Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01670:Cdyl2'

103434

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdyl2

Ensembl Gene

ENSMUSG00000031758

Gene Name

chromodomain protein, Y chromosome-like 2

Synonyms

1700029M19Rik, 4930453I21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.127) question?

Stock #

IGL01670

Quality Score

Status

Chromosome

Chromosomal Location

117301139-117459730 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 117351092 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 13 (V13A)

Ref Sequence

ENSEMBL: ENSMUSP00000104730 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109102]

AlphaFold

Q9D5D8

Predicted Effect

probably damaging
Transcript: ENSMUST00000109102
AA Change: V13A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000104730
Gene: ENSMUSG00000031758
AA Change: V13A

Domain	Start	End	E-Value	Type
CHROMO	6	60	1.25e-17	SMART
Pfam:ECH_1	252	499	5e-33	PFAM
Pfam:ECH_2	258	501	1.6e-14	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acy1	A	C	9: 106,314,006 (GRCm39)		probably benign	Het
Add1	C	A	5: 34,777,407 (GRCm39)	Q57K	probably damaging	Het
Alms1	A	G	6: 85,655,132 (GRCm39)	E3226G	probably benign	Het
Arl1	G	T	10: 88,577,884 (GRCm39)	R151L	probably damaging	Het
Cabs1	T	A	5: 88,127,869 (GRCm39)	D173E	possibly damaging	Het
Cdc34b	T	C	11: 94,632,845 (GRCm39)	L15P	probably benign	Het
Chd7	G	T	4: 8,827,033 (GRCm39)	R1026L	probably damaging	Het
Cldn34b4	T	C	X: 75,441,195 (GRCm39)	S151P	probably damaging	Het
Col14a1	T	A	15: 55,192,662 (GRCm39)	I25N	unknown	Het
Crisp4	T	A	1: 18,198,901 (GRCm39)	T178S	probably benign	Het
Csmd2	C	T	4: 128,407,164 (GRCm39)		probably benign	Het
Csmd3	T	G	15: 47,475,225 (GRCm39)	N2454H	probably damaging	Het
Cytip	A	T	2: 58,023,785 (GRCm39)	I345N	probably damaging	Het
Frem2	A	T	3: 53,564,358 (GRCm39)	S50T	possibly damaging	Het
Gm9747	C	T	1: 82,211,870 (GRCm39)		probably benign	Het
Gpr37	A	G	6: 25,669,833 (GRCm39)	F337S	probably damaging	Het
Herc1	A	G	9: 66,394,342 (GRCm39)	E4182G	probably damaging	Het
Isyna1	C	T	8: 71,049,706 (GRCm39)	P511L	probably benign	Het
Kdm4a	T	C	4: 118,017,698 (GRCm39)	Y456C	probably damaging	Het
Kera	A	T	10: 97,444,939 (GRCm39)	R99S	possibly damaging	Het
Larp7-ps	T	C	4: 92,079,737 (GRCm39)		probably null	Het
Mcm2	A	G	6: 88,864,614 (GRCm39)		probably benign	Het
Myl12a	T	C	17: 71,303,848 (GRCm39)	T10A	probably benign	Het
Nav3	A	G	10: 109,550,102 (GRCm39)	V1876A	possibly damaging	Het
Nkx6-1	T	A	5: 101,809,806 (GRCm39)	Q247L	probably benign	Het
Nol8	A	C	13: 49,814,784 (GRCm39)	K297N	possibly damaging	Het
Or4c119	T	A	2: 88,987,261 (GRCm39)	Y86F	probably benign	Het
Or51e1	A	T	7: 102,358,772 (GRCm39)	Q102L	probably damaging	Het
Or5w18	A	G	2: 87,633,224 (GRCm39)	T164A	probably benign	Het
Pard3b	A	T	1: 62,250,807 (GRCm39)	N579Y	probably damaging	Het
Pdcd11	T	A	19: 47,094,743 (GRCm39)	L509H	probably damaging	Het
Prss29	T	C	17: 25,541,437 (GRCm39)	S266P	probably benign	Het
Rapgef3	G	T	15: 97,647,543 (GRCm39)	H766N	probably benign	Het
Rasa1	A	T	13: 85,373,609 (GRCm39)	S818T	probably damaging	Het
Rtn4ip1	A	G	10: 43,804,322 (GRCm39)	M1V	probably null	Het
Sall1	A	T	8: 89,758,199 (GRCm39)	V635D	probably benign	Het
Slc35b4	C	T	6: 34,147,484 (GRCm39)	V35I	probably benign	Het
Slc5a11	G	A	7: 122,869,172 (GRCm39)	A587T	probably benign	Het
Slc6a21	T	C	7: 44,937,557 (GRCm39)	V616A	possibly damaging	Het
Sorl1	A	G	9: 41,912,788 (GRCm39)	S1398P	possibly damaging	Het
Srcap	A	G	7: 127,127,604 (GRCm39)	K390E	probably damaging	Het
Sycp2	C	T	2: 178,019,843 (GRCm39)	E558K	probably benign	Het
Tcf20	T	C	15: 82,739,564 (GRCm39)	N629S	possibly damaging	Het
Tmem154	A	G	3: 84,591,537 (GRCm39)	Y29C	probably damaging	Het
Tmtc3	A	G	10: 100,282,987 (GRCm39)	I856T	probably benign	Het
Zswim6	A	G	13: 107,865,101 (GRCm39)		noncoding transcript	Het

