Mutagenetix > Incidental Mutation

Incidental Mutation 'R1189:Xirp2'

102407

Institutional Source

Beutler Lab

Gene Symbol

Xirp2

Ensembl Gene

ENSMUSG00000027022

Gene Name

xin actin-binding repeat containing 2

Synonyms

mXin beta, 2310008C07Rik, 2310003D02Rik, Cmya3, myomaxin, A530024P18Rik

MMRRC Submission

039261-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.321) question?

Stock #

R1189 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

67276343-67356964 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 67343805 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 2015 (N2015K)

Ref Sequence

ENSEMBL: ENSMUSP00000107966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028410] [ENSMUST00000112347]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000028410
AA Change: N2015K

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000028410
Gene: ENSMUSG00000027022
AA Change: N2015K

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4e-9	PFAM
Pfam:Xin	384	398	7.6e-10	PFAM
Pfam:Xin	420	435	6.4e-9	PFAM
Pfam:Xin	458	473	5.3e-9	PFAM
Pfam:Xin	536	551	4.1e-12	PFAM
Pfam:Xin	574	588	2.1e-8	PFAM
Pfam:Xin	609	623	6e-9	PFAM
Pfam:Xin	642	656	5.6e-8	PFAM
Pfam:Xin	679	693	5.9e-8	PFAM
Pfam:Xin	784	799	1.1e-10	PFAM
Pfam:Xin	822	837	3.9e-11	PFAM
Pfam:Xin	861	875	8.6e-12	PFAM
Pfam:Xin	894	909	2.8e-10	PFAM
Pfam:Xin	1006	1021	3.1e-9	PFAM
Pfam:Xin	1079	1094	6.7e-10	PFAM
Pfam:Xin	1117	1132	1.5e-10	PFAM
Pfam:Xin	1154	1169	2.4e-8	PFAM
Pfam:Xin	1256	1271	4.6e-8	PFAM
Pfam:Xin	1292	1305	1.6e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC
LIM	3256	3308	4.45e-12	SMART
low complexity region	3356	3367	N/A	INTRINSIC
low complexity region	3549	3565	N/A	INTRINSIC
low complexity region	3614	3625	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000112347
AA Change: N2015K

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000107966
Gene: ENSMUSG00000027022
AA Change: N2015K

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4.3e-8	PFAM
Pfam:Xin	383	398	6.9e-9	PFAM
Pfam:Xin	420	435	1.8e-8	PFAM
Pfam:Xin	458	473	6.9e-8	PFAM
Pfam:Xin	536	551	2.8e-10	PFAM
Pfam:Xin	608	623	2.4e-8	PFAM
Pfam:Xin	642	657	1.7e-7	PFAM
Pfam:Xin	784	799	3.5e-9	PFAM
Pfam:Xin	822	837	8.9e-10	PFAM
Pfam:Xin	861	876	3.9e-10	PFAM
Pfam:Xin	894	909	5.4e-9	PFAM
Pfam:Xin	1006	1021	6.2e-8	PFAM
Pfam:Xin	1079	1094	2.4e-8	PFAM
Pfam:Xin	1117	1132	9.5e-9	PFAM
Pfam:Xin	1291	1306	5.8e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142314

Coding Region Coverage

1x: 98.6%
3x: 97.2%
10x: 92.5%
20x: 81.0%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice have an abnormal heart shape, ventricular septal defects, a failure of mature intercalated disc formation, severe growth retardation, and postnatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted(5)

