Incidental Mutation 'R1146:Rexo1'
ID 102451
Institutional Source Beutler Lab
Gene Symbol Rexo1
Ensembl Gene ENSMUSG00000047417
Gene Name REX1, RNA exonuclease 1
Synonyms Rex1, Tceb3bp1, 2610511M11Rik, 1700021P10Rik
MMRRC Submission 039219-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.413) question?
Stock # R1146 (G1)
Quality Score 124
Status Not validated
Chromosome 10
Chromosomal Location 80376756-80397394 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 80380239 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 919 (S919N)
Ref Sequence ENSEMBL: ENSMUSP00000049705 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057910] [ENSMUST00000183160]
AlphaFold Q7TT28
Predicted Effect probably benign
Transcript: ENSMUST00000057910
AA Change: S919N

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000049705
Gene: ENSMUSG00000047417
AA Change: S919N

DomainStartEndE-ValueType
low complexity region 34 53 N/A INTRINSIC
coiled coil region 83 113 N/A INTRINSIC
low complexity region 180 188 N/A INTRINSIC
low complexity region 365 381 N/A INTRINSIC
low complexity region 383 396 N/A INTRINSIC
low complexity region 440 453 N/A INTRINSIC
low complexity region 468 479 N/A INTRINSIC
low complexity region 507 525 N/A INTRINSIC
low complexity region 533 551 N/A INTRINSIC
low complexity region 561 583 N/A INTRINSIC
low complexity region 667 682 N/A INTRINSIC
Pfam:EloA-BP1 794 954 3.8e-72 PFAM
EXOIII 1051 1210 2.36e-38 SMART
Predicted Effect unknown
Transcript: ENSMUST00000182260
AA Change: S241N
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182604
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182682
Predicted Effect probably benign
Transcript: ENSMUST00000183073
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183139
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183233
Predicted Effect probably benign
Transcript: ENSMUST00000183160
Meta Mutation Damage Score 0.0716 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 97.6%
  • 10x: 85.8%
  • 20x: 55.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A T 13: 81,679,795 (GRCm39) V1848E probably damaging Het
Alpk3 A G 7: 80,727,343 (GRCm39) K158E probably damaging Het
Arrdc4 T A 7: 68,389,756 (GRCm39) E356D probably damaging Het
Asb4 A G 6: 5,423,591 (GRCm39) N246S probably damaging Het
Ctsj G A 13: 61,150,312 (GRCm39) P230L probably benign Het
Eme1 A G 11: 94,536,277 (GRCm39) L564P probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fzd2 A T 11: 102,496,206 (GRCm39) S217C possibly damaging Het
Gaa G T 11: 119,165,730 (GRCm39) R81L probably damaging Het
Gfral A G 9: 76,074,341 (GRCm39) V368A probably benign Het
Gm21738 T C 14: 19,415,963 (GRCm38) K192R probably benign Het
Gucy1a2 T A 9: 3,759,830 (GRCm39) N545K probably damaging Het
Herc2 T C 7: 55,796,444 (GRCm39) S1939P probably benign Het
Ifnk T C 4: 35,152,231 (GRCm39) I53T probably benign Het
Iqub G A 6: 24,505,627 (GRCm39) L94F possibly damaging Het
Kpna1 C T 16: 35,853,749 (GRCm39) R460* probably null Het
Masp1 T C 16: 23,310,865 (GRCm39) E189G probably damaging Het
Mogat1 A G 1: 78,500,250 (GRCm39) I105V probably benign Het
Msh2 C A 17: 87,987,488 (GRCm39) D209E probably benign Het
Nsf G A 11: 103,719,364 (GRCm39) T646I probably damaging Het
Or10g9b A T 9: 39,917,390 (GRCm39) V285D possibly damaging Het
Or4c10b C T 2: 89,711,550 (GRCm39) P127S probably damaging Het
Or5b24 T A 19: 12,912,329 (GRCm39) S76T possibly damaging Het
Or6b2 G A 1: 92,407,612 (GRCm39) H244Y probably damaging Het
Otogl T A 10: 107,722,374 (GRCm39) I327F probably damaging Het
Pappa2 T C 1: 158,682,552 (GRCm39) D832G probably damaging Het
Pfkfb4 A G 9: 108,836,794 (GRCm39) E163G probably benign Het
Phc1 T C 6: 122,300,416 (GRCm39) probably benign Het
Piwil1 T C 5: 128,824,957 (GRCm39) S552P probably benign Het
