Incidental Mutation 'R1183:Atrnl1'
ID 101841
Institutional Source Beutler Lab
Gene Symbol Atrnl1
Ensembl Gene ENSMUSG00000054843
Gene Name attractin like 1
Synonyms Alp
MMRRC Submission 039255-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.182) question?
Stock # R1183 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 57599466-58121775 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 57638725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 288 (S288P)
Ref Sequence ENSEMBL: ENSMUSP00000076514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077282]
AlphaFold Q6A051
Predicted Effect probably damaging
Transcript: ENSMUST00000077282
AA Change: S288P

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000076514
Gene: ENSMUSG00000054843
AA Change: S288P

DomainStartEndE-ValueType
low complexity region 25 32 N/A INTRINSIC
EGF 61 90 5.71e-1 SMART
CUB 92 208 1.43e-11 SMART
EGF 209 244 1.95e1 SMART
Pfam:EGF_2 248 279 5.8e-7 PFAM
Pfam:Kelch_5 350 391 2.1e-9 PFAM
Pfam:Kelch_6 354 401 5.8e-8 PFAM
Pfam:Kelch_4 465 517 4.3e-7 PFAM
Pfam:Kelch_1 519 573 2.7e-6 PFAM
PSI 613 656 3.38e-1 SMART
PSI 665 708 2e-3 SMART
PSI 714 759 1.72e-2 SMART
CLECT 747 872 2.86e-20 SMART
PSI 888 938 6.26e-5 SMART
PSI 941 1011 1.73e-7 SMART
EGF_Lam 1013 1056 1.07e-5 SMART
low complexity region 1157 1173 N/A INTRINSIC
transmembrane domain 1229 1251 N/A INTRINSIC
low complexity region 1261 1272 N/A INTRINSIC
low complexity region 1326 1339 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.0%
  • 20x: 88.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 T G 8: 111,768,206 (GRCm39) Y192* probably null Het
Abcc6 T C 7: 45,634,677 (GRCm39) Y1100C probably damaging Het
Adamtsl2 T C 2: 26,974,092 (GRCm39) W132R probably damaging Het
Adgra2 T A 8: 27,604,416 (GRCm39) V497E probably damaging Het
Adtrp T G 13: 41,981,813 (GRCm39) probably benign Het
Alg9 T A 9: 50,700,833 (GRCm39) L201Q possibly damaging Het
Ap4e1 T A 2: 126,856,121 (GRCm39) I84K probably damaging Het
Bltp1 T A 3: 36,949,452 (GRCm39) L366Q possibly damaging Het
Cacna1a A G 8: 85,306,846 (GRCm39) D1367G probably damaging Het
Card19 C T 13: 49,358,727 (GRCm39) R82Q probably damaging Het
Cep128 T C 12: 91,292,372 (GRCm39) I226V possibly damaging Het
Ces1f A C 8: 93,994,633 (GRCm39) D259E probably benign Het
Ckap5 T A 2: 91,416,611 (GRCm39) M1072K probably benign Het
Dcpp2 T A 17: 24,119,468 (GRCm39) V94D probably benign Het
Dnah2 T C 11: 69,337,474 (GRCm39) D3209G possibly damaging Het
Dsg1c A G 18: 20,416,255 (GRCm39) T719A probably damaging Het
Dsp G A 13: 38,375,716 (GRCm39) W1167* probably null Het
Eml5 T C 12: 98,758,305 (GRCm39) I1874V probably benign Het
Epg5 A G 18: 78,003,926 (GRCm39) T645A probably damaging Het
F2rl2 T C 13: 95,837,621 (GRCm39) L222S probably damaging Het
Fam114a1 T A 5: 65,191,731 (GRCm39) C495S probably damaging Het
Fbn1 A T 2: 125,163,537 (GRCm39) D2106E probably benign Het
Fgf14 T A 14: 124,913,936 (GRCm39) N65I probably benign Het
Fip1l1 T C 5: 74,755,763 (GRCm39) Y497H probably damaging Het
Fn1 A C 1: 71,625,404 (GRCm39) D2376E probably damaging Het
Foxd2 T C 4: 114,764,662 (GRCm39) T453A possibly damaging Het
