Incidental Mutation 'IGL00594:Ifne'
ID10328
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifne
Ensembl Gene ENSMUSG00000045364
Gene Nameinterferon epsilon
SynonymsIfnt1, Ifne1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00594
Quality Score
Status
Chromosome4
Chromosomal Location88879538-88880201 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 88879804 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Aspartic acid at position 126 (N126D)
Ref Sequence ENSEMBL: ENSMUSP00000059199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056014]
Predicted Effect probably benign
Transcript: ENSMUST00000056014
AA Change: N126D

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000059199
Gene: ENSMUSG00000045364
AA Change: N126D

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 37 51 N/A INTRINSIC
IFabd 58 175 2.09e-22 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to HSV-2 and Chlamydia infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A130010J15Rik A G 1: 193,174,801 T154A probably benign Het
Acox1 A G 11: 116,174,505 probably benign Het
Adgrg2 G A X: 160,485,777 V677I probably benign Het
Aifm1 T C X: 48,482,099 T386A probably benign Het
Aspm T C 1: 139,487,422 probably benign Het
Fgfr2 A G 7: 130,228,723 V175A probably damaging Het
Gm14781 C T X: 91,635,485 Q348* probably null Het
Gm382 T C X: 127,063,152 Y987H probably benign Het
Golga3 A T 5: 110,204,975 M911L probably benign Het
Hmgxb3 A G 18: 61,157,739 V354A probably benign Het
Igkv3-7 T C 6: 70,607,823 V49A possibly damaging Het
Kbtbd8 A T 6: 95,126,513 Y381F probably damaging Het
Klc1 C T 12: 111,776,884 T215M probably damaging Het
Lrp2 A T 2: 69,486,280 V2119E probably benign Het
Lrrc7 A G 3: 158,187,010 V322A probably benign Het
Ms4a14 A G 19: 11,301,619 S1192P possibly damaging Het
Ndufaf6 T C 4: 11,062,127 Y168C probably damaging Het
Plcg2 C T 8: 117,556,071 T97I possibly damaging Het
Rasgrp4 T C 7: 29,148,541 probably benign Het
Rgs22 T C 15: 36,083,631 H515R probably benign Het
Rpn1 G T 6: 88,095,629 R318L probably damaging Het
Shroom2 A T X: 152,613,516 F1359Y probably damaging Het
Tarsl2 T A 7: 65,676,132 probably null Het
Tbc1d12 A G 19: 38,896,043 E346G possibly damaging Het
Tbccd1 A G 16: 22,822,544 F361S possibly damaging Het
Tenm1 G T X: 42,715,036 P837T probably benign Het
Tmem144 A G 3: 79,839,167 V27A probably benign Het
Zfp616 T A 11: 74,082,963 N19K possibly damaging Het
Zkscan7 T C 9: 122,895,594 Y543H possibly damaging Het
Other mutations in Ifne
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00978:Ifne APN 4 88880031 missense probably benign 0.17
IGL02167:Ifne APN 4 88879828 missense possibly damaging 0.58
R0212:Ifne UTSW 4 88879735 missense possibly damaging 0.95
R0699:Ifne UTSW 4 88879777 missense probably benign 0.00
R1868:Ifne UTSW 4 88879671 missense probably damaging 1.00
R4480:Ifne UTSW 4 88879601 makesense probably null
R4865:Ifne UTSW 4 88879705 missense probably damaging 1.00
R6752:Ifne UTSW 4 88880082 missense probably benign 0.06
R7319:Ifne UTSW 4 88880006 missense probably damaging 0.98
Posted On2012-12-06