Ppfia3 A C 7: 45,001,639 (GRCm39) D424E probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rbsn A G 6: 92,178,711 (GRCm39) probably null Het
Sec31a T C 5: 100,510,032 (GRCm39) N1152D probably damaging Het
Sel1l3 A T 5: 53,274,445 (GRCm39) F1012I possibly damaging Het
Sema4c A G 1: 36,589,646 (GRCm39) V539A probably benign Het
Sf3b5 A G 10: 12,884,575 (GRCm39) E70G possibly damaging Het
Tmcc2 TTGCTGCTGCTGCTGCTGC TTGCTGCTGCTGCTGC 1: 132,285,493 (GRCm39) probably benign Het
Tor1aip2 T C 1: 155,940,483 (GRCm39) V263A possibly damaging Het
Unc45b A G 11: 82,813,733 (GRCm39) E380G probably damaging Het
Usp16 C T 16: 87,271,536 (GRCm39) T364M possibly damaging Het
Usp50 T C 2: 126,551,392 (GRCm39) Y29C probably benign Het
Vmn2r115 ATCTTCT ATCT 17: 23,578,962 (GRCm39) probably benign Het
Wwox T C 8: 115,438,776 (GRCm39) S281P probably damaging Het
Zfp110 A G 7: 12,580,721 (GRCm39) probably null Het
Zfp335 G A 2: 164,738,043 (GRCm39) A856V probably benign Het
Zfp652 G A 11: 95,640,608 (GRCm39) E178K possibly damaging Het
Other mutations in Rexo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00970:Rexo1 APN 10 80,386,798 (GRCm39) missense probably damaging 0.99
IGL01128:Rexo1 APN 10 80,385,573 (GRCm39) missense probably benign
IGL01890:Rexo1 APN 10 80,378,845 (GRCm39) missense possibly damaging 0.85
PIT4453001:Rexo1 UTSW 10 80,386,231 (GRCm39) missense probably damaging 0.97
R0044:Rexo1 UTSW 10 80,380,212 (GRCm39) missense probably benign 0.16
R0365:Rexo1 UTSW 10 80,378,410 (GRCm39) missense probably damaging 0.99
R0573:Rexo1 UTSW 10 80,380,684 (GRCm39) missense probably damaging 1.00
R1146:Rexo1 UTSW 10 80,380,239 (GRCm39) missense probably benign 0.04
R1511:Rexo1 UTSW 10 80,385,884 (GRCm39) missense possibly damaging 0.93
R1523:Rexo1 UTSW 10 80,378,585 (GRCm39) missense probably benign 0.41
R1807:Rexo1 UTSW 10 80,378,413 (GRCm39) missense possibly damaging 0.95
R1868:Rexo1 UTSW 10 80,378,754 (GRCm39) missense probably damaging 1.00
R1935:Rexo1 UTSW 10 80,386,303 (GRCm39) missense probably benign 0.00
R1936:Rexo1 UTSW 10 80,386,303 (GRCm39) missense probably benign 0.00
R1957:Rexo1 UTSW 10 80,379,200 (GRCm39) missense probably damaging 0.96
R2084:Rexo1 UTSW 10 80,397,100 (GRCm39) missense probably benign 0.01
R2153:Rexo1 UTSW 10 80,379,943 (GRCm39) nonsense probably null
R2262:Rexo1 UTSW 10 80,385,403 (GRCm39) missense probably benign 0.02
R4471:Rexo1 UTSW 10 80,378,492 (GRCm39) missense probably damaging 1.00
R4472:Rexo1 UTSW 10 80,378,492 (GRCm39) missense probably damaging 1.00
R4690:Rexo1 UTSW 10 80,382,255 (GRCm39) missense probably benign 0.01
R4972:Rexo1 UTSW 10 80,385,527 (GRCm39) missense probably damaging 0.96
R6335:Rexo1 UTSW 10 80,379,915 (GRCm39) missense probably damaging 1.00
R6505:Rexo1 UTSW 10 80,378,845 (GRCm39) missense possibly damaging 0.85
R6615:Rexo1 UTSW 10 80,379,848 (GRCm39) missense possibly damaging 0.68
R6949:Rexo1 UTSW 10 80,386,470 (GRCm39) missense possibly damaging 0.46
R7612:Rexo1 UTSW 10 80,385,497 (GRCm39) missense probably benign 0.40
R7807:Rexo1 UTSW 10 80,385,970 (GRCm39) missense probably benign 0.09
R7840:Rexo1 UTSW 10 80,386,572 (GRCm39) missense probably benign
R8779:Rexo1 UTSW 10 80,384,292 (GRCm39) missense probably benign 0.26
R8897:Rexo1 UTSW 10 80,378,437 (GRCm39) missense probably damaging 0.98
R8995:Rexo1 UTSW 10 80,386,095 (GRCm39) missense probably damaging 0.96
R9094:Rexo1 UTSW 10 80,378,854 (GRCm39) missense probably damaging 1.00
R9411:Rexo1 UTSW 10 80,397,248 (GRCm39) missense
R9438:Rexo1 UTSW 10 80,378,848 (GRCm39) missense possibly damaging 0.46
R9524:Rexo1 UTSW 10 80,386,872 (GRCm39) missense probably damaging 1.00
R9648:Rexo1 UTSW 10 80,385,540 (GRCm39) missense probably damaging 0.97
Z1177:Rexo1 UTSW 10 80,385,609 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-01-15