Incidental Mutation 'R1184:Nek10'
ID 101972
Institutional Source Beutler Lab
Gene Symbol Nek10
Ensembl Gene ENSMUSG00000042567
Gene Name NIMA (never in mitosis gene a)- related kinase 10
Synonyms LOC238944
MMRRC Submission 039256-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1184 (G1)
Quality Score 194
Status Validated
Chromosome 14
Chromosomal Location 7457704-7666183 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 14931325 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153142 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112630] [ENSMUST00000112631] [ENSMUST00000224491]
AlphaFold Q3UGM2
Predicted Effect noncoding transcript
Transcript: ENSMUST00000063220
Predicted Effect probably benign
Transcript: ENSMUST00000112630
SMART Domains Protein: ENSMUSP00000108249
Gene: ENSMUSG00000042567

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112631
SMART Domains Protein: ENSMUSP00000108250
Gene: ENSMUSG00000042567

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134866
Predicted Effect probably benign
Transcript: ENSMUST00000136826
SMART Domains Protein: ENSMUSP00000123151
Gene: ENSMUSG00000042567

DomainStartEndE-ValueType
Pfam:Pkinase 1 87 5.1e-13 PFAM
Pfam:Pkinase_Tyr 1 87 4.2e-8 PFAM
low complexity region 103 115 N/A INTRINSIC
low complexity region 143 167 N/A INTRINSIC
low complexity region 212 230 N/A INTRINSIC
low complexity region 257 268 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000224491
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.5%
Validation Efficiency 100% (83/83)
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003E16Rik A G 6: 83,137,894 (GRCm39) R7G probably damaging Het
Ahdc1 T A 4: 132,792,707 (GRCm39) M1316K probably benign Het
Alkal1 A G 1: 6,459,712 (GRCm39) Y96C probably damaging Het
Anxa2r1 A T 13: 120,496,667 (GRCm39) N67K probably benign Het
Arhgap17 T C 7: 122,913,913 (GRCm39) Y199C probably damaging Het
Bmp2 T C 2: 133,403,388 (GRCm39) V313A probably damaging Het
Cacna1b C T 2: 24,577,757 (GRCm39) probably null Het
Cars1 T C 7: 143,140,876 (GRCm39) T141A probably damaging Het
Ccdc57 A G 11: 120,764,637 (GRCm39) probably benign Het
Cenpe T C 3: 134,970,183 (GRCm39) probably null Het
Chadl T C 15: 81,577,258 (GRCm39) S198G probably benign Het
Chd6 G C 2: 160,872,722 (GRCm39) P286R probably damaging Het
Clec4a4 G T 6: 122,989,671 (GRCm39) W104L probably benign Het
Coq4 G A 2: 29,678,346 (GRCm39) probably benign Het
Cplane1 G T 15: 8,245,971 (GRCm39) V1448L probably benign Het
Crtc2 T A 3: 90,169,940 (GRCm39) Y445* probably null Het
Dapk1 A T 13: 60,844,112 (GRCm39) I44F probably damaging Het
Dcbld2 T A 16: 58,270,204 (GRCm39) probably null Het
Dcun1d4 T C 5: 73,668,455 (GRCm39) probably benign Het
Depdc7 A T 2: 104,560,523 (GRCm39) probably benign Het
Dna2 A G 10: 62,794,977 (GRCm39) D416G probably benign Het
Dnah2 A T 11: 69,390,016 (GRCm39) I743N probably damaging Het
Dnah9 A G 11: 65,975,438 (GRCm39) probably null Het
Dock3 A G 9: 106,846,999 (GRCm39) S877P probably damaging Het
Eif3l T A 15: 78,959,966 (GRCm39) probably null Het
