Mutagenetix > Incidental Mutation

Incidental Mutation 'R1186:Tex15'

102130

Institutional Source

Beutler Lab

Gene Symbol

Tex15

Ensembl Gene

ENSMUSG00000009628

Gene Name

testis expressed gene 15

Synonyms

2210014E14Rik

MMRRC Submission

039258-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.291) question?

Stock #

R1186 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

34006766-34075610 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 34061661 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 364 (M364V)

Ref Sequence

ENSEMBL: ENSMUSP00000009772 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124496] [ENSMUST00000124501]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000009772
AA Change: M364V

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: M364V

Domain	Start	End	E-Value	Type
low complexity region	262	274	N/A	INTRINSIC
low complexity region	302	313	N/A	INTRINSIC
low complexity region	524	536	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
low complexity region	713	725	N/A	INTRINSIC
low complexity region	946	961	N/A	INTRINSIC
low complexity region	1497	1508	N/A	INTRINSIC
Pfam:TEX15	1572	1788	1.3e-109	PFAM
Pfam:TEX15	1901	2119	1.1e-16	PFAM
low complexity region	2758	2770	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124496
AA Change: M638V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000120744
Gene: ENSMUSG00000009628
AA Change: M638V

Domain	Start	End	E-Value	Type
Pfam:DUF3715	89	251	1.6e-58	PFAM
low complexity region	536	548	N/A	INTRINSIC
low complexity region	576	587	N/A	INTRINSIC
low complexity region	798	810	N/A	INTRINSIC
low complexity region	939	948	N/A	INTRINSIC
low complexity region	987	999	N/A	INTRINSIC
low complexity region	1220	1235	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124501

SMART Domains

Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

Domain	Start	End	E-Value	Type
Pfam:DUF3715	96	251	2.4e-52	PFAM

Meta Mutation Damage Score

0.0673

Coding Region Coverage

1x: 99.5%
3x: 98.5%
10x: 95.7%
20x: 90.1%

Validation Efficiency

97% (69/71)

