Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01655:Or4q3'

102953

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4q3

Ensembl Gene

ENSMUSG00000046210

Gene Name

olfactory receptor family 4 subfamily Q member 3

Synonyms

Olfr735, GA_x6K02T2PMLR-6042130-6041183, MOR243-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.142) question?

Stock #

IGL01655

Quality Score

Status

Chromosome

Chromosomal Location

50582833-50583897 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 50583641 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 86 (M86T)

Ref Sequence

ENSEMBL: ENSMUSP00000056851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049729] [ENSMUST00000216634]

AlphaFold

Q7TRM4

Predicted Effect

probably benign
Transcript: ENSMUST00000049729
AA Change: M86T

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000056851
Gene: ENSMUSG00000046210
AA Change: M86T

Domain	Start	End	E-Value	Type
transmembrane domain	9	28	N/A	INTRINSIC
Pfam:7tm_4	70	345	1.6e-49	PFAM
Pfam:7tm_1	80	345	1.8e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206145

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206546

Predicted Effect

probably benign
Transcript: ENSMUST00000216634
AA Change: M55T

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp6	G	A	3: 97,073,288 (GRCm39)		probably null	Het
Aida	T	A	1: 183,094,618 (GRCm39)	Y104*	probably null	Het
Cd300lg	T	C	11: 101,937,901 (GRCm39)	S244P	probably benign	Het
Ces4a	T	A	8: 105,873,806 (GRCm39)	L425Q	probably damaging	Het
Chrnb3	T	C	8: 27,884,202 (GRCm39)	V298A	probably damaging	Het
Cnot6	A	C	11: 49,568,131 (GRCm39)	F486C	probably damaging	Het
Ctnna3	A	G	10: 64,708,949 (GRCm39)	T663A	probably benign	Het
Cyp2j12	T	A	4: 96,003,814 (GRCm39)	K267N	possibly damaging	Het
Dclre1a	A	T	19: 56,535,489 (GRCm39)	Y32N	probably damaging	Het
Ddx21	A	G	10: 62,423,270 (GRCm39)	I644T	probably damaging	Het
Epha6	A	C	16: 59,659,666 (GRCm39)	N817K	probably benign	Het
Ercc6l2	T	A	13: 63,967,566 (GRCm39)	Y55*	probably null	Het
Esyt1	A	G	10: 128,358,181 (GRCm39)	I183T	possibly damaging	Het
Exoc8	T	C	8: 125,622,967 (GRCm39)	T467A	probably benign	Het
Fance	T	C	17: 28,541,753 (GRCm39)		probably benign	Het
Fbxo46	C	T	7: 18,870,235 (GRCm39)	R285W	probably damaging	Het
Ffar2	A	T	7: 30,519,012 (GRCm39)	V176E	probably damaging	Het
Fnbp1l	T	C	3: 122,362,398 (GRCm39)		probably null	Het
Gm10288	T	C	3: 146,544,565 (GRCm39)		noncoding transcript	Het
Gm12588	T	A	11: 121,798,777 (GRCm39)			Het
Gm9755	G	A	8: 67,967,885 (GRCm39)		noncoding transcript	Het
Gpr33	A	T	12: 52,070,343 (GRCm39)	M232K	probably damaging	Het
Haus5	A	T	7: 30,362,719 (GRCm39)		probably benign	Het
Ilvbl	A	G	10: 78,413,167 (GRCm39)		probably benign	Het
Kifap3	G	A	1: 163,623,618 (GRCm39)		probably benign	Het
Klhl26	T	C	8: 70,904,533 (GRCm39)	Y378C	probably damaging	Het
Lama4	G	A	10: 38,936,209 (GRCm39)	S628N	probably benign	Het
Lamc3	G	A	2: 31,788,290 (GRCm39)	R150H	probably damaging	Het
Mrgprx2	A	T	7: 48,132,439 (GRCm39)	C126*	probably null	Het
Myo3a	A	T	2: 22,428,137 (GRCm39)	D798V	probably damaging	Het
Ndufs1	A	T	1: 63,190,716 (GRCm39)	L44Q	probably damaging	Het
Nfrkb	G	T	9: 31,314,755 (GRCm39)	R525L	probably benign	Het
Or10ag58	T	A	2: 87,265,229 (GRCm39)	C133S	probably damaging	Het
Or1e34	T	C	11: 73,778,753 (GRCm39)	I148M	probably benign	Het
Or2p2	T	C	13: 21,257,075 (GRCm39)	Y132C	probably damaging	Het
Or2r11	T	C	6: 42,437,474 (GRCm39)	T160A	probably benign	Het
Or4k41	T	C	2: 111,280,234 (GRCm39)	F250L	probably benign	Het
Or5w1	A	G	2: 87,486,773 (GRCm39)	F164S	probably damaging	Het
Or8g17	T	A	9: 38,930,214 (GRCm39)	I208F	probably benign	Het
Or9r7	G	T	10: 129,962,860 (GRCm39)	T22K	probably benign	Het
Pias4	T	C	10: 80,991,492 (GRCm39)	K352E	probably benign	Het
Pkhd1	G	A	1: 20,604,857 (GRCm39)	Q1153*	probably null	Het
Pon1	C	A	6: 5,175,760 (GRCm39)	W254C	probably damaging	Het
Prr14	A	G	7: 127,074,939 (GRCm39)	T447A	probably benign	Het
Serpinb9g	T	A	13: 33,679,088 (GRCm39)	C319*	probably null	Het
Slc9c1	A	T	16: 45,403,335 (GRCm39)	M801L	probably benign	Het
Tenm4	C	T	7: 96,202,931 (GRCm39)	T182M	probably damaging	Het
Ubr4	T	A	4: 139,135,107 (GRCm39)	L813Q	probably damaging	Het
Uimc1	T	C	13: 55,176,517 (GRCm39)	E667G	probably benign	Het
Unc79	A	G	12: 103,134,546 (GRCm39)	T2173A	probably benign	Het
Unkl	T	C	17: 25,429,822 (GRCm39)	S142P	probably benign	Het
Vezt	A	G	10: 93,832,859 (GRCm39)	V204A	probably benign	Het
Vps53	A	T	11: 75,953,860 (GRCm39)	I402N	probably damaging	Het
Zfyve9	T	C	4: 108,499,289 (GRCm39)	D1343G	probably damaging	Het