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930022D16Rik	A	G	11: 109,308,934 (GRCm39)	H100R	unknown	Het
Abcc2	T	A	19: 43,807,852 (GRCm39)	V831D	probably damaging	Het
Akap11	A	T	14: 78,750,787 (GRCm39)	S533R	probably benign	Het
Aldh1a2	G	T	9: 71,171,105 (GRCm39)	A198S	possibly damaging	Het
Cbarp	C	A	10: 79,967,630 (GRCm39)	R537L	possibly damaging	Het
Crybg1	T	A	10: 43,874,790 (GRCm39)	S773C	probably damaging	Het
Cyp3a13	G	T	5: 137,909,892 (GRCm39)		probably null	Het
Gatad1	T	A	5: 3,693,701 (GRCm39)	D156V	probably damaging	Het
Ift172	T	A	5: 31,443,174 (GRCm39)		probably null	Het
Lrrtm2	C	T	18: 35,346,545 (GRCm39)	W252*	probably null	Het
Mitf	T	C	6: 97,983,086 (GRCm39)	C270R	possibly damaging	Het
Muc6	T	A	7: 141,232,122 (GRCm39)	S1002C	probably damaging	Het
Or4k2	A	G	14: 50,424,539 (GRCm39)	I45T	probably damaging	Het
Or5b113	A	T	19: 13,342,543 (GRCm39)	M184L	probably benign	Het
Pcdhb8	C	T	18: 37,489,620 (GRCm39)	Q92*	probably null	Het
Plekhm1	A	G	11: 103,277,888 (GRCm39)	S403P	probably benign	Het
Ppara	A	G	15: 85,682,365 (GRCm39)	I354V	probably benign	Het
Psmd2	T	C	16: 20,480,644 (GRCm39)	M761T	probably benign	Het
Zbtb39	C	G	10: 127,578,175 (GRCm39)	Q250E	probably benign	Het

