Incidental Mutation 'IGL01652:Pla2g4f'
| ID |
102861 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Pla2g4f
|
| Ensembl Gene |
ENSMUSG00000046971 |
| Gene Name |
phospholipase A2, group IVF |
| Synonyms |
4732472I07Rik, Pla2zeta |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
IGL01652
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
120130438-120144646 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 120132716 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 707
(I707V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000062607
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054651]
|
| AlphaFold |
Q50L41 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000054651
AA Change: I707V
PolyPhen 2
Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000062607
Gene: ENSMUSG00000046971
AA Change: I707V
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
45 |
144 |
7.51e-11 |
SMART |
|
PLAc
|
285 |
797 |
1.6e-13 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142183
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alk |
A |
T |
17: 72,910,526 (GRCm39) |
V60E |
probably damaging |
Het |
| Ank2 |
T |
C |
3: 126,726,690 (GRCm39) |
K868R |
probably benign |
Het |
| Ankrd13a |
A |
T |
5: 114,929,397 (GRCm39) |
D158V |
probably damaging |
Het |
| Arhgap12 |
G |
T |
18: 6,061,853 (GRCm39) |
N380K |
possibly damaging |
Het |
| Cpn1 |
A |
T |
19: 43,974,533 (GRCm39) |
F65L |
possibly damaging |
Het |
| Dlec1 |
T |
A |
9: 118,972,975 (GRCm39) |
H1496Q |
probably benign |
Het |
| Dock1 |
C |
T |
7: 134,379,226 (GRCm39) |
|
probably benign |
Het |
| Dok1 |
T |
C |
6: 83,009,543 (GRCm39) |
N143D |
probably damaging |
Het |
| Fcmr |
C |
T |
1: 130,806,244 (GRCm39) |
P363L |
probably benign |
Het |
| Galk2 |
A |
G |
2: 125,738,685 (GRCm39) |
T171A |
probably benign |
Het |
| Hrh3 |
G |
T |
2: 179,742,896 (GRCm39) |
P244Q |
possibly damaging |
Het |
| Icam1 |
T |
C |
9: 20,930,472 (GRCm39) |
Y109H |
probably damaging |
Het |
| Nup93 |
T |
C |
8: 95,023,187 (GRCm39) |
V132A |
possibly damaging |
Het |
| Or4c113 |
A |
T |
2: 88,884,913 (GRCm39) |
Y286N |
probably damaging |
Het |
| Rpgrip1 |
G |
A |
14: 52,382,949 (GRCm39) |
|
probably benign |
Het |
| Sbf2 |
A |
T |
7: 110,046,327 (GRCm39) |
V290E |
probably damaging |
Het |
| Stard3 |
T |
G |
11: 98,269,559 (GRCm39) |
|
probably benign |
Het |
| Sufu |
T |
C |
19: 46,464,059 (GRCm39) |
Y424H |
probably damaging |
Het |
| Trim35 |
T |
G |
14: 66,546,250 (GRCm39) |
V339G |
probably damaging |
Het |
| Vmn1r80 |
A |
G |
7: 11,927,063 (GRCm39) |
I58V |
probably benign |
Het |
|
| Other mutations in Pla2g4f |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Pla2g4f
|
APN |
2 |
120,133,219 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02792:Pla2g4f
|
APN |
2 |
120,133,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0625:Pla2g4f
|
UTSW |
2 |
120,135,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1760:Pla2g4f
|
UTSW |
2 |
120,144,547 (GRCm39) |
unclassified |
probably benign |
|
|
R1799:Pla2g4f
|
UTSW |
2 |
120,141,549 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R2212:Pla2g4f
|
UTSW |
2 |
120,133,587 (GRCm39) |
missense |
probably benign |
|
|
R2351:Pla2g4f
|
UTSW |
2 |
120,130,923 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3412:Pla2g4f
|
UTSW |
2 |
120,133,587 (GRCm39) |
missense |
probably benign |
|
|
R3414:Pla2g4f
|
UTSW |
2 |
120,133,587 (GRCm39) |
missense |
probably benign |
|
|
R3906:Pla2g4f
|
UTSW |
2 |
120,130,980 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4084:Pla2g4f
|
UTSW |
2 |
120,142,806 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4477:Pla2g4f
|
UTSW |
2 |
120,134,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4529:Pla2g4f
|
UTSW |
2 |
120,131,100 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4606:Pla2g4f
|
UTSW |
2 |
120,144,467 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4685:Pla2g4f
|
UTSW |
2 |
120,135,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4728:Pla2g4f
|
UTSW |
2 |
120,131,402 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4782:Pla2g4f
|
UTSW |
2 |
120,133,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4957:Pla2g4f
|
UTSW |
2 |
120,130,980 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5781:Pla2g4f
|
UTSW |
2 |
120,135,504 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6158:Pla2g4f
|
UTSW |
2 |
120,131,552 (GRCm39) |
missense |
probably benign |
0.21 |
|
R6232:Pla2g4f
|
UTSW |
2 |
120,132,702 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6629:Pla2g4f
|
UTSW |
2 |
120,138,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6894:Pla2g4f
|
UTSW |
2 |
120,134,077 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6939:Pla2g4f
|
UTSW |
2 |
120,137,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7131:Pla2g4f
|
UTSW |
2 |
120,135,035 (GRCm39) |
missense |
probably null |
0.01 |
|
R7221:Pla2g4f
|
UTSW |
2 |
120,131,476 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7421:Pla2g4f
|
UTSW |
2 |
120,137,737 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7767:Pla2g4f
|
UTSW |
2 |
120,135,490 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8466:Pla2g4f
|
UTSW |
2 |
120,130,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9389:Pla2g4f
|
UTSW |
2 |
120,132,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9425:Pla2g4f
|
UTSW |
2 |
120,133,264 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9500:Pla2g4f
|
UTSW |
2 |
120,142,713 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9657:Pla2g4f
|
UTSW |
2 |
120,135,138 (GRCm39) |
missense |
probably benign |
|
|
R9714:Pla2g4f
|
UTSW |
2 |
120,142,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2014-01-21 |
Incidental Mutation