Incidental Mutation 'IGL01644:St7l'
ID102598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol St7l
Ensembl Gene ENSMUSG00000045576
Gene Namesuppression of tumorigenicity 7-like
SynonymsSt7r
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.046) question?
Stock #IGL01644
Quality Score
Status
Chromosome3
Chromosomal Location104864005-104930064 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 104919456 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 377 (R377*)
Ref Sequence ENSEMBL: ENSMUSP00000143759 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059271] [ENSMUST00000106769] [ENSMUST00000183914] [ENSMUST00000200132]
Predicted Effect probably null
Transcript: ENSMUST00000059271
AA Change: R455*
SMART Domains Protein: ENSMUSP00000058455
Gene: ENSMUSG00000045576
AA Change: R455*

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 559 1.6e-292 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106769
AA Change: R423*
SMART Domains Protein: ENSMUSP00000102380
Gene: ENSMUSG00000045576
AA Change: R423*

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 420 8.2e-209 PFAM
Pfam:ST7 419 527 1.4e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000183914
SMART Domains Protein: ENSMUSP00000139266
Gene: ENSMUSG00000045576

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
low complexity region 107 120 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000197098
AA Change: R226*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198831
Predicted Effect probably benign
Transcript: ENSMUST00000199335
Predicted Effect probably null
Transcript: ENSMUST00000200132
AA Change: R377*
SMART Domains Protein: ENSMUSP00000143759
Gene: ENSMUSG00000045576
AA Change: R377*

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 212 2.7e-81 PFAM
Pfam:ST7 209 481 1.3e-167 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg16l2 A G 7: 101,297,217 *82R probably null Het
Crb1 T A 1: 139,237,630 R919* probably null Het
Csf1 T C 3: 107,753,842 T120A possibly damaging Het
Defa29 A T 8: 21,326,121 C77S possibly damaging Het
Defb7 A T 8: 19,497,701 probably benign Het
Ece2 T C 16: 20,617,866 V146A possibly damaging Het
Efcab6 T A 15: 84,033,072 S96C probably damaging Het
Gm7729 T C 18: 27,598,819 noncoding transcript Het
Hapln2 G T 3: 88,022,637 R311S probably damaging Het
Impg2 C T 16: 56,259,870 P679L probably benign Het
Kansl1l A G 1: 66,801,316 I275T probably benign Het
Med29 A G 7: 28,390,847 F108L probably damaging Het
Nrxn1 C T 17: 90,620,873 C789Y possibly damaging Het
Olfr1230 T C 2: 89,296,632 I213V probably benign Het
Olfr1490 A T 19: 13,655,404 probably benign Het
Palld T C 8: 61,877,478 K122E probably benign Het
Ppl A T 16: 5,091,855 L864H probably damaging Het
Ptov1 C A 7: 44,867,502 E37* probably null Het
Sspo T C 6: 48,452,502 V482A probably benign Het
Ttn G T 2: 76,755,383 P13643T probably damaging Het
Vcan T A 13: 89,688,675 T2917S probably benign Het
Other mutations in St7l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00785:St7l APN 3 104873579 splice site probably benign
IGL00919:St7l APN 3 104926466 missense probably damaging 1.00
IGL00945:St7l APN 3 104926482 missense probably damaging 0.96
IGL02158:St7l APN 3 104874832 missense possibly damaging 0.48
IGL02164:St7l APN 3 104922281 critical splice donor site probably null
IGL02331:St7l APN 3 104926588 missense probably damaging 0.98
IGL03220:St7l APN 3 104874823 splice site probably benign
R0118:St7l UTSW 3 104889303 missense probably damaging 0.97
R0320:St7l UTSW 3 104870913 nonsense probably null
R0345:St7l UTSW 3 104895809 splice site probably benign
R0714:St7l UTSW 3 104874928 missense probably benign 0.06
R0784:St7l UTSW 3 104870924 missense probably benign 0.13
R1664:St7l UTSW 3 104870898 missense probably damaging 1.00
R1719:St7l UTSW 3 104870987 missense probably benign 0.00
R1800:St7l UTSW 3 104919496 missense probably damaging 1.00
R1882:St7l UTSW 3 104868047 missense probably damaging 1.00
R3692:St7l UTSW 3 104891554 missense probably benign 0.27
R3879:St7l UTSW 3 104926447 missense probably damaging 1.00
R5130:St7l UTSW 3 104895764 missense probably damaging 1.00
R5271:St7l UTSW 3 104868060 missense probably damaging 1.00
R5887:St7l UTSW 3 104874928 missense probably benign 0.06
R6191:St7l UTSW 3 104868033 missense probably damaging 1.00
R6252:St7l UTSW 3 104919503 critical splice donor site probably null
Posted On2014-01-21