Incidental Mutation 'IGL01688:Lrrc63'
| ID |
104028 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lrrc63
|
| Ensembl Gene |
ENSMUSG00000021997 |
| Gene Name |
leucine rich repeat containing 63 |
| Synonyms |
4921509B22Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.106)
|
| Stock # |
IGL01688
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
75321743-75368321 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 75322422 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 561
(S561P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000022574
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022574]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000022574
AA Change: S561P
PolyPhen 2
Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000022574
Gene: ENSMUSG00000021997
AA Change: S561P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
37 |
N/A |
INTRINSIC |
|
low complexity region
|
139 |
152 |
N/A |
INTRINSIC |
|
low complexity region
|
276 |
310 |
N/A |
INTRINSIC |
|
LRR
|
412 |
434 |
2.82e0 |
SMART |
|
LRR
|
435 |
458 |
1.45e1 |
SMART |
|
LRR
|
481 |
504 |
1.53e-1 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 44 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 87,000,985 (GRCm39) |
L59P |
probably damaging |
Het |
| Ccin |
A |
T |
4: 43,984,985 (GRCm39) |
E464V |
possibly damaging |
Het |
| Cfap58 |
A |
G |
19: 47,963,006 (GRCm39) |
D472G |
probably benign |
Het |
| Col28a1 |
C |
T |
6: 7,998,517 (GRCm39) |
E1131K |
probably damaging |
Het |
| Cpne2 |
A |
G |
8: 95,281,381 (GRCm39) |
T196A |
possibly damaging |
Het |
| Cul4a |
A |
T |
8: 13,196,571 (GRCm39) |
R742* |
probably null |
Het |
| Cyp21a1 |
T |
A |
17: 35,021,194 (GRCm39) |
I370F |
probably damaging |
Het |
| Ddx51 |
T |
C |
5: 110,803,513 (GRCm39) |
F332L |
probably benign |
Het |
| Gm8232 |
A |
G |
14: 44,671,179 (GRCm39) |
D29G |
unknown |
Het |
| Got1 |
A |
G |
19: 43,512,775 (GRCm39) |
|
probably null |
Het |
| Gpat4 |
A |
G |
8: 23,671,861 (GRCm39) |
I58T |
probably benign |
Het |
| Hdac3 |
T |
A |
18: 38,087,932 (GRCm39) |
D12V |
possibly damaging |
Het |
| Helb |
T |
C |
10: 119,944,885 (GRCm39) |
H217R |
probably damaging |
Het |
| Hpf1 |
A |
T |
8: 61,349,830 (GRCm39) |
I153L |
probably benign |
Het |
| Lgsn |
G |
A |
1: 31,243,486 (GRCm39) |
D523N |
probably damaging |
Het |
| Myh6 |
G |
A |
14: 55,201,417 (GRCm39) |
T94I |
possibly damaging |
Het |
| Mzt2 |
T |
C |
16: 15,680,793 (GRCm39) |
|
probably benign |
Het |
| Ndufb5 |
T |
A |
3: 32,800,613 (GRCm39) |
L62* |
probably null |
Het |
| Nek1 |
A |
T |
8: 61,558,631 (GRCm39) |
R970* |
probably null |
Het |
| Nepro |
T |
C |
16: 44,556,369 (GRCm39) |
L509P |
probably damaging |
Het |
| Pank1 |
T |
A |
19: 34,818,252 (GRCm39) |
I96F |
probably damaging |
Het |
| Parp11 |
C |
A |
6: 127,448,569 (GRCm39) |
T62K |
probably benign |
Het |
| Pla2g2e |
T |
A |
4: 138,606,781 (GRCm39) |
|
probably benign |
Het |
| Plekha5 |
T |
A |
6: 140,515,115 (GRCm39) |
Y207N |
probably damaging |
Het |
| Pomt2 |
T |
A |
12: 87,194,294 (GRCm39) |
I37F |
probably benign |
Het |
| Prl6a1 |
T |
A |
13: 27,501,969 (GRCm39) |
V117E |
probably damaging |
Het |
| Prmt3 |
T |
A |
7: 49,498,480 (GRCm39) |
|
probably null |
Het |
| Rcor3 |
T |
A |
1: 191,807,900 (GRCm39) |
E20V |
probably damaging |
Het |
| Rere |
A |
G |
4: 150,702,893 (GRCm39) |
D1449G |
probably damaging |
Het |
| Ric1 |
T |
C |
19: 29,555,014 (GRCm39) |
V376A |
probably benign |
Het |
| Rims1 |
G |
A |
1: 22,467,764 (GRCm39) |
T873I |
probably benign |
Het |
| Rras2 |
T |
C |
7: 113,659,632 (GRCm39) |
D44G |
probably damaging |
Het |
| Sbk2 |
C |
T |
7: 4,960,716 (GRCm39) |
|
probably benign |
Het |
| Slit1 |
A |
G |
19: 41,717,545 (GRCm39) |
I73T |
probably damaging |
Het |
| Spice1 |
T |
A |
16: 44,205,073 (GRCm39) |
M793K |
probably benign |
Het |
| Suco |
T |
C |
1: 161,691,480 (GRCm39) |
|
probably null |
Het |
| Tarbp1 |
A |
T |
8: 127,174,290 (GRCm39) |
W839R |
probably damaging |
Het |
| Trpc4 |
T |
A |
3: 54,173,495 (GRCm39) |
