Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01713:Igkv12-89'

104869

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igkv12-89

Ensembl Gene

ENSMUSG00000076534

Gene Name

immunoglobulin kappa chain variable 12-89

Synonyms

Gm16905

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

IGL01713

Quality Score

Status

Chromosome

Chromosomal Location

68811830-68812291 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to T at 68812296 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143728 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103335] [ENSMUST00000199143]

AlphaFold

A0A075B5L4

Predicted Effect

probably benign
Transcript: ENSMUST00000103335

SMART Domains

Protein: ENSMUSP00000100136
Gene: ENSMUSG00000076534

Domain	Start	End	E-Value	Type
IGv	34	106	2.62e-16	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000199143

SMART Domains

Protein: ENSMUSP00000143728
Gene: ENSMUSG00000076534

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
IGv	35	107	1.1e-18	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402N03Rik	A	G	7: 130,740,772 (GRCm39)	I148T	possibly damaging	Het
Aipl1	A	G	11: 71,927,449 (GRCm39)	C89R	probably damaging	Het
Apaf1	G	A	10: 90,897,694 (GRCm39)		probably benign	Het
Atp7b	A	G	8: 22,518,589 (GRCm39)	V83A	probably damaging	Het
Ccdc180	G	T	4: 45,921,025 (GRCm39)		probably null	Het
Crebbp	T	C	16: 3,946,512 (GRCm39)	I418V	possibly damaging	Het
Cyp26b1	G	A	6: 84,551,283 (GRCm39)	P427L	probably benign	Het
Dnal4	A	G	15: 79,646,606 (GRCm39)	Y92H	probably damaging	Het
Dpy19l1	C	T	9: 24,396,365 (GRCm39)	R117Q	probably damaging	Het
Epha3	G	A	16: 63,372,925 (GRCm39)	T926I	probably benign	Het
Fgg	T	C	3: 82,915,723 (GRCm39)	S55P	probably benign	Het
Gosr1	A	T	11: 76,645,582 (GRCm39)	M66K	probably benign	Het
Map3k12	T	C	15: 102,410,756 (GRCm39)	E451G	probably damaging	Het
Phkg1	T	C	5: 129,895,714 (GRCm39)	E179G	probably benign	Het
Pnpla1	A	T	17: 29,100,579 (GRCm39)	D482V	possibly damaging	Het
Pramel1	T	C	4: 143,123,652 (GRCm39)	V109A	probably benign	Het
Prr36	G	A	8: 4,265,243 (GRCm39)	P169L	probably damaging	Het
Pus7l	T	C	15: 94,429,493 (GRCm39)	T442A	probably benign	Het
Sall3	A	G	18: 81,013,062 (GRCm39)	S1125P	probably damaging	Het
Scyl2	A	C	10: 89,490,087 (GRCm39)	I150S	probably damaging	Het
Sf1	T	A	19: 6,424,319 (GRCm39)		probably null	Het
Slco1a6	A	G	6: 142,032,293 (GRCm39)	S611P	possibly damaging	Het
Vmn2r103	G	T	17: 20,014,330 (GRCm39)	C374F	probably damaging	Het
Xntrpc	T	C	7: 101,733,059 (GRCm39)		probably benign	Het

Other mutations in Igkv12-89

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01150:Igkv12-89	APN	6	68,812,127 (GRCm39)	missense	probably benign	0.00
IGL02364:Igkv12-89	APN	6	68,811,970 (GRCm39)	nonsense	probably null
FR4449:Igkv12-89	UTSW	6	68,812,264 (GRCm39)	small insertion	probably benign
R7110:Igkv12-89	UTSW	6	68,812,115 (GRCm39)	missense	probably damaging	1.00
R7283:Igkv12-89	UTSW	6	68,812,061 (GRCm39)	missense	probably damaging	1.00
R7637:Igkv12-89	UTSW	6	68,812,083 (GRCm39)	missense	probably benign	0.26
RF014:Igkv12-89	UTSW	6	68,812,270 (GRCm39)	small insertion	probably benign
RF042:Igkv12-89	UTSW	6	68,812,270 (GRCm39)	small insertion	probably benign

Posted On

2014-01-21