Incidental Mutation 'R1144:Vmn1r219'
ID 102311
Institutional Source Beutler Lab
Gene Symbol Vmn1r219
Ensembl Gene ENSMUSG00000061376
Gene Name vomeronasal 1 receptor 219
Synonyms V1rh13
MMRRC Submission 039217-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R1144 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 23346813-23347751 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 23347383 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 191 (Q191K)
Ref Sequence ENSEMBL: ENSMUSP00000154240 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076180] [ENSMUST00000226845] [ENSMUST00000227388] [ENSMUST00000228113] [ENSMUST00000228666]
AlphaFold Q8R271
Predicted Effect probably damaging
Transcript: ENSMUST00000076180
AA Change: Q191K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000075537
Gene: ENSMUSG00000061376
AA Change: Q191K

DomainStartEndE-ValueType
Pfam:TAS2R 2 301 3.4e-7 PFAM
Pfam:V1R 33 297 3e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226845
AA Change: Q191K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000227388
AA Change: Q191K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228113
AA Change: Q191K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228666
AA Change: Q191K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.2%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 C T 7: 119,960,083 (GRCm39) probably benign Het
Abcc5 A T 16: 20,241,188 (GRCm39) probably benign Het
Acsl5 A C 19: 55,280,275 (GRCm39) D516A probably damaging Het
Adcy1 G A 11: 7,087,400 (GRCm39) A425T probably damaging Het
Aebp1 A G 11: 5,818,475 (GRCm39) T107A probably benign Het
Arhgef33 T C 17: 80,662,473 (GRCm39) S219P probably benign Het
Atm T G 9: 53,422,998 (GRCm39) probably benign Het
C1ql2 A C 1: 120,270,266 (GRCm39) Y276S probably damaging Het
Cacna2d1 T C 5: 16,527,595 (GRCm39) probably null Het
Cmbl A G 15: 31,582,020 (GRCm39) N6D probably benign Het
Cntn3 A G 6: 102,219,087 (GRCm39) V511A possibly damaging Het
Coq9 C A 8: 95,569,251 (GRCm39) R28S probably benign Het
Creld1 T C 6: 113,460,922 (GRCm39) F20S probably benign Het
Dcstamp A G 15: 39,623,764 (GRCm39) K404E possibly damaging Het
Dip2b T A 15: 100,052,131 (GRCm39) I244K probably benign Het
Dnhd1 G A 7: 105,362,238 (GRCm39) E3700K probably damaging Het
Dnmt3l T A 10: 77,887,739 (GRCm39) C110S probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fgfr1 T G 8: 26,048,159 (GRCm39) V172G probably damaging Het
Frem3 C A 8: 81,338,513 (GRCm39) Q269K probably benign Het
Frmd6 C A 12: 70,923,942 (GRCm39) H67N probably damaging Het
Fry A G 5: 150,341,929 (GRCm39) T1532A possibly damaging Het
Git2 G T 5: 114,891,375 (GRCm39) S243R probably benign Het
Grid1 A G 14: 35,284,633 (GRCm39) probably benign Het
Grp A G 18: 66,013,041 (GRCm39) D69G probably damaging Het
Hmbox1 A T 14: 65,063,132 (GRCm39) L347Q probably damaging Het
Hsh2d C T 8: 72,947,436 (GRCm39) probably benign Het
Itpr3 G A 17: 27,333,897 (GRCm39) S2018N probably benign Het
Kif13b T A 14: 64,951,566 (GRCm39) V69D probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lmcd1 T A 6: 112,287,712 (GRCm39) probably benign Het
