Incidental Mutation 'R1167:Vmn2r77'
ID |
101130 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r77
|
Ensembl Gene |
ENSMUSG00000090949 |
Gene Name |
vomeronasal 2, receptor 77 |
Synonyms |
EG546983 |
MMRRC Submission |
039240-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R1167 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 86450954 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Serine
at position 280
(N280S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
AlphaFold |
L7N2B7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000164996
AA Change: N280S
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
SMART Domains |
Protein: ENSMUSP00000129540 Gene: ENSMUSG00000090949 AA Change: N280S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 75 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930433I11Rik |
A |
T |
7: 40,643,003 (GRCm39) |
D315V |
probably damaging |
Het |
Acr |
T |
C |
15: 89,458,177 (GRCm39) |
I286T |
probably damaging |
Het |
Adnp |
A |
G |
2: 168,026,420 (GRCm39) |
S292P |
probably benign |
Het |
Apol6 |
T |
A |
15: 76,931,308 (GRCm39) |
Y17* |
probably null |
Het |
Arhgap22 |
A |
G |
14: 33,065,264 (GRCm39) |
|
probably null |
Het |
Bfar |
A |
G |
16: 13,516,758 (GRCm39) |
K202E |
possibly damaging |
Het |
Bmpr2 |
A |
T |
1: 59,898,463 (GRCm39) |
S470C |
probably damaging |
Het |
Cep135 |
A |
G |
5: 76,772,484 (GRCm39) |
E623G |
probably damaging |
Het |
Clcn3 |
A |
G |
8: 61,375,822 (GRCm39) |
|
probably null |
Het |
Clptm1 |
A |
T |
7: 19,368,136 (GRCm39) |
M523K |
probably damaging |
Het |
Cyp26b1 |
A |
G |
6: 84,561,312 (GRCm39) |
W117R |
probably damaging |
Het |
Dnmt3c |
T |
G |
2: 153,553,701 (GRCm39) |
|
probably null |
Het |
Dst |
A |
G |
1: 34,262,939 (GRCm39) |
E2212G |
probably damaging |
Het |
Edrf1 |
A |
G |
7: 133,245,795 (GRCm39) |
T238A |
probably benign |
Het |
Elmo1 |
T |
C |
13: 20,369,625 (GRCm39) |
V10A |
probably damaging |
Het |
Ermp1 |
A |
G |
19: 29,606,079 (GRCm39) |
S225P |
possibly damaging |
Het |
Fem1al |
C |
T |
11: 29,773,567 (GRCm39) |
R630H |
probably damaging |
Het |
Fes |
A |
T |
7: 80,032,857 (GRCm39) |
L296Q |
probably damaging |
Het |
Foxn1 |
A |
T |
11: 78,249,892 (GRCm39) |
N544K |
probably damaging |
Het |
Gga1 |
C |
G |
15: 78,772,370 (GRCm39) |
N223K |
probably damaging |
Het |
Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably null |
Het |
Gm4884 |
A |
T |
7: 40,693,336 (GRCm39) |
Q435L |
possibly damaging |
Het |
Gm8444 |
T |
C |
15: 81,727,581 (GRCm39) |
|
probably benign |
Het |
Ift140 |
T |
G |
17: 25,254,719 (GRCm39) |
S131A |
probably benign |
Het |
Ipo4 |
A |
G |
14: 55,872,477 (GRCm39) |
L88P |
probably damaging |
Het |
Itgal |
G |
A |
7: 126,900,111 (GRCm39) |
S123N |
probably damaging |
Het |
Kcnn3 |
C |
T |
3: 89,472,259 (GRCm39) |
Q344* |
probably null |
Het |
Lrrc8e |
A |
T |
8: 4,285,337 (GRCm39) |
M521L |
probably benign |
Het |
Myocd |
G |
T |
11: 65,087,203 (GRCm39) |
D113E |
possibly damaging |
Het |
Nek4 |
G |
A |
14: 30,696,302 (GRCm39) |
R499H |
possibly damaging |
Het |
Notch3 |
T |
C |
17: 32,341,719 (GRCm39) |
D2011G |
possibly damaging |
Het |
Ola1 |
A |
G |
2: 72,927,538 (GRCm39) |
V347A |
probably damaging |
Het |
Or13p5 |
C |
A |
4: 118,591,829 (GRCm39) |
F34L |
possibly damaging |
