Incidental Mutation 'R1184:Nek10'
ID |
101972 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nek10
|
Ensembl Gene |
ENSMUSG00000042567 |
Gene Name |
NIMA (never in mitosis gene a)- related kinase 10 |
Synonyms |
LOC238944 |
MMRRC Submission |
039256-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R1184 (G1)
|
Quality Score |
194 |
Status
|
Validated
|
Chromosome |
14 |
Chromosomal Location |
7457704-7666183 bp(-) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to G
at 14931325 bp (GRCm38)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000153142
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112630]
[ENSMUST00000112631]
[ENSMUST00000224491]
|
AlphaFold |
Q3UGM2 |
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000063220
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000112630
|
SMART Domains |
Protein: ENSMUSP00000108249 Gene: ENSMUSG00000042567
Domain | Start | End | E-Value | Type |
ARM
|
197 |
238 |
8.23e1 |
SMART |
ARM
|
278 |
320 |
5.18e0 |
SMART |
low complexity region
|
387 |
400 |
N/A |
INTRINSIC |
ARM
|
401 |
448 |
7.09e1 |
SMART |
S_TKc
|
519 |
791 |
2.36e-75 |
SMART |
low complexity region
|
799 |
811 |
N/A |
INTRINSIC |
low complexity region
|
839 |
863 |
N/A |
INTRINSIC |
low complexity region
|
908 |
926 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000112631
|
SMART Domains |
Protein: ENSMUSP00000108250 Gene: ENSMUSG00000042567
Domain | Start | End | E-Value | Type |
ARM
|
197 |
238 |
8.23e1 |
SMART |
ARM
|
278 |
320 |
5.18e0 |
SMART |
low complexity region
|
387 |
400 |
N/A |
INTRINSIC |
ARM
|
401 |
448 |
7.09e1 |
SMART |
S_TKc
|
519 |
791 |
2.36e-75 |
SMART |
low complexity region
|
799 |
811 |
N/A |
INTRINSIC |
low complexity region
|
839 |
863 |
N/A |
INTRINSIC |
low complexity region
|
908 |
926 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134866
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000136826
|
SMART Domains |
Protein: ENSMUSP00000123151 Gene: ENSMUSG00000042567
Domain | Start | End | E-Value | Type |
Pfam:Pkinase
|
1 |
87 |
5.1e-13 |
PFAM |
Pfam:Pkinase_Tyr
|
1 |
87 |
4.2e-8 |
PFAM |
low complexity region
|
103 |
115 |
N/A |
INTRINSIC |
low complexity region
|
143 |
167 |
N/A |
INTRINSIC |
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
low complexity region
|
257 |
268 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000224491
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 95.9%
- 20x: 91.5%
|
Validation Efficiency |
100% (83/83) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 82 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700003E16Rik |
A |
G |
6: 83,137,894 (GRCm39) |
R7G |
probably damaging |
Het |
Ahdc1 |
T |
A |
4: 132,792,707 (GRCm39) |
M1316K |
probably benign |
Het |
Alkal1 |
A |
G |
1: 6,459,712 (GRCm39) |
Y96C |
probably damaging |
Het |
Anxa2r1 |
A |
T |
13: 120,496,667 (GRCm39) |
N67K |
probably benign |
Het |
Arhgap17 |
T |
C |
7: 122,913,913 (GRCm39) |
Y199C |
probably damaging |
Het |
Bmp2 |
T |
C |
2: 133,403,388 (GRCm39) |
V313A |
probably damaging |
Het |
Cacna1b |
C |
T |
2: 24,577,757 (GRCm39) |
|
probably null |
Het |
Cars1 |
T |
C |