MGI Phenotype

PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700020N01Rik	G	A	10: 21,497,551 (GRCm39)	R64Q	probably benign	Het
9530068E07Rik	G	A	11: 52,293,905 (GRCm39)	V49I	probably benign	Het
A2m	T	C	6: 121,638,493 (GRCm39)	S902P	probably benign	Het
Aatf	A	T	11: 84,361,375 (GRCm39)		probably benign	Het
Adamtsl1	A	G	4: 86,306,746 (GRCm39)	T1395A	probably benign	Het
Alpk2	T	C	18: 65,427,412 (GRCm39)		probably null	Het
Ank3	G	T	10: 69,703,290 (GRCm39)	A308S	probably damaging	Het
Arap1	A	G	7: 101,053,476 (GRCm39)		probably benign	Het
Bltp1	T	C	3: 37,050,461 (GRCm39)		probably benign	Het
C4b	T	C	17: 34,955,283 (GRCm39)	D769G	possibly damaging	Het
Cep350	A	G	1: 155,751,122 (GRCm39)	S2017P	probably damaging	Het
Cfap54	T	A	10: 92,711,856 (GRCm39)	I2704F	unknown	Het
Crip2	G	A	12: 113,108,579 (GRCm39)		probably benign	Het
Cyp4f14	T	C	17: 33,135,760 (GRCm39)	I34V	probably benign	Het
Dcstamp	A	G	15: 39,618,025 (GRCm39)		probably null	Het
Ddx5	T	C	11: 106,674,805 (GRCm39)		probably null	Het
Dnah2	A	T	11: 69,406,526 (GRCm39)	L572Q	probably damaging	Het
Espl1	G	A	15: 102,212,474 (GRCm39)	A527T	probably benign	Het
Fam83d	A	G	2: 158,627,094 (GRCm39)	D261G	probably damaging	Het
Fbxo34	T	C	14: 47,768,043 (GRCm39)	F468L	probably damaging	Het
Gabarapl1	A	T	6: 129,510,368 (GRCm39)		probably benign	Het
Galnt17	G	T	5: 131,140,580 (GRCm39)	T179K	probably damaging	Het
Gm6899	C	T	11: 26,543,685 (GRCm39)		probably benign	Het
Helz2	T	A	2: 180,872,921 (GRCm39)	R2433W	probably damaging	Het
Hivep3	T	C	4: 119,671,920 (GRCm39)		probably benign	Het
Hsh2d	G	A	8: 72,954,304 (GRCm39)	D229N	probably benign	Het
Ica1	A	G	6: 8,672,326 (GRCm39)	L225P	probably damaging	Het
Inpp5f	T	C	7: 128,296,307 (GRCm39)	I195T	probably benign	Het
Isyna1	C	A	8: 71,047,851 (GRCm39)	N115K	probably benign	Het
Ly6g6e	T	C	17: 35,296,984 (GRCm39)	F75S	probably benign	Het
Ly96	A	G	1: 16,771,118 (GRCm39)	D101G	possibly damaging	Het
Mapk9	A	G	11: 49,769,096 (GRCm39)	T243A	probably damaging	Het
Mcc	A	G	18: 44,892,470 (GRCm39)	V48A	probably benign	Het
Mcpt2	C	T	14: 56,281,402 (GRCm39)		probably benign	Het
Med24	T	C	11: 98,608,583 (GRCm39)		probably benign	Het
Mtbp	G	A	15: 55,428,067 (GRCm39)	G162S	probably null	Het
Mtfr2	G	A	10: 20,228,598 (GRCm39)	C48Y	probably benign	Het
Naip2	AGGG	AGG	13: 100,298,545 (GRCm39)		probably null	Het
Naip2	C	T	13: 100,298,489 (GRCm39)	A516T	possibly damaging	Het
Ncoa4-ps	A	C	12: 119,225,206 (GRCm39)		noncoding transcript	Het
Nup107	A	C	10: 117,613,051 (GRCm39)	Y292*	probably null	Het
Nwd2	C	T	5: 63,807,367 (GRCm39)		probably benign	Het
Nxpe4	A	C	9: 48,304,692 (GRCm39)	N260H	probably benign	Het
Ofcc1	C	T	13: 40,362,305 (GRCm39)	G206R	probably benign	Het
Or6z7	T	C	7: 6,483,541 (GRCm39)	I205V	probably benign	Het
Or8b42	T	C	9: 38,342,397 (GRCm39)	V273A	possibly damaging	Het
Or8b47	T	C	9: 38,435,453 (GRCm39)	S142P	probably damaging	Het
Or8k37	A	T	2: 86,469,807 (GRCm39)	L82M	probably damaging	Het
P2rx7	T	C	5: 122,808,514 (GRCm39)	Y299H	probably damaging	Het
Per3	T	A	4: 151,110,595 (GRCm39)	E401V	probably damaging	Het
Rbm34	C	A	8: 127,692,197 (GRCm39)	E182*	probably null	Het
Sdk2	C	T	11: 113,729,472 (GRCm39)		silent	Het
Senp2	T	C	16: 21,830,254 (GRCm39)	S38P	probably damaging	Het
Slc36a2	A	T	11: 55,055,057 (GRCm39)		probably null	Het
Spred1	A	T	2: 117,008,178 (GRCm39)	R361S	possibly damaging	Het
Spry2	A	G	14: 106,130,341 (GRCm39)	C282R	probably damaging	Het
Srp54b	T	C	12: 55,302,313 (GRCm39)		probably benign	Het
Taar8c	G	C	10: 23,977,463 (GRCm39)	Y116*	probably null	Het
Tchh	C	G	3: 93,355,353 (GRCm39)	R1598G	unknown	Het
Ttbk1	T	C	17: 46,778,057 (GRCm39)	R662G	probably damaging	Het
Ttc5	G	A	14: 51,004,683 (GRCm39)	Q374*	probably null	Het
Usp46	C	T	5: 74,162,783 (GRCm39)	A312T	probably benign	Het
Vmn1r176	A	T	7: 23,535,051 (GRCm39)	L34Q	probably damaging	Het
Vmn1r178	A	T	7: 23,593,317 (GRCm39)	R122*	probably null	Het
Vmn2r6	T	A	3: 64,472,488 (GRCm39)	M78L	probably benign	Het
Zfp407	A	T	18: 84,227,573 (GRCm39)	I2012N	probably benign	Het
Zfp980	G	A	4: 145,428,653 (GRCm39)	G461S	probably benign	Het
Zfyve26	G	A	12: 79,310,723 (GRCm39)	L161F	probably damaging	Het