Megf9 C A 4: 70,452,861 (GRCm39) A67S probably benign Het
Myo5b G A 18: 74,758,658 (GRCm39) R213H probably damaging Het
Myo5c T A 9: 75,193,730 (GRCm39) Y1162N probably damaging Het
Nphs1 A G 7: 30,181,103 (GRCm39) probably benign Het
Ntrk1 G A 3: 87,688,849 (GRCm39) T568I probably damaging Het
Pcmtd1 A G 1: 7,190,705 (GRCm39) H58R probably damaging Het
Plaat5 A G 19: 7,590,695 (GRCm39) D74G probably benign Het
Plxna4 A T 6: 32,174,091 (GRCm39) I1168N possibly damaging Het
Ppm1h A G 10: 122,777,183 (GRCm39) D483G probably benign Het
Prdm15 G A 16: 97,609,908 (GRCm39) R579C probably damaging Het
Prickle1 T A 15: 93,410,342 (GRCm39) R41W probably damaging Het
Rbm19 A G 5: 120,261,081 (GRCm39) D235G possibly damaging Het
Smco2 A G 6: 146,772,638 (GRCm39) probably benign Het
Sned1 G C 1: 93,208,298 (GRCm39) G785R probably damaging Het
Stat4 A G 1: 52,123,288 (GRCm39) probably benign Het
Syne2 T A 12: 76,013,298 (GRCm39) F2830I probably benign Het
Tbc1d9 A G 8: 83,963,200 (GRCm39) D304G possibly damaging Het
Thsd7a G A 6: 12,471,026 (GRCm39) probably benign Het
Tmem63b T A 17: 45,977,353 (GRCm39) K383N probably benign Het
Trp53rka C A 2: 165,334,961 (GRCm39) probably benign Het
Trub1 G A 19: 57,473,563 (GRCm39) V207M probably benign Het
Ulk2 A T 11: 61,690,886 (GRCm39) C551S possibly damaging Het
Urb1 A T 16: 90,573,206 (GRCm39) probably null Het
Vmn2r1 A T 3: 63,997,541 (GRCm39) D399V probably damaging Het
Vmn2r87 A G 10: 130,312,098 (GRCm39) probably benign Het
Wars1 A T 12: 108,854,291 (GRCm39) L41* probably null Het
Washc2 G A 6: 116,201,495 (GRCm39) E64K probably damaging Het
Washc4 G A 10: 83,416,194 (GRCm39) R828Q probably damaging Het
Wdr59 A T 8: 112,213,576 (GRCm39) M313K probably benign Het
Wscd2 G A 5: 113,699,151 (GRCm39) probably null Het
Zdhhc20 A C 14: 58,094,135 (GRCm39) L176V probably benign Het
Other mutations in Vmn1r219
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02517:Vmn1r219 APN 13 23,347,266 (GRCm39) missense probably benign 0.01
IGL03339:Vmn1r219 APN 13 23,347,580 (GRCm39) missense possibly damaging 0.88
R0662:Vmn1r219 UTSW 13 23,347,623 (GRCm39) missense possibly damaging 0.51
R4036:Vmn1r219 UTSW 13 23,347,272 (GRCm39) missense probably benign 0.00
R4762:Vmn1r219 UTSW 13 23,346,999 (GRCm39) nonsense probably null
R5311:Vmn1r219 UTSW 13 23,347,063 (GRCm39) missense probably damaging 1.00
R6488:Vmn1r219 UTSW 13 23,347,135 (GRCm39) missense probably benign 0.02
R7157:Vmn1r219 UTSW 13 23,347,525 (GRCm39) missense probably damaging 1.00
R7305:Vmn1r219 UTSW 13 23,347,314 (GRCm39) missense probably benign
R7875:Vmn1r219 UTSW 13 23,347,363 (GRCm39) missense possibly damaging 0.58
R8753:Vmn1r219 UTSW 13 23,347,191 (GRCm39) missense probably damaging 1.00
R9290:Vmn1r219 UTSW 13 23,347,399 (GRCm39) missense probably damaging 1.00
R9345:Vmn1r219 UTSW 13 23,346,769 (GRCm39) start gained probably benign
R9353:Vmn1r219 UTSW 13 23,346,902 (GRCm39) missense probably benign 0.01
Predicted Primers
Posted On 2014-01-15