Incidental Mutation 'R1181:Tas2r121'
ID 101568
Institutional Source Beutler Lab
Gene Symbol Tas2r121
Ensembl Gene ENSMUSG00000071150
Gene Name taste receptor, type 2, member 121
Synonyms mGR21, T2R21, Tas2r21, mT2r48
MMRRC Submission 039253-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R1181 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 132677053-132677970 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 132677132 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 280 (I280N)
Ref Sequence ENSEMBL: ENSMUSP00000093044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095395]
AlphaFold Q7M720
Predicted Effect probably damaging
Transcript: ENSMUST00000095395
AA Change: I280N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000093044
Gene: ENSMUSG00000071150
AA Change: I280N

DomainStartEndE-ValueType
Pfam:TAS2R 1 300 4.5e-108 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 97.9%
  • 10x: 93.9%
  • 20x: 84.2%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn3 T A 19: 4,922,638 (GRCm39) Q64L probably benign Het
Ankrd12 T C 17: 66,349,569 (GRCm39) N88S probably benign Het
Apcdd1 A T 18: 63,070,168 (GRCm39) Y145F probably damaging Het
Bnipl C A 3: 95,152,960 (GRCm39) probably null Het
Bod1 T C 11: 31,616,943 (GRCm39) probably benign Het
Cbarp G T 10: 79,971,328 (GRCm39) H166N probably damaging Het
Cdr2l T A 11: 115,285,005 (GRCm39) I447N probably damaging Het
Cped1 T G 6: 22,215,561 (GRCm39) I698M probably damaging Het
Ecm1 G A 3: 95,642,662 (GRCm39) H404Y possibly damaging Het
Ehbp1 C T 11: 22,012,831 (GRCm39) V902I probably benign Het
Eps8 T C 6: 137,499,852 (GRCm39) Q209R possibly damaging Het
Fastk C T 5: 24,646,729 (GRCm39) probably null Het
Gm6797 T A X: 8,508,004 (GRCm39) noncoding transcript Het
Gp1ba C T 11: 70,532,253 (GRCm39) P673L probably damaging Het
Gstm1 A G 3: 107,922,127 (GRCm39) F170S probably damaging Het
Hgf G C 5: 16,823,923 (GRCm39) G707R probably damaging Het
Klhl5 T C 5: 65,320,228 (GRCm39) M594T probably damaging Het
Kyat3 A C 3: 142,443,531 (GRCm39) probably null Het
Mettl14 C T 3: 123,167,651 (GRCm39) G236S probably damaging Het
Nob1 G A 8: 108,148,122 (GRCm39) P107S probably damaging Het
Nup58 A T 14: 60,482,119 (GRCm39) probably benign Het
Or2a56 T A 6: 42,932,492 (GRCm39) L20Q probably benign Het
Or52e7 T A 7: 104,685,021 (GRCm39) N205K probably damaging Het
Or52n4b C A 7: 108,144,509 (GRCm39) T257N probably benign Het
Or5b109 C A 19: 13,212,195 (GRCm39) H194N probably benign Het
Or5d16 G A 2: 87,773,490 (GRCm39) L161F probably benign Het
Or6c65 A G 10: 129,604,033 (GRCm39) I223V probably benign Het
Pald1 A G 10: 61,183,366 (GRCm39) probably benign Het
Pds5a A T 5: 65,784,545 (GRCm39) probably null Het
Pirb A T 7: 3,720,637 (GRCm39) L287Q probably benign Het
Plekha2 A C 8: 25,549,218 (GRCm39) S189A probably benign Het
Prune2 T C 19: 17,100,469 (GRCm39) V1991A probably benign Het
Sec61g A C 11: 16,454,722 (GRCm39) probably benign Het
Serinc3 T C 2: 163,467,446 (GRCm39) K445R probably damaging Het
Shf G A 2: 122,199,163 (GRCm39) P51S probably damaging Het
Slfn8 T C 11: 82,907,571 (GRCm39) E324G probably benign Het
Spink13 A G 18: 62,741,241 (GRCm39) probably benign Het
Tbc1d7 T C 13: 43,306,615 (GRCm39) I242M probably damaging Het
Tenm2 C T 11: 35,954,004 (GRCm39) G1236R possibly damaging Het
Tnni3k A T 3: 154,581,150 (GRCm39) H600Q probably damaging Het
Trim66 C T 7: 109,083,784 (GRCm39) probably null Het
Ttn A T 2: 76,800,047 (GRCm39) I387N probably damaging Het
Tulp3 A T 6: 128,302,915 (GRCm39) H301Q possibly damaging Het
Ubqln5 T A 7: 103,777,948 (GRCm39) Q292L probably damaging Het
Zfp454 T C 11: 50,764,413 (GRCm39) K229E probably damaging Het
Other mutations in Tas2r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00559:Tas2r121 APN 6 132,677,484 (GRCm39) missense probably benign 0.28
IGL01868:Tas2r121 APN 6 132,677,235 (GRCm39) missense probably benign 0.00
IGL02182:Tas2r121 APN 6 132,677,133 (GRCm39) missense probably damaging 0.99
IGL02728:Tas2r121 APN 6 132,677,480 (GRCm39) missense probably damaging 1.00
R0833:Tas2r121 UTSW 6 132,677,325 (GRCm39) missense probably damaging 1.00
R0836:Tas2r121 UTSW 6 132,677,325 (GRCm39) missense probably damaging 1.00
R1424:Tas2r121 UTSW 6 132,677,645 (GRCm39) missense probably damaging 1.00
R1583:Tas2r121 UTSW 6 132,677,193 (GRCm39) nonsense probably null
R2179:Tas2r121 UTSW 6 132,677,831 (GRCm39) missense probably damaging 1.00
R4711:Tas2r121 UTSW 6 132,677,853 (GRCm39) missense probably benign 0.28
R5274:Tas2r121 UTSW 6 132,677,811 (GRCm39) missense probably damaging 1.00
R5308:Tas2r121 UTSW 6 132,677,480 (GRCm39) missense possibly damaging 0.84
R5663:Tas2r121 UTSW 6 132,677,520 (GRCm39) missense probably benign 0.10
R5668:Tas2r121 UTSW 6 132,677,756 (GRCm39) missense possibly damaging 0.95
R5885:Tas2r121 UTSW 6 132,677,254 (GRCm39) missense probably damaging 1.00
R6395:Tas2r121 UTSW 6 132,677,495 (GRCm39) missense probably benign 0.23
R7552:Tas2r121 UTSW 6 132,677,505 (GRCm39) missense probably benign 0.17
R8094:Tas2r121 UTSW 6 132,677,772 (GRCm39) missense probably benign
R9192:Tas2r121 UTSW 6 132,677,492 (GRCm39) missense probably benign 0.00
R9718:Tas2r121 UTSW 6 132,677,765 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATCTTGCTTATGCCTTCAGTGACAGAG -3'
(R):5'- AGCACTAAAGCCCATGTGAATGCC -3'

Sequencing Primer
(F):5'- TGTACAAGATCACACTACTGTAGC -3'
(R):5'- GAATGCCTTGAGAATTATGGTCTCC -3'
Posted On 2014-01-15