Incidental Mutation 'R1196:Zfp791'
ID101123
Institutional Source Beutler Lab
Gene Symbol Zfp791
Ensembl Gene ENSMUSG00000074194
Gene Namezinc finger protein 791
SynonymsEG244556
MMRRC Submission 039268-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R1196 (G1)
Quality Score225
Status Validated
Chromosome8
Chromosomal Location85108553-85123095 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 85110954 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 94 (K94*)
Ref Sequence ENSEMBL: ENSMUSP00000147335 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098550] [ENSMUST00000211109]
Predicted Effect probably null
Transcript: ENSMUST00000098550
AA Change: K94*
SMART Domains Protein: ENSMUSP00000096150
Gene: ENSMUSG00000074194
AA Change: K94*

DomainStartEndE-ValueType
KRAB 4 64 4.26e-18 SMART
ZnF_C2H2 102 124 2.53e-2 SMART
ZnF_C2H2 139 161 7.78e-3 SMART
ZnF_C2H2 167 189 3.34e-2 SMART
ZnF_C2H2 195 217 2.79e-4 SMART
ZnF_C2H2 223 245 6.78e-3 SMART
ZnF_C2H2 251 273 2.12e-4 SMART
ZnF_C2H2 281 303 2.02e-1 SMART
ZnF_C2H2 309 331 7.78e-3 SMART
ZnF_C2H2 337 359 6.42e-4 SMART
ZnF_C2H2 365 387 2.29e0 SMART
ZnF_C2H2 393 415 1.13e-4 SMART
ZnF_C2H2 421 443 2.75e-3 SMART
ZnF_C2H2 449 471 2.05e-2 SMART
ZnF_C2H2 477 499 3.95e-4 SMART
ZnF_C2H2 505 527 2.71e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158588
Predicted Effect probably null
Transcript: ENSMUST00000211109
AA Change: K94*
Meta Mutation Damage Score 0.538 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.3%
  • 10x: 94.9%
  • 20x: 86.8%
Validation Efficiency 97% (38/39)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb T C 5: 114,245,092 I2112T probably benign Het
Agtpbp1 C A 13: 59,450,318 probably benign Het
Ash1l T C 3: 88,983,316 M834T probably damaging Het
Aspg A G 12: 112,116,524 T213A possibly damaging Het
Chpf2 T C 5: 24,589,648 V272A possibly damaging Het
D6Ertd527e C G 6: 87,111,524 T223S unknown Het
Ddah2 G T 17: 35,061,527 D215Y probably damaging Het
Dna2 C T 10: 62,949,187 R28W probably benign Het
Fam46c T C 3: 100,473,000 T147A possibly damaging Het
Fbrsl1 T A 5: 110,374,519 M150L probably benign Het
Hmces T A 6: 87,936,182 D306E probably benign Het
Itga2 C T 13: 114,866,155 probably null Het
Jmjd1c T C 10: 67,239,236 probably benign Het
Krr1 T A 10: 111,975,657 H85Q probably benign Het
Krt83 C T 15: 101,491,433 R6Q probably benign Het
Krtap24-1 T C 16: 88,611,642 M199V probably benign Het
Krtap5-2 A T 7: 142,174,883 C353* probably null Het
Myo7a T G 7: 98,097,673 I178L possibly damaging Het
Myof G A 19: 37,910,960 T1043I probably damaging Het
Noc4l C T 5: 110,650,584 E247K probably damaging Het
Notch4 T C 17: 34,568,863 C437R probably damaging Het
Nrbp1 T A 5: 31,245,813 I210N probably damaging Het
Olfr1180 A T 2: 88,412,546 N37K probably damaging Het
Olfr859 A G 9: 19,808,632 I105V probably benign Het
Pank4 T C 4: 154,978,173 F584L probably damaging Het
Prl2c2 G C 13: 13,002,201 T47R probably damaging Het
Ranbp2 T A 10: 58,477,053 F1198L probably damaging Het
Sf3b1 C G 1: 55,019,395 E12Q possibly damaging Het
Ttc28 G A 5: 111,225,677 S962N probably damaging Het
Unc13a A G 8: 71,654,986 I554T probably damaging Het
Zfc3h1 A G 10: 115,411,961 D1023G probably damaging Het
Other mutations in Zfp791
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01512:Zfp791 APN 8 85113543 missense probably damaging 1.00
R0004:Zfp791 UTSW 8 85110866 missense probably benign 0.01
R0085:Zfp791 UTSW 8 85112233 nonsense probably null
R0496:Zfp791 UTSW 8 85109980 missense probably benign 0.03
R1927:Zfp791 UTSW 8 85110683 missense probably benign 0.17
R4240:Zfp791 UTSW 8 85109666 missense probably null 1.00
R4370:Zfp791 UTSW 8 85113606 missense probably damaging 1.00
R4637:Zfp791 UTSW 8 85109885 missense possibly damaging 0.93
R4684:Zfp791 UTSW 8 85110930 missense probably benign 0.08
R4713:Zfp791 UTSW 8 85110968 missense probably damaging 0.98
R4822:Zfp791 UTSW 8 85110406 missense probably benign 0.01
R4914:Zfp791 UTSW 8 85110951 missense probably benign 0.06
R4915:Zfp791 UTSW 8 85110951 missense probably benign 0.06
R4916:Zfp791 UTSW 8 85110951 missense probably benign 0.06
R4918:Zfp791 UTSW 8 85110951 missense probably benign 0.06
R5106:Zfp791 UTSW 8 85110630 nonsense probably null
R5549:Zfp791 UTSW 8 85110206 missense probably damaging 1.00
R6093:Zfp791 UTSW 8 85113506 critical splice donor site probably null
R6362:Zfp791 UTSW 8 85119650 start gained probably benign
Predicted Primers
Posted On2014-01-15