Incidental Mutation 'IGL01656:Tc2n'
| ID |
103029 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tc2n
|
| Ensembl Gene |
ENSMUSG00000021187 |
| Gene Name |
tandem C2 domains, nuclear |
| Synonyms |
4933406D09Rik, Mtac2d1, Tac2-N |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.075)
|
| Stock # |
IGL01656
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
101611702-101684782 bp(-) (GRCm39) |
| Type of Mutation |
utr 3 prime |
| DNA Base Change (assembly) |
A to G
at 101615348 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125288
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110047]
[ENSMUST00000160715]
[ENSMUST00000160830]
[ENSMUST00000162735]
|
| AlphaFold |
Q91XT6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110047
|
| SMART Domains |
Protein: ENSMUSP00000105674
Gene: ENSMUSG00000021187
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
162 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
190 |
210 |
N/A |
INTRINSIC |
|
C2
|
238 |
339 |
5.56e0 |
SMART |
|
C2
|
366 |
472 |
1.02e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160715
|
| SMART Domains |
Protein: ENSMUSP00000125099
Gene: ENSMUSG00000021187
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
162 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
190 |
210 |
N/A |
INTRINSIC |
|
Blast:C2
|
238 |
287 |
1e-24 |
BLAST |
|
C2
|
302 |
408 |
1.02e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160830
|
| SMART Domains |
Protein: ENSMUSP00000124287
Gene: ENSMUSG00000021187
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
162 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
190 |
210 |
N/A |
INTRINSIC |
|
C2
|
238 |
339 |
5.56e0 |
SMART |
|
C2
|
366 |
472 |
1.02e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162735
|
| SMART Domains |
Protein: ENSMUSP00000125288
Gene: ENSMUSG00000021187
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
162 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
190 |
210 |
N/A |
INTRINSIC |
|
C2
|
238 |
339 |
5.56e0 |
SMART |
|
C2
|
366 |
472 |
1.02e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162999
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acrbp |
A |
C |
6: 125,030,675 (GRCm39) |
E232A |
possibly damaging |
Het |
| Anapc11 |
T |
A |
11: 120,490,173 (GRCm39) |
F30I |
possibly damaging |
Het |
| Ap5z1 |
A |
G |
5: 142,456,069 (GRCm39) |
D318G |
probably benign |
Het |
| Cfap43 |
T |
C |
19: 47,740,339 (GRCm39) |
E1278G |
possibly damaging |
Het |
| Cylc1 |
A |
G |
X: 110,167,485 (GRCm39) |
T589A |
probably benign |
Het |
| Dcaf15 |
T |
C |
8: 84,824,617 (GRCm39) |
I527V |
probably benign |
Het |
| Ddhd2 |
C |
T |
8: 26,217,739 (GRCm39) |
V713I |
probably benign |
Het |
| Edc4 |
T |
C |
8: 106,613,009 (GRCm39) |
V283A |
possibly damaging |
Het |
| Elf5 |
A |
G |
2: 103,273,206 (GRCm39) |
|
probably benign |
Het |
| Flnb |
C |
T |
14: 7,902,010 (GRCm38) |
|
probably benign |
Het |
| Flnc |
C |
T |
6: 29,443,507 (GRCm39) |
|
probably benign |
Het |
| Fstl4 |
T |
C |
11: 52,891,201 (GRCm39) |
L113P |
probably damaging |
Het |
| Gemin4 |
C |
T |
11: 76,104,636 (GRCm39) |
V42M |
probably damaging |
Het |
| Gm10076 |
A |
G |
14: 105,919,354 (GRCm39) |
|
noncoding transcript |
Het |
| Grina |
A |
G |
15: 76,132,501 (GRCm39) |
Y116C |
probably damaging |
Het |
| Hectd4 |
T |
A |
5: 121,460,763 (GRCm39) |
L914H |
probably damaging |
Het |
| Il17re |
T |
C |
6: 113,439,934 (GRCm39) |
|
probably benign |
Het |
| Ivl |
G |
A |
3: 92,478,962 (GRCm39) |
Q368* |
probably null |
Het |
| Kbtbd8 |
A |
G |
6: 95,095,657 (GRCm39) |
H73R |
probably benign |
Het |
| Krt90 |
T |
A |
15: 101,463,878 (GRCm39) |
Q392L |
probably damaging |
Het |
| Magea3 |
A |
T |
X: 153,732,137 (GRCm39) |
M122K |
probably damaging |
Het |
| Mapk8ip3 |
T |
C |
17: 25,137,003 (GRCm39) |
D237G |
probably damaging |
Het |
| Nln |
T |
C |
13: 104,198,249 (GRCm39) |
|
probably null |
Het |
| Nlrp4d |
T |
C |
7: 10,098,074 (GRCm39) |
Y853C |
noncoding transcript |
Het |
| Nol11 |
T |
C |
11: 107,079,998 (GRCm39) |
D29G |
probably benign |
Het |
| Nr3c2 |
C |
T |
8: 77,914,166 (GRCm39) |
L791F |
