Incidental Mutation 'R1141:Fbxw15'
ID |
102113 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fbxw15
|
Ensembl Gene |
ENSMUSG00000074060 |
Gene Name |
F-box and WD-40 domain protein 15 |
Synonyms |
Fbxo12J |
MMRRC Submission |
039214-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.059)
|
Stock # |
R1141 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
9 |
Chromosomal Location |
109381670-109397330 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 109387314 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Phenylalanine
at position 227
(S227F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000058175
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056745]
[ENSMUST00000198112]
[ENSMUST00000198397]
|
AlphaFold |
L7N1X6 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000056745
AA Change: S227F
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000058175 Gene: ENSMUSG00000074060 AA Change: S227F
Domain | Start | End | E-Value | Type |
FBOX
|
8 |
45 |
3.25e-4 |
SMART |
SCOP:d1flga_
|
73 |
413 |
3e-7 |
SMART |
Blast:WD40
|
137 |
176 |
5e-6 |
BLAST |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000198112
AA Change: S174F
PolyPhen 2
Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000142894 Gene: ENSMUSG00000074060 AA Change: S174F
Domain | Start | End | E-Value | Type |
FBOX
|
8 |
45 |
2.1e-6 |
SMART |
SCOP:d1tbga_
|
73 |
196 |
3e-5 |
SMART |
Blast:WD40
|
84 |
123 |
1e-5 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000198397
|
SMART Domains |
Protein: ENSMUSP00000143385 Gene: ENSMUSG00000074060
Domain | Start | End | E-Value | Type |
FBOX
|
8 |
45 |
3.25e-4 |
SMART |
SCOP:d1tbga_
|
116 |
240 |
1e-3 |
SMART |
Blast:WD40
|
137 |
176 |
6e-6 |
BLAST |
|
Meta Mutation Damage Score |
0.6079 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.0%
- 10x: 94.1%
- 20x: 84.2%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 26 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aak1 |
G |
A |
6: 86,942,458 (GRCm39) |
|
probably null |
Het |
Asap2 |
A |
G |
12: 21,235,111 (GRCm39) |
N71S |
probably damaging |
Het |
Brinp1 |
T |
C |
4: 68,711,215 (GRCm39) |
H331R |
probably benign |
Het |
Brinp2 |
C |
A |
1: 158,074,840 (GRCm39) |
C427F |
probably damaging |
Het |
Ccr6 |
A |
G |
17: 8,474,834 (GRCm39) |
Y13C |
probably damaging |
Het |
Celf4 |
T |
C |
18: 25,637,961 (GRCm39) |
D187G |
probably damaging |
Het |
Clcn6 |
T |
G |
4: 148,098,356 (GRCm39) |
T556P |
probably damaging |
Het |
Dst |
A |
T |
1: 34,227,777 (GRCm39) |
Q1968L |
possibly damaging |
Het |
Elavl4 |
G |
A |
4: 110,108,565 (GRCm39) |
Q53* |
probably null |
Het |
Gli2 |
T |
C |
1: 118,765,667 (GRCm39) |
H828R |
possibly damaging |
Het |
Gpr108 |
A |
G |
17: 57,544,219 (GRCm39) |
V397A |
probably damaging |
Het |
Lrba |
T |
C |
3: 86,526,865 (GRCm39) |
I2241T |
probably damaging |
Het |
Map3k21 |
G |
A |
8: 126,668,471 (GRCm39) |
V686M |
probably benign |
Het |
Nfatc4 |
A |
T |
14: 56,070,088 (GRCm39) |
E752V |
probably damaging |
Het |
R3hdm1 |
G |
A |
1: 128,159,142 (GRCm39) |
R939H |
probably benign |
Het |
Rnf213 |
A |
G |
11: 119,326,809 (GRCm39) |
T1599A |
probably benign |
Het |
Sft2d1rt |
G |
A |
11: 45,942,781 (GRCm39) |
A114V |
possibly damaging |
Het |
Slc3a1 |
T |
C |
17: 85,336,077 (GRCm39) |
F73S |
possibly damaging |
Het |
Sppl3 |
TGG |
TG |
5: 115,226,352 (GRCm39) |
|
probably null |
Het |
Stx1b |
T |
C |
7: 127,410,098 (GRCm39) |
|
probably null |
Het |
Tnc |
C |
T |
4: 63,932,231 (GRCm39) |
V728M |
probably damaging |
Het |
Trim24 |
C |
T |
6: 37,892,228 (GRCm39) |
H254Y |
probably damaging |
Het |
Ttbk2 |
A |
G |
2: 120,637,332 (GRCm39) |
L42P |
probably damaging |
Het |
Vmn2r53 |
G |
A |
7: 12,334,673 (GRCm39) |
T329I |
possibly damaging |
Het |
Zfp174 |
