Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01681:Zc3h10'

103797

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zc3h10

Ensembl Gene

ENSMUSG00000039810

Gene Name

zinc finger CCCH type containing 10

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.895) question?

Stock #

IGL01681

Quality Score

Status

Chromosome

Chromosomal Location

128379429-128383877 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 128381109 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 83 (Q83*)

Ref Sequence

ENSEMBL: ENSMUSP00000151278 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040572] [ENSMUST00000133458] [ENSMUST00000152539] [ENSMUST00000176010] [ENSMUST00000176683] [ENSMUST00000176906] [ENSMUST00000177163]

AlphaFold

Q8R205

Predicted Effect

probably null
Transcript: ENSMUST00000040572
AA Change: Q83*

SMART Domains

Protein: ENSMUSP00000042727
Gene: ENSMUSG00000039810
AA Change: Q83*

Domain	Start	End	E-Value	Type
ZnF_C3H1	36	62	3.44e-4	SMART
ZnF_C3H1	75	98	7.41e0	SMART
ZnF_C3H1	134	160	5.67e-5	SMART
low complexity region	167	186	N/A	INTRINSIC
SCOP:d1fxkc_	241	272	2e-3	SMART
low complexity region	334	357	N/A	INTRINSIC
low complexity region	378	403	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000133458

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135226

Predicted Effect

probably null
Transcript: ENSMUST00000152539
AA Change: Q83*

Predicted Effect

probably benign
Transcript: ENSMUST00000176010

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176184

Predicted Effect

probably benign
Transcript: ENSMUST00000176683

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177513

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188089

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176966

Predicted Effect

probably benign
Transcript: ENSMUST00000176906

Predicted Effect

probably benign
Transcript: ENSMUST00000177163

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219955

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adnp2	T	A	18: 80,171,103 (GRCm39)	E1102V	probably damaging	Het
Appl2	T	A	10: 83,450,165 (GRCm39)	I236F	possibly damaging	Het
Asb15	C	A	6: 24,567,137 (GRCm39)	T486K	probably damaging	Het
Bsdc1	T	C	4: 129,359,141 (GRCm39)		probably null	Het
Cts8	G	T	13: 61,401,433 (GRCm39)	Q61K	probably benign	Het
Cyp2d34	C	T	15: 82,501,332 (GRCm39)		probably null	Het
Dnah12	A	G	14: 26,443,315 (GRCm39)	T575A	probably benign	Het
Dync2h1	T	C	9: 7,142,196 (GRCm39)		probably null	Het
Fam170a	A	G	18: 50,415,302 (GRCm39)	D316G	possibly damaging	Het
Gtf2h3	T	A	5: 124,732,854 (GRCm39)	L216Q	probably damaging	Het
Heatr6	T	A	11: 83,655,826 (GRCm39)	S306T	probably benign	Het
Hey2	A	G	10: 30,710,133 (GRCm39)	S207P	probably benign	Het
Kng2	T	A	16: 22,815,767 (GRCm39)		probably benign	Het
Lama2	C	T	10: 27,141,041 (GRCm39)	E653K	probably benign	Het
Lrrcc1	T	C	3: 14,613,286 (GRCm39)	V37A	probably benign	Het
Neb	T	C	2: 52,091,498 (GRCm39)	D5085G	probably damaging	Het
Nexn	T	C	3: 151,949,507 (GRCm39)	M321V	possibly damaging	Het
Nsmce3	A	G	7: 64,522,221 (GRCm39)	I149T	probably benign	Het
Oxct1	T	G	15: 4,131,326 (GRCm39)	S405A	possibly damaging	Het
Pdpr	T	A	8: 111,859,568 (GRCm39)	N703K	probably damaging	Het
Scn10a	A	T	9: 119,523,143 (GRCm39)	D83E	probably damaging	Het
Slc47a2	C	T	11: 61,228,866 (GRCm39)	A104T	probably damaging	Het
Slc4a2	A	G	5: 24,639,185 (GRCm39)	I393V	probably damaging	Het
Thoc6	A	T	17: 23,888,857 (GRCm39)	L184M	possibly damaging	Het
Tjp2	C	T	19: 24,112,213 (GRCm39)		probably null	Het
Tmem63b	A	G	17: 45,974,497 (GRCm39)	L591P	probably damaging	Het
Tnrc6b	A	G	15: 80,763,512 (GRCm39)		probably null	Het
Trmt5	G	T	12: 73,329,377 (GRCm39)		probably benign	Het
Ubap1l	T	A	9: 65,281,201 (GRCm39)	M293K	probably benign	Het
Yars1	A	G	4: 129,099,935 (GRCm39)	E211G	probably damaging	Het
Zbbx	A	C	3: 74,959,785 (GRCm39)	Y595D	probably damaging	Het
Zcchc3	T	C	2: 152,255,925 (GRCm39)	N258S	probably damaging	Het

Other mutations in Zc3h10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02616:Zc3h10	APN	10	128,380,751 (GRCm39)	missense	probably benign	0.15
R0316:Zc3h10	UTSW	10	128,380,624 (GRCm39)	missense	probably damaging	1.00
R1502:Zc3h10	UTSW	10	128,380,151 (GRCm39)	missense	probably damaging	0.97
R1705:Zc3h10	UTSW	10	128,380,672 (GRCm39)	nonsense	probably null
R5739:Zc3h10	UTSW	10	128,380,670 (GRCm39)	missense	probably benign
R5943:Zc3h10	UTSW	10	128,381,396 (GRCm39)	unclassified	probably benign
R6931:Zc3h10	UTSW	10	128,380,553 (GRCm39)	missense	probably damaging	1.00
R7939:Zc3h10	UTSW	10	128,380,376 (GRCm39)	missense	probably damaging	0.99
R8876:Zc3h10	UTSW	10	128,380,163 (GRCm39)	missense	probably damaging	0.96
Z1176:Zc3h10	UTSW	10	128,380,818 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-01-21