Epha5 A T 5: 84,219,134 (GRCm39) probably null Het
Ffar3 T A 7: 30,554,529 (GRCm39) N264Y probably damaging Het
Fyb1 A T 15: 6,668,381 (GRCm39) I525F probably damaging Het
Fyco1 A G 9: 123,648,218 (GRCm39) F1239L probably damaging Het
Gcdh T C 8: 85,620,071 (GRCm39) probably benign Het
Gk5 T C 9: 96,032,473 (GRCm39) probably benign Het
Grm1 A G 10: 10,595,778 (GRCm39) Y617H probably benign Het
Gvin-ps3 A G 7: 105,683,159 (GRCm39) V32A probably benign Het
Hhipl2 A T 1: 183,206,042 (GRCm39) I131L probably damaging Het
Larp4b T C 13: 9,216,345 (GRCm39) probably benign Het
Lrig2 T A 3: 104,398,227 (GRCm39) I301F possibly damaging Het
Man2a2 A T 7: 80,012,713 (GRCm39) I600N possibly damaging Het
Mylk2 G C 2: 152,755,661 (GRCm39) probably null Het
Myo6 C T 9: 80,193,664 (GRCm39) Q870* probably null Het
Napg T G 18: 63,127,409 (GRCm39) H204Q probably benign Het
Neb G A 2: 52,153,959 (GRCm39) T2384M probably damaging Het
Or11h23 A C 14: 50,948,071 (GRCm39) T95P probably benign Het
Or4c111 A G 2: 88,844,057 (GRCm39) M117T probably damaging Het
Or5an6 T C 19: 12,372,221 (GRCm39) V198A probably benign Het
Or5b108 T G 19: 13,168,739 (GRCm39) L236R probably damaging Het
Pclo A G 5: 14,572,276 (GRCm39) T554A unknown Het
Perm1 C A 4: 156,301,771 (GRCm39) T105K probably damaging Het
Pik3r1 T C 13: 101,822,866 (GRCm39) probably null Het
Pld5 A G 1: 175,872,462 (GRCm39) I225T probably damaging Het
Plxnc1 T C 10: 94,667,195 (GRCm39) probably benign Het
Ptpn12 A C 5: 21,203,354 (GRCm39) S475A possibly damaging Het
Ptprt A G 2: 161,769,692 (GRCm39) V391A possibly damaging Het
Rac2 T G 15: 78,450,145 (GRCm39) D65A possibly damaging Het
Rgl3 A G 9: 21,888,676 (GRCm39) probably null Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Sebox A T 11: 78,394,675 (GRCm39) T47S probably damaging Het
Sema4b A G 7: 79,874,388 (GRCm39) T593A probably benign Het
Serpina3a C T 12: 104,082,787 (GRCm39) Q187* probably null Het
Serpinb1a T C 13: 33,027,199 (GRCm39) K248E probably benign Het
Serpinb9e A C 13: 33,443,757 (GRCm39) E259A probably benign Het
Slc30a3 T A 5: 31,247,510 (GRCm39) H44L probably damaging Het
Smarca2 T C 19: 26,748,333 (GRCm39) probably benign Het
Snrnp200 T A 2: 127,078,737 (GRCm39) C1801S probably damaging Het
Soat1 G A 1: 156,269,944 (GRCm39) probably null Het
Spink6 T C 18: 44,204,605 (GRCm39) probably benign Het
Spta1 G A 1: 174,012,256 (GRCm39) R354H probably damaging Het
Tbck T A 3: 132,543,733 (GRCm39) H861Q probably benign Het
Tgfbrap1 G A 1: 43,088,856 (GRCm39) T849M possibly damaging Het
Tnrc6a A G 7: 122,769,563 (GRCm39) N451S possibly damaging Het
Trim36 T C 18: 46,329,318 (GRCm39) T41A probably damaging Het
Trmt112 C A 19: 6,887,721 (GRCm39) probably benign Het
Trpc4ap A G 2: 155,486,990 (GRCm39) probably benign Het
Ttll7 C T 3: 146,645,746 (GRCm39) P535S probably damaging Het
Ttn A T 2: 76,691,776 (GRCm39) probably benign Het
Txndc11 C T 16: 10,946,364 (GRCm39) R149Q probably benign Het
Ubr4 C T 4: 139,164,509 (GRCm39) probably benign Het
Usp30 G A 5: 114,241,888 (GRCm39) probably null Het