T |
A |
16: 3,667,321 (GRCm39) |
I170N |
probably benign |
Het |
Zfp455 |
T |
A |
13: 67,346,655 (GRCm39) |
L22Q |
probably damaging |
Het |
|
Other mutations in Fbxw15 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02094:Fbxw15
|
APN |
9 |
109,387,308 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL02239:Fbxw15
|
APN |
9 |
109,388,905 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02343:Fbxw15
|
APN |
9 |
109,381,723 (GRCm39) |
utr 3 prime |
probably benign |
|
IGL02748:Fbxw15
|
APN |
9 |
109,387,278 (GRCm39) |
missense |
possibly damaging |
0.66 |
IGL03206:Fbxw15
|
APN |
9 |
109,394,430 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL03370:Fbxw15
|
APN |
9 |
109,384,219 (GRCm39) |
missense |
probably benign |
0.00 |
lagging
|
UTSW |
9 |
109,384,741 (GRCm39) |
splice site |
probably null |
|
R0321:Fbxw15
|
UTSW |
9 |
109,394,453 (GRCm39) |
missense |
probably benign |
0.03 |
R0742:Fbxw15
|
UTSW |
9 |
109,384,624 (GRCm39) |
splice site |
probably null |
|
R1143:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1276:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1282:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1283:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1321:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1324:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1341:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1716:Fbxw15
|
UTSW |
9 |
109,386,204 (GRCm39) |
missense |
probably benign |
0.00 |
R1750:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1757:Fbxw15
|
UTSW |
9 |
109,386,347 (GRCm39) |
missense |
probably damaging |
0.99 |
R1765:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1799:Fbxw15
|
UTSW |
9 |
109,387,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R1826:Fbxw15
|
UTSW |
9 |
109,388,782 (GRCm39) |
splice site |
probably null |
|
R1897:Fbxw15
|
UTSW |
9 |
109,387,271 (GRCm39) |
nonsense |
probably null |
|
R2237:Fbxw15
|
UTSW |
9 |
109,384,303 (GRCm39) |
missense |
probably damaging |
0.99 |
R2346:Fbxw15
|
UTSW |
9 |
109,394,500 (GRCm39) |
missense |
probably damaging |
1.00 |
R4391:Fbxw15
|
UTSW |
9 |
109,397,300 (GRCm39) |
start gained |
probably benign |
|
R4392:Fbxw15
|
UTSW |
9 |
109,397,300 (GRCm39) |
start gained |
probably benign |
|
R4812:Fbxw15
|
UTSW |
9 |
109,388,990 (GRCm39) |
missense |
probably benign |
0.01 |
R5198:Fbxw15
|
UTSW |
9 |
109,387,242 (GRCm39) |
missense |
probably benign |
0.00 |
R5278:Fbxw15
|
UTSW |
9 |
109,384,752 (GRCm39) |
missense |
probably benign |
0.03 |
R5541:Fbxw15
|
UTSW |
9 |
109,394,498 (GRCm39) |
missense |
probably benign |
0.23 |
R5899:Fbxw15
|
UTSW |
9 |
109,384,741 (GRCm39) |
splice site |
probably null |
|
R5975:Fbxw15
|
UTSW |
9 |
109,384,320 (GRCm39) |
missense |
probably damaging |
1.00 |
R6065:Fbxw15
|
UTSW |
9 |
109,397,246 (GRCm39) |
missense |
probably damaging |
1.00 |
R6285:Fbxw15
|
UTSW |
9 |
109,386,234 (GRCm39) |
missense |
probably benign |
0.09 |
R7357:Fbxw15
|
UTSW |
9 |
109,387,308 (GRCm39) |
missense |
probably benign |
0.28 |
R7781:Fbxw15
|
UTSW |
9 |
109,386,330 (GRCm39) |
missense |
possibly damaging |
0.71 |
R8145:Fbxw15
|
UTSW |
9 |
109,384,658 (GRCm39) |
missense |
probably benign |
0.01 |
R8182:Fbxw15
|
UTSW |
9 |
109,384,778 (GRCm39) |
missense |
probably benign |
0.00 |
R8272:Fbxw15
|
UTSW |
9 |
109,388,828 (GRCm39) |
missense |
probably benign |
0.18 |
R8713:Fbxw15
|
UTSW |
9 |
109,384,667 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9069:Fbxw15
|
UTSW |
9 |
109,394,468 (GRCm39) |
nonsense |
probably null |
|
R9496:Fbxw15
|
UTSW |
9 |
109,397,291 (GRCm39) |
missense |
probably benign |
0.01 |
X0026:Fbxw15
|
UTSW |
9 |
109,387,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
|
Posted On |
2014-01-15 |