Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01661:Ttll8'

103175

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ttll8

Ensembl Gene

ENSMUSG00000022388

Gene Name

tubulin tyrosine ligase-like family, member 8

Synonyms

1700019P01Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.214) question?

Stock #

IGL01661

Quality Score

Status

Chromosome

Chromosomal Location

88774836-88838621 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 88820202 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109371] [ENSMUST00000177180]

AlphaFold

A4Q9F1

Predicted Effect

probably benign
Transcript: ENSMUST00000109371

SMART Domains

Protein: ENSMUSP00000104996
Gene: ENSMUSG00000022388

Domain	Start	End	E-Value	Type
low complexity region	4	14	N/A	INTRINSIC
low complexity region	273	285	N/A	INTRINSIC
Pfam:TTL	324	621	3.9e-74	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000177180

SMART Domains

Protein: ENSMUSP00000135381
Gene: ENSMUSG00000022388

Domain	Start	End	E-Value	Type
low complexity region	4	14	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000177254

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca2	T	C	2: 25,333,007 (GRCm39)	F1569L	probably benign	Het
Acly	A	G	11: 100,405,168 (GRCm39)		probably benign	Het
Adgre5	T	A	8: 84,454,564 (GRCm39)	N313I	probably damaging	Het
Ccdc17	A	G	4: 116,455,063 (GRCm39)	H206R	probably benign	Het
Cenpo	C	T	12: 4,284,023 (GRCm39)		probably null	Het
Galnt5	G	T	2: 57,889,494 (GRCm39)	A365S	probably benign	Het
Josd1	G	A	15: 79,561,328 (GRCm39)	P160L	probably damaging	Het
Lamc1	C	A	1: 153,097,319 (GRCm39)	R1575L	possibly damaging	Het
Mrpl32	C	T	13: 14,785,178 (GRCm39)	V153I	probably benign	Het
Mtor	A	G	4: 148,599,308 (GRCm39)	K1452R	possibly damaging	Het
Nob1	T	C	8: 108,139,814 (GRCm39)	Y315C	probably damaging	Het
Or4c58	T	A	2: 89,674,439 (GRCm39)	M293L	probably benign	Het
Or8k28	T	C	2: 86,285,846 (GRCm39)	I256M	possibly damaging	Het
Prex2	A	G	1: 11,278,838 (GRCm39)	N1389S	probably benign	Het
Ptprd	G	A	4: 75,872,320 (GRCm39)	T1383M	probably damaging	Het
Ralbp1	A	G	17: 66,168,384 (GRCm39)	L307P	probably damaging	Het
Sema4f	A	G	6: 82,895,036 (GRCm39)		probably benign	Het
Slc2a3	A	G	6: 122,706,915 (GRCm39)	V486A	probably benign	Het
Spock2	T	A	10: 59,959,692 (GRCm39)	H140Q	probably damaging	Het
Tmc4	A	G	7: 3,669,926 (GRCm39)	I610T	probably damaging	Het
Tnc	T	C	4: 63,888,544 (GRCm39)		probably benign	Het

