Incidental Mutation 'IGL01647:Ly6g6f'
| ID |
102726 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ly6g6f
|
| Ensembl Gene |
ENSMUSG00000034923 |
| Gene Name |
lymphocyte antigen 6 family member G6F |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
IGL01647
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
35299514-35304571 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
A to G
at 35299817 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133753
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000013910]
[ENSMUST00000038507]
[ENSMUST00000172494]
[ENSMUST00000172678]
[ENSMUST00000172959]
|
| AlphaFold |
B2RXM6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000013910
|
| SMART Domains |
Protein: ENSMUSP00000013910
Gene: ENSMUSG00000013766
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
LU
|
28 |
117 |
1.65e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000038507
|
| SMART Domains |
Protein: ENSMUSP00000046380
Gene: ENSMUSG00000034923
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
21 |
127 |
6.02e-7 |
SMART |
|
transmembrane domain
|
237 |
259 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172494
|
| SMART Domains |
Protein: ENSMUSP00000133645
Gene: ENSMUSG00000013766
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Blast:LU
|
28 |
50 |
1e-8 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000172639
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172678
|
| SMART Domains |
Protein: ENSMUSP00000134073
Gene: ENSMUSG00000013766
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
LU
|
28 |
117 |
1.65e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000172745
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172959
|
| SMART Domains |
Protein: ENSMUSP00000133753
Gene: ENSMUSG00000013766
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Activin_recp
|
82 |
143 |
2.3e-7 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173120
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930402F06Rik |
T |
A |
2: 35,266,097 (GRCm39) |
D191V |
probably damaging |
Het |
| Adcy6 |
T |
C |
15: 98,498,156 (GRCm39) |
D382G |
probably damaging |
Het |
| Arhgef33 |
A |
T |
17: 80,672,695 (GRCm39) |
|
probably benign |
Het |
| Armc10 |
A |
G |
5: 21,851,091 (GRCm39) |
|
probably benign |
Het |
| Bcas1 |
T |
A |
2: 170,191,172 (GRCm39) |
Q586L |
probably damaging |
Het |
| Bltp3b |
T |
C |
10: 89,609,982 (GRCm39) |
|
probably null |
Het |
| Ccdc88a |
A |
C |
11: 29,454,321 (GRCm39) |
|
probably benign |
Het |
| Cep250 |
T |
A |
2: 155,825,296 (GRCm39) |
C1057S |
probably benign |
Het |
| Ctsm |
A |
T |
13: 61,688,087 (GRCm39) |
M14K |
probably benign |
Het |
| Dpy19l1 |
C |
T |
9: 24,396,365 (GRCm39) |
R117Q |
probably damaging |
Het |
| Frem1 |
A |
G |
4: 82,868,593 (GRCm39) |
Y1463H |
possibly damaging |
Het |
| Garin3 |
G |
T |
11: 46,296,224 (GRCm39) |
E199* |
probably null |
Het |
| Gck |
A |
T |
11: 5,854,472 (GRCm39) |
M251K |
probably damaging |
Het |
| Gzf1 |
C |
T |
2: 148,525,570 (GRCm39) |
P14S |
probably damaging |
Het |
| Iws1 |
A |
T |
18: 32,230,275 (GRCm39) |
K748* |
probably null |
Het |
| Kif15 |
T |
A |
9: 122,792,536 (GRCm39) |
|
probably benign |
Het |
| Mrps30 |
C |
T |
13: 118,517,146 (GRCm39) |
G358R |
probably damaging |
Het |
| Nfrkb |
T |
A |
9: 31,307,801 (GRCm39) |
|
probably benign |
Het |
| Or5m3b |
C |
T |
2: 85,872,441 (GRCm39) |
P261S |
probably damaging |
Het |
| Pakap |
A |
T |
4: 57,688,477 (GRCm39) |
I107F |
possibly damaging |
Het |
| Pcnt |
T |
A |
10: 76,205,835 (GRCm39) |
K2506* |
probably null |
Het |
| Pgc |
G |
T |
17: 48,043,329 (GRCm39) |
G226W |
probably damaging |
Het |
| Pip5k1a |
C |
T |
3: 94,981,383 (GRCm39) |
V82M |
probably damaging |
Het |
| Plk3 |
A |
G |
4: 116,987,554 (GRCm39) |
V466A |
probably damaging |
Het |
| Prss44 |
C |
A |
9: 110,643,745 (GRCm39) |
Q130K |
probably damaging |
Het |
| Rbck1 |
T |
C |
2: 152,165,152 (GRCm39) |
Y66C |
probably damaging |
Het |
| Rbm6 |
T |
C |
9: 107,730,081 (GRCm39) |
E189G |
probably benign |
Het |
| Rtn4r |
G |
T |
16: 17,969,190 (GRCm39) |
R206L |
probably damaging |
Het |
| Ryr2 |
C |
T |
13: 11,600,366 (GRCm39) |
G4613E |
probably damaging |
Het |
| Sema5a |
T |
G |
15: 32,417,587 (GRCm39) |
L19R |
possibly damaging |
Het |
| Slc30a5 |
T |
C |
13: 100,957,653 (GRCm39) |
T139A |
possibly damaging |
Het |
| Slco2a1 |
T |
G |
9: 102,947,495 (GRCm39) |
S265A |
possibly damaging |
Het |
| Smad4 |
A |
G |
18: 73,773,544 (GRCm39) |
|
probably benign |
Het |
| St13 |
C |
T |
15: 81,255,708 (GRCm39) |
R240Q |
probably damaging |
Het |
| Tcea3 |
A |
C |
4: 136,002,087 (GRCm39) |
|
probably benign |
Het |
| Vmn1r177 |
T |
C |
7: 23,565,600 (GRCm39) |
Y92C |
probably damaging |
Het |
| Wnt8b |
A |
T |
19: 44,499,704 (GRCm39) |
D151V |
probably damaging |
Het |
| Zfp426 |
T |
A |
9: 20,389,453 (GRCm39) |
M1L |
possibly damaging |
Het |
|
| Other mutations in Ly6g6f |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01804:Ly6g6f
|
APN |
17 |
35,300,146 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02280:Ly6g6f
|
APN |
17 |
35,302,194 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02455:Ly6g6f
|
APN |
17 |
35,301,866 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02694:Ly6g6f
|
APN |
17 |
35,300,144 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0519:Ly6g6f
|
UTSW |
17 |
35,301,828 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1169:Ly6g6f
|
UTSW |
17 |
35,302,240 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1796:Ly6g6f
|
UTSW |
17 |
35,302,478 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5549:Ly6g6f
|
UTSW |
17 |
35,302,333 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6717:Ly6g6f
|
UTSW |
17 |
35,304,550 (GRCm39) |
start codon destroyed |
probably benign |
0.01 |
|
R8012:Ly6g6f
|
UTSW |
17 |
35,300,060 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9443:Ly6g6f
|
UTSW |
17 |
35,299,826 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0017:Ly6g6f
|
UTSW |
17 |
35,304,514 (GRCm39) |
missense |
probably benign |
0.17 |
|
X0027:Ly6g6f
|
UTSW |
17 |
35,300,096 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1177:Ly6g6f
|
UTSW |
17 |
35,302,008 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Posted On |
2014-01-21 |
Incidental Mutation