Other mutations in Or4q3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01149:Or4q3	APN	14	50,583,071 (GRCm39)	missense	probably damaging	0.99
IGL02838:Or4q3	APN	14	50,583,312 (GRCm39)	missense	probably damaging	1.00
IGL02874:Or4q3	APN	14	50,583,583 (GRCm39)	missense	probably damaging	1.00
R0609:Or4q3	UTSW	14	50,583,383 (GRCm39)	missense	probably damaging	1.00
R0724:Or4q3	UTSW	14	50,583,374 (GRCm39)	missense	possibly damaging	0.89
R0839:Or4q3	UTSW	14	50,583,545 (GRCm39)	missense	probably damaging	0.98
R1766:Or4q3	UTSW	14	50,583,677 (GRCm39)	missense	probably damaging	1.00
R1799:Or4q3	UTSW	14	50,583,537 (GRCm39)	missense	probably benign	0.32
R4934:Or4q3	UTSW	14	50,583,345 (GRCm39)	missense	probably damaging	1.00
R5753:Or4q3	UTSW	14	50,583,045 (GRCm39)	missense	probably damaging	0.96
R5996:Or4q3	UTSW	14	50,582,969 (GRCm39)	missense	possibly damaging	0.89
R6555:Or4q3	UTSW	14	50,583,303 (GRCm39)	nonsense	probably null
R6736:Or4q3	UTSW	14	50,582,905 (GRCm39)	missense	probably damaging	1.00
R7841:Or4q3	UTSW	14	50,583,285 (GRCm39)	missense	probably benign	0.09
R7922:Or4q3	UTSW	14	50,583,872 (GRCm39)	missense	probably benign	0.03
R8190:Or4q3	UTSW	14	50,583,179 (GRCm39)	missense	probably damaging	0.99
R8308:Or4q3	UTSW	14	50,582,922 (GRCm39)	missense	probably benign	0.06
R8560:Or4q3	UTSW	14	50,583,794 (GRCm39)	missense	probably benign	0.12
X0019:Or4q3	UTSW	14	50,583,263 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-01-21