Incidental Mutation 'IGL01682:Cdk10'
ID 103850
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk10
Ensembl Gene ENSMUSG00000033862
Gene Name cyclin dependent kinase 10
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # IGL01682
Quality Score
Status
Chromosome 8
Chromosomal Location 123951581-123958989 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to G at 123954397 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148435 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036880] [ENSMUST00000098327] [ENSMUST00000127664] [ENSMUST00000166768] [ENSMUST00000212193] [ENSMUST00000212361] [ENSMUST00000213005]
AlphaFold Q3UMM4
Predicted Effect probably null
Transcript: ENSMUST00000036880
SMART Domains Protein: ENSMUSP00000045527
Gene: ENSMUSG00000033862

DomainStartEndE-ValueType
S_TKc 39 323 1.52e-87 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000098327
SMART Domains Protein: ENSMUSP00000095932
Gene: ENSMUSG00000033594

DomainStartEndE-ValueType
low complexity region 74 91 N/A INTRINSIC
low complexity region 209 214 N/A INTRINSIC
low complexity region 294 308 N/A INTRINSIC
low complexity region 309 318 N/A INTRINSIC
low complexity region 340 347 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127664
SMART Domains Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

DomainStartEndE-ValueType
Pfam:Glycos_transf_2 104 287 7.4e-31 PFAM
Pfam:Glyco_transf_7C 261 331 4.9e-8 PFAM
RICIN 406 531 9.28e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166768
SMART Domains Protein: ENSMUSP00000130306
Gene: ENSMUSG00000033594

DomainStartEndE-ValueType
low complexity region 74 91 N/A INTRINSIC
low complexity region 209 214 N/A INTRINSIC
low complexity region 294 308 N/A INTRINSIC
low complexity region 309 318 N/A INTRINSIC
low complexity region 340 347 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211845
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211876
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212021
Predicted Effect probably benign
Transcript: ENSMUST00000212193
Predicted Effect probably benign
Transcript: ENSMUST00000212361
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212784
Predicted Effect probably null
Transcript: ENSMUST00000213005
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212749
Predicted Effect probably benign
Transcript: ENSMUST00000212028
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212497
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212532
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212904
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212035
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agmo T C 12: 37,407,626 (GRCm39) probably benign Het
Atp2c1 C T 9: 105,330,041 (GRCm39) G93D probably damaging Het
C2cd6 T G 1: 59,101,660 (GRCm39) Y333S probably damaging Het
Cacna1a A G 8: 85,263,067 (GRCm39) E414G possibly damaging Het
Capn10 C A 1: 92,868,106 (GRCm39) T191K probably benign Het
Cd226 A T 18: 89,287,187 (GRCm39) R328S probably damaging Het
Cyp4a31 T A 4: 115,435,228 (GRCm39) V486D probably damaging Het
Dgke A T 11: 88,943,267 (GRCm39) L241I probably damaging Het
Dnah6 G T 6: 73,052,785 (GRCm39) A2965E probably damaging Het
Fbn2 A T 18: 58,205,743 (GRCm39) C1112S probably damaging Het
Gm10228 T A 16: 88,838,073 (GRCm39) Y77F unknown Het
Gng3 T C 19: 8,815,944 (GRCm39) I25V probably benign Het
Gramd2a A G 9: 59,619,393 (GRCm39) I61M possibly damaging Het
Hcar2 T C 5: 124,002,582 (GRCm39) N307S probably benign Het
Iars1 G A 13: 49,863,134 (GRCm39) E529K probably damaging Het
Ilvbl C T 10: 78,412,941 (GRCm39) probably benign Het
Itprid2 A G 2: 79,465,981 (GRCm39) Q33R probably damaging Het
Lrp1 T C 10: 127,410,847 (GRCm39) K1447R probably benign Het
Mmp20 A G 9: 7,671,376 (GRCm39) D426G probably benign Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Or4f4b G A 2: 111,314,188 (GRCm39) G138S probably damaging Het
Or51f2 C T 7: 102,526,440 (GRCm39) L38F probably benign Het
Pip4k2a A G 2: 19,002,779 (GRCm39) S10P probably benign Het
Pth1r A T 9: 110,552,774 (GRCm39) probably null Het
Rprd1b T C 2: 157,892,080 (GRCm39) I201T probably damaging Het
Rsbn1 A G 3: 103,869,696 (GRCm39) N719S probably benign Het
Sorcs1 C T 19: 50,169,944 (GRCm39) G939E probably benign Het
St8sia5 A G 18: 77,336,196 (GRCm39) K210E probably damaging Het
Trav3-1 G A 14: 52,818,649 (GRCm39) V108M probably benign Het
Washc4 T C 10: 83,416,170 (GRCm39) I820T possibly damaging Het
Other mutations in Cdk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Cdk10 APN 8 123,957,063 (GRCm39) missense possibly damaging 0.78
IGL01613:Cdk10 APN 8 123,955,126 (GRCm39) missense probably damaging 0.99
IGL02536:Cdk10 APN 8 123,953,754 (GRCm39) missense possibly damaging 0.64
R0612:Cdk10 UTSW 8 123,957,419 (GRCm39) missense probably benign 0.16
R1159:Cdk10 UTSW 8 123,955,062 (GRCm39) splice site probably benign
R2356:Cdk10 UTSW 8 123,955,908 (GRCm39) missense probably damaging 0.99
R4838:Cdk10 UTSW 8 123,957,353 (GRCm39) missense probably damaging 1.00
R5453:Cdk10 UTSW 8 123,953,131 (GRCm39) missense probably benign 0.42
R5517:Cdk10 UTSW 8 123,957,326 (GRCm39) splice site probably null
R5804:Cdk10 UTSW 8 123,955,579 (GRCm39) splice site probably null
R6930:Cdk10 UTSW 8 123,957,347 (GRCm39) missense probably damaging 1.00
R6971:Cdk10 UTSW 8 123,954,413 (GRCm39) missense probably damaging 1.00
R7910:Cdk10 UTSW 8 123,953,105 (GRCm39) missense probably damaging 1.00
R8356:Cdk10 UTSW 8 123,955,096 (GRCm39) missense probably benign 0.00
Posted On 2014-01-21