Vmn1r195 A G 13: 22,463,181 (GRCm39) Y217C probably damaging Het
Vps33b T A 7: 79,932,234 (GRCm39) D135E probably benign Het
Vrk2 A G 11: 26,433,331 (GRCm39) probably benign Het
Wdr81 G T 11: 75,343,809 (GRCm39) P486Q probably damaging Het
Zfp788 T C 7: 41,297,750 (GRCm39) Y129H probably damaging Het
Other mutations in Nek10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01361:Nek10 APN 14 14,850,957 (GRCm38) missense probably damaging 0.99
IGL02067:Nek10 APN 14 14,861,639 (GRCm38) missense probably benign 0.12
IGL02361:Nek10 APN 14 14,843,856 (GRCm38) missense probably damaging 1.00
IGL02687:Nek10 APN 14 14,840,570 (GRCm38) missense probably damaging 1.00
IGL02929:Nek10 APN 14 14,821,119 (GRCm38) missense possibly damaging 0.82
IGL03229:Nek10 APN 14 14,986,686 (GRCm38) missense probably benign 0.10
P0041:Nek10 UTSW 14 14,861,603 (GRCm38) missense probably benign 0.01
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0142:Nek10 UTSW 14 14,861,560 (GRCm38) missense possibly damaging 0.96
R0433:Nek10 UTSW 14 14,860,927 (GRCm38) missense probably benign 0.32
R0633:Nek10 UTSW 14 14,857,782 (GRCm38) critical splice acceptor site probably null
R1087:Nek10 UTSW 14 14,827,059 (GRCm38) missense possibly damaging 0.59
R1250:Nek10 UTSW 14 14,853,887 (GRCm38) missense probably damaging 1.00
R1371:Nek10 UTSW 14 14,850,983 (GRCm38) missense probably damaging 0.98
R1506:Nek10 UTSW 14 14,999,078 (GRCm38) splice site probably benign
R1829:Nek10 UTSW 14 14,863,454 (GRCm38) critical splice acceptor site probably null
R1831:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1833:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1990:Nek10 UTSW 14 14,860,764 (GRCm38) missense probably benign
R1997:Nek10 UTSW 14 14,827,003 (GRCm38) missense probably benign 0.09
R2011:Nek10 UTSW 14 14,885,122 (GRCm38) missense probably damaging 1.00
R2158:Nek10 UTSW 14 14,885,047 (GRCm38) splice site probably null
R2288:Nek10 UTSW 14 14,853,956 (GRCm38) nonsense probably null
R2568:Nek10 UTSW 14 14,999,112 (GRCm38) missense possibly damaging 0.89
R2907:Nek10 UTSW 14 14,980,613 (GRCm38) missense possibly damaging 0.81
R2965:Nek10 UTSW 14 14,836,202 (GRCm38) missense probably damaging 1.00
R3922:Nek10 UTSW 14 14,861,585 (GRCm38) missense possibly damaging 0.88
R4032:Nek10 UTSW 14 14,853,877 (GRCm38) splice site probably null
R4700:Nek10 UTSW 14 14,842,841 (GRCm38) missense possibly damaging 0.69
R4742:Nek10 UTSW 14 14,861,624 (GRCm38) missense probably null 0.03
R4785:Nek10 UTSW 14 14,855,714 (GRCm38) missense probably benign
R4890:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4891:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4920:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4924:Nek10 UTSW 14 14,846,594 (GRCm38) splice site probably null
R4928:Nek10 UTSW 14 14,930,577 (GRCm38) missense probably damaging 1.00
R4948:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4952:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4953:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R5092:Nek10 UTSW 14 14,820,851 (GRCm38) missense possibly damaging 0.81