Galnt1 G T 18: 24,404,647 (GRCm39) W328L probably damaging Het
Gapt A G 13: 110,490,372 (GRCm39) V97A possibly damaging Het
Gatad1 A G 5: 3,693,707 (GRCm39) V154A possibly damaging Het
Gdf15 A G 8: 71,084,202 (GRCm39) F21L probably benign Het
Igdcc4 T C 9: 65,029,182 (GRCm39) F273S possibly damaging Het
Invs A T 4: 48,421,725 (GRCm39) R786W possibly damaging Het
Itfg1 T G 8: 86,507,152 (GRCm39) E236A probably benign Het
Jak3 A T 8: 72,137,194 (GRCm39) I752F probably damaging Het
Kcnip3 C A 2: 127,306,985 (GRCm39) G144W probably damaging Het
Kctd19 T C 8: 106,109,598 (GRCm39) H925R probably benign Het
Kdr C T 5: 76,107,511 (GRCm39) A1011T probably damaging Het
Kif13b C A 14: 65,019,826 (GRCm39) H1398Q probably benign Het
Lrp4 A T 2: 91,307,864 (GRCm39) probably null Het
Lrtm2 T C 6: 119,297,846 (GRCm39) D65G probably benign Het
Lyz1 A G 10: 117,128,715 (GRCm39) L10P probably damaging Het
Metap2 A T 10: 93,706,046 (GRCm39) N245K probably damaging Het
Mms19 T C 19: 41,943,270 (GRCm39) D297G possibly damaging Het
Mocs3 A G 2: 168,073,573 (GRCm39) D340G possibly damaging Het
Mtfr1l A G 4: 134,256,436 (GRCm39) L243P probably damaging Het
Mtss1 A G 15: 58,842,897 (GRCm39) I105T probably damaging Het
Myo18a T C 11: 77,748,571 (GRCm39) S1967P probably damaging Het
Ncor2 T C 5: 125,100,585 (GRCm39) N2248S possibly damaging Het
Nfatc2 T C 2: 168,432,008 (GRCm39) D35G possibly damaging Het
Nup210l T A 3: 90,067,252 (GRCm39) M764K probably benign Het
Or10a3n A G 7: 108,492,948 (GRCm39) L222P probably damaging Het
Otof T C 5: 30,529,256 (GRCm39) S1753G probably damaging Het
Otog G A 7: 45,939,179 (GRCm39) V2070I probably benign Het
Piezo2 A G 18: 63,219,824 (GRCm39) V961A probably damaging Het
Pofut1 C T 2: 153,103,158 (GRCm39) S169L probably benign Het
Ppp1r10 T A 17: 36,240,335 (GRCm39) S542T possibly damaging Het
Prpf8 T C 11: 75,381,156 (GRCm39) Y219H possibly damaging Het
Ptges3l T C 11: 101,312,731 (GRCm39) D113G possibly damaging Het
Pycr3 G A 15: 75,790,647 (GRCm39) L71F probably benign Het
Ramp3 A G 11: 6,624,867 (GRCm39) K54E possibly damaging Het
Rbpms C A 8: 34,294,100 (GRCm39) Q214H possibly damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Robo4 C A 9: 37,319,348 (GRCm39) D565E probably damaging Het
S100a1 C T 3: 90,418,641 (GRCm39) V58I probably benign Het
Setx T A 2: 29,070,104 (GRCm39) D2636E probably benign Het
Sun2 A T 15: 79,612,669 (GRCm39) V417E probably damaging Het
Tbccd1 T C 16: 22,660,519 (GRCm39) N99S probably benign Het
Tex15 A G 8: 34,064,893 (GRCm39) D1441G probably benign Het
Tmc2 T A 2: 130,089,896 (GRCm39) M627K probably damaging Het
Trim32 A G 4: 65,532,628 (GRCm39) Y395C probably benign Het
Trpm2 A G 10: 77,759,398 (GRCm39) Y1129H probably damaging Het
Trpm8 A T 1: 88,275,813 (GRCm39) R470S probably damaging Het
Tsg101 G T 7: 46,539,372 (GRCm39) D389E probably benign Het
Ubn1 T C 16: 4,882,406 (GRCm39) L46P probably damaging Het
Ubr5 T C 15: 37,997,419 (GRCm39) I1745V possibly damaging Het
Usp20 T C 2: 30,901,797 (GRCm39) Y521H probably benign Het
Vmn1r159 A T 7: 22,543,019 (GRCm39) H4Q probably null Het
