Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01647:Tcea3'

102725

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tcea3

Ensembl Gene

ENSMUSG00000001604

Gene Name

transcription elongation factor A (SII), 3

Synonyms

S-II, SII-K1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.210) question?

Stock #

IGL01647

Quality Score

Status

Chromosome

Chromosomal Location

135975253-136002214 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to C at 136002087 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000099592 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102533]

AlphaFold

P23881

PDB Structure

Solution structure of the N-terminal Domain I of mouse transcription elongation factor S-II protein 3 [SOLUTION NMR]

Predicted Effect

probably benign
Transcript: ENSMUST00000102533

SMART Domains

Protein: ENSMUSP00000099592
Gene: ENSMUSG00000001604

Domain	Start	End	E-Value	Type
TFS2N	7	81	1.43e-29	SMART
low complexity region	86	100	N/A	INTRINSIC
low complexity region	124	144	N/A	INTRINSIC
low complexity region	157	168	N/A	INTRINSIC
TFS2M	184	285	1.05e-52	SMART
ZnF_C2C2	307	346	6.87e-18	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136812

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402F06Rik	T	A	2: 35,266,097 (GRCm39)	D191V	probably damaging	Het
Adcy6	T	C	15: 98,498,156 (GRCm39)	D382G	probably damaging	Het
Arhgef33	A	T	17: 80,672,695 (GRCm39)		probably benign	Het
Armc10	A	G	5: 21,851,091 (GRCm39)		probably benign	Het
Bcas1	T	A	2: 170,191,172 (GRCm39)	Q586L	probably damaging	Het
Bltp3b	T	C	10: 89,609,982 (GRCm39)		probably null	Het
Ccdc88a	A	C	11: 29,454,321 (GRCm39)		probably benign	Het
Cep250	T	A	2: 155,825,296 (GRCm39)	C1057S	probably benign	Het
Ctsm	A	T	13: 61,688,087 (GRCm39)	M14K	probably benign	Het
Dpy19l1	C	T	9: 24,396,365 (GRCm39)	R117Q	probably damaging	Het
Frem1	A	G	4: 82,868,593 (GRCm39)	Y1463H	possibly damaging	Het
Garin3	G	T	11: 46,296,224 (GRCm39)	E199*	probably null	Het
Gck	A	T	11: 5,854,472 (GRCm39)	M251K	probably damaging	Het
Gzf1	C	T	2: 148,525,570 (GRCm39)	P14S	probably damaging	Het
Iws1	A	T	18: 32,230,275 (GRCm39)	K748*	probably null	Het
Kif15	T	A	9: 122,792,536 (GRCm39)		probably benign	Het
Ly6g6f	A	G	17: 35,299,817 (GRCm39)		probably benign	Het
Mrps30	C	T	13: 118,517,146 (GRCm39)	G358R	probably damaging	Het
Nfrkb	T	A	9: 31,307,801 (GRCm39)		probably benign	Het
Or5m3b	C	T	2: 85,872,441 (GRCm39)	P261S	probably damaging	Het
Pakap	A	T	4: 57,688,477 (GRCm39)	I107F	possibly damaging	Het
Pcnt	T	A	10: 76,205,835 (GRCm39)	K2506*	probably null	Het
Pgc	G	T	17: 48,043,329 (GRCm39)	G226W	probably damaging	Het
Pip5k1a	C	T	3: 94,981,383 (GRCm39)	V82M	probably damaging	Het
Plk3	A	G	4: 116,987,554 (GRCm39)	V466A	probably damaging	Het
Prss44	C	A	9: 110,643,745 (GRCm39)	Q130K	probably damaging	Het
Rbck1	T	C	2: 152,165,152 (GRCm39)	Y66C	probably damaging	Het
Rbm6	T	C	9: 107,730,081 (GRCm39)	E189G	probably benign	Het
Rtn4r	G	T	16: 17,969,190 (GRCm39)	R206L	probably damaging	Het
Ryr2	C	T	13: 11,600,366 (GRCm39)	G4613E	probably damaging	Het
Sema5a	T	G	15: 32,417,587 (GRCm39)	L19R	possibly damaging	Het
Slc30a5	T	C	13: 100,957,653 (GRCm39)	T139A	possibly damaging	Het
Slco2a1	T	G	9: 102,947,495 (GRCm39)	S265A	possibly damaging	Het
Smad4	A	G	18: 73,773,544 (GRCm39)		probably benign	Het
St13	C	T	15: 81,255,708 (GRCm39)	R240Q	probably damaging	Het
Vmn1r177	T	C	7: 23,565,600 (GRCm39)	Y92C	probably damaging	Het
Wnt8b	A	T	19: 44,499,704 (GRCm39)	D151V	probably damaging	Het
Zfp426	T	A	9: 20,389,453 (GRCm39)	M1L	possibly damaging	Het

Other mutations in Tcea3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00588:Tcea3	APN	4	136,001,003 (GRCm39)	missense	probably damaging	1.00
IGL02153:Tcea3	APN	4	136,000,945 (GRCm39)	splice site	probably benign
IGL02832:Tcea3	APN	4	135,995,424 (GRCm39)	missense	probably damaging	1.00
IGL02951:Tcea3	APN	4	135,985,299 (GRCm39)	critical splice donor site	probably null
R0281:Tcea3	UTSW	4	135,998,677 (GRCm39)	missense	probably damaging	1.00
R0646:Tcea3	UTSW	4	135,975,382 (GRCm39)	nonsense	probably null
R3937:Tcea3	UTSW	4	135,982,454 (GRCm39)	splice site	probably benign
R4944:Tcea3	UTSW	4	135,995,404 (GRCm39)	missense	probably damaging	1.00
R5028:Tcea3	UTSW	4	135,985,246 (GRCm39)	missense	possibly damaging	0.87
R5169:Tcea3	UTSW	4	135,992,181 (GRCm39)	critical splice acceptor site	probably null
R5245:Tcea3	UTSW	4	135,991,813 (GRCm39)	missense	probably benign	0.01
R5511:Tcea3	UTSW	4	135,998,683 (GRCm39)	missense	probably damaging	1.00
R5730:Tcea3	UTSW	4	135,992,204 (GRCm39)	missense	probably benign	0.00
R6208:Tcea3	UTSW	4	135,975,360 (GRCm39)	start codon destroyed	probably damaging	0.96
R7106:Tcea3	UTSW	4	135,998,679 (GRCm39)	missense	probably damaging	1.00
R8018:Tcea3	UTSW	4	135,985,229 (GRCm39)	splice site	probably benign
R8076:Tcea3	UTSW	4	135,995,440 (GRCm39)	missense	probably damaging	1.00
R8078:Tcea3	UTSW	4	135,981,825 (GRCm39)	missense	probably damaging	0.99
R8158:Tcea3	UTSW	4	136,001,027 (GRCm39)	critical splice donor site	probably null
R8861:Tcea3	UTSW	4	135,981,810 (GRCm39)	missense	probably damaging	1.00
R9495:Tcea3	UTSW	4	135,991,885 (GRCm39)	missense	probably damaging	0.98

Posted On

2014-01-21