Other mutations in Xirp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Xirp2	APN	2	67,343,719 (GRCm39)	missense	probably benign	0.37
IGL00336:Xirp2	APN	2	67,342,942 (GRCm39)	missense	possibly damaging	0.93
IGL00596:Xirp2	APN	2	67,345,226 (GRCm39)	missense	probably benign	0.08
IGL00862:Xirp2	APN	2	67,347,247 (GRCm39)	missense	probably benign	0.00
IGL01124:Xirp2	APN	2	67,338,959 (GRCm39)	missense	probably damaging	0.99
IGL01289:Xirp2	APN	2	67,343,525 (GRCm39)	missense	probably damaging	0.99
IGL01293:Xirp2	APN	2	67,345,528 (GRCm39)	missense	possibly damaging	0.51
IGL01372:Xirp2	APN	2	67,344,334 (GRCm39)	missense	possibly damaging	0.93
IGL01385:Xirp2	APN	2	67,340,021 (GRCm39)	missense	probably damaging	0.99
IGL01411:Xirp2	APN	2	67,344,427 (GRCm39)	missense	probably benign	0.00
IGL01413:Xirp2	APN	2	67,340,270 (GRCm39)	missense	probably damaging	1.00
IGL01551:Xirp2	APN	2	67,343,849 (GRCm39)	missense	probably benign
IGL01672:Xirp2	APN	2	67,338,846 (GRCm39)	missense	probably benign
IGL01724:Xirp2	APN	2	67,356,411 (GRCm39)	missense	probably benign
IGL01739:Xirp2	APN	2	67,345,482 (GRCm39)	missense	probably benign	0.15
IGL01807:Xirp2	APN	2	67,345,375 (GRCm39)	missense	probably benign
IGL02006:Xirp2	APN	2	67,342,306 (GRCm39)	missense	possibly damaging	0.85
IGL02030:Xirp2	APN	2	67,339,325 (GRCm39)	missense	probably benign	0.06
IGL02066:Xirp2	APN	2	67,356,415 (GRCm39)	missense	probably benign
IGL02138:Xirp2	APN	2	67,347,300 (GRCm39)	missense	probably benign	0.15
IGL02250:Xirp2	APN	2	67,344,356 (GRCm39)	missense	probably benign	0.03
IGL02265:Xirp2	APN	2	67,347,494 (GRCm39)	missense	possibly damaging	0.94
IGL02274:Xirp2	APN	2	67,338,995 (GRCm39)	missense	probably benign	0.12
IGL02322:Xirp2	APN	2	67,339,082 (GRCm39)	missense	probably benign	0.00
IGL02327:Xirp2	APN	2	67,340,444 (GRCm39)	missense	probably damaging	1.00
IGL02378:Xirp2	APN	2	67,344,112 (GRCm39)	missense	probably benign	0.00
IGL02492:Xirp2	APN	2	67,346,511 (GRCm39)	missense	probably damaging	0.99
IGL02549:Xirp2	APN	2	67,343,446 (GRCm39)	missense	probably benign	0.03
IGL02578:Xirp2	APN	2	67,341,591 (GRCm39)	missense	probably damaging	0.96
IGL02635:Xirp2	APN	2	67,338,254 (GRCm39)	missense	possibly damaging	0.86
IGL02654:Xirp2	APN	2	67,345,015 (GRCm39)	missense	possibly damaging	0.86
IGL02663:Xirp2	APN	2	67,339,802 (GRCm39)	missense	possibly damaging	0.92
IGL02795:Xirp2	APN	2	67,339,480 (GRCm39)	missense	probably damaging	1.00
IGL02934:Xirp2	APN	2	67,346,020 (GRCm39)	missense	probably benign	0.33
IGL03003:Xirp2	APN	2	67,345,906 (GRCm39)	missense	possibly damaging	0.93
IGL03069:Xirp2	APN	2	67,339,876 (GRCm39)	missense	possibly damaging	0.91
IGL03286:Xirp2	APN	2	67,346,654 (GRCm39)	missense	probably damaging	0.99
IGL03326:Xirp2	APN	2	67,312,590 (GRCm39)	missense	probably benign	0.01
IGL03381:Xirp2	APN	2	67,344,570 (GRCm39)	missense	probably benign	0.34
IGL03394:Xirp2	APN	2	67,345,538 (GRCm39)	missense	probably damaging	0.99
Ordovician	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
silurian	UTSW	2	67,349,609 (GRCm39)	missense	probably damaging	0.99
3-1:Xirp2	UTSW	2	67,338,542 (GRCm39)	missense	possibly damaging	0.95
H8562:Xirp2	UTSW	2	67,345,801 (GRCm39)	missense	probably benign
PIT4142001:Xirp2	UTSW	2	67,349,706 (GRCm39)	splice site	probably benign
