Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01712:Tex16'

104831

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex16

Ensembl Gene

ENSMUSG00000034555

Gene Name

testis expressed gene 16

Synonyms

4933403O08Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL01712

Quality Score

Status

Chromosome

Chromosomal Location

110804655-111159053 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 111003451 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 87 (S87P)

Ref Sequence

ENSEMBL: ENSMUSP00000118847 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038546] [ENSMUST00000130247] [ENSMUST00000207962]

AlphaFold

A2RT18

Predicted Effect

probably damaging
Transcript: ENSMUST00000038546
AA Change: S76P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000048187
Gene: ENSMUSG00000034555
AA Change: S76P

Domain	Start	End	E-Value	Type
low complexity region	1	12	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
low complexity region	616	669	N/A	INTRINSIC
low complexity region	674	699	N/A	INTRINSIC
low complexity region	811	824	N/A	INTRINSIC
low complexity region	833	850	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000130247
AA Change: S87P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000118847
Gene: ENSMUSG00000034555
AA Change: S87P

Domain	Start	End	E-Value	Type
low complexity region	10	24	N/A	INTRINSIC
low complexity region	121	133	N/A	INTRINSIC
low complexity region	627	680	N/A	INTRINSIC
low complexity region	685	710	N/A	INTRINSIC
low complexity region	822	835	N/A	INTRINSIC
low complexity region	844	861	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000131304

Predicted Effect

probably benign
Transcript: ENSMUST00000207962

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2fm3	T	A	3: 59,776,321 (GRCm39)	I164N	possibly damaging	Het
Adgrb3	A	G	1: 25,865,360 (GRCm39)	V161A	probably benign	Het
Arhgdib	G	A	6: 136,901,195 (GRCm39)	T178M	probably damaging	Het
Atp11a	T	A	8: 12,901,138 (GRCm39)	I989K	probably benign	Het
Bcam	T	C	7: 19,492,692 (GRCm39)	S498G	probably damaging	Het
Bcas3	A	G	11: 85,471,874 (GRCm39)	I728V	probably damaging	Het
Cep57	G	T	9: 13,724,713 (GRCm39)	P119Q	possibly damaging	Het
Cimip2a	T	C	2: 25,108,804 (GRCm39)		probably benign	Het
Clip4	T	A	17: 72,106,036 (GRCm39)	I73N	probably damaging	Het
Cpa4	A	G	6: 30,590,815 (GRCm39)	D371G	possibly damaging	Het
Dnah7a	A	G	1: 53,462,429 (GRCm39)	S3721P	probably benign	Het
Fcrla	T	C	1: 170,749,192 (GRCm39)		probably null	Het
Foxg1	T	C	12: 49,432,403 (GRCm39)	S379P	possibly damaging	Het
Gatm	T	A	2: 122,431,306 (GRCm39)	Y227F	possibly damaging	Het
Grid2	A	T	6: 64,642,899 (GRCm39)	D887V	possibly damaging	Het
Gtpbp6	A	T	5: 110,252,245 (GRCm39)	I429N	probably benign	Het
Ighmbp2	A	G	19: 3,323,038 (GRCm39)		probably benign	Het
Irs4	T	C	X: 140,505,395 (GRCm39)	N934D	unknown	Het
Kif16b	T	A	2: 142,490,391 (GRCm39)	N1257I	probably damaging	Het
L1cam	T	C	X: 72,908,044 (GRCm39)	Y169C	probably damaging	Het
L3mbtl3	A	T	10: 26,152,133 (GRCm39)	M821K	probably damaging	Het
Lig3	A	G	11: 82,680,367 (GRCm39)		probably benign	Het
Lpin2	T	A	17: 71,522,063 (GRCm39)	D32E	probably damaging	Het
Mcoln3	T	C	3: 145,834,019 (GRCm39)		probably benign	Het
Mgst2	T	C	3: 51,571,992 (GRCm39)	V40A	probably damaging	Het
Mov10l1	T	C	15: 88,908,969 (GRCm39)	S997P	probably damaging	Het
Mycbpap	G	T	11: 94,403,481 (GRCm39)	H187Q	possibly damaging	Het
Onecut2	T	A	18: 64,519,673 (GRCm39)	S478T	probably damaging	Het
Or2n1d	A	T	17: 38,646,848 (GRCm39)	T267S	probably benign	Het
Or52h7	T	C	7: 104,214,226 (GRCm39)	V266A	probably benign	Het
Pcdhb5	A	T	18: 37,454,306 (GRCm39)	I229F	probably damaging	Het
Pfas	A	G	11: 68,881,886 (GRCm39)	V933A	probably benign	Het
Phldb2	A	T	16: 45,571,792 (GRCm39)	I1200N	probably damaging	Het
Pla2g4e	C	A	2: 120,019,884 (GRCm39)		probably null	Het
Prr36	G	A	8: 4,265,243 (GRCm39)	P169L	probably damaging	Het
Rhot2	A	G	17: 26,060,334 (GRCm39)		probably null	Het
Serpina3f	C	T	12: 104,184,657 (GRCm39)	P267L	probably damaging	Het
Sppl2a	C	T	2: 126,746,823 (GRCm39)		probably benign	Het
Tas2r122	A	T	6: 132,688,725 (GRCm39)	M56K	possibly damaging	Het
Tbxas1	A	G	6: 39,057,994 (GRCm39)	T450A	probably benign	Het
Them7	T	A	2: 105,209,230 (GRCm39)	F183L	possibly damaging	Het
Tmbim7	A	G	5: 3,720,074 (GRCm39)	T116A	probably damaging	Het
Tomm40	G	T	7: 19,437,288 (GRCm39)	S224R	probably benign	Het
Top3a	A	T	11: 60,652,562 (GRCm39)	I84N	probably damaging	Het
Vmn1r28	A	G	6: 58,242,393 (GRCm39)	T79A	probably benign	Het
Vmn2r61	A	T	7: 41,909,661 (GRCm39)	Y62F	probably damaging	Het
Zbtb42	T	C	12: 112,646,718 (GRCm39)	C298R	probably benign	Het
Zfp395	G	A	14: 65,623,836 (GRCm39)	E102K	probably damaging	Het

Other mutations in Tex16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02576:Tex16	APN	X	111,028,653 (GRCm39)	missense	probably benign	0.07
IGL03261:Tex16	APN	X	111,028,552 (GRCm39)	missense	possibly damaging	0.90
R1766:Tex16	UTSW	X	111,150,782 (GRCm39)	missense	probably benign	0.02
R2274:Tex16	UTSW	X	111,030,838 (GRCm39)	missense	probably damaging	0.98
R3607:Tex16	UTSW	X	111,003,667 (GRCm39)	missense	probably damaging	1.00
R3794:Tex16	UTSW	X	111,150,375 (GRCm39)	start codon destroyed	probably null	0.27
R4209:Tex16	UTSW	X	111,030,640 (GRCm39)	missense	probably benign	0.01
R4210:Tex16	UTSW	X	111,030,640 (GRCm39)	missense	probably benign	0.01
U24488:Tex16	UTSW	X	111,028,815 (GRCm39)	missense	probably benign	0.05
Z1176:Tex16	UTSW	X	111,151,010 (GRCm39)	missense	probably benign	0.36

Posted On

2014-01-21