Incidental Mutation 'IGL01712:Irs4'
ID104835
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Irs4
Ensembl Gene ENSMUSG00000054667
Gene Nameinsulin receptor substrate 4
SynonymsIRS-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #IGL01712
Quality Score
Status
ChromosomeX
Chromosomal Location141710998-141725263 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 141722399 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Aspartic acid at position 934 (N934D)
Ref Sequence ENSEMBL: ENSMUSP00000067085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067841]
Predicted Effect unknown
Transcript: ENSMUST00000067841
AA Change: N934D
SMART Domains Protein: ENSMUSP00000067085
Gene: ENSMUSG00000054667
AA Change: N934D

DomainStartEndE-ValueType
low complexity region 11 29 N/A INTRINSIC
low complexity region 63 73 N/A INTRINSIC
PH 80 202 7.95e-8 SMART
low complexity region 211 230 N/A INTRINSIC
IRS 232 334 2.16e-33 SMART
PTBI 232 334 2.11e-56 SMART
low complexity region 351 375 N/A INTRINSIC
low complexity region 397 432 N/A INTRINSIC
low complexity region 487 584 N/A INTRINSIC
low complexity region 595 624 N/A INTRINSIC
low complexity region 720 735 N/A INTRINSIC
low complexity region 736 751 N/A INTRINSIC
low complexity region 773 796 N/A INTRINSIC
low complexity region 1040 1060 N/A INTRINSIC
low complexity region 1082 1113 N/A INTRINSIC
low complexity region 1169 1179 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139874
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for a targeted null mutation exhibit a 10% reduction in male adult size, slightly impaired oral glucose tolerance, and decreased reproductive ability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 A G 1: 25,826,279 V161A probably benign Het
Arhgdib G A 6: 136,924,197 T178M probably damaging Het
Atp11a T A 8: 12,851,138 I989K probably benign Het
Bcam T C 7: 19,758,767 S498G probably damaging Het
Bcas3 A G 11: 85,581,048 I728V probably damaging Het
Cep57 G T 9: 13,813,417 P119Q possibly damaging Het
Clip4 T A 17: 71,799,041 I73N probably damaging Het
Cpa4 A G 6: 30,590,816 D371G possibly damaging Het
Dnah7a A G 1: 53,423,270 S3721P probably benign Het
Fam166a T C 2: 25,218,792 probably benign Het
Fcrla T C 1: 170,921,623 probably null Het
Foxg1 T C 12: 49,385,620 S379P possibly damaging Het
Gatm T A 2: 122,600,825 Y227F possibly damaging Het
Gm8298 T A 3: 59,868,900 I164N possibly damaging Het
Grid2 A T 6: 64,665,915 D887V possibly damaging Het
Gtpbp6 A T 5: 110,104,379 I429N probably benign Het
Ighmbp2 A G 19: 3,273,038 probably benign Het
Kif16b T A 2: 142,648,471 N1257I probably damaging Het
L1cam T C X: 73,864,438 Y169C probably damaging Het
L3mbtl3 A T 10: 26,276,235 M821K probably damaging Het
Lig3 A G 11: 82,789,541 probably benign Het
Lpin2 T A 17: 71,215,068 D32E probably damaging Het
Mcoln3 T C 3: 146,128,264 probably benign Het
Mgst2 T C 3: 51,664,571 V40A probably damaging Het
Mov10l1 T C 15: 89,024,766 S997P probably damaging Het
Mycbpap G T 11: 94,512,655 H187Q possibly damaging Het
Olfr136 A T 17: 38,335,957 T267S probably benign Het
Olfr652 T C 7: 104,565,019 V266A probably benign Het
Onecut2 T A 18: 64,386,602 S478T probably damaging Het
Pcdhb5 A T 18: 37,321,253 I229F probably damaging Het
Pfas A G 11: 68,991,060 V933A probably benign Het
Phldb2 A T 16: 45,751,429 I1200N probably damaging Het
Pla2g4e C A 2: 120,189,403 probably null Het
Prr36 G A 8: 4,215,243 P169L probably damaging Het
Rhot2 A G 17: 25,841,360 probably null Het
Serpina3f C T 12: 104,218,398 P267L probably damaging Het
Sppl2a C T 2: 126,904,903 probably benign Het
Tas2r122 A T 6: 132,711,762 M56K possibly damaging Het
Tbxas1 A G 6: 39,081,060 T450A probably benign Het
Tex16 T C X: 112,093,754 S87P probably damaging Het
Them7 T A 2: 105,378,885 F183L possibly damaging Het
Tmbim7 A G 5: 3,670,074 T116A probably damaging Het
Tomm40 G T 7: 19,703,363 S224R probably benign Het
Top3a A T 11: 60,761,736 I84N probably damaging Het
Vmn1r28 A G 6: 58,265,408 T79A probably benign Het
Vmn2r61 A T 7: 42,260,237 Y62F probably damaging Het
Zbtb42 T C 12: 112,680,284 C298R probably benign Het
Zfp395 G A 14: 65,386,387 E102K probably damaging Het
Other mutations in Irs4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00940:Irs4 APN X 141722144 missense unknown
IGL02366:Irs4 APN X 141723904 missense probably damaging 0.99
IGL03032:Irs4 APN X 141722798 missense unknown
IGL03057:Irs4 APN X 141722528 missense unknown
R0603:Irs4 UTSW X 141725075 missense probably damaging 0.97
R2846:Irs4 UTSW X 141724340 missense probably damaging 1.00
R3858:Irs4 UTSW X 141724063 missense probably damaging 1.00
Posted On2014-01-21