PIT4260001:Xirp2	UTSW	2	67,341,941 (GRCm39)	missense	possibly damaging	0.96
PIT4445001:Xirp2	UTSW	2	67,340,116 (GRCm39)	missense	possibly damaging	0.84
PIT4531001:Xirp2	UTSW	2	67,345,826 (GRCm39)	missense	possibly damaging	0.73
R0015:Xirp2	UTSW	2	67,341,243 (GRCm39)	nonsense	probably null
R0063:Xirp2	UTSW	2	67,339,427 (GRCm39)	missense	probably damaging	0.99
R0063:Xirp2	UTSW	2	67,339,427 (GRCm39)	missense	probably damaging	0.99
R0066:Xirp2	UTSW	2	67,342,484 (GRCm39)	missense	possibly damaging	0.85
R0109:Xirp2	UTSW	2	67,349,622 (GRCm39)	missense	probably damaging	1.00
R0111:Xirp2	UTSW	2	67,338,722 (GRCm39)	missense	probably damaging	0.99
R0115:Xirp2	UTSW	2	67,340,253 (GRCm39)	missense	possibly damaging	0.92
R0117:Xirp2	UTSW	2	67,347,464 (GRCm39)	missense	possibly damaging	0.94
R0133:Xirp2	UTSW	2	67,347,468 (GRCm39)	missense	probably benign
R0282:Xirp2	UTSW	2	67,343,724 (GRCm39)	missense	probably damaging	0.96
R0463:Xirp2	UTSW	2	67,345,262 (GRCm39)	missense	probably benign	0.02
R0481:Xirp2	UTSW	2	67,340,253 (GRCm39)	missense	possibly damaging	0.92
R0488:Xirp2	UTSW	2	67,345,165 (GRCm39)	missense	possibly damaging	0.90
R0548:Xirp2	UTSW	2	67,344,758 (GRCm39)	missense	probably benign	0.00
R0557:Xirp2	UTSW	2	67,346,695 (GRCm39)	missense	probably benign	0.33
R0582:Xirp2	UTSW	2	67,339,210 (GRCm39)	missense	probably benign
R0723:Xirp2	UTSW	2	67,342,559 (GRCm39)	missense	probably damaging	0.98
R0835:Xirp2	UTSW	2	67,338,254 (GRCm39)	missense	possibly damaging	0.86
R1160:Xirp2	UTSW	2	67,340,231 (GRCm39)	missense	possibly damaging	0.92
R1474:Xirp2	UTSW	2	67,355,411 (GRCm39)	missense	probably benign	0.00
R1513:Xirp2	UTSW	2	67,341,874 (GRCm39)	missense	probably benign	0.00
R1514:Xirp2	UTSW	2	67,344,667 (GRCm39)	nonsense	probably null
R1519:Xirp2	UTSW	2	67,346,023 (GRCm39)	missense	probably benign	0.44
R1532:Xirp2	UTSW	2	67,344,283 (GRCm39)	missense	probably benign	0.00
R1537:Xirp2	UTSW	2	67,340,357 (GRCm39)	missense	probably damaging	0.98
R1541:Xirp2	UTSW	2	67,342,634 (GRCm39)	missense	possibly damaging	0.70
R1543:Xirp2	UTSW	2	67,338,383 (GRCm39)	missense	probably benign
R1607:Xirp2	UTSW	2	67,340,639 (GRCm39)	nonsense	probably null
R1620:Xirp2	UTSW	2	67,341,179 (GRCm39)	missense	probably damaging	0.98
R1709:Xirp2	UTSW	2	67,340,215 (GRCm39)	missense	probably benign	0.33
R1713:Xirp2	UTSW	2	67,342,762 (GRCm39)	missense	probably benign	0.25
R1828:Xirp2	UTSW	2	67,345,582 (GRCm39)	missense	possibly damaging	0.86
R1834:Xirp2	UTSW	2	67,341,484 (GRCm39)	missense	probably damaging	0.99
R1905:Xirp2	UTSW	2	67,346,700 (GRCm39)	missense	probably damaging	0.98
R1907:Xirp2	UTSW	2	67,346,700 (GRCm39)	missense	probably damaging	0.98
R1943:Xirp2	UTSW	2	67,342,959 (GRCm39)	missense	probably benign	0.34
R1971:Xirp2	UTSW	2	67,342,039 (GRCm39)	missense	possibly damaging	0.48
R1998:Xirp2	UTSW	2	67,339,393 (GRCm39)	missense	probably damaging	0.97
R2075:Xirp2	UTSW	2	67,340,545 (GRCm39)	missense	probably benign	0.33
R2132:Xirp2	UTSW	2	67,338,392 (GRCm39)	missense	possibly damaging	0.72
R2175:Xirp2	UTSW	2	67,340,258 (GRCm39)	missense	probably damaging	0.99
R2310:Xirp2	UTSW	2	67,356,591 (GRCm39)	missense	probably benign	0.19
R2338:Xirp2	UTSW	2	67,341,114 (GRCm39)	missense	probably damaging	0.98