Other mutations in Cdyl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00953:Cdyl2	APN	8	117,321,928 (GRCm39)	splice site	probably benign
IGL01964:Cdyl2	APN	8	117,350,768 (GRCm39)	missense	probably benign	0.00
IGL02148:Cdyl2	APN	8	117,315,983 (GRCm39)	splice site	probably benign
IGL02186:Cdyl2	APN	8	117,306,025 (GRCm39)	missense	possibly damaging	0.78
Allein	UTSW	8	117,305,935 (GRCm39)	missense	probably damaging	1.00
R0449:Cdyl2	UTSW	8	117,309,931 (GRCm39)	missense	probably damaging	1.00
R0630:Cdyl2	UTSW	8	117,350,774 (GRCm39)	missense	probably benign	0.03
R1430:Cdyl2	UTSW	8	117,306,056 (GRCm39)	splice site	probably benign
R1883:Cdyl2	UTSW	8	117,321,902 (GRCm39)	missense	probably damaging	1.00
R2326:Cdyl2	UTSW	8	117,350,537 (GRCm39)	missense	probably benign
R4194:Cdyl2	UTSW	8	117,305,903 (GRCm39)	splice site	probably null
R4916:Cdyl2	UTSW	8	117,305,926 (GRCm39)	missense	probably damaging	1.00
R4977:Cdyl2	UTSW	8	117,302,008 (GRCm39)	missense	probably damaging	0.99
R5092:Cdyl2	UTSW	8	117,350,679 (GRCm39)	missense	possibly damaging	0.50
R5320:Cdyl2	UTSW	8	117,321,794 (GRCm39)	nonsense	probably null
R5727:Cdyl2	UTSW	8	117,309,907 (GRCm39)	missense	probably damaging	1.00
R5830:Cdyl2	UTSW	8	117,321,823 (GRCm39)	missense	probably benign	0.23
R6077:Cdyl2	UTSW	8	117,316,129 (GRCm39)	missense	probably damaging	1.00
R6086:Cdyl2	UTSW	8	117,316,035 (GRCm39)	missense	probably damaging	1.00
R6145:Cdyl2	UTSW	8	117,321,717 (GRCm39)	missense	probably damaging	1.00
R6380:Cdyl2	UTSW	8	117,309,923 (GRCm39)	missense	probably damaging	1.00
R7152:Cdyl2	UTSW	8	117,351,066 (GRCm39)	missense	probably damaging	1.00
R7193:Cdyl2	UTSW	8	117,350,733 (GRCm39)	missense	probably benign	0.09
R7244:Cdyl2	UTSW	8	117,301,999 (GRCm39)	nonsense	probably null
R7394:Cdyl2	UTSW	8	117,350,790 (GRCm39)	missense	not run
R7457:Cdyl2	UTSW	8	117,305,935 (GRCm39)	missense	probably damaging	1.00
R8770:Cdyl2	UTSW	8	117,321,822 (GRCm39)	missense	probably damaging	1.00
R9574:Cdyl2	UTSW	8	117,350,669 (GRCm39)	missense	probably benign	0.00

Posted On

2014-01-21