Incidental Mutation 'IGL01655:Or5w1'
ID 102942
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5w1
Ensembl Gene ENSMUSG00000111747
Gene Name olfactory receptor family 5 subfamily W member 1
Synonyms MOR176-1, Olfr1134, GA_x6K02T2Q125-49162076-49161138
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # IGL01655
Quality Score
Status
Chromosome 2
Chromosomal Location 87486269-87488801 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87486773 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 164 (F164S)
Ref Sequence ENSEMBL: ENSMUSP00000150358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099857] [ENSMUST00000135875] [ENSMUST00000213939]
AlphaFold Q7TR43
Predicted Effect probably damaging
Transcript: ENSMUST00000099854
AA Change: F164S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097440
Gene: ENSMUSG00000075154
AA Change: F164S

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000099857
AA Change: F164S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097443
Gene: ENSMUSG00000111747
AA Change: F164S

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000135875
AA Change: F164S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000213939
AA Change: F164S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 G A 3: 97,073,288 (GRCm39) probably null Het
Aida T A 1: 183,094,618 (GRCm39) Y104* probably null Het
Cd300lg T C 11: 101,937,901 (GRCm39) S244P probably benign Het
Ces4a T A 8: 105,873,806 (GRCm39) L425Q probably damaging Het
Chrnb3 T C 8: 27,884,202 (GRCm39) V298A probably damaging Het
Cnot6 A C 11: 49,568,131 (GRCm39) F486C probably damaging Het
Ctnna3 A G 10: 64,708,949 (GRCm39) T663A probably benign Het
Cyp2j12 T A 4: 96,003,814 (GRCm39) K267N possibly damaging Het
Dclre1a A T 19: 56,535,489 (GRCm39) Y32N probably damaging Het
Ddx21 A G 10: 62,423,270 (GRCm39) I644T probably damaging Het
Epha6 A C 16: 59,659,666 (GRCm39) N817K probably benign Het
Ercc6l2 T A 13: 63,967,566 (GRCm39) Y55* probably null Het
Esyt1 A G 10: 128,358,181 (GRCm39) I183T possibly damaging Het
Exoc8 T C 8: 125,622,967 (GRCm39) T467A probably benign Het
Fance T C 17: 28,541,753 (GRCm39) probably benign Het
Fbxo46 C T 7: 18,870,235 (GRCm39) R285W probably damaging Het
Ffar2 A T 7: 30,519,012 (GRCm39) V176E probably damaging Het
Fnbp1l T C 3: 122,362,398 (GRCm39) probably null Het
Gm10288 T C 3: 146,544,565 (GRCm39) noncoding transcript Het
Gm12588 T A 11: 121,798,777 (GRCm39) Het
Gm9755 G A 8: 67,967,885 (GRCm39) noncoding transcript Het
Gpr33 A T 12: 52,070,343 (GRCm39) M232K probably damaging Het
Haus5 A T 7: 30,362,719 (GRCm39) probably benign Het
Ilvbl A G 10: 78,413,167 (GRCm39) probably benign Het
Kifap3 G A 1: 163,623,618 (GRCm39) probably benign Het
Klhl26 T C 8: 70,904,533 (GRCm39) Y378C probably damaging Het
Lama4 G A 10: 38,936,209 (GRCm39) S628N probably benign Het
Lamc3 G A 2: 31,788,290 (GRCm39) R150H probably damaging Het
Mrgprx2 A T 7: 48,132,439 (GRCm39) C126* probably null Het
Myo3a A T 2: 22,428,137 (GRCm39) D798V probably damaging Het
Ndufs1 A T 1: 63,190,716 (GRCm39) L44Q probably damaging Het
Nfrkb G T 9: 31,314,755 (GRCm39) R525L probably benign Het
Or10ag58 T A 2: 87,265,229 (GRCm39) C133S probably damaging Het
Or1e34 T C 11: 73,778,753 (GRCm39) I148M probably benign Het
Or2p2 T C 13: 21,257,075 (GRCm39) Y132C probably damaging Het
Or2r11 T C 6: 42,437,474 (GRCm39) T160A probably benign Het
Or4k41 T C 2: 111,280,234 (GRCm39) F250L probably benign Het
Or4q3 A G 14: 50,583,641 (GRCm39) M86T probably benign Het
Or8g17 T A 9: 38,930,214 (GRCm39) I208F probably benign Het
Or9r7 G T 10: 129,962,860 (GRCm39) T22K probably benign Het
Pias4 T C 10: 80,991,492 (GRCm39) K352E probably benign Het
Pkhd1 G A 1: 20,604,857 (GRCm39) Q1153* probably null Het
Pon1 C A 6: 5,175,760 (GRCm39) W254C probably damaging Het
Prr14 A G 7: 127,074,939 (GRCm39) T447A probably benign Het
Serpinb9g T A 13: 33,679,088 (GRCm39) C319* probably null Het
Slc9c1 A T 16: 45,403,335 (GRCm39) M801L probably benign Het
Tenm4 C T 7: 96,202,931 (GRCm39) T182M probably damaging Het
Ubr4 T A 4: 139,135,107 (GRCm39) L813Q probably damaging Het
Uimc1 T C 13: 55,176,517 (GRCm39) E667G probably benign Het
Unc79 A G 12: 103,134,546 (GRCm39) T2173A probably benign Het
Unkl T C 17: 25,429,822 (GRCm39) S142P probably benign Het
Vezt A G 10: 93,832,859 (GRCm39) V204A probably benign Het
Vps53 A T 11: 75,953,860 (GRCm39) I402N probably damaging Het
Zfyve9 T C 4: 108,499,289 (GRCm39) D1343G probably damaging Het
Other mutations in Or5w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Or5w1 APN 2 87,486,582 (GRCm39) missense probably benign 0.01
IGL01397:Or5w1 APN 2 87,487,249 (GRCm39) missense probably damaging 0.99
IGL01583:Or5w1 APN 2 87,486,757 (GRCm39) nonsense probably null
IGL02184:Or5w1 APN 2 87,487,136 (GRCm39) missense probably damaging 0.99
IGL02263:Or5w1 APN 2 87,486,543 (GRCm39) missense probably damaging 1.00
IGL02964:Or5w1 APN 2 87,487,058 (GRCm39) missense probably damaging 1.00
IGL03391:Or5w1 APN 2 87,487,032 (GRCm39) missense possibly damaging 0.93
R5171:Or5w1 UTSW 2 87,486,888 (GRCm39) missense possibly damaging 0.95
R6434:Or5w1 UTSW 2 87,486,558 (GRCm39) nonsense probably null
R7466:Or5w1 UTSW 2 87,486,740 (GRCm39) missense possibly damaging 0.73
R7770:Or5w1 UTSW 2 87,486,813 (GRCm39) missense not run
R8810:Or5w1 UTSW 2 87,486,591 (GRCm39) missense possibly damaging 0.54
R9249:Or5w1 UTSW 2 87,486,660 (GRCm39) missense probably benign 0.10
R9572:Or5w1 UTSW 2 87,486,914 (GRCm39) missense probably benign 0.08
Posted On 2014-01-21