Vmn2r27 T A 6: 124,177,491 (GRCm39) E504D probably benign Het
Wdr72 A T 9: 74,086,867 (GRCm39) I612F probably benign Het
Zbtb8a T C 4: 129,251,520 (GRCm39) H317R possibly damaging Het
Zfp507 T C 7: 35,494,315 (GRCm39) S243G probably damaging Het
Zfp764 A G 7: 127,005,419 (GRCm39) W73R probably damaging Het
Zmym4 A T 4: 126,819,632 (GRCm39) D90E probably damaging Het
Other mutations in Atrnl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Atrnl1 APN 19 57,680,249 (GRCm39) missense probably benign 0.02
IGL00707:Atrnl1 APN 19 57,661,697 (GRCm39) missense probably damaging 0.96
IGL00921:Atrnl1 APN 19 57,690,585 (GRCm39) missense probably damaging 1.00
IGL01410:Atrnl1 APN 19 58,119,536 (GRCm39) missense probably damaging 1.00
IGL01468:Atrnl1 APN 19 57,688,144 (GRCm39) missense probably benign 0.02
IGL01756:Atrnl1 APN 19 57,641,380 (GRCm39) missense probably benign
IGL01971:Atrnl1 APN 19 57,741,715 (GRCm39) missense probably damaging 1.00
IGL02019:Atrnl1 APN 19 57,680,195 (GRCm39) splice site probably benign
IGL02580:Atrnl1 APN 19 57,703,008 (GRCm39) splice site probably benign
IGL02649:Atrnl1 APN 19 57,638,873 (GRCm39) splice site probably benign
IGL02676:Atrnl1 APN 19 57,680,316 (GRCm39) missense probably damaging 1.00
IGL03276:Atrnl1 APN 19 57,641,359 (GRCm39) missense probably damaging 0.99
IGL03379:Atrnl1 APN 19 57,630,973 (GRCm39) missense probably benign 0.02
Magnetogorsk UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
polar UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
PIT4812001:Atrnl1 UTSW 19 57,720,055 (GRCm39) missense probably benign 0.08
R0109:Atrnl1 UTSW 19 57,743,949 (GRCm39) missense possibly damaging 0.78
R0308:Atrnl1 UTSW 19 57,741,720 (GRCm39) missense probably benign 0.04
R0394:Atrnl1 UTSW 19 57,661,608 (GRCm39) missense probably benign 0.10
R0734:Atrnl1 UTSW 19 57,643,293 (GRCm39) missense probably damaging 1.00
R0811:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R0812:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R1213:Atrnl1 UTSW 19 57,626,894 (GRCm39) missense probably benign 0.25
R1344:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1418:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1707:Atrnl1 UTSW 19 57,675,169 (GRCm39) missense probably benign 0.00
R1748:Atrnl1 UTSW 19 57,703,134 (GRCm39) missense probably damaging 0.99
R2051:Atrnl1 UTSW 19 57,680,281 (GRCm39) missense probably benign 0.01
R2113:Atrnl1 UTSW 19 57,744,048 (GRCm39) nonsense probably null
R2130:Atrnl1 UTSW 19 57,643,426 (GRCm39) missense probably damaging 1.00
R3710:Atrnl1 UTSW 19 57,645,546 (GRCm39) missense probably damaging 1.00
R3916:Atrnl1 UTSW 19 57,924,084 (GRCm39) missense possibly damaging 0.82
R4524:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R4707:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4712:Atrnl1 UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
R4784:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4785:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4798:Atrnl1 UTSW 19 58,030,793 (GRCm39) missense probably benign
R5172:Atrnl1 UTSW 19 57,673,945 (GRCm39) nonsense probably null
R5226:Atrnl1 UTSW 19 57,638,767 (GRCm39) missense probably benign
