Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01655:Mrgprx2'

102964

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprx2

Ensembl Gene

ENSMUSG00000074109

Gene Name

MAS-related GPR, member X2

Synonyms

Mrgprb10, MrgB10

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL01655

Quality Score

Status

Chromosome

Chromosomal Location

48128367-48149018 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 48132439 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 126 (C126*)

Ref Sequence

ENSEMBL: ENSMUSP00000127022 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098433] [ENSMUST00000186394]

AlphaFold

Q3UG50

Predicted Effect

probably null
Transcript: ENSMUST00000098433
AA Change: C126*

SMART Domains

Protein: ENSMUSP00000127022
Gene: ENSMUSG00000074109
AA Change: C126*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	50	230	4.6e-10	PFAM
Pfam:7tm_1	59	290	1e-6	PFAM
low complexity region	319	334	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000186394

SMART Domains

Protein: ENSMUSP00000140945
Gene: ENSMUSG00000074109

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	11	50	1e-5	SMART
low complexity region	76	91	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp6	G	A	3: 97,073,288 (GRCm39)		probably null	Het
Aida	T	A	1: 183,094,618 (GRCm39)	Y104*	probably null	Het
Cd300lg	T	C	11: 101,937,901 (GRCm39)	S244P	probably benign	Het
Ces4a	T	A	8: 105,873,806 (GRCm39)	L425Q	probably damaging	Het
Chrnb3	T	C	8: 27,884,202 (GRCm39)	V298A	probably damaging	Het
Cnot6	A	C	11: 49,568,131 (GRCm39)	F486C	probably damaging	Het
Ctnna3	A	G	10: 64,708,949 (GRCm39)	T663A	probably benign	Het
Cyp2j12	T	A	4: 96,003,814 (GRCm39)	K267N	possibly damaging	Het
Dclre1a	A	T	19: 56,535,489 (GRCm39)	Y32N	probably damaging	Het
Ddx21	A	G	10: 62,423,270 (GRCm39)	I644T	probably damaging	Het
Epha6	A	C	16: 59,659,666 (GRCm39)	N817K	probably benign	Het
Ercc6l2	T	A	13: 63,967,566 (GRCm39)	Y55*	probably null	Het
Esyt1	A	G	10: 128,358,181 (GRCm39)	I183T	possibly damaging	Het
Exoc8	T	C	8: 125,622,967 (GRCm39)	T467A	probably benign	Het
Fance	T	C	17: 28,541,753 (GRCm39)		probably benign	Het
Fbxo46	C	T	7: 18,870,235 (GRCm39)	R285W	probably damaging	Het
Ffar2	A	T	7: 30,519,012 (GRCm39)	V176E	probably damaging	Het
Fnbp1l	T	C	3: 122,362,398 (GRCm39)		probably null	Het
Gm10288	T	C	3: 146,544,565 (GRCm39)		noncoding transcript	Het
Gm12588	T	A	11: 121,798,777 (GRCm39)			Het
Gm9755	G	A	8: 67,967,885 (GRCm39)		noncoding transcript	Het
Gpr33	A	T	12: 52,070,343 (GRCm39)	M232K	probably damaging	Het
Haus5	A	T	7: 30,362,719 (GRCm39)		probably benign	Het
Ilvbl	A	G	10: 78,413,167 (GRCm39)		probably benign	Het
Kifap3	G	A	1: 163,623,618 (GRCm39)		probably benign	Het
Klhl26	T	C	8: 70,904,533 (GRCm39)	Y378C	probably damaging	Het
Lama4	G	A	10: 38,936,209 (GRCm39)	S628N	probably benign	Het
Lamc3	G	A	2: 31,788,290 (GRCm39)	R150H	probably damaging	Het
Myo3a	A	T	2: 22,428,137 (GRCm39)	D798V	probably damaging	Het
Ndufs1	A	T	1: 63,190,716 (GRCm39)	L44Q	probably damaging	Het
Nfrkb	G	T	9: 31,314,755 (GRCm39)	R525L	probably benign	Het
Or10ag58	T	A	2: 87,265,229 (GRCm39)	C133S	probably damaging	Het
Or1e34	T	C	11: 73,778,753 (GRCm39)	I148M	probably benign	Het
Or2p2	T	C	13: 21,257,075 (GRCm39)	Y132C	probably damaging	Het
Or2r11	T	C	6: 42,437,474 (GRCm39)	T160A	probably benign	Het
Or4k41	T	C	2: 111,280,234 (GRCm39)	F250L	probably benign	Het
Or4q3	A	G	14: 50,583,641 (GRCm39)	M86T	probably benign	Het
Or5w1	A	G	2: 87,486,773 (GRCm39)	F164S	probably damaging	Het
Or8g17	T	A	9: 38,930,214 (GRCm39)	I208F	probably benign	Het
Or9r7	G	T	10: 129,962,860 (GRCm39)	T22K	probably benign	Het
Pias4	T	C	10: 80,991,492 (GRCm39)	K352E	probably benign	Het
Pkhd1	G	A	1: 20,604,857 (GRCm39)	Q1153*	probably null	Het
Pon1	C	A	6: 5,175,760 (GRCm39)	W254C	probably damaging	Het
Prr14	A	G	7: 127,074,939 (GRCm39)	T447A	probably benign	Het
Serpinb9g	T	A	13: 33,679,088 (GRCm39)	C319*	probably null	Het
Slc9c1	A	T	16: 45,403,335 (GRCm39)	M801L	probably benign	Het
Tenm4	C	T	7: 96,202,931 (GRCm39)	T182M	probably damaging	Het
Ubr4	T	A	4: 139,135,107 (GRCm39)	L813Q	probably damaging	Het
Uimc1	T	C	13: 55,176,517 (GRCm39)	E667G	probably benign	Het
Unc79	A	G	12: 103,134,546 (GRCm39)	T2173A	probably benign	Het
Unkl	T	C	17: 25,429,822 (GRCm39)	S142P	probably benign	Het
Vezt	A	G	10: 93,832,859 (GRCm39)	V204A	probably benign	Het
Vps53	A	T	11: 75,953,860 (GRCm39)	I402N	probably damaging	Het
Zfyve9	T	C	4: 108,499,289 (GRCm39)	D1343G	probably damaging	Het

