Incidental Mutation 'IGL00590:Dtymk'
ID10414
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dtymk
Ensembl Gene ENSMUSG00000026281
Gene Namedeoxythymidylate kinase
SynonymsD10Ertd203e, mtmk, TYPK, Tmk, CDC8
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.890) question?
Stock #IGL00590
Quality Score
Status
Chromosome1
Chromosomal Location93792576-93801934 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 93794724 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000108514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027502] [ENSMUST00000027503] [ENSMUST00000112893]
Predicted Effect probably benign
Transcript: ENSMUST00000027502
SMART Domains Protein: ENSMUSP00000027502
Gene: ENSMUSG00000026280

DomainStartEndE-ValueType
Pfam:Peptidase_C54 39 335 4.4e-104 PFAM
low complexity region 375 393 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000027503
SMART Domains Protein: ENSMUSP00000027503
Gene: ENSMUSG00000026281

DomainStartEndE-ValueType
Pfam:Thymidylate_kin 11 191 6.7e-52 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000112893
SMART Domains Protein: ENSMUSP00000108514
Gene: ENSMUSG00000026281

DomainStartEndE-ValueType
Pfam:Thymidylate_kin 16 133 1.9e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144106
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T G 7: 120,423,815 F58C probably damaging Het
Adgrf5 G T 17: 43,453,147 G1320V probably damaging Het
Akap13 A G 7: 75,610,669 K211E probably benign Het
Akap8l T C 17: 32,333,097 D402G possibly damaging Het
Akna T C 4: 63,371,878 I1198V probably benign Het
Apaf1 T A 10: 91,023,788 I832F probably damaging Het
Cbl A C 9: 44,201,198 L67V probably damaging Het
Chl1 T C 6: 103,693,061 Y471H probably benign Het
Cystm1 T A 18: 36,366,675 Y48N unknown Het
Dennd5b T C 6: 149,068,308 T216A probably benign Het
Dpep2 A T 8: 105,988,821 M356K probably damaging Het
Fam91a1 A G 15: 58,415,716 D4G possibly damaging Het
Fbxl20 A G 11: 98,093,129 L306P probably damaging Het
Fchsd1 C T 18: 37,965,893 probably benign Het
Fndc1 G A 17: 7,765,101 T1331I unknown Het
Gpatch8 T C 11: 102,480,549 D721G unknown Het
Gsg1 A T 6: 135,244,350 I17N possibly damaging Het
Heyl A G 4: 123,246,630 *327W probably null Het
Kif13b G T 14: 64,779,462 R1359L probably damaging Het
Map3k14 C T 11: 103,237,554 G414S probably damaging Het
Meis2 C T 2: 115,868,793 A330T probably damaging Het
Mrpl9 T C 3: 94,443,696 L61P probably damaging Het
Mrps6 A G 16: 92,099,660 N38D probably benign Het
Muc4 C T 16: 32,754,347 T1407I probably benign Het
Nup107 A G 10: 117,763,803 Y604H probably damaging Het
Pgm2l1 T C 7: 100,255,619 probably null Het
Pisd T C 5: 32,738,412 I441V probably benign Het
Rb1cc1 T C 1: 6,238,296 F52S probably damaging Het
Rnft1 T A 11: 86,495,914 W383R probably damaging Het
Tas2r104 A T 6: 131,685,567 W60R probably damaging Het
Tlr11 A G 14: 50,360,916 T120A probably benign Het
Tmem150b T G 7: 4,723,897 I71L probably benign Het
Zfp296 A G 7: 19,577,835 D89G possibly damaging Het
Other mutations in Dtymk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Dtymk APN 1 93794743 missense probably benign 0.00
IGL03342:Dtymk APN 1 93794819 missense probably benign 0.01
R0883:Dtymk UTSW 1 93801788 missense possibly damaging 0.64
R4765:Dtymk UTSW 1 93792909 missense probably damaging 1.00
R6799:Dtymk UTSW 1 93798492 missense probably benign
Posted On2012-12-06