Incidental Mutation 'IGL01673:Cyp4f14'
ID103569
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4f14
Ensembl Gene ENSMUSG00000024292
Gene Namecytochrome P450, family 4, subfamily f, polypeptide 14
Synonymsleukotriene B4 omega hydroxylase, 1300014O15Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01673
Quality Score
Status
Chromosome17
Chromosomal Location32905071-32917342 bp(-) (GRCm38)
Type of Mutationsplice site (6 bp from exon)
DNA Base Change (assembly) A to G at 32911151 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136139 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054174] [ENSMUST00000179434]
Predicted Effect probably null
Transcript: ENSMUST00000054174
SMART Domains Protein: ENSMUSP00000050478
Gene: ENSMUSG00000024292

DomainStartEndE-ValueType
Pfam:p450 52 515 2.7e-136 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000179434
SMART Domains Protein: ENSMUSP00000136139
Gene: ENSMUSG00000024292

DomainStartEndE-ValueType
Pfam:p450 52 515 2.7e-136 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced vitamin E-omega-hydroxylase activity and altered levels of tocopherols and their metabolites. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cpz A T 5: 35,512,547 V262E probably benign Het
Ddx46 G T 13: 55,653,048 V339F probably damaging Het
Gpn1 T G 5: 31,494,835 C21W probably damaging Het
Gpr63 A T 4: 25,008,014 Q246L probably benign Het
Hsp90b1 T A 10: 86,693,432 M658L probably damaging Het
Immp2l T C 12: 41,068,321 S4P probably benign Het
Krtap9-5 A T 11: 99,949,551 *359C probably null Het
Lgals7 A G 7: 28,866,196 probably benign Het
Mak G T 13: 41,048,223 probably null Het
Mrps18c A G 5: 100,798,806 R13G possibly damaging Het
Myo7a A G 7: 98,054,708 V1946A probably benign Het
Nfyc T C 4: 120,779,110 probably benign Het
Nkx2-4 C T 2: 147,083,914 V343M possibly damaging Het
Olfr1105 T C 2: 87,033,387 Y278C probably damaging Het
Olfr924 T C 9: 38,849,020 V302A probably benign Het
Rapgef4 G T 2: 72,241,437 S743I probably damaging Het
Tcf7 A G 11: 52,256,996 C210R probably damaging Het
Ubqln3 T A 7: 104,142,398 I162F probably benign Het
Vmn1r216 A G 13: 23,099,471 Q108R probably damaging Het
Vmn1r74 A T 7: 11,847,390 I206F possibly damaging Het
Wdr64 T C 1: 175,800,356 I872T possibly damaging Het
Other mutations in Cyp4f14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Cyp4f14 APN 17 32914566 missense probably benign 0.06
IGL00858:Cyp4f14 APN 17 32911718 splice site probably benign
IGL01716:Cyp4f14 APN 17 32905496 utr 3 prime probably benign
IGL01768:Cyp4f14 APN 17 32908002 missense probably damaging 1.00
IGL02314:Cyp4f14 APN 17 32906291 missense probably benign 0.12
IGL02697:Cyp4f14 APN 17 32905623 missense probably damaging 0.97
IGL03035:Cyp4f14 APN 17 32914634 missense probably benign 0.15
R1186:Cyp4f14 UTSW 17 32916786 missense probably benign
R1230:Cyp4f14 UTSW 17 32916788 missense probably benign 0.00
R1671:Cyp4f14 UTSW 17 32916909 intron probably benign
R1672:Cyp4f14 UTSW 17 32909236 missense probably benign 0.00
R1696:Cyp4f14 UTSW 17 32909171 missense possibly damaging 0.81
R1828:Cyp4f14 UTSW 17 32911235 missense probably damaging 0.98
R1934:Cyp4f14 UTSW 17 32906315 missense probably damaging 1.00
R2023:Cyp4f14 UTSW 17 32906531 missense probably damaging 1.00
R3013:Cyp4f14 UTSW 17 32909165 missense probably benign 0.01
R3783:Cyp4f14 UTSW 17 32916762 missense probably benign 0.00
R4013:Cyp4f14 UTSW 17 32916879 nonsense probably null
R4369:Cyp4f14 UTSW 17 32909258 missense probably benign
R4371:Cyp4f14 UTSW 17 32909258 missense probably benign
R4683:Cyp4f14 UTSW 17 32908011 missense probably null 0.78
R5282:Cyp4f14 UTSW 17 32907985 missense probably damaging 0.99
R5332:Cyp4f14 UTSW 17 32906091 missense probably benign 0.00
R5810:Cyp4f14 UTSW 17 32906098 missense possibly damaging 0.88
R6244:Cyp4f14 UTSW 17 32906317 missense probably benign 0.41
R6622:Cyp4f14 UTSW 17 32914645 missense probably benign
R6972:Cyp4f14 UTSW 17 32905509 missense probably benign 0.00
R6975:Cyp4f14 UTSW 17 32914634 missense probably benign 0.01
R7124:Cyp4f14 UTSW 17 32914588 missense not run
Posted On2014-01-21