Incidental Mutation 'IGL01707:Agbl3'
ID 104652
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Agbl3
Ensembl Gene ENSMUSG00000038836
Gene Name ATP/GTP binding protein-like 3
Synonyms Ccp3, 2900053G10Rik, 6530406M24Rik, Ccp3, 4930431N21Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01707
Quality Score
Status
Chromosome 6
Chromosomal Location 34757367-34836394 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 34816389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 766 (K766N)
Ref Sequence ENSEMBL: ENSMUSP00000110669 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115016] [ENSMUST00000115017] [ENSMUST00000148834]
AlphaFold Q8CDP0
Predicted Effect possibly damaging
Transcript: ENSMUST00000115016
AA Change: K771N

PolyPhen 2 Score 0.673 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000110668
Gene: ENSMUSG00000038836
AA Change: K771N

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Pfam:Peptidase_M14 314 563 2.7e-19 PFAM
low complexity region 614 629 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000115017
AA Change: K766N

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000110669
Gene: ENSMUSG00000038836
AA Change: K766N

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Pfam:Peptidase_M14 309 560 1e-33 PFAM
low complexity region 609 624 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000148834
SMART Domains Protein: ENSMUSP00000116066
Gene: ENSMUSG00000038836

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202017
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice for a targeted allele are viable and fertile. Mice homozygous for a knock-out allele exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 C A 19: 57,027,879 (GRCm39) R404L probably damaging Het
Acot6 C A 12: 84,147,763 (GRCm39) S6R probably benign Het
Adamtsl4 T A 3: 95,591,301 (GRCm39) Q222L probably benign Het
Adgre5 T A 8: 84,450,976 (GRCm39) T725S probably damaging Het
Ankrd12 A G 17: 66,291,273 (GRCm39) S1387P probably damaging Het
Camk2a G A 18: 61,093,122 (GRCm39) probably null Het
Cd209d T C 8: 3,928,296 (GRCm39) I30V probably benign Het
Ces1d A T 8: 93,916,178 (GRCm39) S150T possibly damaging Het
Cox4i2 T C 2: 152,598,956 (GRCm39) Y38H probably damaging Het
Csmd2 T C 4: 128,276,798 (GRCm39) Y867H possibly damaging Het
Dbh G A 2: 27,055,556 (GRCm39) C10Y probably benign Het
Dnajc13 A G 9: 104,106,178 (GRCm39) V332A probably damaging Het
Gnb3 G T 6: 124,816,652 (GRCm39) A11E possibly damaging Het
Herc2 A G 7: 55,814,935 (GRCm39) R2725G probably damaging Het
Kdm4c C T 4: 74,255,164 (GRCm39) L573F probably damaging Het
Kmt2c T A 5: 25,505,096 (GRCm39) Q3404L probably damaging Het
Mmp9 A G 2: 164,791,909 (GRCm39) H231R probably benign Het
Nphp3 A T 9: 103,895,357 (GRCm39) D371V possibly damaging Het
Nphp4 A G 4: 152,623,440 (GRCm39) I705V probably benign Het
Nutm2 A T 13: 50,623,753 (GRCm39) N150I probably damaging Het
Or51a7 T C 7: 102,615,126 (GRCm39) I273T probably damaging Het
Or51aa5 A T 7: 103,167,141 (GRCm39) I150N probably damaging Het
Phb2 A G 6: 124,690,998 (GRCm39) Q52R probably benign Het
Plekhh1 T A 12: 79,125,738 (GRCm39) V1258E probably benign Het
Pou2f1 A T 1: 165,742,685 (GRCm39) N69K probably damaging Het
Rapsn T A 2: 90,873,585 (GRCm39) M297K probably benign Het
Senp5 A C 16: 31,808,588 (GRCm39) V195G probably damaging Het
Trim25 T C 11: 88,890,517 (GRCm39) V68A probably damaging Het
Ttc41 A T 10: 86,612,631 (GRCm39) R1301S probably damaging Het
Vcan T C 13: 89,837,864 (GRCm39) Y1600C probably damaging Het
Washc5 A G 15: 59,213,864 (GRCm39) I864T possibly damaging Het
Wif1 T A 10: 120,919,890 (GRCm39) probably null Het
Zdhhc15 G A X: 103,609,422 (GRCm39) R208C probably damaging Het
Other mutations in Agbl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Agbl3 APN 6 34,823,771 (GRCm39) missense probably damaging 1.00
IGL00835:Agbl3 APN 6 34,776,667 (GRCm39) missense probably damaging 1.00
IGL00840:Agbl3 APN 6 34,776,094 (GRCm39) missense possibly damaging 0.95
IGL01090:Agbl3 APN 6 34,776,822 (GRCm39) missense probably benign 0.40