R5289:Atrnl1 UTSW 19 57,645,514 (GRCm39) missense probably damaging 1.00
R5372:Atrnl1 UTSW 19 57,743,968 (GRCm39) missense probably benign
R5737:Atrnl1 UTSW 19 57,766,320 (GRCm39) missense possibly damaging 0.84
R5782:Atrnl1 UTSW 19 57,741,718 (GRCm39) missense possibly damaging 0.95
R5826:Atrnl1 UTSW 19 57,618,724 (GRCm39) nonsense probably null
R6169:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R6242:Atrnl1 UTSW 19 57,630,910 (GRCm39) missense probably benign 0.02
R6342:Atrnl1 UTSW 19 57,626,942 (GRCm39) missense probably damaging 1.00
R6372:Atrnl1 UTSW 19 57,638,764 (GRCm39) missense probably benign 0.01
R6811:Atrnl1 UTSW 19 57,643,393 (GRCm39) missense probably damaging 0.98
R6897:Atrnl1 UTSW 19 58,030,800 (GRCm39) missense probably benign 0.01
R7024:Atrnl1 UTSW 19 57,626,882 (GRCm39) critical splice acceptor site probably null
R7085:Atrnl1 UTSW 19 57,680,289 (GRCm39) missense probably damaging 1.00
R7144:Atrnl1 UTSW 19 58,030,784 (GRCm39) missense probably damaging 1.00
R7259:Atrnl1 UTSW 19 57,924,038 (GRCm39) nonsense probably null
R7289:Atrnl1 UTSW 19 57,638,846 (GRCm39) missense probably benign 0.13
R7310:Atrnl1 UTSW 19 57,630,856 (GRCm39) missense possibly damaging 0.69
R7372:Atrnl1 UTSW 19 57,924,078 (GRCm39) missense possibly damaging 0.47
R7432:Atrnl1 UTSW 19 57,743,956 (GRCm39) missense probably damaging 1.00
R7478:Atrnl1 UTSW 19 57,684,744 (GRCm39) missense possibly damaging 0.89
R7556:Atrnl1 UTSW 19 57,643,278 (GRCm39) missense probably benign
R7567:Atrnl1 UTSW 19 57,687,955 (GRCm39) missense probably damaging 0.98
R7608:Atrnl1 UTSW 19 57,703,119 (GRCm39) missense probably damaging 1.00
R7632:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R7655:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7656:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7718:Atrnl1 UTSW 19 57,728,615 (GRCm39) nonsense probably null
R7721:Atrnl1 UTSW 19 57,684,763 (GRCm39) missense probably benign 0.00
R7726:Atrnl1 UTSW 19 57,690,504 (GRCm39) missense probably damaging 1.00
R7733:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense probably benign 0.00
R7774:Atrnl1 UTSW 19 57,688,103 (GRCm39) missense probably damaging 1.00
R8010:Atrnl1 UTSW 19 57,670,878 (GRCm39) missense probably benign 0.14
R8119:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R9242:Atrnl1 UTSW 19 57,645,660 (GRCm39) missense probably benign 0.07
R9265:Atrnl1 UTSW 19 57,766,359 (GRCm39) missense probably benign 0.11
R9272:Atrnl1 UTSW 19 57,643,420 (GRCm39) missense probably benign 0.00
R9480:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense possibly damaging 0.61
R9526:Atrnl1 UTSW 19 57,617,551 (GRCm39) missense probably damaging 0.99
R9672:Atrnl1 UTSW 19 57,618,695 (GRCm39) missense possibly damaging 0.87
R9673:Atrnl1 UTSW 19 57,599,786 (GRCm39) start codon destroyed probably null 0.04
RF021:Atrnl1 UTSW 19 57,630,905 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGTTGTTAATTTGCCCATGACCTTTTGG -3'
(R):5'- AGGCATTGACTGCCTATGGTCTCA -3'

Sequencing Primer
(F):5'- TCAGCCTTTTGCCTGATGG -3'
(R):5'- GACTGCCTATGGTCTCAAATTTAGC -3'
Posted On 2014-01-15