Other mutations in Tex15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00639:Tex15	APN	8	34,065,339 (GRCm39)	missense	probably benign	0.18
IGL00705:Tex15	APN	8	34,071,620 (GRCm39)	missense	probably damaging	1.00
IGL00820:Tex15	APN	8	34,069,034 (GRCm39)	splice site	probably benign
IGL01288:Tex15	APN	8	34,061,412 (GRCm39)	missense	probably benign	0.02
IGL01328:Tex15	APN	8	34,061,424 (GRCm39)	nonsense	probably null
IGL01359:Tex15	APN	8	34,071,926 (GRCm39)	missense	probably damaging	0.99
IGL01603:Tex15	APN	8	34,063,575 (GRCm39)	missense	possibly damaging	0.93
IGL01861:Tex15	APN	8	34,060,717 (GRCm39)	missense	probably damaging	1.00
IGL02052:Tex15	APN	8	34,072,493 (GRCm39)	missense	probably benign	0.28
IGL02560:Tex15	APN	8	34,071,779 (GRCm39)	missense	probably benign	0.00
IGL02677:Tex15	APN	8	34,061,108 (GRCm39)	missense	probably benign	0.03
IGL02739:Tex15	APN	8	34,071,721 (GRCm39)	missense	possibly damaging	0.68
Big_gulp	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
P0005:Tex15	UTSW	8	34,060,896 (GRCm39)	missense	probably benign	0.00
P0037:Tex15	UTSW	8	34,071,608 (GRCm39)	missense	probably benign	0.00
PIT4377001:Tex15	UTSW	8	34,061,129 (GRCm39)	missense	probably damaging	1.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0595:Tex15	UTSW	8	34,062,645 (GRCm39)	missense	probably damaging	1.00
R0646:Tex15	UTSW	8	34,072,354 (GRCm39)	missense	possibly damaging	0.83
R0688:Tex15	UTSW	8	34,063,528 (GRCm39)	missense	probably damaging	1.00
R0842:Tex15	UTSW	8	34,061,575 (GRCm39)	missense	possibly damaging	0.95
R0987:Tex15	UTSW	8	34,066,875 (GRCm39)	missense	probably damaging	1.00
R1084:Tex15	UTSW	8	34,067,032 (GRCm39)	missense	probably benign	0.28
R1183:Tex15	UTSW	8	34,064,893 (GRCm39)	missense	probably benign	0.35
R1378:Tex15	UTSW	8	34,065,244 (GRCm39)	missense	probably damaging	0.99
R1500:Tex15	UTSW	8	34,065,120 (GRCm39)	missense	probably damaging	0.96
R1508:Tex15	UTSW	8	34,066,880 (GRCm39)	missense	probably damaging	1.00
R1597:Tex15	UTSW	8	34,061,511 (GRCm39)	missense	probably damaging	0.96
R1636:Tex15	UTSW	8	34,066,415 (GRCm39)	nonsense	probably null
R1639:Tex15	UTSW	8	34,060,845 (GRCm39)	missense	possibly damaging	0.94
R1809:Tex15	UTSW	8	34,064,262 (GRCm39)	missense	probably benign
R1843:Tex15	UTSW	8	34,066,682 (GRCm39)	missense	probably benign	0.27
R2029:Tex15	UTSW	8	34,061,302 (GRCm39)	missense	probably damaging	0.99
R2228:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2229:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2245:Tex15	UTSW	8	34,061,524 (GRCm39)	missense	possibly damaging	0.77
R2246:Tex15	UTSW	8	34,072,540 (GRCm39)	missense	possibly damaging	0.49
R2880:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2881:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2882:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R3001:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3002:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3020:Tex15	UTSW	8	34,066,698 (GRCm39)	missense	probably damaging	1.00
R3084:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3085:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3701:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3702:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3752:Tex15	UTSW	8	34,061,443 (GRCm39)	missense	probably benign
