Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01702:Trim5'

104498

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim5

Ensembl Gene

ENSMUSG00000060441

Gene Name

tripartite motif-containing 5

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL01702

Quality Score

Status

Chromosome

Chromosomal Location

103912593-103937301 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 103928638 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 101 (E101G)

Ref Sequence

ENSEMBL: ENSMUSP00000095781 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051795] [ENSMUST00000098179]

AlphaFold

E9PV98

Predicted Effect

probably damaging
Transcript: ENSMUST00000051795
AA Change: E101G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000050084
Gene: ENSMUSG00000060441
AA Change: E101G

Domain	Start	End	E-Value	Type
RING	15	58	3.64e-7	SMART
BBOX	91	132	4.83e-12	SMART
coiled coil region	172	232	N/A	INTRINSIC
Pfam:SPRY	349	485	9.2e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000098179
AA Change: E101G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000095781
Gene: ENSMUSG00000060441
AA Change: E101G

Domain	Start	End	E-Value	Type
RING	15	58	3.64e-7	SMART
BBOX	91	132	4.83e-12	SMART
Pfam:SPRY	351	493	1.6e-13	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apol7a	T	C	15: 77,273,886 (GRCm39)		probably null	Het
Asb2	C	T	12: 103,302,164 (GRCm39)	G128E	possibly damaging	Het
Atp11c	A	T	X: 59,315,263 (GRCm39)	S683T	probably damaging	Het
Brinp3	A	G	1: 146,627,735 (GRCm39)		probably benign	Het
Cpeb3	A	T	19: 37,103,782 (GRCm39)	M369K	possibly damaging	Het
Exoc5	A	T	14: 49,253,072 (GRCm39)	C580*	probably null	Het
Gm9956	A	G	10: 56,621,335 (GRCm39)			Het
Gzmk	C	T	13: 113,317,084 (GRCm39)	V32I	probably damaging	Het
Hsf4	T	C	8: 105,998,221 (GRCm39)	I129T	probably damaging	Het
Igkv1-115	T	A	6: 68,138,516 (GRCm39)	W40R	probably damaging	Het
Iqub	A	T	6: 24,500,312 (GRCm39)	M314K	probably benign	Het
Krt87	T	C	15: 101,389,099 (GRCm39)	T78A	probably benign	Het
Med28	T	C	5: 45,682,633 (GRCm39)	S100P	probably benign	Het
Prx	G	A	7: 27,219,212 (GRCm39)	V1238I	probably benign	Het
Ptprq	T	C	10: 107,353,727 (GRCm39)	N2263S	probably benign	Het
Rab12	A	G	17: 66,826,384 (GRCm39)	F61S	probably damaging	Het
Serpinb9d	T	C	13: 33,387,006 (GRCm39)	F358S	probably damaging	Het
Slc25a3	A	T	10: 90,953,987 (GRCm39)	Y242N	probably damaging	Het
Smtnl1	T	C	2: 84,649,034 (GRCm39)	I73M	possibly damaging	Het
Tnp1	C	A	1: 73,054,877 (GRCm39)		probably benign	Het

Other mutations in Trim5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02165:Trim5	APN	7	103,928,566 (GRCm39)	missense	probably damaging	1.00
IGL02576:Trim5	APN	7	103,927,624 (GRCm39)	missense	probably damaging	0.97
IGL02660:Trim5	APN	7	103,915,425 (GRCm39)	missense	probably damaging	0.96
IGL02732:Trim5	APN	7	103,927,672 (GRCm39)	missense	probably benign	0.02
R0278:Trim5	UTSW	7	103,928,882 (GRCm39)	missense	probably benign	0.00
R0373:Trim5	UTSW	7	103,914,891 (GRCm39)	missense	probably benign	0.00
R0508:Trim5	UTSW	7	103,914,811 (GRCm39)	missense	probably null	0.98
R0840:Trim5	UTSW	7	103,914,978 (GRCm39)	missense	probably damaging	1.00
R0947:Trim5	UTSW	7	103,914,958 (GRCm39)	missense	probably damaging	1.00
R1432:Trim5	UTSW	7	103,928,728 (GRCm39)	missense	probably benign
R1432:Trim5	UTSW	7	103,928,726 (GRCm39)	missense	probably benign	0.04
R1770:Trim5	UTSW	7	103,925,868 (GRCm39)	missense	probably damaging	1.00
R1782:Trim5	UTSW	7	103,915,023 (GRCm39)	splice site	probably null
R1988:Trim5	UTSW	7	103,914,828 (GRCm39)	missense	probably damaging	0.99
R2140:Trim5	UTSW	7	103,925,998 (GRCm39)	nonsense	probably null
R3110:Trim5	UTSW	7	103,928,845 (GRCm39)	missense	probably damaging	1.00
R3112:Trim5	UTSW	7	103,928,845 (GRCm39)	missense	probably damaging	1.00
R3893:Trim5	UTSW	7	103,926,042 (GRCm39)	missense	probably damaging	0.98
R3948:Trim5	UTSW	7	103,915,727 (GRCm39)	nonsense	probably null
R4114:Trim5	UTSW	7	103,914,947 (GRCm39)	missense	probably damaging	0.99
R4249:Trim5	UTSW	7	103,926,022 (GRCm39)	missense	possibly damaging	0.83
R4352:Trim5	UTSW	7	103,926,015 (GRCm39)	missense	probably damaging	1.00
R4595:Trim5	UTSW	7	103,914,639 (GRCm39)	missense	probably damaging	1.00
R5057:Trim5	UTSW	7	103,914,630 (GRCm39)	missense	probably damaging	1.00
R5583:Trim5	UTSW	7	103,926,042 (GRCm39)	missense	probably damaging	0.98
R5861:Trim5	UTSW	7	103,928,728 (GRCm39)	missense	probably benign
R5861:Trim5	UTSW	7	103,928,726 (GRCm39)	missense	probably benign	0.04
R7027:Trim5	UTSW	7	103,914,875 (GRCm39)	missense	probably benign	0.00
R7078:Trim5	UTSW	7	103,927,681 (GRCm39)	missense	possibly damaging	0.85
R7150:Trim5	UTSW	7	103,926,017 (GRCm39)	missense	probably damaging	0.96
R7657:Trim5	UTSW	7	103,925,884 (GRCm39)	missense	possibly damaging	0.51
R7660:Trim5	UTSW	7	103,928,569 (GRCm39)	missense	probably damaging	1.00
R7737:Trim5	UTSW	7	103,928,771 (GRCm39)	missense	probably damaging	1.00
R7821:Trim5	UTSW	7	103,927,633 (GRCm39)	missense	probably benign	0.32
R7861:Trim5	UTSW	7	103,915,675 (GRCm39)	critical splice donor site	probably null
R8167:Trim5	UTSW	7	103,927,630 (GRCm39)	missense	probably damaging	0.99
R8220:Trim5	UTSW	7	103,926,033 (GRCm39)	missense	probably damaging	0.96
R8296:Trim5	UTSW	7	103,914,993 (GRCm39)	missense	probably damaging	1.00
R8555:Trim5	UTSW	7	103,927,330 (GRCm39)	splice site	probably null
Z1088:Trim5	UTSW	7	103,915,432 (GRCm39)	missense	possibly damaging	0.85

Posted On

2014-01-21