|
probably benign |
Het |
| Tubgcp5 |
T |
C |
7: 55,464,766 (GRCm39) |
V549A |
possibly damaging |
Het |
| Ubap2 |
T |
A |
4: 41,226,308 (GRCm39) |
T182S |
probably benign |
Het |
| Wrn |
A |
C |
8: 33,800,730 (GRCm39) |
|
probably benign |
Het |
| Zc3h15 |
A |
G |
2: 83,492,536 (GRCm39) |
Y337C |
probably damaging |
Het |
| Zfp292 |
T |
A |
4: 34,807,855 (GRCm39) |
I1730F |
possibly damaging |
Het |
| Zfp609 |
A |
G |
9: 65,611,307 (GRCm39) |
V552A |
probably benign |
Het |
|
| Other mutations in Lrrc63 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02222:Lrrc63
|
APN |
14 |
75,323,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02385:Lrrc63
|
APN |
14 |
75,323,640 (GRCm39) |
missense |
probably benign |
|
|
FR4548:Lrrc63
|
UTSW |
14 |
75,362,622 (GRCm39) |
small deletion |
probably benign |
|
|
FR4589:Lrrc63
|
UTSW |
14 |
75,362,622 (GRCm39) |
small deletion |
probably benign |
|
|
R0398:Lrrc63
|
UTSW |
14 |
75,363,910 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0637:Lrrc63
|
UTSW |
14 |
75,335,660 (GRCm39) |
splice site |
probably benign |
|
|
R0669:Lrrc63
|
UTSW |
14 |
75,363,550 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1465:Lrrc63
|
UTSW |
14 |
75,344,829 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1465:Lrrc63
|
UTSW |
14 |
75,344,829 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1478:Lrrc63
|
UTSW |
14 |
75,363,424 (GRCm39) |
missense |
probably benign |
|
|
R1591:Lrrc63
|
UTSW |
14 |
75,363,332 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1753:Lrrc63
|
UTSW |
14 |
75,323,784 (GRCm39) |
splice site |
probably null |
|
|
R3713:Lrrc63
|
UTSW |
14 |
75,344,776 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4013:Lrrc63
|
UTSW |
14 |
75,335,731 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4793:Lrrc63
|
UTSW |
14 |
75,363,601 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4888:Lrrc63
|
UTSW |
14 |
75,363,406 (GRCm39) |
missense |
probably benign |
|
|
R4937:Lrrc63
|
UTSW |
14 |
75,322,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5197:Lrrc63
|
UTSW |
14 |
75,322,322 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5747:Lrrc63
|
UTSW |
14 |
75,363,904 (GRCm39) |
missense |
probably benign |
|
|
R5861:Lrrc63
|
UTSW |
14 |
75,344,806 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5905:Lrrc63
|
UTSW |
14 |
75,323,614 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6028:Lrrc63
|
UTSW |
14 |
75,323,614 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6661:Lrrc63
|
UTSW |
14 |
75,362,633 (GRCm39) |
missense |
unknown |
|
|
R6982:Lrrc63
|
UTSW |
14 |
75,322,211 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7062:Lrrc63
|
UTSW |
14 |
75,323,737 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7439:Lrrc63
|
UTSW |
14 |
75,363,697 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7440:Lrrc63
|
UTSW |
14 |
75,358,453 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7441:Lrrc63
|
UTSW |
14 |
75,363,697 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7474:Lrrc63
|
UTSW |
14 |
75,363,643 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7604:Lrrc63
|
UTSW |
14 |
75,322,409 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7703:Lrrc63
|
UTSW |
14 |
75,360,447 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7819:Lrrc63
|
UTSW |
14 |
75,362,661 (GRCm39) |
small insertion |
probably benign |
|
|
R8519:Lrrc63
|
UTSW |
14 |
75,363,312 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8970:Lrrc63
|
UTSW |
14 |
75,362,631 (GRCm39) |
missense |
unknown |
|
|
R9025:Lrrc63
|
UTSW |
14 |
75,322,284 (GRCm39) |
missense |
probably benign |
|
|
R9547:Lrrc63
|
UTSW |
14 |
75,344,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9589:Lrrc63
|
UTSW |
14 |
75,322,379 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9780:Lrrc63
|
UTSW |
14 |
75,360,500 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Lrrc63
|
UTSW |
14 |
75,363,430 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Posted On |
2014-01-21 |
Incidental Mutation