probably damaging |
Het |
| Nup50l |
A |
G |
6: 96,142,675 (GRCm39) |
V123A |
possibly damaging |
Het |
| Olfm3 |
T |
C |
3: 114,916,282 (GRCm39) |
Y385H |
probably damaging |
Het |
| Or14j5 |
C |
T |
17: 38,162,029 (GRCm39) |
P182L |
possibly damaging |
Het |
| Or51a8 |
A |
G |
7: 102,550,472 (GRCm39) |
I299M |
possibly damaging |
Het |
| Or5b119 |
G |
A |
19: 13,457,454 (GRCm39) |
A36V |
probably benign |
Het |
| Pklr |
G |
T |
3: 89,052,302 (GRCm39) |
G505C |
probably damaging |
Het |
| Plxna2 |
A |
G |
1: 194,472,469 (GRCm39) |
E1071G |
possibly damaging |
Het |
| Prkcq |
G |
T |
2: 11,231,766 (GRCm39) |
A30S |
probably damaging |
Het |
| Rilpl1 |
A |
G |
5: 124,641,712 (GRCm39) |
F104L |
probably damaging |
Het |
| Rsph6a |
C |
T |
7: 18,788,770 (GRCm39) |
T34I |
probably benign |
Het |
| Sec23ip |
C |
T |
7: 128,351,969 (GRCm39) |
P12L |
probably damaging |
Het |
| Slc25a21 |
A |
C |
12: 56,785,280 (GRCm39) |
V199G |
probably damaging |
Het |
| Smc1b |
T |
C |
15: 84,998,977 (GRCm39) |
E483G |
probably damaging |
Het |
| Sucnr1 |
T |
C |
3: 59,993,832 (GRCm39) |
M120T |
possibly damaging |
Het |
| Tas2r116 |
T |
C |
6: 132,832,396 (GRCm39) |
|
probably benign |
Het |
| Tbrg4 |
T |
A |
11: 6,568,522 (GRCm39) |
Q419L |
possibly damaging |
Het |
| Tgfbr2 |
A |
C |
9: 115,938,737 (GRCm39) |
S388R |
probably damaging |
Het |
| Vmn2r1 |
A |
G |
3: 63,989,274 (GRCm39) |
E71G |
probably damaging |
Het |
| Xpc |
A |
T |
6: 91,482,449 (GRCm39) |
I176K |
probably damaging |
Het |
| Xylt1 |
G |
T |
7: 117,148,228 (GRCm39) |
R264L |
probably damaging |
Het |
|
| Other mutations in Tc2n |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02129:Tc2n
|
APN |
12 |
101,656,048 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02630:Tc2n
|
APN |
12 |
101,659,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
upbraided
|
UTSW |
12 |
101,617,460 (GRCm39) |
splice site |
probably null |
|
|
R0517:Tc2n
|
UTSW |
12 |
101,615,454 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0980:Tc2n
|
UTSW |
12 |
101,644,835 (GRCm39) |
nonsense |
probably null |
|
|
R1676:Tc2n
|
UTSW |
12 |
101,655,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2187:Tc2n
|
UTSW |
12 |
101,672,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3771:Tc2n
|
UTSW |
12 |
101,660,833 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4082:Tc2n
|
UTSW |
12 |
101,617,414 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4180:Tc2n
|
UTSW |
12 |
101,631,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Tc2n
|
UTSW |
12 |
101,660,832 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4793:Tc2n
|
UTSW |
12 |
101,617,376 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4917:Tc2n
|
UTSW |
12 |
101,631,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Tc2n
|
UTSW |
12 |
101,659,461 (GRCm39) |
nonsense |
probably null |
|
|
R5870:Tc2n
|
UTSW |
12 |
101,619,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6034:Tc2n
|
UTSW |
12 |
101,617,460 (GRCm39) |
splice site |
probably null |
|
|
R6034:Tc2n
|
UTSW |
12 |
101,617,460 (GRCm39) |
splice site |
probably null |
|
|
R6128:Tc2n
|
UTSW |
12 |
101,675,748 (GRCm39) |
start codon destroyed |
probably null |
0.99 |
|
R7200:Tc2n
|
UTSW |
12 |
101,655,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7469:Tc2n
|
UTSW |
12 |
101,631,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7471:Tc2n
|
UTSW |
12 |
101,672,716 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7730:Tc2n
|
UTSW |
12 |
101,617,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7836:Tc2n
|
UTSW |
12 |
101,619,112 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8432:Tc2n
|
UTSW |
12 |
101,615,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8435:Tc2n
|
UTSW |
12 |
101,615,376 (GRCm39) |
nonsense |
probably null |
|
|
R8530:Tc2n
|
UTSW |
12 |
101,617,444 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8669:Tc2n
|
UTSW |
12 |
101,660,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9684:Tc2n
|
UTSW |
12 |
101,660,818 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Posted On |
2014-01-21 |
Incidental Mutation