R2426:Xirp2	UTSW	2	67,344,815 (GRCm39)	missense	probably benign	0.02
R2483:Xirp2	UTSW	2	67,355,336 (GRCm39)	missense	probably benign
R3084:Xirp2	UTSW	2	67,339,393 (GRCm39)	missense	probably damaging	0.97
R3113:Xirp2	UTSW	2	67,340,491 (GRCm39)	missense	probably benign	0.33
R3903:Xirp2	UTSW	2	67,338,380 (GRCm39)	missense	probably benign	0.40
R3916:Xirp2	UTSW	2	67,341,766 (GRCm39)	missense	probably benign	0.25
R3928:Xirp2	UTSW	2	67,342,013 (GRCm39)	missense	possibly damaging	0.85
R4025:Xirp2	UTSW	2	67,341,746 (GRCm39)	missense	probably benign	0.12
R4135:Xirp2	UTSW	2	67,355,741 (GRCm39)	missense	probably benign	0.00
R4223:Xirp2	UTSW	2	67,346,837 (GRCm39)	missense	possibly damaging	0.66
R4257:Xirp2	UTSW	2	67,346,383 (GRCm39)	missense	probably benign	0.31
R4499:Xirp2	UTSW	2	67,343,782 (GRCm39)	missense	probably benign	0.08
R4577:Xirp2	UTSW	2	67,344,241 (GRCm39)	missense	probably damaging	0.99
R4739:Xirp2	UTSW	2	67,349,609 (GRCm39)	missense	probably damaging	0.99
R4758:Xirp2	UTSW	2	67,346,879 (GRCm39)	missense	probably damaging	0.98
R4834:Xirp2	UTSW	2	67,346,750 (GRCm39)	missense	probably benign	0.26
R4855:Xirp2	UTSW	2	67,341,408 (GRCm39)	missense	possibly damaging	0.96
R4923:Xirp2	UTSW	2	67,343,237 (GRCm39)	missense	probably benign
R4936:Xirp2	UTSW	2	67,340,163 (GRCm39)	missense	possibly damaging	0.85
R5032:Xirp2	UTSW	2	67,356,014 (GRCm39)	missense	possibly damaging	0.84
R5049:Xirp2	UTSW	2	67,347,478 (GRCm39)	missense	probably benign	0.03
R5077:Xirp2	UTSW	2	67,344,821 (GRCm39)	missense	probably benign
R5090:Xirp2	UTSW	2	67,355,814 (GRCm39)	missense	possibly damaging	0.83
R5107:Xirp2	UTSW	2	67,340,054 (GRCm39)	missense	probably damaging	0.99
R5107:Xirp2	UTSW	2	67,342,205 (GRCm39)	missense	probably damaging	1.00
R5187:Xirp2	UTSW	2	67,345,711 (GRCm39)	missense	probably benign	0.01
R5241:Xirp2	UTSW	2	67,312,704 (GRCm39)	nonsense	probably null
R5307:Xirp2	UTSW	2	67,341,506 (GRCm39)	missense	probably damaging	0.99
R5342:Xirp2	UTSW	2	67,343,805 (GRCm39)	missense	probably damaging	0.96
R5370:Xirp2	UTSW	2	67,342,496 (GRCm39)	missense	possibly damaging	0.72
R5375:Xirp2	UTSW	2	67,342,250 (GRCm39)	missense	probably damaging	0.99
R5407:Xirp2	UTSW	2	67,341,313 (GRCm39)	missense	probably benign	0.33
R5514:Xirp2	UTSW	2	67,335,465 (GRCm39)	missense	probably benign	0.03
R5531:Xirp2	UTSW	2	67,345,646 (GRCm39)	missense	probably benign	0.42
R5590:Xirp2	UTSW	2	67,344,379 (GRCm39)	missense	probably benign	0.23
R5646:Xirp2	UTSW	2	67,341,134 (GRCm39)	missense	probably damaging	0.99
R5649:Xirp2	UTSW	2	67,347,239 (GRCm39)	missense	probably benign	0.00
R5686:Xirp2	UTSW	2	67,312,642 (GRCm39)	missense	probably damaging	0.99
R5761:Xirp2	UTSW	2	67,341,311 (GRCm39)	missense	probably benign	0.00
R5777:Xirp2	UTSW	2	67,340,348 (GRCm39)	missense	possibly damaging	0.92
R5785:Xirp2	UTSW	2	67,340,006 (GRCm39)	missense	probably damaging	0.96
R5843:Xirp2	UTSW	2	67,307,129 (GRCm39)	start gained	probably benign
R5846:Xirp2	UTSW	2	67,339,587 (GRCm39)	missense	probably damaging	0.98
R5875:Xirp2	UTSW	2	67,335,424 (GRCm39)	missense	probably benign	0.00
R5896:Xirp2	UTSW	2	67,340,290 (GRCm39)	missense	possibly damaging	0.91
R5896:Xirp2	UTSW	2	67,339,042 (GRCm39)	missense	probably benign	0.32
R5901:Xirp2	UTSW	2	67,343,410 (GRCm39)	missense	possibly damaging	0.91
