Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01667:Clec4a3'

103353

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Clec4a3

Ensembl Gene

ENSMUSG00000043832

Gene Name

C-type lectin domain family 4, member a3

Synonyms

mDcir3, 3110037K17Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01667

Quality Score

Status

Chromosome

Chromosomal Location

122929474-122946834 bp(+) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

A to C at 122929819 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000144856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088468] [ENSMUST00000117173] [ENSMUST00000204427]

AlphaFold

Q8JZX6

Predicted Effect

probably benign
Transcript: ENSMUST00000088468

SMART Domains

Protein: ENSMUSP00000085816
Gene: ENSMUSG00000043832

Domain	Start	End	E-Value	Type
transmembrane domain	45	67	N/A	INTRINSIC
CLECT	107	231	1.97e-32	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117173

SMART Domains

Protein: ENSMUSP00000112716
Gene: ENSMUSG00000043832

Domain	Start	End	E-Value	Type
transmembrane domain	45	67	N/A	INTRINSIC
CLECT	107	231	1.97e-32	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000204427

SMART Domains

Protein: ENSMUSP00000144856
Gene: ENSMUSG00000043832

Domain	Start	End	E-Value	Type
transmembrane domain	45	67	N/A	INTRINSIC
SCOP:d1e87a_	71	109	1e-8	SMART
Blast:CLECT	73	109	2e-20	BLAST
PDB:3VYK\|A	73	109	7e-13	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap13	A	G	7: 75,219,767 (GRCm39)	T57A	probably damaging	Het
Akna	G	T	4: 63,297,396 (GRCm39)	T886N	probably benign	Het
Aqp9	A	G	9: 71,045,495 (GRCm39)	V38A	probably benign	Het
Awat2	C	T	X: 99,447,860 (GRCm39)	G124D	probably damaging	Het
Camsap1	A	G	2: 25,835,293 (GRCm39)		probably benign	Het
Catsperg2	T	C	7: 29,409,558 (GRCm39)	Y545C	probably damaging	Het
Cldn23	A	G	8: 36,293,074 (GRCm39)	F138S	possibly damaging	Het
Dlgap3	C	A	4: 127,127,690 (GRCm39)	T786K	probably benign	Het
Dnah2	A	C	11: 69,435,221 (GRCm39)	S50A	probably benign	Het
Dnah2	A	T	11: 69,411,767 (GRCm39)	I285N	probably damaging	Het
Dnah7a	A	G	1: 53,586,451 (GRCm39)	Y1467H	probably damaging	Het
Fgf22	C	T	10: 79,592,588 (GRCm39)	P115L	probably damaging	Het
Fzd2	G	T	11: 102,496,608 (GRCm39)	V351L	possibly damaging	Het
Gapdhs	T	A	7: 30,436,062 (GRCm39)	E174V	possibly damaging	Het
Gjc2	A	C	11: 59,068,344 (GRCm39)	I46S	probably damaging	Het
Gm5581	T	C	6: 131,144,735 (GRCm39)		noncoding transcript	Het
Krt1c	C	A	15: 101,724,765 (GRCm39)	V282L	possibly damaging	Het
Myh15	G	A	16: 49,015,942 (GRCm39)	V1873M	probably benign	Het
Myo1b	T	C	1: 51,799,536 (GRCm39)	T931A	probably damaging	Het
Myo6	A	T	9: 80,197,175 (GRCm39)	K965N	unknown	Het
Or5a3	T	C	19: 12,400,120 (GRCm39)	V149A	probably benign	Het
Pcnx3	T	C	19: 5,736,658 (GRCm39)	R160G	probably benign	Het
Slc22a16	T	C	10: 40,461,014 (GRCm39)	I272T	probably damaging	Het
Slc35b4	A	G	6: 34,144,610 (GRCm39)	Y82H	possibly damaging	Het
Spdya	T	C	17: 71,863,254 (GRCm39)	M1T	probably null	Het
St6gal1	A	G	16: 23,140,174 (GRCm39)	N115S	probably benign	Het
Tbc1d12	A	T	19: 38,902,744 (GRCm39)		probably benign	Het
Tfrc	A	G	16: 32,443,261 (GRCm39)		probably benign	Het
Trip11	A	C	12: 101,845,121 (GRCm39)	F1539C	probably damaging	Het
Ttn	A	T	2: 76,611,422 (GRCm39)	I15624N	possibly damaging	Het
Vmn1r169	A	T	7: 23,277,225 (GRCm39)	M206L	probably benign	Het
Zfp362	A	G	4: 128,680,902 (GRCm39)	L141P	probably damaging	Het
Zfp692	A	G	11: 58,202,379 (GRCm39)	H378R	probably damaging	Het
Zfp799	T	C	17: 33,040,794 (GRCm39)	Q52R	possibly damaging	Het

Other mutations in Clec4a3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02210:Clec4a3	APN	6	122,931,067 (GRCm39)	missense	probably damaging	0.98
IGL02874:Clec4a3	APN	6	122,944,519 (GRCm39)	missense	probably benign	0.16
IGL02983:Clec4a3	APN	6	122,944,526 (GRCm39)	critical splice donor site	probably null
R0035:Clec4a3	UTSW	6	122,944,508 (GRCm39)	missense	probably damaging	1.00
R0035:Clec4a3	UTSW	6	122,944,508 (GRCm39)	missense	probably damaging	1.00
R0334:Clec4a3	UTSW	6	122,946,329 (GRCm39)	missense	possibly damaging	0.81
R0671:Clec4a3	UTSW	6	122,930,993 (GRCm39)	critical splice acceptor site	probably null
R1508:Clec4a3	UTSW	6	122,944,467 (GRCm39)	missense	probably benign	0.05
R1739:Clec4a3	UTSW	6	122,931,000 (GRCm39)	nonsense	probably null
R3547:Clec4a3	UTSW	6	122,941,239 (GRCm39)	missense	probably damaging	1.00
R5836:Clec4a3	UTSW	6	122,929,861 (GRCm39)	missense	possibly damaging	0.66
R5953:Clec4a3	UTSW	6	122,946,451 (GRCm39)	missense	probably benign	0.12
R7178:Clec4a3	UTSW	6	122,941,251 (GRCm39)	missense	probably benign	0.02
R7664:Clec4a3	UTSW	6	122,943,381 (GRCm39)	missense	probably benign	0.03
R7763:Clec4a3	UTSW	6	122,941,299 (GRCm39)	missense	probably benign	0.01
R8739:Clec4a3	UTSW	6	122,944,508 (GRCm39)	missense	probably damaging	1.00
R8925:Clec4a3	UTSW	6	122,946,328 (GRCm39)	missense	probably damaging	1.00
R8927:Clec4a3	UTSW	6	122,946,328 (GRCm39)	missense	probably damaging	1.00
R8955:Clec4a3	UTSW	6	122,943,479 (GRCm39)	missense	possibly damaging	0.94
R9457:Clec4a3	UTSW	6	122,931,045 (GRCm39)	missense	probably benign	0.20

Posted On

2014-01-21