Incidental Mutation 'IGL01666:Ankrd61'
ID103316
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ankrd61
Ensembl Gene ENSMUSG00000029607
Gene Nameankyrin repeat domain 61
Synonyms4921520G13Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.107) question?
Stock #IGL01666
Quality Score
Status
Chromosome5
Chromosomal Location143890741-143897685 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 143891136 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Phenylalanine at position 297 (L297F)
Ref Sequence ENSEMBL: ENSMUSP00000106346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079624] [ENSMUST00000100487] [ENSMUST00000110717] [ENSMUST00000110718]
Predicted Effect probably damaging
Transcript: ENSMUST00000079624
AA Change: L298F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000078571
Gene: ENSMUSG00000029607
AA Change: L298F

DomainStartEndE-ValueType
ANK 36 61 2.55e2 SMART
ANK 65 118 8.5e2 SMART
ANK 124 153 1.27e-2 SMART
ANK 157 186 7.95e-4 SMART
ANK 191 230 3.74e0 SMART
ANK 234 263 3.46e-4 SMART
Blast:ANK 267 300 4e-11 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000100487
SMART Domains Protein: ENSMUSP00000098056
Gene: ENSMUSG00000029613

DomainStartEndE-ValueType
low complexity region 12 28 N/A INTRINSIC
low complexity region 62 81 N/A INTRINSIC
Pfam:Pkinase_Tyr 167 242 5.6e-6 PFAM
Pfam:Pkinase 167 257 1.9e-15 PFAM
low complexity region 314 320 N/A INTRINSIC
Pfam:Pkinase 365 580 1.3e-31 PFAM
Pfam:Pkinase_Tyr 373 578 1.9e-19 PFAM
coiled coil region 585 619 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110717
AA Change: L340F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106345
Gene: ENSMUSG00000029607
AA Change: L340F

DomainStartEndE-ValueType
Blast:ANK 28 57 6e-11 BLAST
ANK 78 103 1.6e0 SMART
ANK 107 160 5.6e0 SMART
ANK 166 195 8.4e-5 SMART
ANK 199 228 5.3e-6 SMART
ANK 233 272 2.4e-2 SMART
ANK 276 305 2.3e-6 SMART
Blast:ANK 309 342 5e-11 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000110718
AA Change: L297F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106346
Gene: ENSMUSG00000029607
AA Change: L297F

DomainStartEndE-ValueType
ANK 35 60 2.55e2 SMART
ANK 64 117 8.5e2 SMART
ANK 123 152 1.27e-2 SMART
ANK 156 185 7.95e-4 SMART
ANK 190 229 3.74e0 SMART
ANK 233 262 3.46e-4 SMART
Blast:ANK 266 299 4e-11 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik G A 7: 28,153,292 V1335M probably damaging Het
9530077C05Rik A G 9: 22,431,698 D163G probably benign Het
Adgrb3 C A 1: 25,460,751 A664S probably damaging Het
Chrnd A T 1: 87,198,736 S513C possibly damaging Het
Col24a1 G A 3: 145,344,686 V645M possibly damaging Het
Csn3 T C 5: 87,930,157 V174A unknown Het
D630039A03Rik C T 4: 57,910,570 V81I possibly damaging Het
Deptor G A 15: 55,149,379 R54Q probably damaging Het
Ell A G 8: 70,585,813 H400R probably benign Het
Itga2 A G 13: 114,837,091 probably null Het
Itpr3 A G 17: 27,117,178 I2293V probably benign Het
Mrps27 A G 13: 99,409,816 E241G probably damaging Het
Mut T C 17: 40,958,811 L687P probably damaging Het
Myh9 C T 15: 77,761,931 A1951T probably benign Het
Oca2 G A 7: 56,314,811 probably null Het
Olfr135 C T 17: 38,208,889 L215F probably benign Het
Olfr215 T A 6: 116,582,335 I204F possibly damaging Het
Ptgdr2 T C 19: 10,940,910 F264L probably benign Het
Ptpn23 T C 9: 110,386,545 T1384A possibly damaging Het
Rasgrf2 A T 13: 92,038,210 D170E probably damaging Het
Rnf20 C T 4: 49,654,486 Q848* probably null Het
Other mutations in Ankrd61
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0037:Ankrd61 UTSW 5 143894977 missense probably damaging 1.00
R0372:Ankrd61 UTSW 5 143891175 missense probably benign 0.00
R0631:Ankrd61 UTSW 5 143894879 missense probably damaging 1.00
R2106:Ankrd61 UTSW 5 143891746 missense probably damaging 1.00
R2508:Ankrd61 UTSW 5 143897076 unclassified probably benign
R3873:Ankrd61 UTSW 5 143891828 missense probably damaging 1.00
R5057:Ankrd61 UTSW 5 143894795 missense probably benign 0.01
R5386:Ankrd61 UTSW 5 143891664 missense possibly damaging 0.63
R6651:Ankrd61 UTSW 5 143893620 missense probably damaging 0.98
X0024:Ankrd61 UTSW 5 143891800 missense probably damaging 1.00
X0024:Ankrd61 UTSW 5 143891801 missense probably null 1.00
Posted On2014-01-21