R4162:Tex15	UTSW	8	34,071,586 (GRCm39)	missense	probably damaging	1.00
R4231:Tex15	UTSW	8	34,062,165 (GRCm39)	missense	probably damaging	0.99
R4589:Tex15	UTSW	8	34,047,401 (GRCm39)	missense	probably damaging	1.00
R4707:Tex15	UTSW	8	34,072,525 (GRCm39)	missense	probably benign	0.00
R4773:Tex15	UTSW	8	34,072,760 (GRCm39)	missense	probably benign	0.42
R4967:Tex15	UTSW	8	34,064,498 (GRCm39)	missense	probably benign	0.34
R5063:Tex15	UTSW	8	34,072,638 (GRCm39)	missense	possibly damaging	0.59
R5121:Tex15	UTSW	8	34,061,794 (GRCm39)	missense	probably damaging	1.00
R5147:Tex15	UTSW	8	34,062,340 (GRCm39)	nonsense	probably null
R5166:Tex15	UTSW	8	34,066,420 (GRCm39)	missense	probably benign	0.07
R5173:Tex15	UTSW	8	34,061,768 (GRCm39)	missense	possibly damaging	0.73
R5439:Tex15	UTSW	8	34,064,199 (GRCm39)	missense	possibly damaging	0.93
R5537:Tex15	UTSW	8	34,061,641 (GRCm39)	missense	probably damaging	1.00
R5580:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R5588:Tex15	UTSW	8	34,067,215 (GRCm39)	missense	probably damaging	1.00
R5696:Tex15	UTSW	8	34,063,220 (GRCm39)	missense	probably benign	0.01
R5734:Tex15	UTSW	8	34,036,364 (GRCm39)	missense	probably benign	0.01
R5756:Tex15	UTSW	8	34,065,861 (GRCm39)	missense	probably benign	0.17
R5823:Tex15	UTSW	8	34,060,962 (GRCm39)	missense	possibly damaging	0.67
R6126:Tex15	UTSW	8	34,063,591 (GRCm39)	missense	probably benign	0.19
R6129:Tex15	UTSW	8	34,064,158 (GRCm39)	missense	possibly damaging	0.90
R6276:Tex15	UTSW	8	34,067,217 (GRCm39)	missense	possibly damaging	0.93
R6374:Tex15	UTSW	8	34,065,940 (GRCm39)	missense	probably damaging	1.00
R6430:Tex15	UTSW	8	34,061,329 (GRCm39)	missense	probably benign	0.01
R6452:Tex15	UTSW	8	34,062,844 (GRCm39)	missense	probably damaging	1.00
R6471:Tex15	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
R6700:Tex15	UTSW	8	34,064,917 (GRCm39)	missense	possibly damaging	0.93
R6918:Tex15	UTSW	8	34,063,212 (GRCm39)	missense	probably benign	0.27
R6958:Tex15	UTSW	8	34,060,899 (GRCm39)	missense	probably benign	0.01
R6970:Tex15	UTSW	8	34,047,456 (GRCm39)	missense	probably benign	0.03
R7059:Tex15	UTSW	8	34,064,758 (GRCm39)	missense	possibly damaging	0.57
R7069:Tex15	UTSW	8	34,060,748 (GRCm39)	missense	probably benign
R7072:Tex15	UTSW	8	34,065,459 (GRCm39)	missense	possibly damaging	0.85
R7212:Tex15	UTSW	8	34,063,023 (GRCm39)	missense	probably damaging	1.00
R7212:Tex15	UTSW	8	34,060,854 (GRCm39)	nonsense	probably null
R7216:Tex15	UTSW	8	34,063,014 (GRCm39)	missense	possibly damaging	0.93
R7219:Tex15	UTSW	8	34,036,268 (GRCm39)	missense	probably benign	0.40
R7313:Tex15	UTSW	8	34,064,845 (GRCm39)	missense	possibly damaging	0.82
R7315:Tex15	UTSW	8	34,071,544 (GRCm39)	missense	probably benign	0.01
R7444:Tex15	UTSW	8	34,066,590 (GRCm39)	missense	possibly damaging	0.92
R7455:Tex15	UTSW	8	34,067,025 (GRCm39)	missense	possibly damaging	0.91
R7643:Tex15	UTSW	8	34,065,148 (GRCm39)	missense	probably damaging	1.00
R7644:Tex15	UTSW	8	34,064,445 (GRCm39)	missense	probably benign	0.01