R5097:Nek10 UTSW 14 14,857,851 (GRCm38) missense probably benign 0.00
R5593:Nek10 UTSW 14 14,980,544 (GRCm38) nonsense probably null
R5696:Nek10 UTSW 14 14,860,736 (GRCm38) splice site probably null
R5813:Nek10 UTSW 14 14,986,704 (GRCm38) missense probably benign 0.01
R5829:Nek10 UTSW 14 14,865,404 (GRCm38) missense probably damaging 1.00
R5872:Nek10 UTSW 14 14,850,896 (GRCm38) missense probably benign 0.06
R5939:Nek10 UTSW 14 14,931,290 (GRCm38) missense possibly damaging 0.58
R6025:Nek10 UTSW 14 14,865,633 (GRCm38) missense probably benign 0.41
R6235:Nek10 UTSW 14 14,821,113 (GRCm38) nonsense probably null
R6539:Nek10 UTSW 14 14,860,789 (GRCm38) missense possibly damaging 0.94
R6542:Nek10 UTSW 14 14,999,108 (GRCm38) missense probably benign 0.44
R6561:Nek10 UTSW 14 14,828,448 (GRCm38) missense possibly damaging 0.48
R6659:Nek10 UTSW 14 14,861,684 (GRCm38) missense probably benign 0.29
R7039:Nek10 UTSW 14 14,986,700 (GRCm38) missense probably damaging 0.99
R7039:Nek10 UTSW 14 14,826,946 (GRCm38) missense possibly damaging 0.63
R7102:Nek10 UTSW 14 14,828,517 (GRCm38) missense probably damaging 1.00
R7185:Nek10 UTSW 14 14,846,621 (GRCm38) missense probably benign 0.03
R7198:Nek10 UTSW 14 14,850,947 (GRCm38) missense probably damaging 0.99
R7202:Nek10 UTSW 14 14,836,171 (GRCm38) missense probably benign 0.01
R7251:Nek10 UTSW 14 14,853,965 (GRCm38) missense probably benign
R7345:Nek10 UTSW 14 14,955,503 (GRCm38) missense probably benign
R7590:Nek10 UTSW 14 15,006,693 (GRCm38) makesense probably null
R7593:Nek10 UTSW 14 14,826,955 (GRCm38) missense probably benign 0.04
R7616:Nek10 UTSW 14 14,937,759 (GRCm38) missense probably benign 0.27
R7635:Nek10 UTSW 14 14,850,932 (GRCm38) missense probably benign 0.01
R7817:Nek10 UTSW 14 15,001,017 (GRCm38) missense probably benign 0.00
R7826:Nek10 UTSW 14 14,860,846 (GRCm38) splice site probably null
R7986:Nek10 UTSW 14 15,001,020 (GRCm38) missense probably benign 0.17
R8765:Nek10 UTSW 14 14,999,104 (GRCm38) missense probably damaging 0.97
R8856:Nek10 UTSW 14 14,937,610 (GRCm38) missense probably damaging 0.96
R8973:Nek10 UTSW 14 14,931,321 (GRCm38) critical splice donor site probably null
R9002:Nek10 UTSW 14 14,980,590 (GRCm38) missense probably damaging 1.00
R9088:Nek10 UTSW 14 14,931,314 (GRCm38) missense probably damaging 1.00
R9195:Nek10 UTSW 14 14,821,139 (GRCm38) missense probably benign 0.03
R9464:Nek10 UTSW 14 14,937,766 (GRCm38) missense probably benign
R9511:Nek10 UTSW 14 14,828,511 (GRCm38) missense probably benign 0.05
R9529:Nek10 UTSW 14 14,850,833 (GRCm38) missense probably benign
R9590:Nek10 UTSW 14 14,853,888 (GRCm38) missense probably damaging 1.00
Z1177:Nek10 UTSW 14 15,001,157 (GRCm38) nonsense probably null
Z1177:Nek10 UTSW 14 14,853,948 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCTAGAACTGGCTAACTTGCACTG -3'
(R):5'- AATTCAGGAGGAGCTTGACACTGC -3'

Sequencing Primer
(F):5'- AACTGGCTAACTTGCACTGATTTTC -3'
(R):5'- TCTTGTAGATCGGCCTAATAGC -3'
Posted On 2014-01-15