Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01710:Gstt2'

104775

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gstt2

Ensembl Gene

ENSMUSG00000033318

Gene Name

glutathione S-transferase, theta 2

Synonyms

Yrs, mGSTT2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01710

Quality Score

Status

Chromosome

Chromosomal Location

75667676-75673253 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 75669579 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151239 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038257] [ENSMUST00000218500] [ENSMUST00000220195] [ENSMUST00000220440]

AlphaFold

Q61133

Predicted Effect

probably benign
Transcript: ENSMUST00000038257

SMART Domains

Protein: ENSMUSP00000046324
Gene: ENSMUSG00000033318

Domain	Start	End	E-Value	Type
Pfam:GST_N	1	76	4.6e-12	PFAM
Pfam:GST_N_3	5	84	1.4e-11	PFAM
Pfam:GST_N_2	11	77	3.5e-10	PFAM
Pfam:GST_C	73	199	1.5e-10	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218034

Predicted Effect

probably benign
Transcript: ENSMUST00000218500

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218646

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218745

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219343

Predicted Effect

probably benign
Transcript: ENSMUST00000220195

Predicted Effect

probably benign
Transcript: ENSMUST00000220440

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a disruption in this gene display a normal phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim3	G	A	18: 62,004,645 (GRCm39)	T48I	probably damaging	Het
Ccpg1	T	C	9: 72,904,723 (GRCm39)		probably benign	Het
Chkb	G	A	15: 89,310,843 (GRCm39)	Q379*	probably null	Het
Chst15	T	A	7: 131,872,236 (GRCm39)	D15V	probably benign	Het
Cntn4	G	A	6: 106,527,392 (GRCm39)	V425I	possibly damaging	Het
Cpa6	T	A	1: 10,395,497 (GRCm39)	N390I	probably damaging	Het
Efhd2	A	G	4: 141,587,872 (GRCm39)	F193S	probably damaging	Het
Ell3	T	C	2: 121,271,993 (GRCm39)	H128R	probably damaging	Het
Ercc5	T	G	1: 44,203,235 (GRCm39)	L291V	probably damaging	Het
Eva1c	A	G	16: 90,701,235 (GRCm39)	Y302C	probably damaging	Het
Fmo3	A	C	1: 162,810,612 (GRCm39)	L26R	probably damaging	Het
Galntl6	T	A	8: 58,989,002 (GRCm39)	D17V	probably damaging	Het
Gm6483	C	T	8: 19,741,629 (GRCm39)	P55S	probably damaging	Het
Hmcn2	T	A	2: 31,233,114 (GRCm39)	L221Q	probably damaging	Het
Hoxa3	T	C	6: 52,147,554 (GRCm39)		probably benign	Het
Kctd12b	T	C	X: 152,472,479 (GRCm39)	D70G	probably damaging	Het
Kdm7a	T	A	6: 39,152,320 (GRCm39)	E125D	probably benign	Het
Klk1b21	T	A	7: 43,755,919 (GRCm39)	F249L	probably benign	Het
Mrpl41	T	C	2: 24,864,429 (GRCm39)	D81G	possibly damaging	Het
Nomo1	T	A	7: 45,687,980 (GRCm39)	L82Q	probably damaging	Het
Or5p58	G	T	7: 107,694,449 (GRCm39)	F109L	probably benign	Het
Papolg	A	T	11: 23,814,026 (GRCm39)	S718T	probably damaging	Het
Pex6	A	G	17: 47,036,252 (GRCm39)		probably benign	Het
Pi4k2a	T	A	19: 42,093,418 (GRCm39)	L253Q	probably damaging	Het
Prdx6b	T	A	2: 80,123,490 (GRCm39)	F100I	probably damaging	Het
Prr36	G	A	8: 4,265,243 (GRCm39)	P169L	probably damaging	Het
Ptgfrn	T	C	3: 100,980,404 (GRCm39)	E312G	probably damaging	Het
Rasgrf1	A	G	9: 89,873,745 (GRCm39)	I685V	probably benign	Het
Setdb1	T	C	3: 95,246,164 (GRCm39)	E586G	probably damaging	Het
Sez6l2	C	A	7: 126,567,388 (GRCm39)	T841K	probably damaging	Het
Slc25a17	A	T	15: 81,211,527 (GRCm39)	L163*	probably null	Het
Slc35f3	A	T	8: 127,115,900 (GRCm39)	I276F	probably benign	Het
Tcerg1l	T	A	7: 137,996,789 (GRCm39)	K149N	possibly damaging	Het
Tex28	T	A	X: 73,195,939 (GRCm39)	K278*	probably null	Het
Tmprss9	A	G	10: 80,733,793 (GRCm39)		probably benign	Het
Tnfaip8l1	A	G	17: 56,478,782 (GRCm39)	K24R	probably benign	Het
Trim36	T	C	18: 46,321,455 (GRCm39)		probably benign	Het
Uba1	C	T	X: 20,537,604 (GRCm39)	T274I	possibly damaging	Het
Ubr2	T	C	17: 47,254,335 (GRCm39)	T1439A	probably benign	Het
Ubr4	A	G	4: 139,145,772 (GRCm39)	D1523G	possibly damaging	Het
Uchl4	A	T	9: 64,142,788 (GRCm39)	T90S	probably benign	Het

Other mutations in Gstt2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01571:Gstt2	APN	10	75,670,005 (GRCm39)	splice site	probably benign
IGL02642:Gstt2	APN	10	75,668,652 (GRCm39)	missense	probably benign	0.17
IGL03375:Gstt2	APN	10	75,668,655 (GRCm39)	splice site	probably null
R0389:Gstt2	UTSW	10	75,668,266 (GRCm39)	missense	probably damaging	1.00
R1751:Gstt2	UTSW	10	75,670,098 (GRCm39)	missense	probably damaging	1.00
R1767:Gstt2	UTSW	10	75,670,098 (GRCm39)	missense	probably damaging	1.00
R1971:Gstt2	UTSW	10	75,668,499 (GRCm39)	missense	probably benign	0.10
R2367:Gstt2	UTSW	10	75,668,524 (GRCm39)	missense	probably benign	0.44
R5027:Gstt2	UTSW	10	75,667,726 (GRCm39)	missense	probably damaging	0.99
R7457:Gstt2	UTSW	10	75,668,354 (GRCm39)	missense	probably damaging	1.00
R7579:Gstt2	UTSW	10	75,670,019 (GRCm39)	missense	probably benign	0.00
R7910:Gstt2	UTSW	10	75,667,736 (GRCm39)	missense	probably benign	0.25
R7912:Gstt2	UTSW	10	75,668,418 (GRCm39)	missense	probably benign	0.27
R8282:Gstt2	UTSW	10	75,668,291 (GRCm39)	missense	probably benign	0.00
R8348:Gstt2	UTSW	10	75,668,526 (GRCm39)	missense	probably damaging	0.98
R8448:Gstt2	UTSW	10	75,668,526 (GRCm39)	missense	probably damaging	0.98
R8488:Gstt2	UTSW	10	75,667,823 (GRCm39)	missense	possibly damaging	0.69
R9259:Gstt2	UTSW	10	75,669,511 (GRCm39)	missense	possibly damaging	0.77
R9261:Gstt2	UTSW	10	75,669,511 (GRCm39)	missense	possibly damaging	0.77

Posted On

2014-01-21