7: 143,140,876 (GRCm39) |
T141A |
probably damaging |
Het |
Ccdc57 |
A |
G |
11: 120,764,637 (GRCm39) |
|
probably benign |
Het |
Cenpe |
T |
C |
3: 134,970,183 (GRCm39) |
|
probably null |
Het |
Chadl |
T |
C |
15: 81,577,258 (GRCm39) |
S198G |
probably benign |
Het |
Chd6 |
G |
C |
2: 160,872,722 (GRCm39) |
P286R |
probably damaging |
Het |
Clec4a4 |
G |
T |
6: 122,989,671 (GRCm39) |
W104L |
probably benign |
Het |
Coq4 |
G |
A |
2: 29,678,346 (GRCm39) |
|
probably benign |
Het |
Cplane1 |
G |
T |
15: 8,245,971 (GRCm39) |
V1448L |
probably benign |
Het |
Crtc2 |
T |
A |
3: 90,169,940 (GRCm39) |
Y445* |
probably null |
Het |
Dapk1 |
A |
T |
13: 60,844,112 (GRCm39) |
I44F |
probably damaging |
Het |
Dcbld2 |
T |
A |
16: 58,270,204 (GRCm39) |
|
probably null |
Het |
Dcun1d4 |
T |
C |
5: 73,668,455 (GRCm39) |
|
probably benign |
Het |
Depdc7 |
A |
T |
2: 104,560,523 (GRCm39) |
|
probably benign |
Het |
Dna2 |
A |
G |
10: 62,794,977 (GRCm39) |
D416G |
probably benign |
Het |
Dnah2 |
A |
T |
11: 69,390,016 (GRCm39) |
I743N |
probably damaging |
Het |
Dnah9 |
A |
G |
11: 65,975,438 (GRCm39) |
|
probably null |
Het |
Dock3 |
A |
G |
9: 106,846,999 (GRCm39) |
S877P |
probably damaging |
Het |
Eif3l |
T |
A |
15: 78,959,966 (GRCm39) |
|
probably null |
Het |
Epha5 |
A |
T |
5: 84,219,134 (GRCm39) |
|
probably null |
Het |
Ffar3 |
T |
A |
7: 30,554,529 (GRCm39) |
N264Y |
probably damaging |
Het |
Fyb1 |
A |
T |
15: 6,668,381 (GRCm39) |
I525F |
probably damaging |
Het |
Fyco1 |
A |
G |
9: 123,648,218 (GRCm39) |
F1239L |
probably damaging |
Het |
Gcdh |
T |
C |
8: 85,620,071 (GRCm39) |
|
probably benign |
Het |
Gk5 |
T |
C |
9: 96,032,473 (GRCm39) |
|
probably benign |
Het |
Grm1 |
A |
G |
10: 10,595,778 (GRCm39) |
Y617H |
probably benign |
Het |
Gvin-ps3 |
A |
G |
7: 105,683,159 (GRCm39) |
V32A |
probably benign |
Het |
Hhipl2 |
A |
T |
1: 183,206,042 (GRCm39) |
I131L |
probably damaging |
Het |
Larp4b |
T |
C |
13: 9,216,345 (GRCm39) |
|
probably benign |
Het |
Lrig2 |
T |
A |
3: 104,398,227 (GRCm39) |
I301F |
possibly damaging |
Het |
Man2a2 |
A |
T |
7: 80,012,713 (GRCm39) |
I600N |
possibly damaging |
Het |
Mylk2 |
G |
C |
2: 152,755,661 (GRCm39) |
|
probably null |
Het |
Myo6 |
C |
T |
9: 80,193,664 (GRCm39) |
Q870* |
probably null |
Het |
Napg |
T |
G |
18: 63,127,409 (GRCm39) |
H204Q |
probably benign |
Het |
Neb |
G |
A |
2: 52,153,959 (GRCm39) |
T2384M |
probably damaging |
Het |
Or11h23 |
A |
C |
14: 50,948,071 (GRCm39) |
T95P |
probably benign |
Het |
Or4c111 |
A |
G |
2: 88,844,057 (GRCm39) |
M117T |
probably damaging |
Het |
Or5an6 |
T |
C |
19: 12,372,221 (GRCm39) |
V198A |
probably benign |
Het |
Or5b108 |
T |
G |
19: 13,168,739 (GRCm39) |
L236R |
probably damaging |
Het |
Pclo |
A |
G |
5: 14,572,276 (GRCm39) |
T554A |
unknown |
Het |
Perm1 |
C |
A |
4: 156,301,771 (GRCm39) |
T105K |
probably damaging |
Het |
Pik3r1 |
T |
C |
13: 101,822,866 (GRCm39) |
|
probably null |
Het |
Pld5 |
A |
G |
1: 175,872,462 (GRCm39) |
I225T |
probably damaging |
Het |
Plxnc1 |
T |
C |
10: 94,667,195 (GRCm39) |
|
probably benign |
Het |
Ptpn12 |
A |
C |
5: 21,203,354 (GRCm39) |
S475A |
