Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01702:Krt87'

104499

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Krt87

Ensembl Gene

ENSMUSG00000047641

Gene Name

keratin 87

Synonyms

Krt2-25, Krt83

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01702

Quality Score

Status

Chromosome

Chromosomal Location

101329371-101336685 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 101389099 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 78 (T78A)

Ref Sequence

ENSEMBL: ENSMUSP00000023718 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023718]

AlphaFold

Q6IMF0

Predicted Effect

probably benign
Transcript: ENSMUST00000023718
AA Change: T78A

PolyPhen 2 Score 0.176 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000023718
Gene: ENSMUSG00000067613
AA Change: T78A

Domain	Start	End	E-Value	Type
Pfam:Keratin_2_head	2	100	5.9e-16	PFAM
Filament	103	414	7.02e-149	SMART
low complexity region	422	436	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159029

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apol7a	T	C	15: 77,273,886 (GRCm39)		probably null	Het
Asb2	C	T	12: 103,302,164 (GRCm39)	G128E	possibly damaging	Het
Atp11c	A	T	X: 59,315,263 (GRCm39)	S683T	probably damaging	Het
Brinp3	A	G	1: 146,627,735 (GRCm39)		probably benign	Het
Cpeb3	A	T	19: 37,103,782 (GRCm39)	M369K	possibly damaging	Het
Exoc5	A	T	14: 49,253,072 (GRCm39)	C580*	probably null	Het
Gm9956	A	G	10: 56,621,335 (GRCm39)			Het
Gzmk	C	T	13: 113,317,084 (GRCm39)	V32I	probably damaging	Het
Hsf4	T	C	8: 105,998,221 (GRCm39)	I129T	probably damaging	Het
Igkv1-115	T	A	6: 68,138,516 (GRCm39)	W40R	probably damaging	Het
Iqub	A	T	6: 24,500,312 (GRCm39)	M314K	probably benign	Het
Med28	T	C	5: 45,682,633 (GRCm39)	S100P	probably benign	Het
Prx	G	A	7: 27,219,212 (GRCm39)	V1238I	probably benign	Het
Ptprq	T	C	10: 107,353,727 (GRCm39)	N2263S	probably benign	Het
Rab12	A	G	17: 66,826,384 (GRCm39)	F61S	probably damaging	Het
Serpinb9d	T	C	13: 33,387,006 (GRCm39)	F358S	probably damaging	Het
Slc25a3	A	T	10: 90,953,987 (GRCm39)	Y242N	probably damaging	Het
Smtnl1	T	C	2: 84,649,034 (GRCm39)	I73M	possibly damaging	Het
Tnp1	C	A	1: 73,054,877 (GRCm39)		probably benign	Het
Trim5	T	C	7: 103,928,638 (GRCm39)	E101G	probably damaging	Het

