Incidental Mutation 'IGL01650:Zkscan7'
| ID |
102817 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zkscan7
|
| Ensembl Gene |
ENSMUSG00000063488 |
| Gene Name |
zinc finger with KRAB and SCAN domains 7 |
| Synonyms |
Zfp167 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01650
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
122715883-122727684 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 122723892 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 287
(D287G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000071695
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063980]
[ENSMUST00000215872]
|
| AlphaFold |
E9PVW1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063980
AA Change: D287G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000071695
Gene: ENSMUSG00000063488
AA Change: D287G
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
45 |
156 |
1.18e-65 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
8.4e1 |
SMART |
|
ZnF_C2H2
|
487 |
509 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
515 |
537 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
543 |
565 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
571 |
593 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
599 |
621 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
627 |
649 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
655 |
677 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
683 |
705 |
1.04e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000180486
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000180877
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214426
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000215872
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216429
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216924
|
| Meta Mutation Damage Score |
0.0746 |
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Agbl1 |
A |
G |
7: 76,070,067 (GRCm39) |
D281G |
probably damaging |
Het |
| Arhgap28 |
T |
C |
17: 68,180,127 (GRCm39) |
E236G |
probably damaging |
Het |
| Bltp1 |
G |
A |
3: 37,046,822 (GRCm39) |
|
probably benign |
Het |
| Btbd3 |
A |
T |
2: 138,126,025 (GRCm39) |
D334V |
probably damaging |
Het |
| Cabp4 |
T |
C |
19: 4,189,323 (GRCm39) |
E78G |
probably benign |
Het |
| Clcn4 |
T |
C |
7: 7,287,280 (GRCm39) |
|
probably benign |
Het |
| Col14a1 |
A |
G |
15: 55,270,089 (GRCm39) |
Y600C |
unknown |
Het |
| Cpne4 |
A |
G |
9: 104,778,710 (GRCm39) |
D167G |
probably damaging |
Het |
| Eif3a |
T |
A |
19: 60,762,434 (GRCm39) |
I450F |
probably damaging |
Het |
| Enpp2 |
T |
A |
15: 54,783,329 (GRCm39) |
Y10F |
probably benign |
Het |
| Fam227a |
A |
T |
15: 79,518,274 (GRCm39) |
H339Q |
possibly damaging |
Het |
| Far2 |
C |
A |
6: 148,074,985 (GRCm39) |
T406K |
possibly damaging |
Het |
| Fmo1 |
A |
G |
1: 162,661,153 (GRCm39) |
S377P |
probably benign |
Het |
| Fsip2 |
G |
A |
2: 82,821,430 (GRCm39) |
S5721N |
probably benign |
Het |
| Gatb |
T |
C |
3: 85,520,791 (GRCm39) |
I300T |
possibly damaging |
Het |
| Gpam |
T |
C |
19: 55,070,132 (GRCm39) |
N375D |
probably benign |
Het |
| Gsdma |
G |
T |
11: 98,564,513 (GRCm39) |
D331Y |
probably damaging |
Het |
| Kif13b |
T |
C |
14: 65,002,594 (GRCm39) |
V1073A |
probably benign |
Het |
| Mfsd4b1 |
T |
A |
10: 39,879,115 (GRCm39) |
M261L |
probably benign |
Het |
| Nav1 |
A |
T |
1: 135,382,498 (GRCm39) |
D1321E |
probably damaging |
Het |
| Or4f59 |
A |
G |
2: 111,872,720 (GRCm39) |
I219T |
possibly damaging |
Het |
| Or52j3 |
A |
G |
7: 102,836,286 (GRCm39) |
I159M |
probably benign |
Het |
| Or6c69 |
A |
G |
10: 129,747,550 (GRCm39) |
V199A |
probably benign |
Het |
| Or6c76b |
T |
A |
10: 129,692,936 (GRCm39) |
L183Q |
probably damaging |
Het |
| Or8g32 |
G |
T |
9: 39,305,252 (GRCm39) |
S55I |
probably damaging |
Het |
| Ppp1r10 |
G |
T |
17: 36,242,053 (GRCm39) |
R857L |
unknown |
Het |
| Prune2 |
T |
A |
19: 17,145,656 (GRCm39) |
I2752N |
possibly damaging |
Het |
| Pxdn |
T |
C |
12: 30,052,400 (GRCm39) |
I859T |
probably benign |
Het |
| Ros1 |
T |
C |
10: 52,031,075 (GRCm39) |
D510G |
probably damaging |
Het |
| Sema3g |
C |
A |
14: 30,943,744 (GRCm39) |
P208H |
probably benign |
Het |
| Smcr8 |
T |
C |
11: 60,669,010 (GRCm39) |
F53L |
probably damaging |
Het |
| Tnfsf13b |
A |
T |
8: 10,081,411 (GRCm39) |
I219F |
probably damaging |
Het |
| Vmn1r62 |
T |
C |
7: 5,679,024 (GRCm39) |
V235A |
probably damaging |
Het |
| Vmn2r44 |
C |
A |
7: 8,383,103 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Zkscan7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00594:Zkscan7
|
APN |
9 |
122,724,659 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01905:Zkscan7
|
APN |
9 |
122,719,826 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02466:Zkscan7
|
APN |
9 |
122,717,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0310:Zkscan7
|
UTSW |
9 |
122,717,958 (GRCm39) |
nonsense |
probably null |
|
|
R0355:Zkscan7
|
UTSW |
9 |
122,717,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0477:Zkscan7
|
UTSW |
9 |
122,719,874 (GRCm39) |
splice site |
probably null |
|
|
R1276:Zkscan7
|
UTSW |
9 |
122,719,788 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1426:Zkscan7
|
UTSW |
9 |
122,724,228 (GRCm39) |
missense |
probably benign |
|
|
R2055:Zkscan7
|
UTSW |
9 |
122,718,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2195:Zkscan7
|
UTSW |
9 |
122,724,686 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2354:Zkscan7
|
UTSW |
9 |
122,723,892 (GRCm39) |
missense |
probably benign |
|
|
R4878:Zkscan7
|
UTSW |
9 |
122,719,865 (GRCm39) |
nonsense |
probably null |
|
|
R5106:Zkscan7
|
UTSW |
9 |
122,725,198 (GRCm39) |
unclassified |
probably benign |
|
|
R6266:Zkscan7
|
UTSW |
9 |
122,724,299 (GRCm39) |
nonsense |
probably null |
|
|
R6299:Zkscan7
|
UTSW |
9 |
122,717,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6513:Zkscan7
|
UTSW |
9 |
122,725,170 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6881:Zkscan7
|
UTSW |
9 |
122,717,766 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7640:Zkscan7
|
UTSW |
9 |
122,725,121 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7920:Zkscan7
|
UTSW |
9 |
122,724,974 (GRCm39) |
missense |
probably benign |
0.19 |
|
| Posted On |
2014-01-21 |
Incidental Mutation