Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01653:Or5a3'

102875

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5a3

Ensembl Gene

ENSMUSG00000050815

Gene Name

olfactory receptor family 5 subfamily A member 3

Synonyms

MOR215-2, GA_x6K02T2RE5P-2753221-2754177, Olfr1441

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.109) question?

Stock #

IGL01653

Quality Score

Status

Chromosome

Chromosomal Location

12399675-12400631 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 12399736 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 21 (R21H)

Ref Sequence

ENSEMBL: ENSMUSP00000150739 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059033] [ENSMUST00000214153] [ENSMUST00000216506]

AlphaFold

Q8VFV3

Predicted Effect

probably benign
Transcript: ENSMUST00000059033
AA Change: R21H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000061963
Gene: ENSMUSG00000050815
AA Change: R21H

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	2.7e-52	PFAM
Pfam:7tm_1	42	313	5e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214153
AA Change: R21H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000216506
AA Change: R21H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933421I07Rik	T	C	7: 42,096,398 (GRCm39)	D119G	probably damaging	Het
Apol7c	A	G	15: 77,410,500 (GRCm39)	C149R	probably damaging	Het
Arfgef1	G	A	1: 10,230,133 (GRCm39)	R1235*	probably null	Het
Bpifb4	A	G	2: 153,786,703 (GRCm39)	D285G	probably damaging	Het
Cep192	T	A	18: 67,986,043 (GRCm39)	H1682Q	possibly damaging	Het
Cerk	G	T	15: 86,033,552 (GRCm39)	Y290*	probably null	Het
Cyld	A	T	8: 89,467,998 (GRCm39)	I544F	probably damaging	Het
Dcp1a	T	C	14: 30,227,528 (GRCm39)	S134P	possibly damaging	Het
Epha6	A	C	16: 59,659,666 (GRCm39)	N817K	probably benign	Het
Ephb4	A	G	5: 137,364,003 (GRCm39)		probably benign	Het
Fcgr3	A	T	1: 170,886,849 (GRCm39)	L25Q	probably damaging	Het
Heatr3	A	G	8: 88,871,245 (GRCm39)	I83V	probably benign	Het
Hormad1	T	A	3: 95,485,608 (GRCm39)	N265K	possibly damaging	Het
Kpna1	A	G	16: 35,840,562 (GRCm39)	T201A	probably benign	Het
Krt6b	T	A	15: 101,587,549 (GRCm39)	T182S	probably damaging	Het
Macc1	A	G	12: 119,414,088 (GRCm39)	K755E	probably damaging	Het
Med12l	C	T	3: 59,169,314 (GRCm39)	T1568M	probably damaging	Het
Muc4	G	T	16: 32,581,722 (GRCm39)		probably null	Het
Myt1l	T	C	12: 29,960,770 (GRCm39)	S1028P	unknown	Het
Nhlrc2	C	T	19: 56,559,282 (GRCm39)	R256C	probably benign	Het
Or4c123	T	A	2: 89,127,471 (GRCm39)	T48S	probably benign	Het
Pfkfb4	G	A	9: 108,828,202 (GRCm39)	R79H	probably damaging	Het
Piezo2	T	C	18: 63,315,904 (GRCm39)		probably benign	Het
Pramel5	C	T	4: 144,000,429 (GRCm39)	R49H	probably benign	Het
Ralgapb	T	A	2: 158,304,079 (GRCm39)	S613T	possibly damaging	Het
Ryr1	T	C	7: 28,778,022 (GRCm39)	E2158G	probably damaging	Het
Scgb2b19	T	A	7: 32,979,153 (GRCm39)	Y43F	probably damaging	Het
Slc17a6	A	G	7: 51,317,770 (GRCm39)	T468A	possibly damaging	Het
Slc36a1	A	G	11: 55,119,147 (GRCm39)	D374G	possibly damaging	Het
Wdtc1	T	C	4: 133,022,543 (GRCm39)	D601G	probably damaging	Het
Zfp1007	A	C	5: 109,825,182 (GRCm39)	Y89*	probably null	Het

Other mutations in Or5a3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01446:Or5a3	APN	19	12,400,165 (GRCm39)	missense	possibly damaging	0.91
IGL01667:Or5a3	APN	19	12,400,120 (GRCm39)	missense	probably benign
IGL01903:Or5a3	APN	19	12,400,047 (GRCm39)	missense	probably benign	0.00
IGL02547:Or5a3	APN	19	12,399,675 (GRCm39)	start codon destroyed	probably benign	0.38
IGL02571:Or5a3	APN	19	12,400,250 (GRCm39)	missense	possibly damaging	0.79
IGL03310:Or5a3	APN	19	12,400,291 (GRCm39)	missense	probably benign
R0539:Or5a3	UTSW	19	12,400,173 (GRCm39)	missense	probably damaging	0.97
R0918:Or5a3	UTSW	19	12,400,599 (GRCm39)	missense	probably benign	0.25
R1463:Or5a3	UTSW	19	12,400,252 (GRCm39)	missense	probably benign	0.41
R4301:Or5a3	UTSW	19	12,400,081 (GRCm39)	missense	probably damaging	0.98
R4785:Or5a3	UTSW	19	12,400,341 (GRCm39)	missense	probably damaging	0.99
R5513:Or5a3	UTSW	19	12,400,047 (GRCm39)	missense	probably benign	0.00
R6188:Or5a3	UTSW	19	12,399,974 (GRCm39)	missense	probably benign	0.01
R6411:Or5a3	UTSW	19	12,400,350 (GRCm39)	missense	probably benign	0.08
R6625:Or5a3	UTSW	19	12,400,205 (GRCm39)	missense	probably damaging	1.00
R6944:Or5a3	UTSW	19	12,400,628 (GRCm39)	missense	probably benign
R7425:Or5a3	UTSW	19	12,400,204 (GRCm39)	missense	probably damaging	1.00
R7465:Or5a3	UTSW	19	12,400,509 (GRCm39)	missense	probably damaging	1.00
R9400:Or5a3	UTSW	19	12,400,274 (GRCm39)	missense	possibly damaging	0.62
R9427:Or5a3	UTSW	19	12,399,889 (GRCm39)	missense

Posted On

2014-01-21