possibly damaging |
Het |
Ptprt |
A |
G |
2: 161,769,692 (GRCm39) |
V391A |
possibly damaging |
Het |
Rac2 |
T |
G |
15: 78,450,145 (GRCm39) |
D65A |
possibly damaging |
Het |
Rgl3 |
A |
G |
9: 21,888,676 (GRCm39) |
|
probably null |
Het |
Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
Sebox |
A |
T |
11: 78,394,675 (GRCm39) |
T47S |
probably damaging |
Het |
Sema4b |
A |
G |
7: 79,874,388 (GRCm39) |
T593A |
probably benign |
Het |
Serpina3a |
C |
T |
12: 104,082,787 (GRCm39) |
Q187* |
probably null |
Het |
Serpinb1a |
T |
C |
13: 33,027,199 (GRCm39) |
K248E |
probably benign |
Het |
Serpinb9e |
A |
C |
13: 33,443,757 (GRCm39) |
E259A |
probably benign |
Het |
Slc30a3 |
T |
A |
5: 31,247,510 (GRCm39) |
H44L |
probably damaging |
Het |
Smarca2 |
T |
C |
19: 26,748,333 (GRCm39) |
|
probably benign |
Het |
Snrnp200 |
T |
A |
2: 127,078,737 (GRCm39) |
C1801S |
probably damaging |
Het |
Soat1 |
G |
A |
1: 156,269,944 (GRCm39) |
|
probably null |
Het |
Spink6 |
T |
C |
18: 44,204,605 (GRCm39) |
|
probably benign |
Het |
Spta1 |
G |
A |
1: 174,012,256 (GRCm39) |
R354H |
probably damaging |
Het |
Tbck |
T |
A |
3: 132,543,733 (GRCm39) |
H861Q |
probably benign |
Het |
Tgfbrap1 |
G |
A |
1: 43,088,856 (GRCm39) |
T849M |
possibly damaging |
Het |
Tnrc6a |
A |
G |
7: 122,769,563 (GRCm39) |
N451S |
possibly damaging |
Het |
Trim36 |
T |
C |
18: 46,329,318 (GRCm39) |
T41A |
probably damaging |
Het |
Trmt112 |
C |
A |
19: 6,887,721 (GRCm39) |
|
probably benign |
Het |
Trpc4ap |
A |
G |
2: 155,486,990 (GRCm39) |
|
probably benign |
Het |
Ttll7 |
C |
T |
3: 146,645,746 (GRCm39) |
P535S |
probably damaging |
Het |
Ttn |
A |
T |
2: 76,691,776 (GRCm39) |
|
probably benign |
Het |
Txndc11 |
C |
T |
16: 10,946,364 (GRCm39) |
R149Q |
probably benign |
Het |
Ubr4 |
C |
T |
4: 139,164,509 (GRCm39) |
|
probably benign |
Het |
Usp30 |
G |
A |
5: 114,241,888 (GRCm39) |
|
probably null |
Het |
Vmn1r195 |
A |
G |
13: 22,463,181 (GRCm39) |
Y217C |
probably damaging |
Het |
Vps33b |
T |
A |
7: 79,932,234 (GRCm39) |
D135E |
probably benign |
Het |
Vrk2 |
A |
G |
11: 26,433,331 (GRCm39) |
|
probably benign |
Het |
Wdr81 |
G |
T |
11: 75,343,809 (GRCm39) |
P486Q |
probably damaging |
Het |
Zfp788 |
T |
C |
7: 41,297,750 (GRCm39) |
Y129H |
probably damaging |
Het |
|
Other mutations in Nek10 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01361:Nek10
|
APN |
14 |
14,850,957 (GRCm38) |
missense |
probably damaging |
0.99 |
IGL02067:Nek10
|
APN |
14 |
14,861,639 (GRCm38) |
missense |
probably benign |
0.12 |
IGL02361:Nek10
|
APN |
14 |
14,843,856 (GRCm38) |
missense |
probably damaging |
1.00 |
IGL02687:Nek10
|
APN |
14 |
14,840,570 (GRCm38) |
missense |
probably damaging |
1.00 |
IGL02929:Nek10
|
APN |
14 |
14,821,119 (GRCm38) |
missense |
possibly damaging |
0.82 |
IGL03229:Nek10
|
APN |
14 |
14,986,686 (GRCm38) |
missense |
probably benign |
0.10 |
P0041:Nek10
|
UTSW |
14 |
14,861,603 (GRCm38) |
missense |
probably benign |
0.01 |
R0007:Nek10
|
UTSW |
14 |
14,840,574 (GRCm38) |
missense |
probably benign |
0.10 |
R0007:Nek10
|
UTSW |
14 |
14,840,574 (GRCm38) |
missense |
probably benign |