Other mutations in Krt87

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00481:Krt87	APN	15	101,386,092 (GRCm39)	missense	probably benign	0.17
IGL00987:Krt87	APN	15	101,336,327 (GRCm39)	missense	probably benign	0.00
IGL01019:Krt87	APN	15	101,336,312 (GRCm39)	missense	possibly damaging	0.84
IGL01066:Krt87	APN	15	101,336,266 (GRCm39)	critical splice donor site	probably null
IGL01087:Krt87	APN	15	101,329,706 (GRCm39)	missense	probably benign	0.27
IGL01315:Krt87	APN	15	101,384,848 (GRCm39)	splice site	probably benign
IGL01572:Krt87	APN	15	101,334,414 (GRCm39)	missense	probably benign	0.33
IGL02123:Krt87	APN	15	101,385,466 (GRCm39)	missense	possibly damaging	0.49
IGL02353:Krt87	APN	15	101,383,339 (GRCm39)	missense	probably benign
IGL02360:Krt87	APN	15	101,383,339 (GRCm39)	missense	probably benign
IGL02395:Krt87	APN	15	101,385,833 (GRCm39)	missense	probably benign	0.18
IGL02633:Krt87	APN	15	101,389,095 (GRCm39)	missense	probably damaging	1.00
IGL02716:Krt87	APN	15	101,332,485 (GRCm39)	missense	possibly damaging	0.52
IGL03287:Krt87	APN	15	101,330,218 (GRCm39)	splice site	probably benign
R0144:Krt87	UTSW	15	101,336,542 (GRCm39)	missense	probably benign	0.04
R0357:Krt87	UTSW	15	101,384,900 (GRCm39)	missense	probably benign	0.17
R0650:Krt87	UTSW	15	101,384,921 (GRCm39)	missense	probably damaging	0.99
R0928:Krt87	UTSW	15	101,389,161 (GRCm39)	missense	probably benign	0.00
R1126:Krt87	UTSW	15	101,385,363 (GRCm39)	missense	probably damaging	0.98
R1196:Krt87	UTSW	15	101,389,314 (GRCm39)	missense	probably benign	0.03
R1252:Krt87	UTSW	15	101,385,711 (GRCm39)	missense	probably damaging	1.00
R1513:Krt87	UTSW	15	101,387,538 (GRCm39)	missense	probably benign	0.30
R1612:Krt87	UTSW	15	101,386,092 (GRCm39)	missense	probably benign	0.17
R1870:Krt87	UTSW	15	101,385,071 (GRCm39)	missense	probably benign
R2173:Krt87	UTSW	15	101,385,818 (GRCm39)	missense	probably damaging	0.98
R2196:Krt87	UTSW	15	101,336,314 (GRCm39)	missense	probably damaging	0.99
R2209:Krt87	UTSW	15	101,330,989 (GRCm39)	missense	probably benign	0.42
R2432:Krt87	UTSW	15	101,386,037 (GRCm39)	nonsense	probably null
R2568:Krt87	UTSW	15	101,385,708 (GRCm39)	missense	possibly damaging	0.67
R2696:Krt87	UTSW	15	101,384,890 (GRCm39)	missense	probably benign	0.01
R3508:Krt87	UTSW	15	101,386,039 (GRCm39)	missense	probably benign	0.04
R4364:Krt87	UTSW	15	101,385,395 (GRCm39)	missense	probably benign
R4366:Krt87	UTSW	15	101,385,395 (GRCm39)	missense	probably benign
R4606:Krt87	UTSW	15	101,384,930 (GRCm39)	missense	probably benign	0.18
R4721:Krt87	UTSW	15	101,385,863 (GRCm39)	missense	probably damaging	1.00
R4784:Krt87	UTSW	15	101,385,837 (GRCm39)	missense	probably damaging	1.00
R4987:Krt87	UTSW	15	101,384,890 (GRCm39)	missense	probably benign
R5008:Krt87	UTSW	15	101,389,105 (GRCm39)	missense	probably damaging	1.00
R5101:Krt87	UTSW	15	101,385,391 (GRCm39)	missense	probably benign	0.14
R5367:Krt87	UTSW	15	101,384,875 (GRCm39)	missense	probably damaging	1.00
R5516:Krt87	UTSW	15	101,385,002 (GRCm39)	nonsense	probably null
R5651:Krt87	UTSW	15	101,331,910 (GRCm39)	missense	possibly damaging	0.94
R5949:Krt87	UTSW	15	101,385,476 (GRCm39)	missense	probably damaging	0.99
R5972:Krt87	UTSW	15	101,385,467 (GRCm39)	missense	probably benign
R6036:Krt87	UTSW	15	101,385,412 (GRCm39)	missense	possibly damaging	0.78
R6036:Krt87	UTSW	15	101,385,412 (GRCm39)	missense	possibly damaging	0.78
R6135:Krt87	UTSW	15	101,385,415 (GRCm39)	missense	probably damaging	1.00
R6437:Krt87	UTSW	15	101,336,273 (GRCm39)	missense	possibly damaging	0.95
R6615:Krt87	UTSW	15	101,334,443 (GRCm39)	missense	probably benign	0.02
R6680:Krt87	UTSW	15	101,331,859 (GRCm39)	missense	probably damaging	1.00
R7151:Krt87	UTSW	15	101,387,529 (GRCm39)	missense	probably damaging	1.00
R7186:Krt87	UTSW	15	101,385,083 (GRCm39)	splice site	probably null
R7297:Krt87	UTSW	15	101,387,528 (GRCm39)	missense	probably benign	0.42
R7541:Krt87	UTSW	15	101,336,515 (GRCm39)	missense	probably damaging	1.00
R7617:Krt87	UTSW	15	101,336,426 (GRCm39)	missense	probably benign	0.38
R7708:Krt87	UTSW	15	101,385,813 (GRCm39)	missense	probably benign	0.00
R7796:Krt87	UTSW	15	101,383,865 (GRCm39)	missense	possibly damaging	0.95
R8172:Krt87	UTSW	15	101,383,284 (GRCm39)	missense	probably benign	0.25
R8463:Krt87	UTSW	15	101,332,506 (GRCm39)	missense	probably benign	0.05
R8669:Krt87	UTSW	15	101,385,777 (GRCm39)	missense	probably benign	0.00
R8695:Krt87	UTSW	15	101,331,901 (GRCm39)	missense	probably benign	0.00
R8771:Krt87	UTSW	15	101,385,779 (GRCm39)	missense	probably benign	0.00
R9478:Krt87	UTSW	15	101,385,449 (GRCm39)	missense	probably benign	0.06
R9489:Krt87	UTSW	15	101,336,484 (GRCm39)	nonsense	probably null
R9592:Krt87	UTSW	15	101,386,060 (GRCm39)	missense	probably benign
R9605:Krt87	UTSW	15	101,336,484 (GRCm39)	nonsense	probably null
R9629:Krt87	UTSW	15	101,389,048 (GRCm39)	missense	probably benign	0.01
R9642:Krt87	UTSW	15	101,385,074 (GRCm39)	missense	probably benign	0.00

Posted On

2014-01-21