Other mutations in Mrgprx2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01603:Mrgprx2	APN	7	48,132,374 (GRCm39)	missense	probably damaging	1.00
IGL02052:Mrgprx2	APN	7	48,132,042 (GRCm39)	missense	possibly damaging	0.75
IGL02254:Mrgprx2	APN	7	48,132,686 (GRCm39)	missense	probably benign	0.16
IGL02985:Mrgprx2	APN	7	48,132,245 (GRCm39)	missense	probably damaging	0.98
R0026:Mrgprx2	UTSW	7	48,131,771 (GRCm39)	missense	possibly damaging	0.66
R0387:Mrgprx2	UTSW	7	48,148,908 (GRCm39)	start codon destroyed	probably null	0.98
R0514:Mrgprx2	UTSW	7	48,132,712 (GRCm39)	start codon destroyed	probably null
R0650:Mrgprx2	UTSW	7	48,132,666 (GRCm39)	missense	probably damaging	0.96
R1014:Mrgprx2	UTSW	7	48,132,306 (GRCm39)	splice site	probably null
R2011:Mrgprx2	UTSW	7	48,132,282 (GRCm39)	missense	probably damaging	0.96
R2224:Mrgprx2	UTSW	7	48,132,608 (GRCm39)	missense	probably benign	0.43
R4238:Mrgprx2	UTSW	7	48,132,738 (GRCm39)	missense	probably benign
R4846:Mrgprx2	UTSW	7	48,132,584 (GRCm39)	missense	probably damaging	1.00
R5385:Mrgprx2	UTSW	7	48,132,753 (GRCm39)	missense	probably benign	0.11
R5891:Mrgprx2	UTSW	7	48,131,994 (GRCm39)	missense	probably benign
R6490:Mrgprx2	UTSW	7	48,132,617 (GRCm39)	missense	probably damaging	1.00
R6576:Mrgprx2	UTSW	7	48,132,380 (GRCm39)	missense	probably damaging	1.00
R6934:Mrgprx2	UTSW	7	48,131,813 (GRCm39)	missense	possibly damaging	0.79
R6948:Mrgprx2	UTSW	7	48,132,464 (GRCm39)	missense	possibly damaging	0.52
R7938:Mrgprx2	UTSW	7	48,132,240 (GRCm39)	missense	probably benign	0.01
R7944:Mrgprx2	UTSW	7	48,132,753 (GRCm39)	missense	probably benign	0.11
R7945:Mrgprx2	UTSW	7	48,132,753 (GRCm39)	missense	probably benign	0.11
R8221:Mrgprx2	UTSW	7	48,132,527 (GRCm39)	missense	probably benign	0.00
R8750:Mrgprx2	UTSW	7	48,131,778 (GRCm39)	missense	probably benign
R8782:Mrgprx2	UTSW	7	48,132,299 (GRCm39)	missense	probably damaging	0.98
R9015:Mrgprx2	UTSW	7	48,148,938 (GRCm39)	unclassified	probably benign
X0027:Mrgprx2	UTSW	7	48,132,246 (GRCm39)	missense	probably damaging	1.00
X0063:Mrgprx2	UTSW	7	48,132,546 (GRCm39)	missense	probably benign	0.04
Z1176:Mrgprx2	UTSW	7	48,132,090 (GRCm39)	missense	probably damaging	0.98

Posted On

2014-01-21