Het |
Or6c75 |
G |
A |
10: 129,337,019 (GRCm39) |
V89I |
probably benign |
Het |
Or8u10 |
A |
G |
2: 85,915,635 (GRCm39) |
V162A |
probably benign |
Het |
Oxct2b |
A |
G |
4: 123,011,378 (GRCm39) |
T433A |
probably damaging |
Het |
P2ry14 |
T |
C |
3: 59,022,552 (GRCm39) |
R312G |
probably damaging |
Het |
Pbrm1 |
A |
G |
14: 30,772,099 (GRCm39) |
N398D |
probably damaging |
Het |
Pdc |
T |
C |
1: 150,208,996 (GRCm39) |
Y160H |
probably damaging |
Het |
Pdlim2 |
C |
T |
14: 70,402,228 (GRCm39) |
R296H |
probably damaging |
Het |
Pop4 |
A |
T |
7: 37,962,693 (GRCm39) |
D190E |
probably benign |
Het |
Prb1c |
G |
A |
6: 132,338,553 (GRCm39) |
P222S |
unknown |
Het |
R3hdm4 |
A |
G |
10: 79,747,907 (GRCm39) |
|
probably null |
Het |
Rab1a |
C |
A |
11: 20,173,172 (GRCm39) |
T91K |
possibly damaging |
Het |
Rad9a |
A |
G |
19: 4,247,501 (GRCm39) |
V215A |
possibly damaging |
Het |
Rassf3 |
A |
G |
10: 121,252,159 (GRCm39) |
V84A |
probably damaging |
Het |
Rftn2 |
G |
A |
1: 55,243,458 (GRCm39) |
T270M |
probably damaging |
Het |
Rho |
A |
G |
6: 115,912,384 (GRCm39) |
T100A |
probably damaging |
Het |
Rnft2 |
T |
C |
5: 118,366,947 (GRCm39) |
I264V |
possibly damaging |
Het |
Robo3 |
A |
T |
9: 37,335,203 (GRCm39) |
Y567* |
probably null |
Het |
Rpp14 |
T |
A |
14: 8,083,705 (GRCm38) |
|
probably null |
Het |
Rtkn2 |
T |
C |
10: 67,833,450 (GRCm39) |
S98P |
probably damaging |
Het |
Ryr2 |
A |
G |
13: 11,674,999 (GRCm39) |
V3376A |
possibly damaging |
Het |
Sbf2 |
A |
T |
7: 109,963,756 (GRCm39) |
W1030R |
probably damaging |
Het |
Setbp1 |
G |
A |
18: 78,900,451 (GRCm39) |
A1072V |
possibly damaging |
Het |
Slc4a10 |
A |
G |
2: 62,058,918 (GRCm39) |
K142E |
probably damaging |
Het |
Slc52a2 |
A |
G |
15: 76,423,791 (GRCm39) |
E40G |
probably benign |
Het |
Slc8a2 |
A |
G |
7: 15,891,312 (GRCm39) |
N784S |
possibly damaging |
Het |
Spats2l |
A |
T |
1: 57,982,270 (GRCm39) |
Q384L |
probably damaging |
Het |
Steap4 |
A |
C |
5: 8,026,520 (GRCm39) |
K161T |
probably benign |
Het |
Taf10 |
T |
C |
7: 105,392,438 (GRCm39) |
S188G |
probably benign |
Het |
Tbc1d4 |
C |
T |
14: 101,845,455 (GRCm39) |
D148N |
probably damaging |
Het |
Tenm2 |
T |
G |
11: 36,755,511 (GRCm39) |
K162N |
probably benign |
Het |
Tmem147 |
A |
G |
7: 30,427,221 (GRCm39) |
V146A |
probably benign |
Het |
Tnfsf8 |
A |
G |
4: 63,755,323 (GRCm39) |
S100P |
possibly damaging |
Het |
Trim56 |
T |
C |
5: 137,141,374 (GRCm39) |
Y714C |
probably damaging |
Het |
Ubxn8 |
A |
G |
8: 34,131,929 (GRCm39) |
S13P |
probably damaging |
Het |
Usp49 |
A |
G |
17: 47,983,151 (GRCm39) |
D52G |
possibly damaging |
Het |
Vegfc |
A |
C |
8: 54,639,078 (GRCm39) |
Y408S |
probably benign |
Het |
Vmn2r8 |
T |
A |
5: 108,951,042 (GRCm39) |
L134F |
probably benign |
Het |
Wdfy3 |
T |
A |
5: 102,023,797 (GRCm39) |
I2437F |
probably benign |
Het |
Wwc2 |
A |
T |
8: 48,311,814 (GRCm39) |
L783* |
probably null |
Het |
Zer1 |
C |
T |
2: 29,998,258 (GRCm39) |
R351H |
probably benign |
Het |
Zfp715 |
A |
T |
7: 42,947,861 (GRCm39) |
F700I |
possibly damaging |
Het |
Zfp995 |
G |
A |
17: 22,098,960 (GRCm39) |
H425Y |
probably damaging |
Het |
|
Other mutations in Vmn2r77 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
Predicted Primers |
|
Posted On |
2014-01-15 |