Other mutations in Ttll8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00671:Ttll8	APN	15	88,798,356 (GRCm39)	missense	probably benign
IGL00895:Ttll8	APN	15	88,817,731 (GRCm39)	missense	probably damaging	1.00
IGL01061:Ttll8	APN	15	88,801,453 (GRCm39)	missense	possibly damaging	0.85
IGL01992:Ttll8	APN	15	88,799,848 (GRCm39)	missense	possibly damaging	0.48
IGL02212:Ttll8	APN	15	88,801,450 (GRCm39)	missense	probably benign	0.04
IGL02234:Ttll8	APN	15	88,798,252 (GRCm39)	missense	possibly damaging	0.53
IGL02569:Ttll8	APN	15	88,818,129 (GRCm39)	nonsense	probably null
IGL02935:Ttll8	APN	15	88,798,759 (GRCm39)	missense	probably benign	0.10
IGL03064:Ttll8	APN	15	88,803,797 (GRCm39)	missense	probably benign	0.22
R0969:Ttll8	UTSW	15	88,818,138 (GRCm39)	missense	probably damaging	1.00
R1637:Ttll8	UTSW	15	88,798,647 (GRCm39)	missense	probably benign	0.12
R1939:Ttll8	UTSW	15	88,799,689 (GRCm39)	missense	probably damaging	1.00
R1992:Ttll8	UTSW	15	88,798,654 (GRCm39)	missense	probably benign	0.00
R2173:Ttll8	UTSW	15	88,798,800 (GRCm39)	missense	probably damaging	1.00
R2201:Ttll8	UTSW	15	88,818,156 (GRCm39)	missense	possibly damaging	0.57
R2414:Ttll8	UTSW	15	88,820,336 (GRCm39)	splice site	probably benign
R2905:Ttll8	UTSW	15	88,798,680 (GRCm39)	missense	probably benign	0.00
R4159:Ttll8	UTSW	15	88,801,444 (GRCm39)	missense	probably benign	0.00
R4368:Ttll8	UTSW	15	88,798,384 (GRCm39)	missense	possibly damaging	0.88
R4395:Ttll8	UTSW	15	88,799,783 (GRCm39)	missense	possibly damaging	0.80
R4707:Ttll8	UTSW	15	88,801,293 (GRCm39)	missense	probably damaging	0.99
R4926:Ttll8	UTSW	15	88,798,368 (GRCm39)	missense	probably damaging	0.98
R4983:Ttll8	UTSW	15	88,809,785 (GRCm39)	missense	probably benign	0.08
R5698:Ttll8	UTSW	15	88,823,209 (GRCm39)	missense	possibly damaging	0.85
R5752:Ttll8	UTSW	15	88,816,931 (GRCm39)	missense	probably benign	0.00
R5834:Ttll8	UTSW	15	88,801,449 (GRCm39)	missense	possibly damaging	0.48
R5889:Ttll8	UTSW	15	88,818,142 (GRCm39)	missense	probably damaging	1.00
R6528:Ttll8	UTSW	15	88,798,441 (GRCm39)	missense	probably benign	0.03
R6931:Ttll8	UTSW	15	88,798,507 (GRCm39)	missense	possibly damaging	0.55
R7133:Ttll8	UTSW	15	88,799,630 (GRCm39)	missense	probably damaging	0.99
R7268:Ttll8	UTSW	15	88,819,159 (GRCm39)	critical splice donor site	probably null
R7286:Ttll8	UTSW	15	88,801,442 (GRCm39)	missense	probably benign	0.01
R7502:Ttll8	UTSW	15	88,817,639 (GRCm39)	critical splice donor site	probably null
R7580:Ttll8	UTSW	15	88,818,132 (GRCm39)	missense	probably damaging	0.99
R7734:Ttll8	UTSW	15	88,798,368 (GRCm39)	missense	probably damaging	0.98
R7978:Ttll8	UTSW	15	88,799,565 (GRCm39)	missense	probably benign	0.09
R8074:Ttll8	UTSW	15	88,799,578 (GRCm39)	missense	probably damaging	1.00
R8351:Ttll8	UTSW	15	88,798,638 (GRCm39)	missense	probably benign	0.06
R8407:Ttll8	UTSW	15	88,798,741 (GRCm39)	missense	probably benign	0.01
R8901:Ttll8	UTSW	15	88,818,146 (GRCm39)	missense	probably benign	0.00
R9199:Ttll8	UTSW	15	88,798,818 (GRCm39)	missense	probably benign	0.16
R9443:Ttll8	UTSW	15	88,809,863 (GRCm39)	missense	possibly damaging	0.91
X0058:Ttll8	UTSW	15	88,801,333 (GRCm39)	nonsense	probably null

Posted On

2014-01-21