Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00091:Zfp58'

1013

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp58

Ensembl Gene

ENSMUSG00000071291

Gene Name

zinc finger protein 58

Synonyms

Mfg1, Zfp817, A530094I17Rik, Mfg-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.126) question?

Stock #

IGL00091

Quality Score

Status

Chromosome

Chromosomal Location

67638286-67648641 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 67639114 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 459 (V459A)

Ref Sequence

ENSEMBL: ENSMUSP00000132285 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076123] [ENSMUST00000091523] [ENSMUST00000163534] [ENSMUST00000167914] [ENSMUST00000171518]

AlphaFold

P16372

Predicted Effect

probably benign
Transcript: ENSMUST00000076123
AA Change: V459A

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000075487
Gene: ENSMUSG00000071291
AA Change: V459A

Domain	Start	End	E-Value	Type
KRAB	2	62	2.19e-29	SMART
ZnF_C2H2	106	128	4.01e-5	SMART
ZnF_C2H2	134	156	9.73e-4	SMART
ZnF_C2H2	162	184	5.67e-5	SMART
ZnF_C2H2	190	212	3.21e-4	SMART
ZnF_C2H2	218	240	2.57e-3	SMART
ZnF_C2H2	246	268	2.91e-2	SMART
ZnF_C2H2	274	296	9.73e-4	SMART
ZnF_C2H2	302	324	6.23e-2	SMART
ZnF_C2H2	330	352	1.03e-2	SMART
ZnF_C2H2	358	380	1.45e-2	SMART
ZnF_C2H2	386	408	2.99e-4	SMART
ZnF_C2H2	410	432	4.87e-4	SMART
ZnF_C2H2	438	460	2.75e-3	SMART
ZnF_C2H2	466	488	1.58e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000091523

SMART Domains

Protein: ENSMUSP00000089108
Gene: ENSMUSG00000071291

Domain	Start	End	E-Value	Type
KRAB	2	62	2.19e-29	SMART
ZnF_C2H2	106	128	4.01e-5	SMART
ZnF_C2H2	134	156	9.73e-4	SMART
ZnF_C2H2	162	184	5.67e-5	SMART
ZnF_C2H2	190	212	3.21e-4	SMART
ZnF_C2H2	218	240	2.57e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000163534

SMART Domains

Protein: ENSMUSP00000129177
Gene: ENSMUSG00000071291

Domain	Start	End	E-Value	Type
KRAB	2	62	2.19e-29	SMART
ZnF_C2H2	106	128	4.01e-5	SMART
ZnF_C2H2	134	156	9.73e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000167914

SMART Domains

Protein: ENSMUSP00000137830
Gene: ENSMUSG00000097565

Domain	Start	End	E-Value	Type
KRAB	5	65	4.41e-34	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000171518
AA Change: V459A

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000132285
Gene: ENSMUSG00000071291
AA Change: V459A