0.10 |
R0142:Nek10
|
UTSW |
14 |
14,861,560 (GRCm38) |
missense |
possibly damaging |
0.96 |
R0433:Nek10
|
UTSW |
14 |
14,860,927 (GRCm38) |
missense |
probably benign |
0.32 |
R0633:Nek10
|
UTSW |
14 |
14,857,782 (GRCm38) |
critical splice acceptor site |
probably null |
|
R1087:Nek10
|
UTSW |
14 |
14,827,059 (GRCm38) |
missense |
possibly damaging |
0.59 |
R1250:Nek10
|
UTSW |
14 |
14,853,887 (GRCm38) |
missense |
probably damaging |
1.00 |
R1371:Nek10
|
UTSW |
14 |
14,850,983 (GRCm38) |
missense |
probably damaging |
0.98 |
R1506:Nek10
|
UTSW |
14 |
14,999,078 (GRCm38) |
splice site |
probably benign |
|
R1829:Nek10
|
UTSW |
14 |
14,863,454 (GRCm38) |
critical splice acceptor site |
probably null |
|
R1831:Nek10
|
UTSW |
14 |
14,842,789 (GRCm38) |
missense |
probably benign |
|
R1833:Nek10
|
UTSW |
14 |
14,842,789 (GRCm38) |
missense |
probably benign |
|
R1990:Nek10
|
UTSW |
14 |
14,860,764 (GRCm38) |
missense |
probably benign |
|
R1997:Nek10
|
UTSW |
14 |
14,827,003 (GRCm38) |
missense |
probably benign |
0.09 |
R2011:Nek10
|
UTSW |
14 |
14,885,122 (GRCm38) |
missense |
probably damaging |
1.00 |
R2158:Nek10
|
UTSW |
14 |
14,885,047 (GRCm38) |
splice site |
probably null |
|
R2288:Nek10
|
UTSW |
14 |
14,853,956 (GRCm38) |
nonsense |
probably null |
|
R2568:Nek10
|
UTSW |
14 |
14,999,112 (GRCm38) |
missense |
possibly damaging |
0.89 |
R2907:Nek10
|
UTSW |
14 |
14,980,613 (GRCm38) |
missense |
possibly damaging |
0.81 |
R2965:Nek10
|
UTSW |
14 |
14,836,202 (GRCm38) |
missense |
probably damaging |
1.00 |
R3922:Nek10
|
UTSW |
14 |
14,861,585 (GRCm38) |
missense |
possibly damaging |
0.88 |
R4032:Nek10
|
UTSW |
14 |
14,853,877 (GRCm38) |
splice site |
probably null |
|
R4700:Nek10
|
UTSW |
14 |
14,842,841 (GRCm38) |
missense |
possibly damaging |
0.69 |
R4742:Nek10
|
UTSW |
14 |
14,861,624 (GRCm38) |
missense |
probably null |
0.03 |
R4785:Nek10
|
UTSW |
14 |
14,855,714 (GRCm38) |
missense |
probably benign |
|
R4890:Nek10
|
UTSW |
14 |
14,860,986 (GRCm38) |
missense |
possibly damaging |
0.47 |
R4891:Nek10
|
UTSW |
14 |
14,860,986 (GRCm38) |
missense |
possibly damaging |
0.47 |
R4920:Nek10
|
UTSW |
14 |
14,860,986 (GRCm38) |
missense |
possibly damaging |
0.47 |
R4924:Nek10
|
UTSW |
14 |
14,846,594 (GRCm38) |
splice site |
probably null |
|
R4928:Nek10
|
UTSW |
14 |
14,930,577 (GRCm38) |
missense |
probably damaging |
1.00 |
R4948:Nek10
|
UTSW |
14 |
14,860,986 (GRCm38) |
missense |
possibly damaging |
0.47 |
R4952:Nek10
|
UTSW |
14 |
14,860,986 (GRCm38) |
missense |
possibly damaging |
0.47 |
R4953:Nek10
|
UTSW |
14 |
14,860,986 (GRCm38) |
missense |
possibly damaging |
0.47 |
R5092:Nek10
|
UTSW |
14 |
14,820,851 (GRCm38) |
missense |
possibly damaging |
0.81 |
R5097:Nek10
|
UTSW |
14 |
14,857,851 (GRCm38) |
missense |
probably benign |
0.00 |
R5593:Nek10
|
UTSW |
14 |
14,980,544 (GRCm38) |
nonsense |
probably null |
|
R5696:Nek10
|
UTSW |
14 |
14,860,736 (GRCm38) |
splice site |
probably null |
|
R5813:Nek10
|
UTSW |
14 |
14,986,704 (GRCm38) |
missense |
probably benign |
0.01 |
R5829:Nek10
|
UTSW |
14 |
14,865,404 (GRCm38) |
missense |
probably damaging |
1.00 |