R5934:Xirp2	UTSW	2	67,355,148 (GRCm39)	missense	possibly damaging	0.92
R5950:Xirp2	UTSW	2	67,341,664 (GRCm39)	missense	possibly damaging	0.95
R5996:Xirp2	UTSW	2	67,341,994 (GRCm39)	missense	possibly damaging	0.91
R6013:Xirp2	UTSW	2	67,341,287 (GRCm39)	missense	possibly damaging	0.48
R6048:Xirp2	UTSW	2	67,338,587 (GRCm39)	missense	possibly damaging	0.96
R6111:Xirp2	UTSW	2	67,342,161 (GRCm39)	missense	possibly damaging	0.86
R6180:Xirp2	UTSW	2	67,335,921 (GRCm39)	critical splice donor site	probably null
R6342:Xirp2	UTSW	2	67,341,994 (GRCm39)	missense	possibly damaging	0.91
R6346:Xirp2	UTSW	2	67,346,425 (GRCm39)	missense	probably benign	0.00
R6603:Xirp2	UTSW	2	67,346,888 (GRCm39)	missense	probably benign
R6604:Xirp2	UTSW	2	67,340,189 (GRCm39)	missense	possibly damaging	0.86
R6669:Xirp2	UTSW	2	67,343,699 (GRCm39)	missense	possibly damaging	0.78
R6701:Xirp2	UTSW	2	67,346,569 (GRCm39)	missense	possibly damaging	0.94
R6726:Xirp2	UTSW	2	67,343,212 (GRCm39)	missense	possibly damaging	0.88
R6833:Xirp2	UTSW	2	67,340,294 (GRCm39)	missense	probably benign	0.12
R6897:Xirp2	UTSW	2	67,338,911 (GRCm39)	missense	probably damaging	1.00
R6933:Xirp2	UTSW	2	67,345,201 (GRCm39)	missense	probably benign	0.34
R7020:Xirp2	UTSW	2	67,355,913 (GRCm39)	missense	probably benign
R7042:Xirp2	UTSW	2	67,343,633 (GRCm39)	missense	probably benign	0.12
R7060:Xirp2	UTSW	2	67,345,952 (GRCm39)	missense	probably damaging	1.00
R7179:Xirp2	UTSW	2	67,340,177 (GRCm39)	missense	probably benign	0.00
R7229:Xirp2	UTSW	2	67,355,895 (GRCm39)	missense	probably damaging	0.99
R7253:Xirp2	UTSW	2	67,343,826 (GRCm39)	missense	probably benign
R7284:Xirp2	UTSW	2	67,347,173 (GRCm39)	missense	probably benign
R7450:Xirp2	UTSW	2	67,340,159 (GRCm39)	missense	possibly damaging	0.86
R7476:Xirp2	UTSW	2	67,340,978 (GRCm39)	missense	probably benign	0.01
R7489:Xirp2	UTSW	2	67,355,904 (GRCm39)	missense	possibly damaging	0.83
R7513:Xirp2	UTSW	2	67,341,108 (GRCm39)	missense	possibly damaging	0.86
R7549:Xirp2	UTSW	2	67,339,241 (GRCm39)	missense	possibly damaging	0.91
R7563:Xirp2	UTSW	2	67,340,245 (GRCm39)	missense	probably damaging	0.99
R7567:Xirp2	UTSW	2	67,346,326 (GRCm39)	missense	probably benign	0.02
R7577:Xirp2	UTSW	2	67,345,309 (GRCm39)	missense	possibly damaging	0.65
R7597:Xirp2	UTSW	2	67,356,099 (GRCm39)	missense	possibly damaging	0.84
R7610:Xirp2	UTSW	2	67,356,306 (GRCm39)	missense	possibly damaging	0.92
R7613:Xirp2	UTSW	2	67,344,842 (GRCm39)	missense	probably benign	0.00
R7669:Xirp2	UTSW	2	67,342,521 (GRCm39)	missense	probably benign	0.00
R7670:Xirp2	UTSW	2	67,340,917 (GRCm39)	missense	possibly damaging	0.91
R7673:Xirp2	UTSW	2	67,347,431 (GRCm39)	missense	probably damaging	1.00
R7682:Xirp2	UTSW	2	67,339,193 (GRCm39)	missense	probably damaging	0.99
R7755:Xirp2	UTSW	2	67,345,526 (GRCm39)	missense	probably benign
R7805:Xirp2	UTSW	2	67,340,325 (GRCm39)	missense	probably benign	0.23
R7815:Xirp2	UTSW	2	67,339,756 (GRCm39)	missense	probably damaging	1.00
R7823:Xirp2	UTSW	2	67,342,118 (GRCm39)	missense	probably damaging	1.00
R7842:Xirp2	UTSW	2	67,355,289 (GRCm39)	missense	probably benign	0.00
R7863:Xirp2	UTSW	2	67,343,074 (GRCm39)	missense	probably benign	0.03
R7895:Xirp2	UTSW	2	67,339,841 (GRCm39)	missense	probably damaging	0.96