Domain	Start	End	E-Value	Type
KRAB	2	62	2.19e-29	SMART
ZnF_C2H2	106	128	4.01e-5	SMART
ZnF_C2H2	134	156	9.73e-4	SMART
ZnF_C2H2	162	184	5.67e-5	SMART
ZnF_C2H2	190	212	3.21e-4	SMART
ZnF_C2H2	218	240	2.57e-3	SMART
ZnF_C2H2	246	268	2.91e-2	SMART
ZnF_C2H2	274	296	9.73e-4	SMART
ZnF_C2H2	302	324	6.23e-2	SMART
ZnF_C2H2	330	352	1.03e-2	SMART
ZnF_C2H2	358	380	1.45e-2	SMART
ZnF_C2H2	386	408	2.99e-4	SMART
ZnF_C2H2	410	432	4.87e-4	SMART
ZnF_C2H2	438	460	2.75e-3	SMART
ZnF_C2H2	466	488	1.58e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abraxas2	A	T	7: 132,485,157 (GRCm39)	Y400F	probably benign	Het
Adamts8	C	A	9: 30,864,796 (GRCm39)	T429K	probably damaging	Het
Adgrv1	C	T	13: 81,726,220 (GRCm39)	D602N	probably damaging	Het
Ano7	A	T	1: 93,329,888 (GRCm39)	H775L	probably benign	Het
Apoo-ps	A	T	13: 107,551,134 (GRCm39)		noncoding transcript	Het
Arid2	T	C	15: 96,270,183 (GRCm39)	V1432A	probably benign	Het
Atoh1	T	C	6: 64,706,568 (GRCm39)	S88P	possibly damaging	Het
C130050O18Rik	A	G	5: 139,400,601 (GRCm39)	E218G	probably damaging	Het
Cacna2d1	T	A	5: 16,417,942 (GRCm39)	F155L	probably damaging	Het
Car4	C	T	11: 84,856,593 (GRCm39)	P294S	probably damaging	Het
Cyp1a2	G	T	9: 57,589,352 (GRCm39)	S154*	probably null	Het
Cyp3a25	A	T	5: 145,938,273 (GRCm39)	Y68*	probably null	Het
Dmbt1	C	A	7: 130,681,270 (GRCm39)		probably benign	Het
Dnajc22	T	A	15: 98,999,059 (GRCm39)	F81L	possibly damaging	Het
Eml5	G	A	12: 98,839,468 (GRCm39)		probably benign	Het
Fpgs	A	T	2: 32,576,559 (GRCm39)		probably benign	Het
Gab2	T	C	7: 96,951,650 (GRCm39)	S537P	possibly damaging	Het
Gmds	G	A	13: 32,418,373 (GRCm39)	S37L	probably damaging	Het
Ipo13	T	C	4: 117,760,602 (GRCm39)	E626G	probably benign	Het
Kcng1	T	C	2: 168,110,684 (GRCm39)	H160R	probably benign	Het
Lama3	A	G	18: 12,713,349 (GRCm39)	T1608A	probably benign	Het
Lama4	A	C	10: 38,948,801 (GRCm39)	S855R	probably damaging	Het
Ltbp1	C	T	17: 75,532,333 (GRCm39)	H454Y	probably damaging	Het
Map3k14	C	A	11: 103,118,405 (GRCm39)	G594C	probably damaging	Het
Mcph1	A	G	8: 18,682,636 (GRCm39)	N591S	possibly damaging	Het
Moxd1	G	A	10: 24,155,762 (GRCm39)	V289I	probably damaging	Het
Mptx2	T	G	1: 173,102,455 (GRCm39)	N78T	probably damaging	Het
Muc4	G	A	16: 32,754,086 (GRCm38)	G1321R	probably benign	Het
Muc6	A	C	7: 141,218,497 (GRCm39)	S2059A	probably benign	Het
Nup50	T	A	15: 84,819,605 (GRCm39)	F293Y	probably benign	Het
Ogn	A	G	13: 49,774,514 (GRCm39)	Y219C	probably damaging	Het
Pdia3	T	C	2: 121,244,659 (GRCm39)	L47P	probably damaging	Het
Piwil4	A	T	9: 14,614,393 (GRCm39)	D786E	probably damaging	Het
Pspc1	A	G	14: 57,009,168 (GRCm39)	L222P	probably damaging	Het
Ptchd3	T	A	11: 121,721,972 (GRCm39)	Y282N	probably damaging	Het
Reln	C	A	5: 22,244,563 (GRCm39)	G805V	possibly damaging	Het
Serpini2	T	C	3: 75,156,549 (GRCm39)	Y327C	probably damaging	Het
Spire2	A	G	8: 124,080,798 (GRCm39)	D14G	probably damaging	Het
Stab2	A	T	10: 86,705,070 (GRCm39)		probably null	Het
Timeless	T	C	10: 128,077,577 (GRCm39)	L219P	probably damaging	Het
Tmem63a	C	T	1: 180,790,653 (GRCm39)	T437M	probably damaging	Het
Tslp	A	G	18: 32,948,448 (GRCm39)		probably benign	Het
Ttbk2	C	A	2: 120,579,314 (GRCm39)	G534*	probably null	Het
Uggt1	T	C	1: 36,218,633 (GRCm39)		probably benign	Het
Vmn2r118	T	C	17: 55,899,708 (GRCm39)	E732G	probably damaging	Het
Zfhx2	G	A	14: 55,304,022 (GRCm39)	P1321S	possibly damaging	Het
Zfp831	T	C	2: 174,487,451 (GRCm39)	S709P	possibly damaging	Het

Other mutations in Zfp58

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02618:Zfp58	APN	13	67,639,475 (GRCm39)	missense	possibly damaging	0.92
IGL03188:Zfp58	APN	13	67,639,528 (GRCm39)	missense	probably benign	0.03
R0535:Zfp58	UTSW	13	67,640,201 (GRCm39)	nonsense	probably null
R1470:Zfp58	UTSW	13	67,640,144 (GRCm39)	missense	possibly damaging	0.71
R1470:Zfp58	UTSW	13	67,640,144 (GRCm39)	missense	possibly damaging	0.71
R1750:Zfp58	UTSW	13	67,639,598 (GRCm39)	nonsense	probably null
R1862:Zfp58	UTSW	13	67,639,307 (GRCm39)	missense	probably damaging	1.00
R2697:Zfp58	UTSW	13	67,639,124 (GRCm39)	missense	probably damaging	1.00
R3031:Zfp58	UTSW	13	67,640,231 (GRCm39)	missense	probably benign	0.06
R3033:Zfp58	UTSW	13	67,639,741 (GRCm39)	missense	probably damaging	1.00
R4200:Zfp58	UTSW	13	67,639,440 (GRCm39)	missense	probably benign	0.25
R5827:Zfp58	UTSW	13	67,639,412 (GRCm39)	missense	probably damaging	0.99
R6723:Zfp58	UTSW	13	67,642,192 (GRCm39)	missense	probably damaging	1.00
R7230:Zfp58	UTSW	13	67,640,082 (GRCm39)	nonsense	probably null
R7890:Zfp58	UTSW	13	67,640,114 (GRCm39)	missense	possibly damaging	0.95
R9189:Zfp58	UTSW	13	67,640,035 (GRCm39)	missense	possibly damaging	0.93
R9338:Zfp58	UTSW	13	67,639,394 (GRCm39)	missense	probably benign	0.43
R9477:Zfp58	UTSW	13	67,640,158 (GRCm39)	missense	probably damaging	1.00
R9587:Zfp58	UTSW	13	67,639,823 (GRCm39)	missense	probably damaging	0.99

Posted On

2011-07-12