R5872:Nek10
|
UTSW |
14 |
14,850,896 (GRCm38) |
missense |
probably benign |
0.06 |
R5939:Nek10
|
UTSW |
14 |
14,931,290 (GRCm38) |
missense |
possibly damaging |
0.58 |
R6025:Nek10
|
UTSW |
14 |
14,865,633 (GRCm38) |
missense |
probably benign |
0.41 |
R6235:Nek10
|
UTSW |
14 |
14,821,113 (GRCm38) |
nonsense |
probably null |
|
R6539:Nek10
|
UTSW |
14 |
14,860,789 (GRCm38) |
missense |
possibly damaging |
0.94 |
R6542:Nek10
|
UTSW |
14 |
14,999,108 (GRCm38) |
missense |
probably benign |
0.44 |
R6561:Nek10
|
UTSW |
14 |
14,828,448 (GRCm38) |
missense |
possibly damaging |
0.48 |
R6659:Nek10
|
UTSW |
14 |
14,861,684 (GRCm38) |
missense |
probably benign |
0.29 |
R7039:Nek10
|
UTSW |
14 |
14,986,700 (GRCm38) |
missense |
probably damaging |
0.99 |
R7039:Nek10
|
UTSW |
14 |
14,826,946 (GRCm38) |
missense |
possibly damaging |
0.63 |
R7102:Nek10
|
UTSW |
14 |
14,828,517 (GRCm38) |
missense |
probably damaging |
1.00 |
R7185:Nek10
|
UTSW |
14 |
14,846,621 (GRCm38) |
missense |
probably benign |
0.03 |
R7198:Nek10
|
UTSW |
14 |
14,850,947 (GRCm38) |
missense |
probably damaging |
0.99 |
R7202:Nek10
|
UTSW |
14 |
14,836,171 (GRCm38) |
missense |
probably benign |
0.01 |
R7251:Nek10
|
UTSW |
14 |
14,853,965 (GRCm38) |
missense |
probably benign |
|
R7345:Nek10
|
UTSW |
14 |
14,955,503 (GRCm38) |
missense |
probably benign |
|
R7590:Nek10
|
UTSW |
14 |
15,006,693 (GRCm38) |
makesense |
probably null |
|
R7593:Nek10
|
UTSW |
14 |
14,826,955 (GRCm38) |
missense |
probably benign |
0.04 |
R7616:Nek10
|
UTSW |
14 |
14,937,759 (GRCm38) |
missense |
probably benign |
0.27 |
R7635:Nek10
|
UTSW |
14 |
14,850,932 (GRCm38) |
missense |
probably benign |
0.01 |
R7817:Nek10
|
UTSW |
14 |
15,001,017 (GRCm38) |
missense |
probably benign |
0.00 |
R7826:Nek10
|
UTSW |
14 |
14,860,846 (GRCm38) |
splice site |
probably null |
|
R7986:Nek10
|
UTSW |
14 |
15,001,020 (GRCm38) |
missense |
probably benign |
0.17 |
R8765:Nek10
|
UTSW |
14 |
14,999,104 (GRCm38) |
missense |
probably damaging |
0.97 |
R8856:Nek10
|
UTSW |
14 |
14,937,610 (GRCm38) |
missense |
probably damaging |
0.96 |
R8973:Nek10
|
UTSW |
14 |
14,931,321 (GRCm38) |
critical splice donor site |
probably null |
|
R9002:Nek10
|
UTSW |
14 |
14,980,590 (GRCm38) |
missense |
probably damaging |
1.00 |
R9088:Nek10
|
UTSW |
14 |
14,931,314 (GRCm38) |
missense |
probably damaging |
1.00 |
R9195:Nek10
|
UTSW |
14 |
14,821,139 (GRCm38) |
missense |
probably benign |
0.03 |
R9464:Nek10
|
UTSW |
14 |
14,937,766 (GRCm38) |
missense |
probably benign |
|
R9511:Nek10
|
UTSW |
14 |
14,828,511 (GRCm38) |
missense |
probably benign |
0.05 |
R9529:Nek10
|
UTSW |
14 |
14,850,833 (GRCm38) |
missense |
probably benign |
|
R9590:Nek10
|
UTSW |
14 |
14,853,888 (GRCm38) |
missense |
probably damaging |
1.00 |
Z1177:Nek10
|
UTSW |
14 |
15,001,157 (GRCm38) |
nonsense |
probably null |
|
Z1177:Nek10
|
UTSW |
14 |
14,853,948 (GRCm38) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GCCTAGAACTGGCTAACTTGCACTG -3'
(R):5'- AATTCAGGAGGAGCTTGACACTGC -3'
Sequencing Primer
(F):5'- AACTGGCTAACTTGCACTGATTTTC -3'
(R):5'- TCTTGTAGATCGGCCTAATAGC -3'
|
Posted On |
2014-01-15 |