Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01674:Vmn1r5'

103573

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r5

Ensembl Gene

ENSMUSG00000090346

Gene Name

vomeronasal 1 receptor 5

Synonyms

V1rc19

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01674

Quality Score

Status

Chromosome

Chromosomal Location

56947320-56963335 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 56962911 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 195 (S195R)

Ref Sequence

ENSEMBL: ENSMUSP00000154081 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164307] [ENSMUST00000226130] [ENSMUST00000228276]

AlphaFold

B2RQT2

Predicted Effect

probably damaging
Transcript: ENSMUST00000164307
AA Change: S195R

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000131092
Gene: ENSMUSG00000090346
AA Change: S195R

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	9.7e-53	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226130
AA Change: S195R

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228276
AA Change: S195R

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgef39	A	G	4: 43,497,590 (GRCm39)	L222P	probably damaging	Het
Art3	T	A	5: 92,551,473 (GRCm39)	Y17*	probably null	Het
Cadps2	A	G	6: 23,355,851 (GRCm39)	L859P	probably damaging	Het
Celsr2	A	G	3: 108,322,159 (GRCm39)	Y218H	probably damaging	Het
Ces5a	A	G	8: 94,228,847 (GRCm39)	V461A	probably damaging	Het
Clic4	C	A	4: 134,966,204 (GRCm39)	V51L	probably benign	Het
Col6a3	A	G	1: 90,730,236 (GRCm39)	L1083P	probably damaging	Het
Cul5	T	C	9: 53,546,307 (GRCm39)	E328G	probably damaging	Het
Erap1	T	C	13: 74,812,350 (GRCm39)		probably benign	Het
Fn1	G	A	1: 71,645,900 (GRCm39)	P1527L	probably damaging	Het
Gm20547	T	A	17: 35,100,631 (GRCm39)	Q63L	probably benign	Het
Gm5089	T	C	14: 122,673,575 (GRCm39)	T49A	unknown	Het
Ippk	T	C	13: 49,602,740 (GRCm39)	L362S	probably damaging	Het
Krt23	T	C	11: 99,377,593 (GRCm39)	M138V	probably benign	Het
Magi3	A	G	3: 104,013,037 (GRCm39)		probably benign	Het
Mcc	T	A	18: 44,624,223 (GRCm39)	I266F	probably benign	Het
Mcph1	A	G	8: 18,681,535 (GRCm39)	E224G	probably damaging	Het
Neurod4	A	T	10: 130,106,887 (GRCm39)	L129H	probably damaging	Het
Or14j5	T	A	17: 37,920,853 (GRCm39)	D263V	probably damaging	Het
Or4c123	T	A	2: 89,127,014 (GRCm39)	N200I	probably damaging	Het
Or5b24	T	C	19: 12,912,926 (GRCm39)	S275P	probably damaging	Het
Or8h7	T	C	2: 86,721,093 (GRCm39)	Y142C	probably benign	Het
Piezo2	A	T	18: 63,160,630 (GRCm39)	I2342N	probably damaging	Het
Pnpt1	A	G	11: 29,105,787 (GRCm39)	Q632R	probably benign	Het
Ppp2r2c	T	C	5: 37,097,570 (GRCm39)	M252T	possibly damaging	Het
Ppp4r2	A	G	6: 100,841,644 (GRCm39)	N142D	possibly damaging	Het
Prex2	G	T	1: 11,240,965 (GRCm39)	K1024N	probably damaging	Het
Rimklb	T	A	6: 122,436,129 (GRCm39)	I150F	probably damaging	Het
Slco4c1	T	C	1: 96,770,218 (GRCm39)	Q282R	probably damaging	Het
Tmem92	T	C	11: 94,669,519 (GRCm39)	E148G	probably damaging	Het
Traf7	T	C	17: 24,729,349 (GRCm39)		probably benign	Het
Ubr5	G	A	15: 37,998,623 (GRCm39)	T1622M	probably damaging	Het
Vmn2r67	C	T	7: 84,785,651 (GRCm39)	V785I	probably damaging	Het
Ythdc2	G	A	18: 44,993,471 (GRCm39)	D839N	probably benign	Het
Zfp184	T	C	13: 22,134,395 (GRCm39)		probably benign	Het
Zfp654	T	C	16: 64,605,004 (GRCm39)	N525S	probably benign	Het

Other mutations in Vmn1r5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02027:Vmn1r5	APN	6	56,962,640 (GRCm39)	missense	probably damaging	0.97
IGL03133:Vmn1r5	APN	6	56,962,600 (GRCm39)	missense	probably benign	0.10
IGL03412:Vmn1r5	APN	6	56,962,918 (GRCm39)	missense	possibly damaging	0.90
R0316:Vmn1r5	UTSW	6	56,962,784 (GRCm39)	missense	probably benign	0.27
R0378:Vmn1r5	UTSW	6	56,962,570 (GRCm39)	missense	probably benign	0.00
R0946:Vmn1r5	UTSW	6	56,963,150 (GRCm39)	missense	possibly damaging	0.64
R1511:Vmn1r5	UTSW	6	56,962,771 (GRCm39)	missense	probably benign	0.02
R1553:Vmn1r5	UTSW	6	56,962,483 (GRCm39)	missense	probably benign	0.00
R1823:Vmn1r5	UTSW	6	56,962,580 (GRCm39)	missense	probably damaging	0.98
R3980:Vmn1r5	UTSW	6	56,962,636 (GRCm39)	missense	probably damaging	1.00
R4473:Vmn1r5	UTSW	6	56,962,633 (GRCm39)	missense	probably benign	0.01
R4742:Vmn1r5	UTSW	6	56,963,236 (GRCm39)	nonsense	probably null
R5321:Vmn1r5	UTSW	6	56,962,592 (GRCm39)	missense	probably damaging	1.00
R5364:Vmn1r5	UTSW	6	56,962,583 (GRCm39)	missense	probably damaging	0.98
R6102:Vmn1r5	UTSW	6	56,963,099 (GRCm39)	missense	probably damaging	0.96
R6581:Vmn1r5	UTSW	6	56,962,366 (GRCm39)	missense	probably benign
R6885:Vmn1r5	UTSW	6	56,963,042 (GRCm39)	missense	possibly damaging	0.89
R7297:Vmn1r5	UTSW	6	56,963,204 (GRCm39)	missense	possibly damaging	0.94
R8063:Vmn1r5	UTSW	6	56,962,583 (GRCm39)	missense	probably damaging	0.98
R8766:Vmn1r5	UTSW	6	56,963,100 (GRCm39)	missense	possibly damaging	0.76
R8968:Vmn1r5	UTSW	6	56,963,182 (GRCm39)	nonsense	probably null
R9440:Vmn1r5	UTSW	6	56,962,415 (GRCm39)	missense	possibly damaging	0.67
R9460:Vmn1r5	UTSW	6	56,962,829 (GRCm39)	missense
Z1176:Vmn1r5	UTSW	6	56,962,933 (GRCm39)	missense	possibly damaging	0.75

Posted On

2014-01-21