R7724:Tex15	UTSW	8	34,036,291 (GRCm39)	missense	possibly damaging	0.60
R7779:Tex15	UTSW	8	34,065,309 (GRCm39)	missense	probably damaging	1.00
R7798:Tex15	UTSW	8	34,071,875 (GRCm39)	missense	possibly damaging	0.69
R7816:Tex15	UTSW	8	34,071,683 (GRCm39)	missense	probably benign	0.14
R7820:Tex15	UTSW	8	34,065,090 (GRCm39)	missense	probably damaging	0.98
R8041:Tex15	UTSW	8	34,065,874 (GRCm39)	missense	probably damaging	1.00
R8150:Tex15	UTSW	8	34,063,534 (GRCm39)	missense	probably benign	0.06
R8152:Tex15	UTSW	8	34,062,921 (GRCm39)	missense	possibly damaging	0.82
R8237:Tex15	UTSW	8	34,067,427 (GRCm39)	missense	possibly damaging	0.72
R8250:Tex15	UTSW	8	34,055,233 (GRCm39)	missense	probably null	0.27
R8264:Tex15	UTSW	8	34,072,390 (GRCm39)	missense	probably benign	0.18
R8279:Tex15	UTSW	8	34,061,765 (GRCm39)	missense	probably damaging	0.96
R8353:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8388:Tex15	UTSW	8	34,065,237 (GRCm39)	missense	probably benign	0.00
R8432:Tex15	UTSW	8	34,066,572 (GRCm39)	missense	probably damaging	0.99
R8453:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8489:Tex15	UTSW	8	34,067,574 (GRCm39)	missense	probably benign	0.02
R8670:Tex15	UTSW	8	34,064,746 (GRCm39)	missense	probably benign	0.19
R8703:Tex15	UTSW	8	34,062,724 (GRCm39)	missense	probably benign	0.00
R8871:Tex15	UTSW	8	34,066,992 (GRCm39)	missense	possibly damaging	0.62
R8945:Tex15	UTSW	8	34,064,724 (GRCm39)	missense	probably benign	0.00
R9104:Tex15	UTSW	8	34,060,950 (GRCm39)	missense	possibly damaging	0.86
R9132:Tex15	UTSW	8	34,067,554 (GRCm39)	missense	possibly damaging	0.84
R9207:Tex15	UTSW	8	34,065,784 (GRCm39)	missense	probably damaging	1.00
R9210:Tex15	UTSW	8	34,064,319 (GRCm39)	missense	possibly damaging	0.91
R9330:Tex15	UTSW	8	34,065,143 (GRCm39)	missense	probably benign	0.01
R9354:Tex15	UTSW	8	34,063,344 (GRCm39)	missense	possibly damaging	0.86
R9365:Tex15	UTSW	8	34,064,564 (GRCm39)	missense	possibly damaging	0.56
R9440:Tex15	UTSW	8	34,072,273 (GRCm39)	missense	possibly damaging	0.90
R9534:Tex15	UTSW	8	34,060,999 (GRCm39)	missense	probably benign	0.45
R9570:Tex15	UTSW	8	34,067,309 (GRCm39)	missense	probably damaging	0.96
R9574:Tex15	UTSW	8	34,064,509 (GRCm39)	missense	probably benign	0.09
R9618:Tex15	UTSW	8	34,062,397 (GRCm39)	missense	probably benign	0.35
R9655:Tex15	UTSW	8	34,066,784 (GRCm39)	nonsense	probably null
R9786:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R9798:Tex15	UTSW	8	34,062,721 (GRCm39)	missense	probably damaging	0.98
RF005:Tex15	UTSW	8	34,066,705 (GRCm39)	missense	probably benign	0.05
X0020:Tex15	UTSW	8	34,066,607 (GRCm39)	missense	probably benign	0.03
X0065:Tex15	UTSW	8	34,065,545 (GRCm39)	nonsense	probably null
Z1088:Tex15	UTSW	8	34,061,343 (GRCm39)	missense	possibly damaging	0.89
Z1088:Tex15	UTSW	8	34,064,898 (GRCm39)	missense	probably benign
Z1088:Tex15	UTSW	8	34,061,838 (GRCm39)	missense	possibly damaging	0.68
Z1176:Tex15	UTSW	8	34,064,754 (GRCm39)	missense	possibly damaging	0.84

Predicted Primers

PCR Primer
(F):5'- GAGTCACGGAACTCCGATGAATCAG -3'
(R):5'- CTTCATGCTCCAAAGAGTGTTGCG -3'

Sequencing Primer
(F):5'- GAAAATACTTGTAGCAACGACTCTC -3'
(R):5'- CCAATGCTGCACGATATAGTTC -3'

Posted On

2014-01-15