Incidental Mutation 'R1158:Zfp385c'
ID101900
Institutional Source Beutler Lab
Gene Symbol Zfp385c
Ensembl Gene ENSMUSG00000014198
Gene Namezinc finger protein 385C
SynonymsA930006D11Rik
MMRRC Submission 039231-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.259) question?
Stock #R1158 (G1)
Quality Score218
Status Validated
Chromosome11
Chromosomal Location100627543-100692455 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 100629883 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000017981] [ENSMUST00000051947] [ENSMUST00000103119] [ENSMUST00000107376] [ENSMUST00000142993]
Predicted Effect probably benign
Transcript: ENSMUST00000017981
SMART Domains Protein: ENSMUSP00000017981
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 168 4.3e-9 PFAM
Pfam:Roc 6 124 2.2e-13 PFAM
Pfam:MMR_HSR1 6 165 3.1e-6 PFAM
Pfam:Ras 6 170 2.9e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000051947
SMART Domains Protein: ENSMUSP00000059559
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 168 5.6e-9 PFAM
Pfam:Miro 6 123 2.2e-21 PFAM
Pfam:Ras 6 170 4.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000103119
SMART Domains Protein: ENSMUSP00000099408
Gene: ENSMUSG00000014198

DomainStartEndE-ValueType
low complexity region 2 24 N/A INTRINSIC
ZnF_U1 72 108 4.36e-2 SMART
ZnF_C2H2 77 99 1.51e0 SMART
low complexity region 125 141 N/A INTRINSIC
low complexity region 143 161 N/A INTRINSIC
low complexity region 181 200 N/A INTRINSIC
ZnF_U1 225 259 5.72e-4 SMART
ZnF_C2H2 228 252 7.11e0 SMART
ZnF_U1 294 328 7.44e-3 SMART
ZnF_C2H2 297 321 4.34e0 SMART
low complexity region 347 365 N/A INTRINSIC
low complexity region 382 405 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107376
SMART Domains Protein: ENSMUSP00000102999
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 168 5.6e-9 PFAM
Pfam:Miro 6 123 2.2e-21 PFAM
Pfam:Ras 6 170 4.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142993
SMART Domains Protein: ENSMUSP00000114456
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 151 1.3e-8 PFAM
Pfam:Miro 6 123 1.4e-21 PFAM
Pfam:MMR_HSR1 6 145 4.5e-6 PFAM
Pfam:Ras 6 153 2.9e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148560
Predicted Effect probably benign
Transcript: ENSMUST00000151589
SMART Domains Protein: ENSMUSP00000119259
Gene: ENSMUSG00000014198

DomainStartEndE-ValueType
ZnF_U1 40 74 6.04e-3 SMART
ZnF_C2H2 43 67 6.31e1 SMART
low complexity region 79 104 N/A INTRINSIC
ZnF_U1 152 188 4.36e-2 SMART
ZnF_C2H2 157 179 1.51e0 SMART
low complexity region 205 221 N/A INTRINSIC
low complexity region 223 241 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155840
Meta Mutation Damage Score 0.0508 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.3%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adpgk T C 9: 59,310,283 V193A possibly damaging Het
Ahnak A C 19: 9,013,926 E4191D probably benign Het
BC024139 T A 15: 76,120,342 probably benign Het
Bpifb9a T G 2: 154,262,264 I209S probably benign Het
Bst1 T G 5: 43,840,492 probably null Het
Cacna1c C T 6: 118,612,625 R1446H probably damaging Het
Carf A G 1: 60,147,839 K499E probably benign Het
Casq2 A G 3: 102,116,883 E147G probably damaging Het
Cd8a T A 6: 71,373,728 V59D probably damaging Het
Chrm5 T C 2: 112,479,869 T301A probably benign Het
Cog5 G A 12: 31,870,057 probably benign Het
Csmd3 T C 15: 48,292,774 probably null Het
Dopey1 T C 9: 86,485,556 S31P probably damaging Het
Epb41 T C 4: 132,000,191 probably benign Het
Fhod3 C T 18: 24,985,236 A210V probably damaging Het
Gdpgp1 T C 7: 80,238,502 F94L probably benign Het
Gm10264 A T 12: 88,329,668 I139F unknown Het
Hlx G T 1: 184,731,987 A52D probably damaging Het
Htr3b T C 9: 48,936,090 K375R possibly damaging Het
Inhbe G A 10: 127,351,317 R77W probably damaging Het
Itgb8 T C 12: 119,202,496 E100G probably damaging Het
Jakmip1 T C 5: 37,091,128 V44A possibly damaging Het
Lrp12 A G 15: 39,878,431 V315A probably damaging Het
Lrp1b T A 2: 40,677,494 T305S unknown Het
Map3k2 A G 18: 32,217,158 T354A probably benign Het
Mmp16 T C 4: 17,987,726 probably null Het
Mphosph10 T C 7: 64,388,859 probably benign Het
Olfr1263 T A 2: 90,015,254 I108N possibly damaging Het
Olfr1297 T C 2: 111,621,741 E111G probably damaging Het
Olfr1328 A T 4: 118,934,417 C144S probably damaging Het
Olfr472 G A 7: 107,902,923 V69I possibly damaging Het
Olfr514 A G 7: 108,825,178 S274P probably damaging Het
Slc43a3 C A 2: 84,937,796 F37L probably benign Het
Slf2 G T 19: 44,931,416 A36S probably damaging Het
Sorcs1 T C 19: 50,144,160 probably benign Het
Thsd7b A C 1: 130,189,935 probably null Het
Tnfrsf18 A C 4: 156,028,282 I142L probably benign Het
Ttn A G 2: 76,802,511 probably benign Het
Tufm T A 7: 126,489,442 probably null Het
Vmn2r69 A T 7: 85,409,850 probably benign Het
Zfp964 T A 8: 69,663,853 C368S unknown Het
Zswim8 G A 14: 20,721,668 probably benign Het
Other mutations in Zfp385c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Zfp385c APN 11 100629019 missense probably damaging 1.00
IGL02542:Zfp385c APN 11 100629916 missense probably damaging 1.00
IGL02579:Zfp385c APN 11 100630779 missense probably damaging 1.00
IGL03243:Zfp385c APN 11 100634747 missense probably damaging 1.00
R0054:Zfp385c UTSW 11 100629956 missense probably benign 0.08
R0054:Zfp385c UTSW 11 100629956 missense probably benign 0.08
R1884:Zfp385c UTSW 11 100630706 missense probably benign
R1892:Zfp385c UTSW 11 100637804 missense probably damaging 1.00
R6010:Zfp385c UTSW 11 100657537 missense probably benign 0.00
R6020:Zfp385c UTSW 11 100632768 missense probably benign
R6901:Zfp385c UTSW 11 100632759 missense probably benign 0.06
R7008:Zfp385c UTSW 11 100630687 missense probably damaging 0.99
R7272:Zfp385c UTSW 11 100630039 missense possibly damaging 0.50
Predicted Primers
Posted On2014-01-15