Incidental Mutation 'R1185:Zfp459'
ID 102067
Institutional Source Beutler Lab
Gene Symbol Zfp459
Ensembl Gene ENSMUSG00000055560
Gene Name zinc finger protein 459
Synonyms Rslcan-14, 9930025G17Rik
MMRRC Submission 039257-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1185 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 67553831-67569537 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 67556600 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Threonine at position 161 (N161T)
Ref Sequence ENSEMBL: ENSMUSP00000153407 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056470] [ENSMUST00000223644] [ENSMUST00000224113]
AlphaFold Q8BZ17
Predicted Effect probably benign
Transcript: ENSMUST00000056470
AA Change: N161T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000063027
Gene: ENSMUSG00000055560
AA Change: N161T

DomainStartEndE-ValueType
KRAB 2 62 2.22e-30 SMART
ZnF_C2H2 106 128 5.9e-3 SMART
ZnF_C2H2 134 156 2.2e-2 SMART
ZnF_C2H2 162 184 2.4e-3 SMART
ZnF_C2H2 190 210 2.97e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000223644
Predicted Effect probably benign
Transcript: ENSMUST00000224113
AA Change: N161T

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224496
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225810
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 96.3%
  • 10x: 87.8%
  • 20x: 68.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aimp2 A G 5: 143,841,509 (GRCm39) S110P possibly damaging Het
Akap9 A G 5: 3,998,783 (GRCm39) T51A probably benign Het
Arhgef25 A G 10: 127,019,650 (GRCm39) F430L possibly damaging Het
Brap T C 5: 121,813,342 (GRCm39) V235A probably damaging Het
Cd69 C T 6: 129,247,148 (GRCm39) G23D probably damaging Het
Cecr2 C T 6: 120,735,166 (GRCm39) R24* probably null Het
Celsr2 T C 3: 108,307,025 (GRCm39) D1974G possibly damaging Het
Cps1 A G 1: 67,234,358 (GRCm39) K915R probably benign Het
Csmd1 T C 8: 16,408,362 (GRCm39) D401G probably damaging Het
Dusp13b A G 14: 21,785,086 (GRCm39) F141S probably damaging Het
Eif1ad19 A G 12: 87,740,478 (GRCm39) V27A probably benign Het
Fam162b A G 10: 51,466,439 (GRCm39) W27R probably benign Het
Focad A G 4: 88,096,424 (GRCm39) T269A probably benign Het
Ghr T A 15: 3,357,544 (GRCm39) R241S possibly damaging Het
Hirip3 AAGAG AAG 7: 126,462,832 (GRCm39) probably null Het
Ift70a1 A T 2: 75,810,696 (GRCm39) N462K probably damaging Het
Itgb2l A G 16: 96,230,240 (GRCm39) Y357H possibly damaging Het
Jrkl T C 9: 13,244,938 (GRCm39) D241G possibly damaging Het
Lmod1 A G 1: 135,291,967 (GRCm39) D274G probably benign Het
Lrrn2 A G 1: 132,866,959 (GRCm39) S675G probably benign Het
Ltbp4 G C 7: 27,009,960 (GRCm39) P1200R probably damaging Het
Mdn1 T C 4: 32,735,576 (GRCm39) L3414P possibly damaging Het
Myo16 T A 8: 10,683,624 (GRCm39) S1856T probably damaging Het
Neb A G 2: 52,186,310 (GRCm39) Y921H probably damaging Het
Or2n1c T A 17: 38,520,074 (GRCm39) *313R probably null Het
Pgap3 T C 11: 98,281,960 (GRCm39) D117G probably damaging Het
Ppp1r9b T C 11: 94,892,812 (GRCm39) F671L possibly damaging Het
Proser3 G A 7: 30,245,572 (GRCm39) A144V probably benign Het
Purg T G 8: 33,876,897 (GRCm39) Y178* probably null Het
Sfi1 TCGC TC 11: 3,096,254 (GRCm39) probably null Het
Sfi1 CCTCTC CCTCTCTC 11: 3,127,419 (GRCm39) probably benign Het
Sorbs1 T A 19: 40,371,050 (GRCm39) D79V probably damaging Het
Tcaf3 T C 6: 42,568,368 (GRCm39) T663A probably damaging Het
Timd4 C A 11: 46,708,475 (GRCm39) T167K probably damaging Het
Tjp2 A G 19: 24,108,527 (GRCm39) L195P possibly damaging Het
Tnr G A 1: 159,679,856 (GRCm39) A277T probably benign Het
Unc13a C T 8: 72,114,477 (GRCm39) G181D probably benign Het
Vmn1r11 T A 6: 57,114,492 (GRCm39) L52Q possibly damaging Het
Vmn2r125 C A 4: 156,703,396 (GRCm39) A258D probably benign Het
Zfp27 T C 7: 29,595,254 (GRCm39) D237G possibly damaging Het
Zfp39 T C 11: 58,793,670 (GRCm39) T23A possibly damaging Het
Other mutations in Zfp459
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03115:Zfp459 APN 13 67,556,796 (GRCm39) nonsense probably null
FR4304:Zfp459 UTSW 13 67,556,393 (GRCm39) frame shift probably null
FR4589:Zfp459 UTSW 13 67,556,394 (GRCm39) frame shift probably null
FR4976:Zfp459 UTSW 13 67,556,395 (GRCm39) frame shift probably null
FR4976:Zfp459 UTSW 13 67,556,394 (GRCm39) frame shift probably null
FR4976:Zfp459 UTSW 13 67,556,393 (GRCm39) frame shift probably null
R1185:Zfp459 UTSW 13 67,556,600 (GRCm39) missense probably benign 0.00
R1185:Zfp459 UTSW 13 67,556,600 (GRCm39) missense probably benign 0.00
R2130:Zfp459 UTSW 13 67,556,395 (GRCm39) missense probably benign 0.04
R2994:Zfp459 UTSW 13 67,556,853 (GRCm39) missense possibly damaging 0.73
R4180:Zfp459 UTSW 13 67,556,562 (GRCm39) missense probably benign 0.41
R4306:Zfp459 UTSW 13 67,561,307 (GRCm39) missense probably damaging 1.00
R5306:Zfp459 UTSW 13 67,561,249 (GRCm39) missense probably damaging 0.99
R5493:Zfp459 UTSW 13 67,556,498 (GRCm39) missense probably damaging 1.00
R7683:Zfp459 UTSW 13 67,556,615 (GRCm39) missense probably damaging 1.00
R9004:Zfp459 UTSW 13 67,556,714 (GRCm39) missense probably damaging 1.00
R9145:Zfp459 UTSW 13 67,556,735 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGCCACAGTCTTGGCAGGTGTA -3'
(R):5'- AGCCCACTAATTGTGAATCACTCCTTC -3'

Sequencing Primer
(F):5'- ccagtatgaactctcttgtgtatcc -3'
(R):5'- ttaatacaggggagaaaccctac -3'
Posted On 2014-01-15