R7948:Xirp2	UTSW	2	67,349,658 (GRCm39)	missense	possibly damaging	0.95
R8083:Xirp2	UTSW	2	67,339,043 (GRCm39)	missense	possibly damaging	0.71
R8125:Xirp2	UTSW	2	67,342,379 (GRCm39)	missense	probably benign	0.25
R8154:Xirp2	UTSW	2	67,342,017 (GRCm39)	missense	possibly damaging	0.48
R8169:Xirp2	UTSW	2	67,343,543 (GRCm39)	missense	probably benign	0.00
R8213:Xirp2	UTSW	2	67,307,210 (GRCm39)	missense	probably damaging	0.96
R8215:Xirp2	UTSW	2	67,346,853 (GRCm39)	missense	probably benign	0.08
R8230:Xirp2	UTSW	2	67,346,009 (GRCm39)	missense	probably damaging	0.99
R8266:Xirp2	UTSW	2	67,338,918 (GRCm39)	missense	probably damaging	0.98
R8350:Xirp2	UTSW	2	67,355,713 (GRCm39)	missense	probably benign
R8432:Xirp2	UTSW	2	67,340,962 (GRCm39)	missense	probably benign
R8441:Xirp2	UTSW	2	67,343,159 (GRCm39)	missense	possibly damaging	0.85
R8677:Xirp2	UTSW	2	67,346,978 (GRCm39)	missense	probably damaging	0.98
R8773:Xirp2	UTSW	2	67,355,527 (GRCm39)	missense	probably benign
R8794:Xirp2	UTSW	2	67,341,557 (GRCm39)	missense	probably damaging	0.98
R8930:Xirp2	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
R8932:Xirp2	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
R8939:Xirp2	UTSW	2	67,346,488 (GRCm39)	missense	probably benign	0.04
R9263:Xirp2	UTSW	2	67,345,289 (GRCm39)	missense	possibly damaging	0.76
R9313:Xirp2	UTSW	2	67,347,322 (GRCm39)	missense	probably damaging	0.99
R9350:Xirp2	UTSW	2	67,349,653 (GRCm39)	missense	probably damaging	1.00
R9375:Xirp2	UTSW	2	67,342,118 (GRCm39)	missense	probably damaging	1.00
R9442:Xirp2	UTSW	2	67,342,235 (GRCm39)	nonsense	probably null
R9447:Xirp2	UTSW	2	67,338,950 (GRCm39)	missense	probably damaging	0.98
R9457:Xirp2	UTSW	2	67,345,976 (GRCm39)	missense	probably benign	0.03
R9507:Xirp2	UTSW	2	67,344,280 (GRCm39)	missense	possibly damaging	0.95
R9529:Xirp2	UTSW	2	67,355,540 (GRCm39)	missense	possibly damaging	0.93
R9569:Xirp2	UTSW	2	67,341,242 (GRCm39)	missense	probably damaging	1.00
R9607:Xirp2	UTSW	2	67,341,106 (GRCm39)	missense	possibly damaging	0.72
R9648:Xirp2	UTSW	2	67,346,599 (GRCm39)	missense	probably benign
R9651:Xirp2	UTSW	2	67,344,167 (GRCm39)	missense	possibly damaging	0.72
R9678:Xirp2	UTSW	2	67,339,788 (GRCm39)	missense	possibly damaging	0.91
R9691:Xirp2	UTSW	2	67,340,539 (GRCm39)	missense	possibly damaging	0.91
R9777:Xirp2	UTSW	2	67,347,379 (GRCm39)	missense	possibly damaging	0.85
RF035:Xirp2	UTSW	2	67,355,888 (GRCm39)	utr 3 prime	probably benign
RF040:Xirp2	UTSW	2	67,355,888 (GRCm39)	utr 3 prime	probably benign
X0063:Xirp2	UTSW	2	67,346,467 (GRCm39)	missense	probably benign	0.04
X0065:Xirp2	UTSW	2	67,345,462 (GRCm39)	missense	probably benign	0.34
Z1088:Xirp2	UTSW	2	67,343,665 (GRCm39)	missense	probably benign	0.03
Z1176:Xirp2	UTSW	2	67,344,923 (GRCm39)	missense	probably benign	0.17
Z1176:Xirp2	UTSW	2	67,341,737 (GRCm39)	missense	probably damaging	0.99
Z1176:Xirp2	UTSW	2	67,355,576 (GRCm39)	missense	probably damaging	1.00
Z1177:Xirp2	UTSW	2	67,355,715 (GRCm39)	missense	probably benign
Z1177:Xirp2	UTSW	2	67,340,537 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- ACACAGTGTACCAGGAGTGACAGTC -3'
(R):5'- TCTCATCTACAGGTGGTGGAGGAAG -3'

Sequencing Primer
(F):5'- TGACAGTCTCTGGGAAAAACC -3'
(R):5'- GAGAGGCTTTCAAATTCAGTCC -3'

Posted On

2014-01-15