IGL01123:Agbl3 APN 6 34,823,911 (GRCm39) nonsense probably null
IGL01728:Agbl3 APN 6 34,759,092 (GRCm39) start codon destroyed probably null
IGL02335:Agbl3 APN 6 34,776,685 (GRCm39) missense probably damaging 1.00
IGL02420:Agbl3 APN 6 34,762,242 (GRCm39) missense possibly damaging 0.47
IGL02551:Agbl3 APN 6 34,800,006 (GRCm39) missense possibly damaging 0.88
IGL02974:Agbl3 APN 6 34,776,757 (GRCm39) missense probably damaging 1.00
IGL03167:Agbl3 APN 6 34,834,594 (GRCm39) missense possibly damaging 0.92
IGL03182:Agbl3 APN 6 34,780,435 (GRCm39) missense probably damaging 1.00
R0044:Agbl3 UTSW 6 34,776,834 (GRCm39) missense probably damaging 1.00
R0499:Agbl3 UTSW 6 34,816,270 (GRCm39) missense probably benign
R0639:Agbl3 UTSW 6 34,776,640 (GRCm39) missense probably damaging 1.00
R0850:Agbl3 UTSW 6 34,776,139 (GRCm39) missense probably damaging 1.00
R1004:Agbl3 UTSW 6 34,780,386 (GRCm39) missense probably damaging 0.99
R1080:Agbl3 UTSW 6 34,805,170 (GRCm39) missense probably benign 0.14
R1589:Agbl3 UTSW 6 34,834,452 (GRCm39) missense possibly damaging 0.77
R2361:Agbl3 UTSW 6 34,809,440 (GRCm39) missense possibly damaging 0.87
R2495:Agbl3 UTSW 6 34,823,699 (GRCm39) missense probably damaging 1.00
R3236:Agbl3 UTSW 6 34,800,022 (GRCm39) splice site probably null
R3237:Agbl3 UTSW 6 34,800,022 (GRCm39) splice site probably null
R3420:Agbl3 UTSW 6 34,770,900 (GRCm39) missense probably benign 0.36
R3421:Agbl3 UTSW 6 34,770,900 (GRCm39) missense probably benign 0.36
R3422:Agbl3 UTSW 6 34,770,900 (GRCm39) missense probably benign 0.36
R3810:Agbl3 UTSW 6 34,776,664 (GRCm39) missense probably damaging 1.00
R3811:Agbl3 UTSW 6 34,776,664 (GRCm39) missense probably damaging 1.00
R4059:Agbl3 UTSW 6 34,823,834 (GRCm39) missense probably damaging 1.00
R4499:Agbl3 UTSW 6 34,834,533 (GRCm39) missense probably benign 0.00
R4687:Agbl3 UTSW 6 34,775,261 (GRCm39) missense probably damaging 1.00
R4854:Agbl3 UTSW 6 34,762,219 (GRCm39) missense probably damaging 0.97
R5354:Agbl3 UTSW 6 34,791,687 (GRCm39) missense probably benign 0.03
R5386:Agbl3 UTSW 6 34,776,131 (GRCm39) missense probably damaging 1.00
R5897:Agbl3 UTSW 6 34,780,508 (GRCm39) missense probably benign 0.21
R6018:Agbl3 UTSW 6 34,776,190 (GRCm39) missense probably damaging 1.00
R6148:Agbl3 UTSW 6 34,834,688 (GRCm39) missense possibly damaging 0.87
R6305:Agbl3 UTSW 6 34,759,145 (GRCm39) missense unknown
R6525:Agbl3 UTSW 6 34,780,529 (GRCm39) nonsense probably null
R6546:Agbl3 UTSW 6 34,776,234 (GRCm39) missense probably damaging 1.00
R6743:Agbl3 UTSW 6 34,823,888 (GRCm39) missense probably benign 0.03
R6986:Agbl3 UTSW 6 34,816,387 (GRCm39) missense probably benign 0.42
R7023:Agbl3 UTSW 6 34,791,704 (GRCm39) missense probably benign 0.02
R7411:Agbl3 UTSW 6 34,791,754 (GRCm39) missense probably damaging 0.99
R7469:Agbl3 UTSW 6 34,791,349 (GRCm39) missense probably damaging 1.00
R7631:Agbl3 UTSW 6 34,834,606 (GRCm39) missense possibly damaging 0.95
R7658:Agbl3 UTSW 6 34,809,443 (GRCm39) missense probably benign 0.11
R7743:Agbl3 UTSW 6 34,823,765 (GRCm39) missense probably damaging 1.00
R7801:Agbl3 UTSW 6 34,816,300 (GRCm39) missense probably benign 0.00
R8033:Agbl3 UTSW 6 34,816,429 (GRCm39) missense possibly damaging 0.95
R8203:Agbl3 UTSW 6 34,776,414 (GRCm39) missense probably damaging 1.00
R8769:Agbl3 UTSW 6 34,834,549 (GRCm39) missense probably damaging 0.96
R9072:Agbl3 UTSW 6 34,776,387 (GRCm39) missense probably damaging 1.00
R9073:Agbl3 UTSW 6 34,776,387 (GRCm39) missense probably damaging 1.00
R9210:Agbl3 UTSW 6 34,775,177 (GRCm39) missense probably damaging 0.98
R9255:Agbl3 UTSW 6 34,789,840 (GRCm39) missense probably damaging 1.00
R9536:Agbl3 UTSW 6 34,823,861 (GRCm39) missense probably benign
R9560:Agbl3 UTSW 6 34,823,843 (GRCm39) missense possibly damaging 0.94
R9662:Agbl3 UTSW 6 34,809,468 (GRCm39) nonsense probably null
RF014:Agbl3 UTSW 6 34,776,293 (GRCm39) missense possibly damaging 0.53
Z1177:Agbl3 UTSW 6 34,776,343 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21