|
probably null |
Het |
| Or10d5j |
A |
T |
9: 39,868,264 (GRCm39) |
M1K |
probably null |
Het |
| Or1j21 |
T |
A |
2: 36,683,350 (GRCm39) |
M34K |
probably damaging |
Het |
| Or2f2 |
C |
A |
6: 42,767,451 (GRCm39) |
H159Q |
probably benign |
Het |
| Or5k8 |
T |
A |
16: 58,644,922 (GRCm39) |
Y50F |
probably benign |
Het |
| Or8c8 |
G |
T |
9: 38,165,501 (GRCm39) |
V263F |
probably damaging |
Het |
| Pcdhb16 |
A |
G |
18: 37,612,926 (GRCm39) |
R629G |
probably damaging |
Het |
| Pde3b |
A |
T |
7: 114,118,810 (GRCm39) |
M650L |
probably benign |
Het |
| Rfwd3 |
C |
T |
8: 112,014,874 (GRCm39) |
R326Q |
probably damaging |
Het |
| Skint3 |
T |
A |
4: 112,092,939 (GRCm39) |
M1K |
probably null |
Het |
| Strn |
T |
C |
17: 78,999,855 (GRCm39) |
Q127R |
possibly damaging |
Het |
| Taar2 |
T |
G |
10: 23,816,927 (GRCm39) |
W156G |
probably damaging |
Het |
| Trpt1 |
G |
T |
19: 6,974,138 (GRCm39) |
M45I |
probably benign |
Het |
| Ubap2l |
T |
C |
3: 89,930,882 (GRCm39) |
T357A |
probably damaging |
Het |
| Ubr3 |
C |
T |
2: 69,851,525 (GRCm39) |
R1831* |
probably null |
Het |
| Unc79 |
T |
A |
12: 103,013,271 (GRCm39) |
Y287* |
probably null |
Het |
| Utrn |
T |
A |
10: 12,509,777 (GRCm39) |
K2398N |
probably benign |
Het |
| Vav2 |
A |
T |
2: 27,182,792 (GRCm39) |
|
probably null |
Het |
| Vps9d1 |
A |
T |
8: 123,974,706 (GRCm39) |
H249Q |
possibly damaging |
Het |
| Vwf |
T |
A |
6: 125,576,215 (GRCm39) |
C432S |
probably damaging |
Het |
| Zfp369 |
T |
A |
13: 65,439,776 (GRCm39) |
Y153* |
probably null |
Het |
| Zswim2 |
A |
C |
2: 83,754,039 (GRCm39) |
V207G |
possibly damaging |
Het |
|
| Other mutations in Zfp760 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Zfp760
|
APN |
17 |
21,942,457 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL00862:Zfp760
|
APN |
17 |
21,941,265 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02198:Zfp760
|
APN |
17 |
21,941,193 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0478:Zfp760
|
UTSW |
17 |
21,940,995 (GRCm39) |
nonsense |
probably null |
|
|
R0835:Zfp760
|
UTSW |
17 |
21,942,559 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1760:Zfp760
|
UTSW |
17 |
21,941,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2698:Zfp760
|
UTSW |
17 |
21,939,935 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3722:Zfp760
|
UTSW |
17 |
21,941,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Zfp760
|
UTSW |
17 |
21,942,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4700:Zfp760
|
UTSW |
17 |
21,941,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4859:Zfp760
|
UTSW |
17 |
21,942,516 (GRCm39) |
nonsense |
probably null |
|
|
R4859:Zfp760
|
UTSW |
17 |
21,942,511 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4897:Zfp760
|
UTSW |
17 |
21,942,229 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6675:Zfp760
|
UTSW |
17 |
21,941,991 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7286:Zfp760
|
UTSW |
17 |
21,941,760 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7336:Zfp760
|
UTSW |
17 |
21,942,814 (GRCm39) |
missense |
unknown |
|
|
R7356:Zfp760
|
UTSW |
17 |
21,941,601 (GRCm39) |
missense |
probably benign |
|
|
R7369:Zfp760
|
UTSW |
17 |
21,942,214 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7504:Zfp760
|
UTSW |
17 |
21,941,655 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7553:Zfp760
|
UTSW |
17 |
21,941,872 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7577:Zfp760
|
UTSW |
17 |
21,941,242 (GRCm39) |
nonsense |
probably null |
|
|
R7579:Zfp760
|
UTSW |
17 |
21,941,907 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7608:Zfp760
|
UTSW |
17 |
21,941,797 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7973:Zfp760
|
UTSW |
17 |
21,941,084 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8078:Zfp760
|
UTSW |
17 |
21,942,436 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8332:Zfp760
|
UTSW |
17 |
21,942,301 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8750:Zfp760
|
UTSW |
17 |
21,941,356 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9094:Zfp760
|
UTSW |
17 |
21,941,932 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9264:Zfp760
|
UTSW |
17 |
21,942,663 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9372:Zfp760
|
UTSW |
17 |
21,941,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9520:Zfp760
|
UTSW |
17 |
21,941,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9564:Zfp760
|
UTSW |
17 |
21,942,272 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9743:Zfp760
|
UTSW |
17 |
21,942,338 (GRCm39) |
missense |
probably benign |
|
|
X0057:Zfp760
|
UTSW |
17 |
21,942,663 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Predicted Primers |
|
| Posted On |
2014-01-15 |
Incidental Mutation